Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium – identification of a novel 11-oxidase activity

Applied Microbiology and Biotechnology

Volumn 99, Issue 20, 2015, Pages 8495-8514

  Kiss, Flora Marta ^a   Schmitz, Daniela ^a   Zapp, Josef ^a   Dier, Tobias K F ^a   Volmer, Dietrich A ^a   Bernhardt, Rita ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

11 Hydroxysteroid dehydrogenation; Cortisol; Cortisone; CYP106A1; CYP106A2

Indexed keywords

AMINO ACIDS; BACTERIOLOGY; CORTISOL; ENZYMES; HYDROXYLATION; ORGANIC COMPOUNDS; SUBSTRATES;

AMINO ACID SEQUENCE; CORTISONE; CYP106A1; CYP106A2; HYDROXYLASE ACTIVITY; PHARMACEUTICAL INDUSTRY; STEREOSELECTIVE MANNER; STRUCTURE CHARACTERIZATION;

LIPIDS;

CYP106A1 PROTEIN; CYP106A2 PROTEIN; HYDROXYSTEROID; OXIDOREDUCTASE; STEROID; UNCLASSIFIED DRUG; 17 HYDROXYCORTICOSTEROID; CYTOCHROME P450;

BACTERIUM; BIOTECHNOLOGY; COMPARATIVE STUDY; DRUG DEVELOPMENT; ENZYME ACTIVITY; IDENTIFICATION METHOD; NUCLEAR MAGNETIC RESONANCE; PHARMACEUTICAL INDUSTRY; STEROID; TERPENE;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS MEGATERIUM; BACTERIAL CELL; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; COMPARATIVE STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE HOMOLOGY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BACILLUS MEGATERIUM;

17-HYDROXYCORTICOSTEROIDS; BACILLUS MEGATERIUM; CYTOCHROME P-450 ENZYME SYSTEM; MAGNETIC RESONANCE SPECTROSCOPY; SUBSTRATE SPECIFICITY;

EID: 84941993531     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6563-8     Document Type: Article

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