Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

Nature Communications

Volumn 6, Issue , 2015, Pages

  Fukuyama, Satoshi ^a,b   Katsura, Hiroaki ^b   Zhao, Dongming ^a,b   Ozawa, Makoto ^c   Ando, Tomomi ^a,b   Shoemaker, Jason E ^a,b   Ishikawa, Izumi ^a,b   Yamada, Shinya ^b   Neumann, Gabriele ^d   Watanabe, Shinji ^a,e   Kitano, Hiroaki ^a,f,g,h   Kawaoka, Yoshihiro ^a,b,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF MIYAZAKI   (Japan)

^f Systems Biology Institute   (Japan)

^g SONY COMPUTER SCIENCE LABORATORIES INC   (Japan)

^h OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; VIRUS PROTEIN; BACTERIAL PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; PHOTOPROTEIN; RED FLUORESCENT PROTEIN; VIRAL PROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

AVIAN INFLUENZA; EPIDEMIC; FLUORESCENCE; GENE EXPRESSION; PATHOLOGY; PROTEIN; PUBLIC HEALTH; RODENT; VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; IN VIVO STUDY; INFLUENZA VIRUS; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; VIRUS EXPRESSION; VIRUS PATHOGENESIS; ANIMAL; C57BL MOUSE; GENE FUSION; GENETICS; INFLUENZA A VIRUS (H1N1); LUNG; ORTHOMYXOVIRUS INFECTION; REPORTER GENE; VIROLOGY; VIRUS REPLICATION;

ANIMALIA; AVES; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

ANIMALS; ARTIFICIAL GENE FUSION; BACTERIAL PROTEINS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; INFLUENZA A VIRUS, H1N1 SUBTYPE; LUMINESCENT PROTEINS; LUNG; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84925711188     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7600     Document Type: Article

References (38)

1. Wright, P. F., Neumann, G. & Kawaoka, Y. Orthomyxoviruses, Fields Virology 6th edn, Vol. 1 (eds Knipe, D. M. & Howley, P. M.) 1186-1243 (Lippincott Williams & Wiilkins, 2013).
2. Watanabe, T. et al. Characterization of H7N9 influenza A viruses isolated from humans. Nature 501, 551-555 (2013).
3. Zhang, Q. et al. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science 341, 410-414 (2013).
4. Yu, W. C. et al. Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses. J. Virol. 85, 6844-6855 (2011).
5. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
6. Pichlmair, A. et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 314, 997-1001 (2006).
7. Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644-658 (2006).
8. Garcia-Sastre, A. Induction and evasion of type I interferon responses by influenza viruses. Virus Res. 162, 12-18 (2011).
9. Herold, S. et al. Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. J. Exp. Med. 205, 3065-3077 (2008).
10. Perrone, L. A., Plowden, J. K., Garcia-Sastre, A., Katz, J. M. & Tumpey, T. M. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS. Pathog. 4, e1000115 (2008).
11. Fukuyama, S. & Kawaoka, Y. The pathogenesis of influenza virus infections: the contributions of virus and host factors. Curr. Opin. Immunol. 23, 481-486 (2011).
12. Kittel, C. et al. Rescue of influenza virus expressing GFP from the NS1 reading frame. Virology 324, 67-73 (2004).
13. Shinya, K., Fujii, Y., Ito, H., Ito, T. & Kawaoka, Y. Characterization of a neuraminidase-deficient influenza a virus as a potential gene delivery vector and a live vaccine. J. Virol. 78, 3083-3088 (2004).
14. Manicassamy, B. et al. Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus. Proc. Natl Acad. Sci. USA 107, 11531-11536 (2010).
15. Helft, J. et al. Cross-presenting CD103\+ dendritic cells are protected from influenza virus infection. J. Clin. Invest. 122, 4037-4047 (2012).
16. Nagai, T. et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat. Biotechnol. 20, 87-90 (2002).
17. Patterson, G., Day, R. N. & Piston, D. Fluorescent protein spectra. J. Cell Sci. 114, 837-838 (2001).
18. Shaner, N. C. et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572 (2004).
19. Go, J. T. et al. (2009pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models. BMC Genomics 13, 627 (2012).
20. Zhao, D. et al. Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses. Proteomics 12, 1970-1982 (2012).
21. Salomon, R. et al. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J. Exp. Med. 203, 689-697 (2006).
22. Hatta, M. et al. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS. Pathog. 3, 1374-1379 (2007).
23. Weissleder, R. A clearer vision for in vivo imaging. Nat. Biotechnol. 19, 316-317 (2001).
24. Jobsis, F. F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198, 1264-1267 (1977).
25. Tran, V., Moser, L. A., Poole, D. S. & Mehle, A. Highly sensitive real-time in vivo imaging of an influenza reporter virus reveals dynamics of replication and spread. J. Virol. 87, 13321-13329 (2013).
26. Pan, W. et al. Visualizing influenza virus infection in living mice. Nat. Commun. 4, 2369 (2013).
27. Heaton, N. S. et al. In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies. J. Virol. 87, 8272-8281 (2013).
28. Ghaznavi, F., Evans, A., Madabhushi, A. & Feldman, M. Digital imaging in pathology: whole-slide imaging and beyond. Annu. Rev. Pathol. 8, 331-359 (2013).
29. Scholtissek, C., Rohde, W., Von Hoyningen, V. & Rott, R. On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology 87, 13-20 (1978).
30. Kawaoka, Y., Krauss, S. & Webster, R. G. Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J. Virol. 63, 4603-4608 (1989).
31. Smith, G. J. et al. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459, 1122-1125 (2009).
32. Itoh, Y. et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460, 1021-1025 (2009).
33. Gambotto, A., Barratt-Boyes, S. M., de Jong, M. D., Neumann, G. & Kawaoka, Y. Human infection with highly pathogenic H5N1 influenza virus. Lancet 371, 1464-1475 (2008).
34. Shieh, W. J. et al. (2009 Pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am. J. Pathol. 177, 166-175 (2010).
35. Basler, C. F. et al. Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc. Natl Acad. Sci. USA 98, 2746-2751 (2001).
36. Neumann, G. et al. Generation of influenza A viruses entirely from cloned cDNAs. Proc. Natl Acad. Sci. USA 96, 9345-9350 (1999).
37. Smyth, G. K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article3 (2004).
38. Kaimal, V., Bardes, E. E., Tabar, S. C., Jegga, A. G. & Aronow, B. J. ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res. 38, W96-W102 (2010).