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Volumn 5, Issue , 2015, Pages

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Author keywords

[No Author keywords available]

Indexed keywords

CPG-OLIGONUCLEOTIDE; CYTOKINE; IMMUNOLOGICAL ADJUVANT; NANOPARTICLE; OLIGODEOXYRIBONUCLEOTIDE;

EID: 84942133028     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14274     Document Type: Article
Times cited : (40)

References (56)
  • 1
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larché, M., Akdis, C. A. & Valenta, R. Immunological mechanisms of allergen-specific immunotherapy. Nat. Rev. Immunol. 6, 761-771 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 761-771
    • Larché, M.1    Akdis, C.A.2    Valenta, R.3
  • 2
    • 0033604657 scopus 로고    scopus 로고
    • The role of allergy in the development of asthma
    • Holt, P. G., Macaubas, C., Stumbles, P. A. & Sly, P. D. The role of allergy in the development of asthma. Nature 402, B12-17 (1999).
    • (1999) Nature , vol.402 , pp. B12-17
    • Holt, P.G.1    Macaubas, C.2    Stumbles, P.A.3    Sly, P.D.4
  • 4
    • 33748790719 scopus 로고    scopus 로고
    • TLR9-based immunotherapy for allergic disease
    • Hayashi, T. & Raz, E. TLR9-based immunotherapy for allergic disease. Am. J. Med. 119, 897.e891-897.e896 (2006).
    • (2006) Am. J. Med. , vol.119 , pp. 897e891-897e896
    • Hayashi, T.1    Raz, E.2
  • 5
    • 33750341074 scopus 로고    scopus 로고
    • Novel vaccines and adjuvants for allergen-specific immunotherapy
    • Crameri, R. & Rhyner, C. Novel vaccines and adjuvants for allergen-specific immunotherapy. Curr. Opin. Immunol. 18, 761-768 (2006).
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 761-768
    • Crameri, R.1    Rhyner, C.2
  • 6
    • 84904318420 scopus 로고    scopus 로고
    • Immunotherapy of type-1 allergies with virus-like particles and CpGmotifs
    • Klimek, L., Bachmann, M. F., Senti, G. & Kündig, T. M. Immunotherapy of type-1 allergies with virus-like particles and CpGmotifs. Expert Rev. Clin. Immunol. 10, 1059-1067 (2014).
    • (2014) Expert Rev. Clin. Immunol. , vol.10 , pp. 1059-1067
    • Klimek, L.1    Bachmann, M.F.2    Senti, G.3    Kündig, T.M.4
  • 7
    • 84859489110 scopus 로고    scopus 로고
    • CpG still rocks! Update on an accidental drug
    • Krieg, A. M. CpG still rocks! Update on an accidental drug. Nucleic Acid Ther. 22, 77-89 (2012).
    • (2012) Nucleic Acid Ther. , vol.22 , pp. 77-89
    • Krieg, A.M.1
  • 8
    • 33749436870 scopus 로고    scopus 로고
    • Immunotherapy with a ragweed-Toll-like receptor 9 agonist vaccine for allergic rhinitis
    • Creticos, P. S. et al. Immunotherapy with a ragweed-Toll-like receptor 9 agonist vaccine for allergic rhinitis. N. Engl. J. Med. 335, 1445 (2006).
    • (2006) N. Engl. J. Med. , vol.335 , pp. 1445
    • Creticos, P.S.1
  • 9
    • 84861167204 scopus 로고    scopus 로고
    • TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen
    • Reuter, S. et al. TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen. J. Immunol. 188, 5123-5131 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 5123-5131
    • Reuter, S.1
  • 10
    • 61749093073 scopus 로고    scopus 로고
    • Use of CpG oligonucleotides in treatment of asthma and allergic disease
    • Fonseca, D. E. & Kline, J. N. Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv. Drug Deliver. Rev. 61, 256-262 (2009).
    • (2009) Adv. Drug Deliver. Rev. , vol.61 , pp. 256-262
    • Fonseca, D.E.1    Kline, J.N.2
  • 11
    • 0035005506 scopus 로고    scopus 로고
    • CpG oligonucleotide modulation of allergic inflammation
    • Wild, J. S. & Sur, S. CpG oligonucleotide modulation of allergic inflammation. Allergy 56, 365-376 (2001).
    • (2001) Allergy , vol.56 , pp. 365-376
    • Wild, J.S.1    Sur, S.2
  • 12
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • Weiner, G., Liu, H., Wooldridge, J., Dahle, C. & Krieg, A. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA. 94, 10833 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA. , vol.94 , pp. 10833
    • Weiner, G.1    Liu, H.2    Wooldridge, J.3    Dahle, C.4    Krieg, A.5
  • 13
    • 0036844343 scopus 로고    scopus 로고
    • Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses
    • Kitagaki, K., Jain, V. V., Businga, T. R., Hussain, I. & Kline, J. N. Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses. Clin. Vaccine Immunol. 9, 1260-1269 (2002).
    • (2002) Clin. Vaccine Immunol. , vol.9 , pp. 1260-1269
    • Kitagaki, K.1    Jain, V.V.2    Businga, T.R.3    Hussain, I.4    Kline, J.N.5
  • 14
    • 42449119776 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis
    • Fransson, M. et al. Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis. Respir. Res. 8, 17 (2007).
    • (2007) Respir. Res. , vol.8 , pp. 17
    • Fransson, M.1
  • 15
    • 0142150951 scopus 로고    scopus 로고
    • Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure
    • Jain, V. V. et al. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. Am. J. Physiol. Lung Cell Mol. Physiol. 285, L1137-1146 (2003).
    • (2003) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.285 , pp. L1137-1146
    • Jain, V.V.1
  • 16
    • 4444281202 scopus 로고    scopus 로고
    • Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis
    • Rhee, C.-S. et al. Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis. Immunology 113, 106-113 (2004).
    • (2004) Immunology , vol.113 , pp. 106-113
    • Rhee, C.-S.1
  • 17
    • 39049094126 scopus 로고    scopus 로고
    • Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in Balb/c mice
    • Hayashi, T., Hasegawa, K. & Sasaki, Y. Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in Balb/c mice. Inflammation 31, 47-56 (2007).
    • (2007) Inflammation , vol.31 , pp. 47-56
    • Hayashi, T.1    Hasegawa, K.2    Sasaki, Y.3
  • 18
    • 80053908774 scopus 로고    scopus 로고
    • IFN-γ-mediated efficacy of allergen-free immunotherapy using mycobacterial antigens and CpG-ODN
    • Fonseca, D. M. et al. IFN-γ-mediated efficacy of allergen-free immunotherapy using mycobacterial antigens and CpG-ODN. Immunol. Cell Biol. 89, 777-785 (2011).
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 777-785
    • Fonseca, D.M.1
  • 19
    • 84901243043 scopus 로고    scopus 로고
    • A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice
    • Campbell, J. D. et al. A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice. Thorax 69, 565-573 (2014).
    • (2014) Thorax , vol.69 , pp. 565-573
    • Campbell, J.D.1
  • 20
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline, J. N. et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160, 2555-2559 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 2555-2559
    • Kline, J.N.1
  • 21
    • 0033429176 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides do not requireTH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
    • Kline, J. N. et al. CpG oligodeoxynucleotides do not requireTH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. J. Allergy Clin. Immunol. 104, 1258-1264 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1258-1264
    • Kline, J.N.1
  • 22
    • 0037379515 scopus 로고    scopus 로고
    • Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice
    • Takabayashi, K., Libet, L., Chisholm, D., Zubeldia, J. & Horner, A. A. Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice. J. Immunol. 170, 3898-3905 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3898-3905
    • Takabayashi, K.1    Libet, L.2    Chisholm, D.3    Zubeldia, J.4    Horner, A.A.5
  • 24
    • 84876561994 scopus 로고    scopus 로고
    • Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice
    • Kourtis, I. C. et al. Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice. PLoS One 8, e61646 (2013).
    • (2013) PLoS One , vol.8
    • Kourtis, I.C.1
  • 25
    • 84889650175 scopus 로고    scopus 로고
    • Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose
    • de Titta, A. et al. Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose. Proc. Natl. Acad. Sci. USA. 110, 19902-19907 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA. , vol.110 , pp. 19902-19907
    • De Titta, A.1
  • 26
    • 84908589994 scopus 로고    scopus 로고
    • Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes
    • Jeanbart, L. et al. Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes. Cancer Immunol. Res. 2, 436-447 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 436-447
    • Jeanbart, L.1
  • 27
    • 77951275912 scopus 로고    scopus 로고
    • Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins
    • van der Vlies, A. J., O'neil, C. P., Hasegawa, U., Hammond, N. & Hubbell, J. A. Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins. Bioconjug. Chem. 21, 653-662 (2010).
    • (2010) Bioconjug. Chem. , vol.21 , pp. 653-662
    • Van Der Vlies, A.J.1    O'neil, C.P.2    Hasegawa, U.3    Hammond, N.4    Hubbell, J.A.5
  • 28
    • 80052339594 scopus 로고    scopus 로고
    • Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis
    • Ballester, M. et al. Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine 29, 6959-6966 (2011).
    • (2011) Vaccine , vol.29 , pp. 6959-6966
    • Ballester, M.1
  • 29
    • 81055130325 scopus 로고    scopus 로고
    • Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination
    • Nembrini, C. et al. Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. Proc. Natl. Acad. Sci. USA. 108, E989-997 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA. , vol.108 , pp. E989-997
    • Nembrini, C.1
  • 30
    • 34548570058 scopus 로고    scopus 로고
    • A protective allergy vaccine based on CpG-and protamine-containing PLGA microparticles
    • Gómez, J. M. M. et al. A protective allergy vaccine based on CpG-and protamine-containing PLGA microparticles. Pharm. Res. 24, 1927-1935 (2007).
    • (2007) Pharm. Res. , vol.24 , pp. 1927-1935
    • Gómez, J.M.M.1
  • 31
    • 80051794923 scopus 로고    scopus 로고
    • Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: A phase IIb study
    • Klimek, L. et al. Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study. Clin. Exp. Allergy 41, 1305-1312 (2011).
    • (2011) Clin. Exp. Allergy , vol.41 , pp. 1305-1312
    • Klimek, L.1
  • 32
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • Hammad, H. et al. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15, 410-416 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 410-416
    • Hammad, H.1
  • 33
    • 80051930931 scopus 로고    scopus 로고
    • Orchestrating house dust mite-associated allergy in the lung
    • Gregory, L. G. & Lloyd, C. M. Orchestrating house dust mite-associated allergy in the lung. Trends Immunol. 32, 402-411 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 402-411
    • Gregory, L.G.1    Lloyd, C.M.2
  • 34
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette, A. et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 20, 159-166 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 159-166
    • Trompette, A.1
  • 35
    • 78650546875 scopus 로고    scopus 로고
    • PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration
    • Stano, A. et al. PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine 29, 804-812 (2011).
    • (2011) Vaccine , vol.29 , pp. 804-812
    • Stano, A.1
  • 36
    • 78649265672 scopus 로고    scopus 로고
    • The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling
    • Li, J., Jiang, H., Wen, W., Zheng, J. & Xu, G. The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling. Clin. Exp. Immunol. 162, 251-261 (2010).
    • (2010) Clin. Exp. Immunol. , vol.162 , pp. 251-261
    • Li, J.1    Jiang, H.2    Wen, W.3    Zheng, J.4    Xu, G.5
  • 37
    • 0033855772 scopus 로고    scopus 로고
    • Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
    • Lambrecht, B. N. et al. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. 106, 551-559 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 551-559
    • Lambrecht, B.N.1
  • 39
    • 80051897184 scopus 로고    scopus 로고
    • Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism
    • Nembrini, C. et al. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism. Thorax 66, 755-763 (2011).
    • (2011) Thorax , vol.66 , pp. 755-763
    • Nembrini, C.1
  • 40
    • 84908263310 scopus 로고    scopus 로고
    • Transforming growth factor β and severe asthma: A perfect storm
    • Al-Alawi, M., Hassan, T. & Chotirmall, S. H. Transforming growth factor β and severe asthma: A perfect storm. Respir. Med. 108, 1409-1423 (2014).
    • (2014) Respir. Med. , vol.108 , pp. 1409-1423
    • Al-Alawi, M.1    Hassan, T.2    Chotirmall, S.H.3
  • 41
    • 84902352161 scopus 로고    scopus 로고
    • Cell biology of disease: The cell biology of asthma
    • Erle, D. J. & Sheppard, D. Cell biology of disease: The cell biology of asthma. J. Cell Biol. 205, 621-631 (2014).
    • (2014) J. Cell Biol. , vol.205 , pp. 621-631
    • Erle, D.J.1    Sheppard, D.2
  • 42
    • 0037134046 scopus 로고    scopus 로고
    • Allergy, parasites, and the hygiene hypothesis
    • Yazdanbakhsh, M., Kremsner, P. G. & van Ree, R. Allergy, parasites, and the hygiene hypothesis. Science 296, 490-494 (2002).
    • (2002) Science , vol.296 , pp. 490-494
    • Yazdanbakhsh, M.1    Kremsner, P.G.2    Van Ree, R.3
  • 43
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg, A. M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5, 471-484 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 44
    • 78751691489 scopus 로고    scopus 로고
    • Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease
    • Fattouh, R. et al. Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease. Am. J. Respir. Crit. Care Med. 183, 179-188 (2011).
    • (2011) Am. J. Respir. Crit. Care Med. , vol.183 , pp. 179-188
    • Fattouh, R.1
  • 45
    • 77957745031 scopus 로고    scopus 로고
    • Inflammatory dendritic cells - Not basophils - Are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    • Hammad, H. et al. Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J. Exp. Med. 207, 2097-2111 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2097-2111
    • Hammad, H.1
  • 47
    • 84884676871 scopus 로고    scopus 로고
    • Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination
    • Li, A. V. et al. Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Sci. Transl. Med. 5, 204ra130 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 204ra130
    • Li, A.V.1
  • 48
    • 84908356299 scopus 로고    scopus 로고
    • Development of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergy
    • Joshi, V. B. et al. Development of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergy. AAPS Journal 16, 975-985 (2014).
    • (2014) AAPS Journal , vol.16 , pp. 975-985
    • Joshi, V.B.1
  • 49
    • 84878707549 scopus 로고    scopus 로고
    • High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway
    • Volpi, C. et al. High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway. Nature Communications 4, 1852-1811 (2013).
    • (2013) Nature Communications , vol.4 , pp. 1852-1811
    • Volpi, C.1
  • 50
    • 84878303560 scopus 로고    scopus 로고
    • Immunotherapy of allergic rhinitis: New therapeutic opportunities with virus-like particles filled with CpG motifs
    • Klimek, L., Schendzielorz, P., Mueller, P., Saudan, P. & Willers, J. Immunotherapy of allergic rhinitis: New therapeutic opportunities with virus-like particles filled with CpG motifs. American Journal of Rhinology and Allergy 27, 206-212 (2013).
    • (2013) American Journal of Rhinology and Allergy , vol.27 , pp. 206-212
    • Klimek, L.1    Schendzielorz, P.2    Mueller, P.3    Saudan, P.4    Willers, J.5
  • 51
    • 62449179406 scopus 로고    scopus 로고
    • Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: A phase I/IIa clinical trial
    • Senti, G. et al. Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin. Exp. Allergy 39, 562-570 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 562-570
    • Senti, G.1
  • 52
    • 47049100427 scopus 로고    scopus 로고
    • Nanoparticles target distinct dendritic cell populations according to their size
    • Manolova, V. et al. Nanoparticles target distinct dendritic cell populations according to their size. Eur. J. Immunol. 38, 1404-1413 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1404-1413
    • Manolova, V.1
  • 53
    • 1642566566 scopus 로고    scopus 로고
    • Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects
    • Storni, T. et al. Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. J. Immunol. 172, 1777-1785 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 1777-1785
    • Storni, T.1
  • 54
    • 84883137539 scopus 로고    scopus 로고
    • Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes
    • Blank, F. et al. Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes. Am. J. Respir. Cell Mol. Biol. 49, 67-77 (2013).
    • (2013) Am. J. Respir. Cell Mol. Biol. , vol.49 , pp. 67-77
    • Blank, F.1
  • 55
    • 79955106944 scopus 로고    scopus 로고
    • Opportunities and challenges of the pulmonary route for vaccination
    • Blank, F., Stumbles, P. & von Garnier, C. Opportunities and challenges of the pulmonary route for vaccination. Expert Opin. Drug Del. 8, 547-563 (2011).
    • (2011) Expert Opin. Drug Del. , vol.8 , pp. 547-563
    • Blank, F.1    Stumbles, P.2    Von Garnier, C.3
  • 56
    • 78650012703 scopus 로고    scopus 로고
    • Rapid translocation of nanoparticles from the lung airspaces to the body
    • Choi, H. S. et al. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat. Biotechnol. 28, 1300-1303 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1300-1303
    • Choi, H.S.1


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