Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation

Journal of Molecular and Cellular Cardiology

Volumn 88, Issue , 2015, Pages 14-28

  Kang, Patrick T ^a   Chen, Chwen Lih ^a   Ohanyan, Vahagn ^a   Luther, Daniel J ^a   Meszaros, J Gary ^a   Chilian, William M ^a   Chen, Yeong Renn ^a  

^a Northeastern Ohio Medical University   (United States)

Author keywords

Bioenergetics; Cardiac function; Metabolic dilation; Mitochondria; Redox regulation; Superoxide dismutase 2 (SOD2); Transgenic mice

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; HYDROXYLAMINE; MANGANESE SUPEROXIDE DISMUTASE; N(G) NITROARGININE METHYL ESTER; NITROXIDE; NORADRENALIN; OXYGEN; SEMIQUINONE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CYTOSOL; ECHOCARDIOGRAPHY; ELECTRON SPIN RESONANCE; ENERGY YIELD; EXCITATION CONTRACTION COUPLING; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE BLOOD FLOW; HEART RATE; HEART WORK; MEAN ARTERIAL PRESSURE; MITOCHONDRION; MOUSE; MUSCLE CELL; MYOCARDIAL PERFUSION IMAGING; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHENOTYPE; POLAROGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATION CONTROL; RESPIRATORY CHAIN; TRANSTHORACIC ECHOCARDIOGRAPHY; VASODILATATION; ANIMAL; ARTERIAL PRESSURE; BIOSYNTHESIS; BLOOD FLOW VELOCITY; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETICS; HEART MITOCHONDRION; HEART STROKE VOLUME; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ARTERIAL PRESSURE; BLOOD FLOW VELOCITY; CATALASE; ECHOCARDIOGRAPHY; FEMALE; GENE EXPRESSION; HYDROGEN PEROXIDE; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIUM; MYOCYTES, CARDIAC; NG-NITROARGININE METHYL ESTER; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; SIGNAL TRANSDUCTION; STROKE VOLUME; SUPEROXIDE DISMUTASE; VASODILATION;

EID: 84942106829     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.09.001     Document Type: Article

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