-
1
-
-
33845992179
-
Evidence for airway surface dehydration as the initiating event in CF airway disease
-
Boucher RC. Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med 2007; 261(1): 5-16.
-
(2007)
J Intern Med
, vol.261
, Issue.1
, pp. 5-16
-
-
Boucher, R.C.1
-
2
-
-
0020610435
-
Abnormal ion permeation through cystic fibrosis respiratory epithelium
-
Knowles MR, Stutts MJ, Spock A, Fischer N, Gatzy JT, Boucher RC. Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science 1983; 221(4615): 1067-70.
-
(1983)
Science
, vol.221
, Issue.4615
, pp. 1067-1070
-
-
Knowles, M.R.1
Stutts, M.J.2
Spock, A.3
Fischer, N.4
Gatzy, J.T.5
Boucher, R.C.6
-
3
-
-
0022973473
-
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation
-
Boucher RC, Stutts MJ, Knowles MR, Cantley L, Gatzy JT. Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 1986; 78(5): 1245-52.
-
(1986)
J Clin Invest
, vol.78
, Issue.5
, pp. 1245-1252
-
-
Boucher, R.C.1
Stutts, M.J.2
Knowles, M.R.3
Cantley, L.4
Gatzy, J.T.5
-
4
-
-
0023789980
-
Evidence for reduced Cl-and increased Na+ permeability in cystic fibrosis human primary cell cultures
-
Boucher RC, Cotton CU, Gatzy JT, Knowles MR, Yankaskas JR. Evidence for reduced Cl-and increased Na+ permeability in cystic fibrosis human primary cell cultures. J Physiol (Lond) 1988; 405: 77-103.
-
(1988)
J Physiol (Lond)
, vol.405
, pp. 77-103
-
-
Boucher, R.C.1
Cotton, C.U.2
Gatzy, J.T.3
Knowles, M.R.4
Yankaskas, J.R.5
-
5
-
-
0028880448
-
Na+ and Cl-conductances in airway epithelial cells: Increased Na+ conductance in cystic fibrosis
-
Kunzelmann K, Kathöfer S, Greger R. Na+ and Cl-conductances in airway epithelial cells: increased Na+ conductance in cystic fibrosis. Pflügers Arch -Europ J Physiol 1995; 431: 1-9.
-
(1995)
Pflügers Arch -Europ J Physiol
, vol.431
, pp. 1-9
-
-
Kunzelmann, K.1
Kathöfer, S.2
Greger, R.3
-
6
-
-
0032986769
-
Minor role of Cl-secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium
-
Rückes-Nilges C, Weber U, Lindemann H, Münker G, Clauss W, Weber W-M. Minor role of Cl-secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium. Cell Physiol Biochem 1999; 9: 1-11.
-
(1999)
Cell Physiol Biochem
, vol.9
, pp. 1-11
-
-
Rückes-Nilges, C.1
Weber, U.2
Lindemann, H.3
Münker, G.4
Clauss, W.5
Weber, W.-M.6
-
7
-
-
43249098548
-
Upregulated expression of ENaC in human CF nasal epithelium
-
Bangel N, Dahlhoff C, Sobczak K, Weber WM, Kusche-Vihrog K. Upregulated expression of ENaC in human CF nasal epithelium. J Cyst Fibros 2008; 7(3): 197-205.
-
(2008)
J Cyst Fibros
, vol.7
, Issue.3
, pp. 197-205
-
-
Bangel, N.1
Dahlhoff, C.2
Sobczak, K.3
Weber, W.M.4
Kusche-Vihrog, K.5
-
8
-
-
2442718786
-
Increased airway epithelial Na+ absorption produces cystic fibrosislike lung disease in mice
-
Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosislike lung disease in mice. Nat Med 2004; 10(5): 487-93.
-
(2004)
Nat Med
, vol.10
, Issue.5
, pp. 487-493
-
-
Mall, M.1
Grubb, B.R.2
Harkema, J.R.3
O'Neal, W.K.4
Boucher, R.C.5
-
9
-
-
84861879494
-
The CFTR and ENaC debate: How important is ENaC in CF lung disease?
-
Collawn JF, Lazrak A, Bebok Z, Matalon S. The CFTR and ENaC debate: how important is ENaC in CF lung disease? Am J Physiol Lung Cell Mol Physiol 2012; 302(11): L1141-L1146.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, Issue.11
, pp. L1141-L1146
-
-
Collawn, J.F.1
Lazrak, A.2
Bebok, Z.3
Matalon, S.4
-
10
-
-
79958142002
-
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
-
Zhou Z, Duerr J, Johannesson B, et al. The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease. J Cyst Fibros 2011; 10 Suppl 2: S172-S182.
-
(2011)
J Cyst Fibros
, vol.10
, pp. S172-S182
-
-
Zhou, Z.1
Duerr, J.2
Johannesson, B.3
-
11
-
-
84855338066
-
Transgenic hCFTR expression fails to correct beta-ENaC mouse lung disease
-
Grubb BR, O'Neal WK, Ostrowski LE, Kreda SM, Button B, Boucher RC. Transgenic hCFTR expression fails to correct beta-ENaC mouse lung disease. Am J Physiol Lung Cell Mol Physiol 2012; 302(2): L238-L247.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, Issue.2
, pp. L238-L247
-
-
Grubb, B.R.1
O'Neal, W.K.2
Ostrowski, L.E.3
Kreda, S.M.4
Button, B.5
Boucher, R.C.6
-
13
-
-
0027928745
-
CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cell
-
Cozens AL, Yezzi MJ, Kunzelmann K, et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cell. Am J Respir Cell Mol Biol 1994; 10: 38-47.
-
(1994)
Am J Respir Cell Mol Biol
, vol.10
, pp. 38-47
-
-
Cozens, A.L.1
Yezzi, M.J.2
Kunzelmann, K.3
-
14
-
-
70349484831
-
Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis
-
Sobczak K, Segal A, Bangel-Ruland N, et al. Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis. J Gene Med 2009; 11(9): 813-23.
-
(2009)
J Gene Med
, vol.11
, Issue.9
, pp. 813-823
-
-
Sobczak, K.1
Segal, A.2
Bangel-Ruland, N.3
-
15
-
-
0031921269
-
Cl-transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC
-
Briel M, Greger R, Kunzelmann K. Cl-transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC. J Physiol (Lond) 1998; 508: 825-36.
-
(1998)
J Physiol (Lond)
, vol.508
, pp. 825-836
-
-
Briel, M.1
Greger, R.2
Kunzelmann, K.3
-
16
-
-
0033009521
-
Downregulation of epithelial sodium channel (ENaC) by CFTR co-expressing in Xenopus oocytes is independent of Cl-conductance
-
Chabot H, Vives MF, Dagenais A, Grygorczyk C, Berthiaume Y, Grygorczyk R. Downregulation of epithelial sodium channel (ENaC) by CFTR co-expressing in Xenopus oocytes is independent of Cl-conductance. J Membr Biol 1999; 169: 175-88.
-
(1999)
J Membr Biol
, vol.169
, pp. 175-188
-
-
Chabot, H.1
Vives, M.F.2
Dagenais, A.3
Grygorczyk, C.4
Berthiaume, Y.5
Grygorczyk, R.6
-
17
-
-
0035065745
-
Nonspecific activation of the epithelial sodium channel by the CFTR chloride channel
-
Nagel G, Szellas T, Riordan JR, Friedrich T, Hartung K. Nonspecific activation of the epithelial sodium channel by the CFTR chloride channel. EMBO rep 2001; 2: 249-54.
-
(2001)
EMBO rep
, vol.2
, pp. 249-254
-
-
Nagel, G.1
Szellas, T.2
Riordan, J.R.3
Friedrich, T.4
Hartung, K.5
-
18
-
-
18944378388
-
Downregulation of epithelial sodium channel (ENaC) by CFTR co-expressing in Xenopus oocytes is independent of Cl-conductance -Erratum
-
Chabot H, Vives MF, Dagenais A, Grygorczyk C, Berthiaume Y, Grygorczyk R. Downregulation of epithelial sodium channel (ENaC) by CFTR co-expressing in Xenopus oocytes is independent of Cl-conductance -Erratum. J Membr Biol 2002; 186: 185.
-
(2002)
J Membr Biol
, vol.186
, pp. 185
-
-
Chabot, H.1
Vives, M.F.2
Dagenais, A.3
Grygorczyk, C.4
Berthiaume, Y.5
Grygorczyk, R.6
-
19
-
-
0037181486
-
Rat ENaC expressed in Xenopus laevis oocytes is activated by cAMP and blocked Ni2+
-
Segal A, Cucu D, Van Driessche W, Weber W-M. Rat ENaC expressed in Xenopus laevis oocytes is activated by cAMP and blocked Ni2+. FEBS Lett 2002; 515: 132-8.
-
(2002)
FEBS Lett
, vol.515
, pp. 132-138
-
-
Segal, A.1
Cucu, D.2
Van Driessche, W.3
Weber, W.-M.4
-
20
-
-
18944361982
-
CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes
-
Nagel G, Barbry P, Chabot H, Brochiero E, Hartung K, Grygorczyk R. CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes. J Physiol 2005; 564(Pt 3): 671-82.
-
(2005)
J Physiol
, vol.564
, pp. 671-682
-
-
Nagel, G.1
Barbry, P.2
Chabot, H.3
Brochiero, E.4
Hartung, K.5
Grygorczyk, R.6
-
21
-
-
84885679220
-
Proteases, cystic fibrosis and the epithelial sodium channel (ENaC)
-
Thibodeau PH, Butterworth MB. Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). Cell Tissue Res 2013; 351(2): 309-23.
-
(2013)
Cell Tissue Res
, vol.351
, Issue.2
, pp. 309-323
-
-
Thibodeau, P.H.1
Butterworth, M.B.2
-
22
-
-
0141643333
-
Regulation of the epithelial Na+ channel by cytosolic ATP
-
Ishikawa T, Jiang C, Stutts MJ, Marunaka Y, Rotin D. Regulation of the epithelial Na+ channel by cytosolic ATP. J Biol Chem 2003; 278(40): 38276-86.
-
(2003)
J Biol Chem
, vol.278
, Issue.40
, pp. 38276-38286
-
-
Ishikawa, T.1
Jiang, C.2
Stutts, M.J.3
Marunaka, Y.4
Rotin, D.5
-
23
-
-
84859812575
-
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors
-
Kashlan OB, Kleyman TR. Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res 2012; 318(9): 1011-9.
-
(2012)
Exp Cell Res
, vol.318
, Issue.9
, pp. 1011-1019
-
-
Kashlan, O.B.1
Kleyman, T.R.2
-
24
-
-
84857631596
-
Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways
-
Enuka Y, Hanukoglu I, Edelheit O, Vaknine H, Hanukoglu A. Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways. Histochem Cell Biol 2012; 137(3): 339-53.
-
(2012)
Histochem Cell Biol
, vol.137
, Issue.3
, pp. 339-353
-
-
Enuka, Y.1
Hanukoglu, I.2
Edelheit, O.3
Vaknine, H.4
Hanukoglu, A.5
-
25
-
-
77950810893
-
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases
-
Gaillard EA, Kota P, Gentzsch M, Dokholyan NV, Stutts MJ, Tarran R. Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch 2010; 460(1): 1-17.
-
(2010)
Pflugers Arch
, vol.460
, Issue.1
, pp. 1-17
-
-
Gaillard, E.A.1
Kota, P.2
Gentzsch, M.3
Dokholyan, N.V.4
Stutts, M.J.5
Tarran, R.6
-
26
-
-
77957767326
-
The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel
-
Gentzsch M, Dang H, Dang Y, et al. The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel. J Biol Chem 2010; 285(42): 32227-32.
-
(2010)
J Biol Chem
, vol.285
, Issue.42
, pp. 32227-32232
-
-
Gentzsch, M.1
Dang, H.2
Dang, Y.3
-
27
-
-
0027958441
-
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
-
Canessa CM, Schild L, Buell G, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 1994; 367: 463-7.
-
(1994)
Nature
, vol.367
, pp. 463-467
-
-
Canessa, C.M.1
Schild, L.2
Buell, G.3
-
29
-
-
0036307827
-
Epithelial sodium channel/degenerin family of ion channels: A variety of functions for a shared structure
-
Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Phys Rev 2002; 82: 735-67.
-
(2002)
Phys Rev
, vol.82
, pp. 735-767
-
-
Kellenberger, S.1
Schild, L.2
-
30
-
-
34548813656
-
Structure of acidsensing ion channel 1 at 1.9 A resolution and low pH
-
Jasti J, Furukawa H, Gonzales EB, Gouaux E. Structure of acidsensing ion channel 1 at 1.9 A resolution and low pH. Nature 2007; 449(7160): 316-23.
-
(2007)
Nature
, vol.449
, Issue.7160
, pp. 316-323
-
-
Jasti, J.1
Furukawa, H.2
Gonzales, E.B.3
Gouaux, E.4
-
31
-
-
56149115546
-
Insight toward epithelial Na+ channel mechanism revealed by the acid-sensing ion channel 1 structure
-
Stockand JD, Staruschenko A, Pochynyuk O, Booth RE, Silverthorn DU. Insight toward epithelial Na+ channel mechanism revealed by the acid-sensing ion channel 1 structure. IUBMB Life 2008; 60(9): 620-8.
-
(2008)
IUBMB Life
, vol.60
, Issue.9
, pp. 620-628
-
-
Stockand, J.D.1
Staruschenko, A.2
Pochynyuk, O.3
Booth, R.E.4
Silverthorn, D.U.5
-
32
-
-
0028874955
-
Molecular cloning and functional expression of a novel amiloridesensitive Na+ channel
-
Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M. Molecular cloning and functional expression of a novel amiloridesensitive Na+ channel. J Biol Chem 1995; 270: 27411-4.
-
(1995)
J Biol Chem
, vol.270
, pp. 27411-27414
-
-
Waldmann, R.1
Champigny, G.2
Bassilana, F.3
Voilley, N.4
Lazdunski, M.5
-
33
-
-
84871317491
-
delta ENaC: A novel divergent amiloride-inhibitable sodium channel
-
Ji HL, Zhao RZ, Chen ZX, Shetty S, Idell S, Matalon S. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol 2012; 303(12): L1013-L1026.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, Issue.12
, pp. L1013-L1026
-
-
Ji, H.L.1
Zhao, R.Z.2
Chen, Z.X.3
Shetty, S.4
Idell, S.5
Matalon, S.6
-
34
-
-
84864780642
-
The epithelial sodium channel delta-subunit: New notes for an old song
-
Giraldez T, Rojas P, Jou J, Flores C, Alvarez dlR. The epithelial sodium channel delta-subunit: new notes for an old song. Am J Physiol Renal Physiol 2012; 303(3): F328-F338.
-
(2012)
Am J Physiol Renal Physiol
, vol.303
, Issue.3
, pp. F328-F338
-
-
Giraldez, T.1
Rojas, P.2
Jou, J.3
Flores, C.4
-
35
-
-
84862630506
-
Characterization of a novel splice variant of delta ENaC subunit in human lungs
-
Zhao RZ, Nie HG, Su XF, et al. Characterization of a novel splice variant of delta ENaC subunit in human lungs. Am J Physiol Lung Cell Mol Physiol 2012; 302(12): L1262-L1272.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, Issue.12
, pp. L1262-L1272
-
-
Zhao, R.Z.1
Nie, H.G.2
Su, X.F.3
-
36
-
-
77950500687
-
Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium
-
Bangel-Ruland N, Sobczak K, Christmann T, et al. Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium. Am J Respir Cell Mol Biol 2010; 42(4): 498-505.
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, Issue.4
, pp. 498-505
-
-
Bangel-Ruland, N.1
Sobczak, K.2
Christmann, T.3
-
37
-
-
84884282606
-
ENaC inhibitors and airway re-hydration in cystic fibrosis: State of the art
-
Althaus M. ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art. Curr Mol Pharmacol 2013; 6(1): 3-12.
-
(2013)
Curr Mol Pharmacol
, vol.6
, Issue.1
, pp. 3-12
-
-
Althaus, M.1
-
38
-
-
0023807201
-
Amiloride and its analogs as tools in the study of ion transport
-
Kleyman TR, Cragoe EJ. Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 1988; 105: 1-21.
-
(1988)
J Membr Biol
, vol.105
, pp. 1-21
-
-
Kleyman, T.R.1
Cragoe, E.J.2
-
39
-
-
0022988338
-
Inhalation of amiloride improves the mucociliary and the cough clearance in patients with cystic fibroses
-
Kohler D, App E, Schmitz-Schumann M, Wurtemberger G, Matthys H. Inhalation of amiloride improves the mucociliary and the cough clearance in patients with cystic fibroses. Eur J Respir Dis Suppl 1986; 146: 319-26.
-
(1986)
Eur J Respir Dis Suppl
, vol.146
, pp. 319-326
-
-
Kohler, D.1
App, E.2
Schmitz-Schumann, M.3
Wurtemberger, G.4
Matthys, H.5
-
40
-
-
0025274624
-
Acute and long-term amiloride inhalation in cystic fibrosis lung disease. A rational approach to cystic fibrosis therapy
-
App EM, King M, Helfesrieder R, Kohler D, Matthys H. Acute and long-term amiloride inhalation in cystic fibrosis lung disease. A rational approach to cystic fibrosis therapy. Am Rev Respir Dis 1990; 141(3): 605-12.
-
(1990)
Am Rev Respir Dis
, vol.141
, Issue.3
, pp. 605-612
-
-
App, E.M.1
King, M.2
Helfesrieder, R.3
Kohler, D.4
Matthys, H.5
-
41
-
-
0030982349
-
Aerosolized amiloride: Dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis
-
Hofmann T, Senier I, Bittner P, Huls G, Schwandt HJ, Lindemann H. Aerosolized amiloride: dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis. J Aerosol Med 1997; 10(2): 147-58.
-
(1997)
J Aerosol Med
, vol.10
, Issue.2
, pp. 147-158
-
-
Hofmann, T.1
Senier, I.2
Bittner, P.3
Huls, G.4
Schwandt, H.J.5
Lindemann, H.6
-
42
-
-
0025236867
-
A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis
-
Knowles MR, Church NL, Waltner WE, et al. A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. N Engl J Med 1990; 322(17): 1189-94.
-
(1990)
N Engl J Med
, vol.322
, Issue.17
, pp. 1189-1194
-
-
Knowles, M.R.1
Church, N.L.2
Waltner, W.E.3
-
43
-
-
0027486593
-
No added benefit from nebulized amiloride in patients with cystic fibrosis
-
Graham A, Hasani A, Alton EW, et al. No added benefit from nebulized amiloride in patients with cystic fibrosis. Eur Respir J 1993; 6(9): 1243-8.
-
(1993)
Eur Respir J
, vol.6
, Issue.9
, pp. 1243-1248
-
-
Graham, A.1
Hasani, A.2
Alton, E.W.3
-
45
-
-
10044235073
-
Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease
-
Hirsh AJ, Sabater JR, Zamurs A, et al. Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. J Pharmacol Exp Ther 2004; 311(3): 929-38.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, Issue.3
, pp. 929-938
-
-
Hirsh, A.J.1
Sabater, J.R.2
Zamurs, A.3
-
46
-
-
0031862236
-
Effects of topically delivered benzamil and amiloride on nasal potential difference and sodium absorption in cystic fibrosis respiratory epithelium
-
Hofmann T, Stutts MJ, Ziersch A, et al. Effects of topically delivered benzamil and amiloride on nasal potential difference and sodium absorption in cystic fibrosis respiratory epithelium. Am J Respir Crit Care Med 1998; 157: 1844-9.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1844-1849
-
-
Hofmann, T.1
Stutts, M.J.2
Ziersch, A.3
-
48
-
-
57149104917
-
Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
-
Zhou Z, Treis D, Schubert SC, et al. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice. Am J Respir Crit Care Med 2008; 178(12): 1245-56.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, Issue.12
, pp. 1245-1256
-
-
Zhou, Z.1
Treis, D.2
Schubert, S.C.3
-
49
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett CF, Swayze EE. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 2010; 50: 259-93.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
50
-
-
0031694735
-
Antisense technology: Selection and delivery of optimally acting antisense oligonucleotides
-
Akhtar S. Antisense technology: selection and delivery of optimally acting antisense oligonucleotides. J Drug Target 1998; 5(4): 225-34.
-
(1998)
J Drug Target
, vol.5
, Issue.4
, pp. 225-234
-
-
Akhtar, S.1
-
51
-
-
84868208876
-
Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
-
Southwell AL, Skotte NH, Bennett CF, Hayden MR. Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases. Trends Mol Med 2012; 18(11): 634-43.
-
(2012)
Trends Mol Med
, vol.18
, Issue.11
, pp. 634-643
-
-
Southwell, A.L.1
Skotte, N.H.2
Bennett, C.F.3
Hayden, M.R.4
-
52
-
-
0029935712
-
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
-
Hummler E, Barker P, Gatzy J, et al. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 1996; 12(3): 325-8.
-
(1996)
Nat Genet
, vol.12
, Issue.3
, pp. 325-328
-
-
Hummler, E.1
Barker, P.2
Gatzy, J.3
-
53
-
-
0036199295
-
Conditional gene targeting of the Scnn1a (alphaENaC) gene locus
-
Hummler E, Merillat AM, Rubera I, Rossier BC, Beermann F. Conditional gene targeting of the Scnn1a (alphaENaC) gene locus. Genesis 2002; 32(2): 169-72.
-
(2002)
Genesis
, vol.32
, Issue.2
, pp. 169-172
-
-
Hummler, E.1
Merillat, A.M.2
Rubera, I.3
Rossier, B.C.4
Beermann, F.5
-
54
-
-
0033060575
-
Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity
-
Jain L, Chen XJ, Malik B, Al-Khalili O, Eaton DC. Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity. Am J Physiol 1999; 276(6 Pt 1): L1046-L1051.
-
(1999)
Am J Physiol
, vol.276
, Issue.6
, pp. L1046-L1051
-
-
Jain, L.1
Chen, X.J.2
Malik, B.3
Al-Khalili, O.4
Eaton, D.C.5
-
55
-
-
58749104364
-
The promises and pitfalls of RNAinterference-based therapeutics
-
Castanotto D, Rossi JJ. The promises and pitfalls of RNAinterference-based therapeutics. Nature 2009; 457(7228): 426-33.
-
(2009)
Nature
, vol.457
, Issue.7228
, pp. 426-433
-
-
Castanotto, D.1
Rossi, J.J.2
-
56
-
-
84867652280
-
The Business of RNAi Therapeutics in 2012
-
Haussecker D. The Business of RNAi Therapeutics in 2012. Mol Ther Nucleic Acids 2012; 1: e8.
-
(2012)
Mol Ther Nucleic Acids
, vol.1
-
-
Haussecker, D.1
-
57
-
-
84856389509
-
RNA-based therapeutics: Current progress and future prospects
-
Burnett JC, Rossi JJ. RNA-based therapeutics: current progress and future prospects. Chem Biol 2012; 19(1): 60-71.
-
(2012)
Chem Biol
, vol.19
, Issue.1
, pp. 60-71
-
-
Burnett, J.C.1
Rossi, J.J.2
-
58
-
-
59149088885
-
Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA
-
Caci E, Melani R, Pedemonte N, et al. Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA. Am J Respir Cell Mol Biol 2009; 40(2): 211-6.
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, Issue.2
, pp. 211-216
-
-
Caci, E.1
Melani, R.2
Pedemonte, N.3
-
59
-
-
84883473714
-
Epithelial sodium channel silencing as a strategy to correct the airway surface fluid deficit in cystic fibrosis
-
Gianotti A, Melani R, Caci E, et al. Epithelial sodium channel silencing as a strategy to correct the airway surface fluid deficit in cystic fibrosis. Am J Respir Cell Mol Biol 2013; 49(3): 445-52.
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, Issue.3
, pp. 445-452
-
-
Gianotti, A.1
Melani, R.2
Caci, E.3
-
60
-
-
84878888912
-
Pharmacological Characterization of a Novel ENaCalpha siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis
-
Clark KL, Hughes SA, Bulsara P, et al. Pharmacological Characterization of a Novel ENaCalpha siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis. Mol Ther Nucleic Acids 2013; 2: e65.
-
(2013)
Mol Ther Nucleic Acids
, vol.2
-
-
Clark, K.L.1
Hughes, S.A.2
Bulsara, P.3
-
61
-
-
48549089331
-
Tissue-specific shRNA delivery: A novel approach for gene therapy in cancer
-
Ghatak S, Hascall VC, Berger FG, et al. Tissue-specific shRNA delivery: a novel approach for gene therapy in cancer. Connect Tissue Res 2008; 49(3): 265-9.
-
(2008)
Connect Tissue Res
, vol.49
, Issue.3
, pp. 265-269
-
-
Ghatak, S.1
Hascall, V.C.2
Berger, F.G.3
-
62
-
-
80052627990
-
Current progress of siRNA/shRNA therapeutics in clinical trials
-
Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J 2011; 6(9): 1130-46.
-
(2011)
Biotechnol J
, vol.6
, Issue.9
, pp. 1130-1146
-
-
Burnett, J.C.1
Rossi, J.J.2
Tiemann, K.3
-
63
-
-
84886530607
-
Posttranscriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs
-
Ramachandran S, Karp PH, Osterhaus SR, et al. Posttranscriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs. Am J Respir Cell Mol Biol 2013; 49(4): 544-51.
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, Issue.4
, pp. 544-551
-
-
Ramachandran, S.1
Karp, P.H.2
Osterhaus, S.R.3
-
64
-
-
84885737547
-
Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology
-
McKiernan PJ, Cunningham O, Greene CM, Cryan SA. Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology. Int J Nanomedicine 2013; 8: 3907-15.
-
(2013)
Int J Nanomedicine
, vol.8
, pp. 3907-3915
-
-
McKiernan, P.J.1
Cunningham, O.2
Greene, C.M.3
Cryan, S.A.4
-
65
-
-
0028019410
-
Gene inhibition using antisense oligodeoxynucleotides
-
Nov 24
-
Wagner RW. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994 Nov 24; 372(6504): 333-5.
-
(1994)
Nature
, vol.372
, Issue.6504
, pp. 333-335
-
-
Wagner, R.W.1
-
67
-
-
84909583944
-
Delivery of genes into the CF airway
-
Gill DR, Hyde SC. Delivery of genes into the CF airway. Thorax 2014; 69(10): 962-4.
-
(2014)
Thorax
, vol.69
, Issue.10
, pp. 962-964
-
-
Gill, D.R.1
Hyde, S.C.2
-
68
-
-
84898545067
-
Gene therapy in cystic fibrosis
-
Armstrong DK, Cunningham S, Davies JC, Alton EW. Gene therapy in cystic fibrosis. Arch Dis Child 2014; 99(5): 465-8.
-
(2014)
Arch Dis Child
, vol.99
, Issue.5
, pp. 465-468
-
-
Armstrong, D.K.1
Cunningham, S.2
Davies, J.C.3
Alton, E.W.4
-
69
-
-
0025242929
-
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
-
Cheng SH, Gregory RJ, Marshall J, et al. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell 1990; 63: 827-34.
-
(1990)
Cell
, vol.63
, pp. 827-834
-
-
Cheng, S.H.1
Gregory, R.J.2
Marshall, J.3
-
70
-
-
84861354967
-
Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease
-
Leier G, Bangel-Ruland N, Sobczak K, Knieper Y, Weber WM. Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease. Cell Physiol Biochem 2012; 29(5-6): 775-90.
-
(2012)
Cell Physiol Biochem
, vol.29
, Issue.5-6
, pp. 775-790
-
-
Leier, G.1
Bangel-Ruland, N.2
Sobczak, K.3
Knieper, Y.4
Weber, W.M.5
-
71
-
-
84891091804
-
Cystic fibrosis transmembrane conductance regulator-mRNA delivery: A novel alternative for cystic fibrosis gene therapy
-
Bangel-Ruland N, Tomczak K, Fernandez FE, et al. Cystic fibrosis transmembrane conductance regulator-mRNA delivery: a novel alternative for cystic fibrosis gene therapy. J Gene Med 2013; 15(11-12): 414-26.
-
(2013)
J Gene Med
, vol.15
, Issue.11-12
, pp. 414-426
-
-
Bangel-Ruland, N.1
Tomczak, K.2
Fernandez, F.E.3
-
72
-
-
84901610159
-
Early cystic fibrosis lung disease: Role of airway surface dehydration and lessons from preventive rehydration therapies in mice
-
Mall MA, Graeber SY, Stahl M, Zhou-Suckow Z. Early cystic fibrosis lung disease: Role of airway surface dehydration and lessons from preventive rehydration therapies in mice. Int J Biochem Cell Biol 2014; 52: 174-9.
-
(2014)
Int J Biochem Cell Biol
, vol.52
, pp. 174-179
-
-
Mall, M.A.1
Graeber, S.Y.2
Stahl, M.3
Zhou-Suckow, Z.4
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