Investigating Nephrotoxicity of Polymyxin Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging

Chemical Research in Toxicology

Volumn 28, Issue 9, 2015, Pages 1823-1830

  Nilsson, Anna ^a   Goodwin, Richard J A ^b   Swales, John G ^b   Gallagher, Richard ^b   Shankaran, Harish ^b   Sathe, Abhishek ^b   Pradeepan, Selvi ^b   Xue, Aixiang ^b   Keirstead, Natalie ^b   Sasaki, Jennifer C ^b   Andren, Per E ^a   Gupta, Anshul ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; POLYMYXIN B NONAPEPTIDE; POLYMYXIN B1; POLYMYXIN DERIVATIVE; UNCLASSIFIED DRUG; POLYMYXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; KIDNEY HOMOGENATE; KIDNEY PARENCHYMA; LIQUID CHROMATOGRAPHY; MALE; NEPHROTOXICITY; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATE; TISSUE SECTION; URINALYSIS; ANIMAL; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; KIDNEY; PROCEDURES; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; KIDNEY; MALE; POLYMYXINS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84941949845     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00262     Document Type: Article

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