MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation

Molecular Imaging and Biology

Volumn 17, Issue 5, 2015, Pages 680-687

  Matusiak, Nathalie ^a   van Waarde, Aren ^a   Rozeveld, Dennie ^a   van Oosterhout, Antoon J M ^a   Heijink, Irene H ^a   Castelli, Riccardo ^b   Overkleeft, Herman S ^b   Bischoff, Rainer ^c   Dierckx, Rudi A J O ^a   Elsinga, Philip H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

BALF; COPD; Lung imaging; MicroPET; MMP ADAM inhibitor

Indexed keywords

1 [[[1 AMINO 6 (4 FLUOROBENZAMIDO) 1 OXOHEXAN 2 YL]AMINO] 1 OXO 3 PHENYLPROPAN 2YL] N 4 HYDROXY 2 ISOBUTYLSUCCINAMIDE; CIGARETTE SMOKE; FLUORODEOXYGLUCOSE F 18; HYDROXAMIC ACID; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG; [[(1,6 DIAMINO 1 OXOHEXAN 2 YL)AMINO] 1 OXO 3 PHENYLPROPANY 2YL] N4 HYDROXY 2 ISOBUTYLSUCCINAMIDE; MATRIX METALLOPROTEINASE INHIBITOR; SMOKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG SCREENING; DRUG UPTAKE; ISOTOPE LABELING; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; ADVERSE EFFECTS; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; CHEMISTRY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE MODEL; METABOLISM; PATHOLOGY; PNEUMONIA; PROCEDURES; SMOKE; TOBACCO;

ANIMALS; DISEASE MODELS, ANIMAL; MALE; MATRIX METALLOPROTEINASE INHIBITORS; MICE, INBRED BALB C; PNEUMONIA; POSITRON-EMISSION TOMOGRAPHY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; TOBACCO;

EID: 84941994082     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-015-0847-3     Document Type: Article

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