Protein thiyl radical mediates S-glutathionylation of complex i

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 962-973

  Kang, Patrick T ^a   Zhang, Liwen ^b   Chen, Chwen Lih ^a   Chen, Jingfeng ^a,c   Green, Kari B ^b   Chen, Yeong Renn ^a  

^a Northeast Ohio Medical University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Complex I; Free radicals; Immuno spin trapping; Myocytes; Protein thiyl radical; S glutathionylation

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ANTIBODY; CYSTEINE; GLUTATHIONE; MENADIONE; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIYL RADICAL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIQUID CHROMATOGRAPHY; MITOCHONDRION; MUSCLE CELL; PRIORITY JOURNAL; S GLUTATHIONYLATION; SPIN TRAPPING; TANDEM MASS SPECTROMETRY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CELL LINE; CYCLIC N-OXIDES; CYSTEINE; ELECTRON TRANSPORT COMPLEX I; FREE RADICAL SCAVENGERS; FREE RADICALS; GLUTATHIONE; MICE; MITOCHONDRIA, HEART; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE CELLS; ONIUM COMPOUNDS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; RATS; ROTENONE; STRUCTURAL HOMOLOGY, PROTEIN; SUPEROXIDES;

RATTUS;

EID: 84864970382     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.025     Document Type: Article

References (36)

1. J. Hirst, J. Carroll, I.M. Fearnley, R.J. Shannon, and J.E. Walker The nuclear encoded subunits of complex I from bovine heart mitochondria Biochim. Biophys. Acta 1604 2003 135 150
2. J. Carroll, I.M. Fearnley, R.J. Shannon, J. Hirst, and J.E. Walker Analysis of the subunit composition of complex I from bovine heart mitochondria Mol. Cell. Proteomics 2 2003 117 126
3. J.E. Walker The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains Q. Rev. Biophys. 25 1992 253 324
4. A. Galkin, and U. Brandt Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica J. Biol. Chem. 280 2005 30129 30135
5. A.P. Kudin, N.Y. Bimpong-Buta, S. Vielhaber, C.E. Elger, and W.S. Kunz Characterization of superoxide-producing sites in isolated brain mitochondria J. Biol. Chem. 279 2004 4127 4135
6. J.F. Turrens, and A. Boveris Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria Biochem. J. 191 1980 421 427
7. Y.R. Chen, C.L. Chen, L. Zhang, K.B. Green-Church, and J.L. Zweier Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation J. Biol. Chem. 280 2005 37339 37348
8. A.J. Lambert, and M.D. Brand Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) J. Biol. Chem 279 2004 39414 39420
9. S.T. Ohnishi, T. Ohnishi, S. Muranaka, H. Fujita, H. Kimura, K. Uemura, K. Yoshida, and K. Utsumi A possible site of superoxide generation in the complex I segment of rat heart mitochondria J. Bioenerg. Biomembr. 37 2005 1 15
10. J. Chen, C. Chen, S. Rawale, C. Chen, J. Zweier, P. Kaumaya, and Y. Chen Peptide-based antibodies against glutathione-binding domains suppress superoxide production mediated by mitochondrial complex I J. Biol. Chem. 285 2010 3168 3180
11. N.J. Costa, C.C. Dahm, F. Hurrell, E.R. Taylor, and M.P. Murphy Interactions of mitochondrial thiols with nitric oxide Antioxid. Redox Signaling 5 2003 291 305
12. S.M. Beer, E.R. Taylor, S.E. Brown, C.C. Dahm, N.J. Costa, M.J. Runswick, and M.P. Murphy Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant defense J. Biol. Chem. 279 2004 47939 47951
13. E.R. Taylor, F. Hurrell, R.J. Shannon, T.K. Lin, J. Hirst, and M.P. Murphy Reversible glutathionylation of complex I increases mitochondrial superoxide formation J. Biol. Chem. 278 2003 19603 19610
14. B. Beltran, A. Orsi, E. Clementi, and S. Moncada Oxidative stress and S-nitrosylation of proteins in cells Br. J. Pharmacol. 129 2000 953 960
15. E. Clementi, G.C. Brown, M. Feelisch, and S. Moncada Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione Proc. Natl. Acad. Sci. USA 95 1998 7631 7636
16. T.R. Hurd, A. Filipovska, N.J. Costa, C.C. Dahm, and M.P. Murphy Disulphide formation on mitochondrial protein thiols Biochem. Soc. Trans. 33 2005 1390 1393
17. T.R. Hurd, N.J. Costa, C.C. Dahm, S.M. Beer, S.E. Brown, A. Filipovska, and M.P. Murphy Glutathionylation of mitochondrial proteins Antioxid. Redox Signaling 7 2005 999 1010
18. C.L. Chen, L. Zhang, A. Yeh, C.A. Chen, K.B. Green-Church, J.L. Zweier, and Y.R. Chen Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase Biochemistry 46 2007 5754 5765
19. T.R. Hurd, R. Requejo, A. Filipovska, S. Brown, T.A. Prime, A.J. Robinson, I.M. Fearnley, and M.P. Murphy Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage J. Biol. Chem. 283 2008 24801 24815
20. J.J. Mieyal, M.M. Gallogly, S. Qanungo, E.A. Sabens, and M.D. Shelton Molecular mechanisms and clinical implications of reversible protein S-glutathionylation Antioxid. Redox Signaling 10 2008 1941 1988
21. M.M. Gallogly, and J.J. Mieyal Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress Curr. Opin. Pharmacol. 7 2007 381 391
22. Y.M. Galante, and Y. Hatefi Purification and molecular and enzymic properties of mitochondrial NADH dehydrogenase Arch. Biochem. Biophys. 192 1979 559 568
23. E.R. Redfearn, and P.A. Whittaker The determination of the oxidation-reduction states of ubiquinone (coenzyme Q) in rat-liver mitochondria Biochim. Biophys. Acta 118 1966 413 418
24. Y. Hatefi Preparation and properties of NADH:ubiquinone oxidoreductase (complex I), EC 1.6.5.3 Methods Enzymol. 53 1978 11 14
25. D.R. Duling Simulation of multiple isotropic spin-trap EPR spectra J. Magn. Reson. B 104 1994 105 110
26. L. Zhang, C. Chen, P. Kang, V. Garg, K. Hu, K. Green-Church, and Y. Chen Peroxynitrite-mediated oxidative modifications of complex II: relevance in myocardial infarction Biochemistry 49 2010 2529 2539
27. H. Xu, and M.A. Freitas A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data BMC Bioinformatics 8 2007 133
28. S. White, P. Constantin, and W. Claycomb Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function Am. J. Physiol. Heart Circ. Physiol 286 2004 H823 829
29. P. Kang, J. Yun, P. Kaumaya, and Y. Chen Design and use of peptide-based antibodies decreasing superoxide production by mitochondrial complex I and complex II Biopolym. Pept. Sci 96 2011 207 220
30. C. Chen, T. Wang, S. Varadharaj, L. Reyes, C. Hemann, M. Talukder, Y. Chen, L. Druhan, and J. Zweier S-glutathionylation uncouples eNOS and regulates its cellular and vascular function Nature 468 2010 1115 1118
31. G. Roos, and J. Messens Protein sulfenic acid formation: from cellular damage to redox regulation Free Radic. Biol. Med. 51 2011 314 326
32. L.A. Sazanov, and P. Hinchliffe Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Science 311 2006 1430 1436
33. G. Rosen, and B. Freeman Detection of superoxide generated by endothelial cells Proc. Natl. Acad. Sci. USA 81 1984 7269 7273
34. J.L. Zweier Measurement of superoxide-derived free radicals in the reperfused heart: evidence for a free radical mechanism of reperfusion injury J. Biol. Chem 263 1988 1353 1357
35. J.M. Hansen, Y.M. Go, and D.P. Jones Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling Annu. Rev. Pharmacol. Toxicol. 46 2006 215 234
36. H. Lee, C. Chen, S. Yeh, J. Zweier, and Y. Chen Biphasic modulation of the mitochondrial electron transport chain in myocardial ischemia and reperfusion Am. J. Physiol. Heart Circ. Physiol 302 2012 H1410 1422