The role of exercise in the management of rheumatoid arthritis

Expert Review of Clinical Immunology

Volumn 11, Issue 10, 2015, Pages 1121-1130

  Metsios, George S ^a,b,c   Stavropoulos Kalinoglou, Antonis ^c   Kitas, George D ^b,d,e  

^a UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^b RUSSELLS HALL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF THESSALY   (Greece)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

arthritis; cardiovascular disease; exercise; exercise as medicine; inflammation; physical activity; rheumatoid arthritis

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; MESSENGER RNA;

ARTHRALGIA; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL PRACTICE; EXERCISE; HUMAN; INFLAMMATION; JOINT STIFFNESS; JOINT SWELLING; PHYSICAL ACTIVITY; REVIEW; RHEUMATOID ARTHRITIS; ANIMAL; ARTHRITIS, RHEUMATOID; CARDIOVASCULAR DISEASES; COMPLICATION; PHYSIOLOGY; PHYSIOTHERAPY; TREATMENT OUTCOME;

ANIMALS; ARTHRITIS, RHEUMATOID; CARDIOVASCULAR DISEASES; EXERCISE; HUMANS; PHYSICAL THERAPY MODALITIES; TREATMENT OUTCOME;

EID: 84942118165     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2015.1067606     Document Type: Review

References (83)

1. Kitas GD, Gabriel SE. Cardiovascular disease in rheumatoid arthritis: state of the art and future perspectives. Ann Rheum Dis 2011;70:8-14
2. Nikolaus S, Van de Laar MA. Measuring fatigue in rheumatoid arthritis. Nat Rev Rheumatol 2011;7:562-4
3. Matcham F, Rayner L, Steer S, et al. The prevalence of depression in rheumatoid arthritis: A systematic review and meta-analysis. Rheumatology (Oxford) 2013;52:2136-48
4. Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 2010;69:631-7
5. Hayashino Y, Jackson JL, Hirata T, et al. Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Metabolism 2014;63:431-40
6. Pedersen BK, Akerstrom TC, Nielsen AR, et al. Role of myokines in exercise and metabolism. J Appl Physiol (1985) 2007;103:1093-8
7. Croisier JL, Camus G, Venneman I, et al. Effects of training on exercise-induced muscle damage and interleukin 6 production. Muscle Nerve 1999;22: 208-12
8. Steensberg A, Febbraio MA, Osada T, et al. Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 2001;537:633-9
9. Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 2004;53:1643-8
10. Steensberg A, Fischer CP, Keller C, et al. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 2003;285:E433-7
11. Ostrowski K, Rohde T, Zacho M, et al. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 1998;508(Pt3):949-53
12. Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults Epidemiology 2002;13:561-8
13. Lakka TA, Lakka HM, Rankinen T, et al. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. Eur Heart J 2005;26:2018-25
14. McLaughlin T, Abbasi F, Lamendola C, et al. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation 2002;106: 2908-12
15. Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial. JAMA 2003;289:1799-804
16. Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, et al. Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis. Clin Rheumatol 2009;28:439-44
17. Stavropoulos-Kalinoglou A, Metsios GS, Veldhuijzen van Zanten JJ, et al. Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis. Ann Rheum Dis 2013;72:1819-25
18. Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, et al. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol 2010;6:445-51
19. Metsios GS, Stavropoulos-Kalinoglou A, Panoulas VF, et al. New resting energy expenditure prediction equations for patients with rheumatoid arthritis. Rheumatology (Oxford) 2008;47:500-6
20. Stavropoulos-Kalinoglou A, Metsios GS, Koutedakis Y, et al. Redefining overweight and obesity in rheumatoid arthritis patients. Ann Rheum Dis 2007;66:1316-21
21. Sandoo A, van Zanten JJ, Metsios GS, et al. The endothelium and its role in regulating vascular tone. Open Cardiovasc Med J 2010;4:302-12
22. Scheller J, Ohnesorge N, Rose-John S. Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand J Immunol 2006;63:321-9
23. Adamopoulos S, Parissis J, Kroupis C, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22:791-7
24. Maiorana A, O'Driscoll G, Taylor R, et al. Exercise and the nitric oxide vasodilator system. Sports Med 2003;33:1013-35
25. Metsios GS, Stavropoulos-Kalinoglou A, Sandoo A, et al. Vascular function and inflammation in rheumatoid arthritis: the role of physical activity. Open Cardiovasc Med J 2010;4:89-96
26. Metsios GS, Stavropoulos-Kalinoglou A, Panoulas VF, et al. Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. Eur J Cardiovasc Prev Rehabil 2009;16:188-94
27. Metsios GS, Stavropoulos-Kalinoglou A, Veldhuijzen van Zanten JJ, et al. Individualised exercise improves endothelial function in patients with rheumatoid arthritis. Ann Rheum Dis 2014;73:748-51
28. Metsios GS, Stavropoulos-Kalinoglou A, Treharne GJ, et al. Disease activity and low physical activity associate with number of hospital admissions and length of hospitalisation in patients with rheumatoid arthritis. Arthritis Res Ther 2011;13:R108
29. Lemmey AB. Efficacy of progressive resistance training for patients with rheumatoid arthritis and recommendations regarding its prescription. Int J Clin Rheumatol 2011;6:189-205
30. Hurkmans E, Van der Giesen FJ, Vliet Vlieland TP, et al. Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis. Cochrane Database Syst Rev 2009(4):CD006853
31. Van Den Ende CH, Vliet Vlieland TP, Munneke M, et al. Dynamic exercise therapy for rheumatoid arthritis. Cochrane Database Syst Rev 2000(2):CD000322
32. de Jong Z, Munneke M, Kroon HM, et al. Long-term follow-up of a high-intensity exercise program in patients with rheumatoid arthritis. Clin Rheumatol 2009;28:663-71
33. Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review. Semin Arthritis Rheum 2006;36:182-8
34. Avina-Zubieta JA, Choi HK, Sadatsafavi M, et al. Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies. Arthritis Rheum 2008;59:1690-7
35. Panoulas VF, Metsios GS, Pace AV, et al. Hypertension in rheumatoid arthritis. Rheumatology (Oxford) 2008;47:1286-98
36. Panoulas VF, Douglas KM, Smith JP, et al. Transforming growth factor-beta1 869T/C, but not interleukin-6-174G/C, polymorphism associates with hypertension in rheumatoid arthritis. Rheumatology (Oxford) 2009;48:113-18
37. Dessein PH, Joffe BI, Stanwix AE. Inflammation, insulin resistance, and aberrant lipid metabolism as cardiovascular risk factors in rheumatoid arthritis. J Rheumatol 2003;30:1403-5
38. Toms TE, Panoulas VF, Smith JP, et al. Rheumatoid arthritis susceptibility genes associate with lipid levels in patients with rheumatoid arthritis. Ann Rheum Dis 2011;70:1025-32
39. Stavropoulos-Kalinoglou A, Metsios GS, Koutedakis Y, et al. Obesity in rheumatoid arthritis. Rheumatology (Oxford) 2011;50: 450-62
40. Sandoo A, Carroll D, Metsios GS, et al. The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: A cross-sectional study. Arthritis Res Ther 2011;13:R99
41. Sandoo A, Veldhuijzen van Zanten JJ, Metsios GS, et al. Vascular function and morphology in rheumatoid arthritis: A systematic review. Rheumatology (Oxford) 2011;50:2125-39
42. Goodson NJ, Symmons DP, Scott DG, et al. Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: A ten-year followup study of a primary care-based inception cohort. Arthritis Rheum 2005;52:2293-9
43. Maradit-Kremers H, Nicola PJ, Crowson CS, et al. Cardiovascular death in rheumatoid arthritis: A population-based study. Arthritis Rheum 2005;52:722-32
44. Myers J, Prakash M, Froelicher V, et al. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 2002;346:793-801
45. Sui X, LaMonte MJ, Laditka JN, et al. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA 2007;298:2507-16
46. Metsios GS, Stavropoulos-Kalinoglou A, Veldhuijzen van Zanten JJ, et al. Rheumatoid arthritis, cardiovascular disease and physical exercise: A systematic review. Rheumatology (Oxford) 2008;47:239-48
47. Wadley AJ, van Zanten JJ, Stavropoulos-Kalinoglou A, et al. Three months of moderate-intensity exercise reduced plasma 3-nitrotyrosine in rheumatoid arthritis patients. Eur J Appl Physiol 2014;114(7):1483-92
48. Metsios GS, Koutedakis Y, Veldhuijzen van Zanten JJCS, et al. Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: A cross-sectional study. Rheumatology (Oxford) 2015;In press
49. Cornelissen VA, Smart NA. Exercise training for blood pressure: A systematic review and meta-analysis. J Am Heart Assoc 2013;2:e004473
50. Kodama S, Tanaka S, Saito K, et al. Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: A meta-analysis. Arch Intern Med 2007;167: 999-1008
51. Conn VS, Koopman RJ, Ruppar TM, et al. Insulin sensitivity following exercise interventions: systematic review and meta-analysis of outcomes among healthy adults. J Prim Care Community Health 2014;5(3):211-22
52. Vissers D, Hens W, Taeymans J, et al. The effect of exercise on visceral adipose tissue in overweight adults: A systematic review and meta-analysis. PLoS One 2013;8:e56415
53. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-74
54. Ristic GG, Lepic T, Glisic B, et al. Rheumatoid arthritis is an independent risk factor for increased carotid intima-media thickness: impact of anti-inflammatory treatment. Rheumatology (Oxford) 2010;49: 1076-81
55. Sattar N, McCarey DW, Capell H, et al. Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 2003;108: 2957-63
56. Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, et al. What predicts obesity in patients with rheumatoid arthritis? An investigation of the interactions between lifestyle and inflammation. Int J Obes (Lond) 2010;34:295-301
57. Treharne GJ, Lyons AC, Booth DA, et al. Psychological well-being across 1 year with rheumatoid arthritis: coping resources as buffers of perceived stress. Br J Health Psychol 2007;12:323-45
58. VanDyke MM, Parker JC, Smarr KL, et al. Anxiety in rheumatoid arthritis. Arthritis Rheum 2004;51:408-12
59. Treharne GJ, Lyons AC, Kitas GD. Suicidal ideation in patients with rheumatoid arthritis. Research may help identify patients at high risk. BMJ 2000;321:1290
60. Wolfe F, Michaud K. Resistance of rheumatoid arthritis patients to changing therapy: discordance between disease activity and patients' treatment choices. Arthritis Rheum 2007;56:2135-42
61. Evers AW, Kraaimaat FW, Van Riel PL, et al. Tailored cognitive-behavioral therapy in early rheumatoid arthritis for patients at risk: A randomized controlled trial. Pain 2002;100:141-53
62. Sharpe L, Sensky T, Timberlake N, et al. Long-term efficacy of a cognitive behavioural treatment from a randomized controlled trial for patients recently diagnosed with rheumatoid arthritis. Rheumatology (Oxford) 2003;42:435-41
63. Neuberger GB, Aaronson LS, Gajewski B, et al. Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis. Arthritis Rheum 2007;57:943-52
64. Mead GE, Morley W, Campbell P, et al. Exercise for depression. Cochrane Database Syst Rev 2009(3):CD004366
65. Fichna J, Janecka A, Costentin J, et al. The endomorphin system and its evolving neurophysiological role. Pharmacol Rev 2007;59:88-123
66. Tierney M, Fraser A, Kennedy N. Physical activity in rheumatoid arthritis: A systematic review. J Phys Act Health 2012;9:1036-48
67. Makelainen P, Vehvilainen-Julkunen K, Pietila AM. Rheumatoid arthritis patients' knowledge of the disease and its treatments: A descriptive study. Musculoskelet Care 2009;7:31-44
68. Munneke M, de Jong Z, Zwinderman AH, et al. High intensity exercise or conventional exercise for patients with rheumatoid arthritis? Outcome expectations of patients, rheumatologists, and physiotherapists. Ann Rheum Dis 2004;63:804-8
69. Stoffer MA, Smolen JS, Woolf A, et al. Development of patient-centred standards of care for rheumatoid arthritis in Europe: the eumusc.net project. Ann Rheum Dis 2014;73:902-5
70. EUMUSC.net, The European Musculoskeletal Conditions Surveillance and Information Network (eumusc.net). Standards of Care for People with Rheumatoid Arthritis. Available from: www. eumusc.net/myUploadData/files/ RA-Full-draft-FINAL-V2[1].pdf [Last accessed 18 May 2015]
71. Metsios GS, Lemmey A. Exercise as medicine in rheumatoid arthritis: effects on function, body composition, and cardiovascular disease risk. J Clin Exe Physiol 2015;4:14-22
72. Stenstrom CH, Lindell B, Swanberg E, et al. Functional and psychosocial consequences of disease and experience of pain and exertion in a group of rheumatic patients considered for active training. Result of a survey in Bollnas Medical District. I Scand J Rheumatol 1990;19: 374-82
73. Law RJ, Markland DA, Jones JG, et al. Perceptions of issues relating to exercise and joint health in rheumatoid arthritis: A UK-based questionnaire study. Musculoskelet Care 2013;11:147-58
74. Wilcox S, Der Ananian C, Abbott J, et al. Perceived exercise barriers, enablers, and benefits among exercising and nonexercising adults with arthritis: results from a qualitative study. Arthritis Rheum 2006;55: 616-27
75. Moe RH, Petersson IF, Carmona L, et al. Facilitators to implement standards of care for rheumatoid arthritis and osteoarthritis: the EUMUSC.NET project. Ann Rheum Dis 2014;73:1545-8
76. John H, Hale ED, Treharne GJ, et al. A randomized controlled trial of a cognitive behavioural patient education intervention vs a traditional information leaflet to address the cardiovascular aspects of rheumatoid disease. Rheumatology (Oxford) 2013;52:81-90
77. Piepoli MF, Corra U, Benzer W, et al. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil 2010;17:1-17
78. de Jong Z, Munneke M, Zwinderman AH, et al. Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial. Arthritis Rheum 2003;48:2415-24
79. Mechanic D, Schlesinger M. The impact of managed care on patients' trust in medical care and their physicians. JAMA 1996;275: 1693-7
80. American College of Sports Medicine, Guidelines for exercise testing and prescription. 7th edition. Lippincott Wiliams & Wilkins, Philadelphia; 2005
81. Williams MA, Haskell WL, Ades PA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: A scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2007;116:572-84
82. Pozehl B, Duncan K, Hertzog M, et al. Study of adherence to exercise in heart failure: the HEART camp trial protocol. BMC Cardiovasc Disord 2014;14:172
83. Hawley-Hague H, Horne M, Campbell M, et al. Multiple levels of influence on older adults' attendance and adherence to community exercise classes. Gerontologist 2013;1-12; doi:10.1093/geront/gnt075