Optimisations and challenges involved in the creation of various bioluminescent and fluorescent influenza a virus strains for in vitro and in vivo applications

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Spronken, Monique I ^a   Short, Kirsty R ^a,b   Herfst, Sander ^a   Bestebroer, Theo M ^a   Vaes, Vincent P ^a   Van Der Hoeven, Barbara ^c   Koster, Abraham J ^c   Kremers, Gert Jan ^a   Scott, Dana P ^d   Gultyaev, Alexander P ^a,e   Sorell, Erin M ^a,f   De Graaf, Miranda ^a   Barcena, Montserrat ^c   Rimmelzwaan, Guus F ^a   Fouchier, Ron A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e LEIDEN UNIVERSITY   (Netherlands)

^f GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; FIREFLY LUCIFERASE; FLUORESCENT DYE; NEAR INFRARED FLUORESCENT PROTEIN; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; PA PROTEIN, INFLUENZA VIRUSES; PHOTOPROTEIN; RECOMBINANT PROTEIN; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL LABELING; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A; INFLUENZA A VIRUS; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; REPORTER GENE; VIRUS ATTENUATION; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; COMPARATIVE STUDY; DOG; FLUORESCENCE; GENETIC ENGINEERING; GENETICS; HUMAN; INTRAVITAL MICROSCOPY; LUMINESCENCE; LUNG; MDCK CELL LINE; MUTATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; PROCEDURES; PROMOTER REGION; SATELLITE VIRUS; TRANSGENIC ORGANISM; ULTRASTRUCTURE; VERY ELDERLY; VIROLOGY; VIRUS LOAD;

AGED, 80 AND OVER; ANIMALS; DEFECTIVE VIRUSES; DOGS; FEMALE; FLUORESCENCE; GENES, REPORTER; GENETIC ENGINEERING; HUMANS; IN VITRO TECHNIQUES; INFLUENZA A VIRUS; INTRAVITAL MICROSCOPY; LUMINESCENT MEASUREMENTS; LUMINESCENT PROTEINS; LUNG; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; MUTATION; ORGANISMS, GENETICALLY MODIFIED; ORTHOMYXOVIRIDAE INFECTIONS; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; RNA REPLICASE; VIRAL LOAD; VIRAL PROTEINS; VIROLOGY; VIRUS REPLICATION;

EID: 84942134200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133888     Document Type: Article

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