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Volumn 21, Issue 9, 2015, Pages 1995-2000

Molecular pathways: A novel approach to targeting hypoxia and improving radiotherapy efficacy via reduction in oxygen demand

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE F 18; CISPLATIN; DICLOFENAC; INDOMETACIN; METFORMIN; NELFINAVIR; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PIROXICAM; RADIOPHARMACEUTICAL AGENT; ROSIGLITAZONE; UNCLASSIFIED DRUG; RADIOSENSITIZING AGENT;

EID: 84941945907     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0858     Document Type: Article
Times cited : (43)

References (49)
  • 1
    • 34447506424 scopus 로고    scopus 로고
    • Detection and characterization of tumor hypoxia using pO2 histography
    • Vaupel P, Hockel M, Mayer A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 2007;9:1221-35.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1221-1235
    • Vaupel, P.1    Hockel, M.2    Mayer, A.3
  • 2
    • 12144290194 scopus 로고    scopus 로고
    • Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding
    • Evans SM, Judy KD, Dunphy I, Jenkins WT, Nelson PT, Collins R, et al. Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding. Cancer Res 2004;64:1886-92.
    • (2004) Cancer Res , vol.64 , pp. 1886-1892
    • Evans, S.M.1    Judy, K.D.2    Dunphy, I.3    Jenkins, W.T.4    Nelson, P.T.5    Collins, R.6
  • 3
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 1999;53:113-7.
    • (1999) Radiother Oncol , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 4
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 2011;11:393-410.
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 5
    • 84878656302 scopus 로고    scopus 로고
    • Oxygen effect and reoxygenation
    • 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins
    • Hall EJ, Giaccia AJ. Oxygen effect and reoxygenation. In: radiobiology for the radiologist. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2012. p. 86-103.
    • (2012) Radiobiology for the Radiologist , pp. 86-103
    • Hall, E.J.1    Giaccia, A.J.2
  • 6
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953;26:638-48.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 7
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, et al. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 2002;20:680-7.
    • (2002) J Clin Oncol , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6
  • 9
    • 26444466467 scopus 로고    scopus 로고
    • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    • Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77:18-24.
    • (2005) Radiother Oncol , vol.77 , pp. 18-24
    • Nordsmark, M.1    Bentzen, S.M.2    Rudat, V.3    Brizel, D.4    Lartigau, E.5    Stadler, P.6
  • 10
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
    • Nordsmark M, Alsner J, Keller J, Nielsen OS, Jensen OM, Horsman MR, et al. Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br J Cancer 2001;84:1070-5.
    • (2001) Br J Cancer , vol.84 , pp. 1070-1075
    • Nordsmark, M.1    Alsner, J.2    Keller, J.3    Nielsen, O.S.4    Jensen, O.M.5    Horsman, M.R.6
  • 11
    • 0017379628 scopus 로고
    • Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial
    • Henk JM, Kunkler PB, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet 1977;2:101-3.
    • (1977) Lancet , vol.2 , pp. 101-103
    • Henk, J.M.1    Kunkler, P.B.2    Smith, C.W.3
  • 12
    • 0017404572 scopus 로고
    • Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial
    • Henk JM, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial. Lancet 1977; 2:104-5.
    • (1977) Lancet , vol.2 , pp. 104-105
    • Henk, J.M.1    Smith, C.W.2
  • 13
    • 0018123111 scopus 로고
    • Hyperbaric oxygen and radiotherapy: A Medical Research Council trial in carcinoma of the cervix
    • Watson ER, Halnan KE, Dische S, Saunders MI, Cade IS, McEwen JB, et al. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 1978;51:879-87.
    • (1978) Br J Radiol , vol.51 , pp. 879-887
    • Watson, E.R.1    Halnan, K.E.2    Dische, S.3    Saunders, M.I.4    Cade, I.S.5    McEwen, J.B.6
  • 14
    • 0018077143 scopus 로고
    • Hyperbaric oxygen and radiotherapy: A Medical Research Council trial in carcinoma of the bladder
    • Cade IS, McEwen JB, Dische S, Saunders MI, Watson ER, Halnan KE, et al. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the bladder. Br J Radiol 1978;51:876-8.
    • (1978) Br J Radiol , vol.51 , pp. 876-878
    • Cade, I.S.1    McEwen, J.B.2    Dische, S.3    Saunders, M.I.4    Watson, E.R.5    Halnan, K.E.6
  • 15
    • 0024331256 scopus 로고
    • Sensitization of hypoxic tumour cells-clinical experience
    • Overgaard J. Sensitization of hypoxic tumour cells-clinical experience. Int J Radiat Biol 1989;56:801-11.
    • (1989) Int J Radiat Biol , vol.56 , pp. 801-811
    • Overgaard, J.1
  • 16
    • 0024384825 scopus 로고
    • Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DAHANCA 2 study
    • Overgaard J, Hansen HS, Andersen AP, Hjelm-Hansen M, Jorgensen K, Sandberg E, et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study. Int J Radiat Oncol Biol Phys 1989;16:1065-8.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 1065-1068
    • Overgaard, J.1    Hansen, H.S.2    Andersen, A.P.3    Hjelm-Hansen, M.4    Jorgensen, K.5    Sandberg, E.6
  • 17
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 1998;46:135-46.
    • (1998) Radiother Oncol , vol.46 , pp. 135-146
    • Overgaard, J.1    Hansen, H.S.2    Overgaard, M.3    Bastholt, L.4    Berthelsen, A.5    Specht, L.6
  • 18
    • 0029066473 scopus 로고
    • Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas
    • Lee DJ, Cosmatos D, Marcial VA, Fu KK, Rotman M, Cooper JS, et al. Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas. Int J Radiat Oncol Biol Phys 1995;32:567-76.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 567-576
    • Lee, D.J.1    Cosmatos, D.2    Marcial, V.A.3    Fu, K.K.4    Rotman, M.5    Cooper, J.S.6
  • 19
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles asmodifiers of hypoxia in solid tumors
    • Overgaard J. Clinical evaluation of nitroimidazoles asmodifiers of hypoxia in solid tumors. Oncol Res 1994;6:509-18.
    • (1994) Oncol Res , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 20
    • 0027408134 scopus 로고
    • A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: An interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix
    • Medical Research Council Working Party on Advanced Carcinoma of the Cervix. A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix. Radiother Oncol 1993;26:93-103.
    • (1993) Radiother Oncol , vol.26 , pp. 93-103
  • 21
    • 79960344338 scopus 로고    scopus 로고
    • Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck-A systematic review and meta-analysis
    • Overgaard J. Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck-a systematic review and meta-analysis. Radiother Oncol 2011;100:22-32.
    • (2011) Radiother Oncol , vol.100 , pp. 22-32
    • Overgaard, J.1
  • 22
    • 0027358606 scopus 로고
    • MitomycinCas an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: Results from two randomized clinical trials
    • Haffty BG, Son YH, Sasaki CT, Papac R, Fischer D, Rockwell S, et al. MitomycinCas an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials. Int J Radiat Oncol Biol Phys 1993;27:241-50.
    • (1993) Int J Radiat Oncol Biol Phys , vol.27 , pp. 241-250
    • Haffty, B.G.1    Son, Y.H.2    Sasaki, C.T.3    Papac, R.4    Fischer, D.5    Rockwell, S.6
  • 24
    • 0028964029 scopus 로고
    • Mitomycin C (MMC) and unconventional fractionation (V-CHART) in advanced head and neck cancer
    • Dobrowsky W, Naude J, Dobrowsky E, Millesi W, Pavelka R, Grasl M, et al. Mitomycin C (MMC) and unconventional fractionation (V-CHART) in advanced head and neck cancer. Acta Oncol 1995;34:270-2.
    • (1995) Acta Oncol , vol.34 , pp. 270-272
    • Dobrowsky, W.1    Naude, J.2    Dobrowsky, E.3    Millesi, W.4    Pavelka, R.5    Grasl, M.6
  • 25
    • 0038030600 scopus 로고    scopus 로고
    • Radiotherapy with or withoutmitomycin c in the treatment of locally advanced head and neck cancer: Results of the IAEA multicentre randomised trial
    • Grau C, Prakash Agarwal J, Jabeen K, Rab Khan A, Abeyakoon S, Hadjieva T, et al. Radiotherapy with or withoutmitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial. Radiother Oncol 2003;67:17-26.
    • (2003) Radiother Oncol , vol.67 , pp. 17-26
    • Grau, C.1    Prakash Agarwal, J.2    Jabeen, K.3    Rab Khan, A.4    Abeyakoon, S.5    Hadjieva, T.6
  • 26
    • 77954600498 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group
    • Rischin D, Peters LJ, O'Sullivan B, Giralt J, Fisher R, Yuen K, et al. Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. J Clin Oncol 2010;28:2989-95.
    • (2010) J Clin Oncol , vol.28 , pp. 2989-2995
    • Rischin, D.1    Peters, L.J.2    O'Sullivan, B.3    Giralt, J.4    Fisher, R.5    Yuen, K.6
  • 27
    • 77957955293 scopus 로고    scopus 로고
    • Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
    • Rischin D, Young RJ, Fisher R, Fox SB, Le QT, Peters LJ, et al. Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol 2010;28:4142-8.
    • (2010) J Clin Oncol , vol.28 , pp. 4142-4148
    • Rischin, D.1    Young, R.J.2    Fisher, R.3    Fox, S.B.4    Le, Q.T.5    Peters, L.J.6
  • 28
    • 33646454133 scopus 로고    scopus 로고
    • Prognostic significance of [18F]-misonidazole positron emission tomographydetected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: A substudy of Trans-Tasman Radiation Oncology Group Study 98.02
    • Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, et al. Prognostic significance of [18F]-misonidazole positron emission tomographydetected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02. J Clin Oncol 2006;24:2098-104.
    • (2006) J Clin Oncol , vol.24 , pp. 2098-2104
    • Rischin, D.1    Hicks, R.J.2    Fisher, R.3    Binns, D.4    Corry, J.5    Porceddu, S.6
  • 29
    • 2442606603 scopus 로고    scopus 로고
    • Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: A theoretical model
    • Secomb TW, Hsu R, Dewhirst MW. Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. Int J Radiat Oncol Biol Phys 2004;59:572-8.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 572-578
    • Secomb, T.W.1    Hsu, R.2    Dewhirst, M.W.3
  • 30
    • 0017329778 scopus 로고
    • Radiosensitization of hypoxic cells of an in vitro tumor model by respiratory inhibitors
    • Durand RE, Biaglow JE. Radiosensitization of hypoxic cells of an in vitro tumor model by respiratory inhibitors. Radiat Res 1977;69:359-66.
    • (1977) Radiat Res , vol.69 , pp. 359-366
    • Durand, R.E.1    Biaglow, J.E.2
  • 32
    • 84855865176 scopus 로고    scopus 로고
    • Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors
    • Diepart C, Karroum O, Magat J, Feron O, Verrax J, Calderon PB, et al. Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors. Cancer Res 2012;72:482-90.
    • (2012) Cancer Res , vol.72 , pp. 482-490
    • Diepart, C.1    Karroum, O.2    Magat, J.3    Feron, O.4    Verrax, J.5    Calderon, P.B.6
  • 33
    • 0141509869 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration: A novel strategy to enhance druginduced apoptosis in human leukemia cells by a reactive oxygen speciesmediated mechanism
    • Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, et al. Inhibition of mitochondrial respiration: a novel strategy to enhance druginduced apoptosis in human leukemia cells by a reactive oxygen speciesmediated mechanism. J Biol Chem 2003;278:37832-9.
    • (2003) J Biol Chem , vol.278 , pp. 37832-37839
    • Pelicano, H.1    Feng, L.2    Zhou, Y.3    Carew, J.S.4    Hileman, E.O.5    Plunkett, W.6
  • 34
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
    • Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 2004;53:1052-9.
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1    Staniek, K.2    Gras, F.3    Scharf, N.4    Althaym, A.5    Clara, R.6
  • 35
    • 84890642780 scopus 로고    scopus 로고
    • Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response
    • Zannella VE, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, et al. Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response. Clin Cancer Res 2013;19:6741-50.
    • (2013) Clin Cancer Res , vol.19 , pp. 6741-6750
    • Zannella, V.E.1    Dal Pra, A.2    Muaddi, H.3    McKee, T.D.4    Stapleton, S.5    Sykes, J.6
  • 36
    • 84878561961 scopus 로고    scopus 로고
    • Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
    • Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, et al. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 2013;108: 2021-32.
    • (2013) Br J Cancer , vol.108 , pp. 2021-2032
    • Storozhuk, Y.1    Hopmans, S.N.2    Sanli, T.3    Barron, C.4    Tsiani, E.5    Cutz, J.C.6
  • 41
    • 84855371890 scopus 로고    scopus 로고
    • Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature
    • Fokas E, Im JH, Hill S, Yameen S, Stratford M, Beech J, et al. Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res 2012;72:239-48.
    • (2012) Cancer Res , vol.72 , pp. 239-248
    • Fokas, E.1    Im, J.H.2    Hill, S.3    Yameen, S.4    Stratford, M.5    Beech, J.6
  • 42
    • 33749472340 scopus 로고    scopus 로고
    • Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: Implications for radiotherapy
    • Pore N, Gupta AK, Cerniglia GJ, Jiang Z, Bernhard EJ, Evans SM, et al. Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res 2006;66:9252-9.
    • (2006) Cancer Res , vol.66 , pp. 9252-9259
    • Pore, N.1    Gupta, A.K.2    Cerniglia, G.J.3    Jiang, Z.4    Bernhard, E.J.5    Evans, S.M.6
  • 43
    • 68349137598 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
    • Cerniglia GJ, Pore N, Tsai JH, Schultz S, Mick R, Choe R, et al. Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS ONE 2009;4:e6539.
    • (2009) PLoS ONE , vol.4 , pp. e6539
    • Cerniglia, G.J.1    Pore, N.2    Tsai, J.H.3    Schultz, S.4    Mick, R.5    Choe, R.6
  • 44
    • 24944520308 scopus 로고    scopus 로고
    • HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo
    • Gupta AK, Cerniglia GJ, Mick R, McKenna WG, Muschel RJ. HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. Cancer Res 2005;65:8256-65.
    • (2005) Cancer Res , vol.65 , pp. 8256-8265
    • Gupta, A.K.1    Cerniglia, G.J.2    Mick, R.3    McKenna, W.G.4    Muschel, R.J.5
  • 45
    • 84902121858 scopus 로고    scopus 로고
    • Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
    • Kelly CJ, Hussien K, Fokas E, Kannan P, Shipley RJ, Ashton TM, et al. Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia. Radiother Oncol 2014;111: 72-80.
    • (2014) Radiother Oncol , vol.111 , pp. 72-80
    • Kelly, C.J.1    Hussien, K.2    Fokas, E.3    Kannan, P.4    Shipley, R.J.5    Ashton, T.M.6
  • 46
    • 24744451015 scopus 로고    scopus 로고
    • Tumor radiosensitization by antiinflammatory drugs: Evidence for a new mechanism involving the oxygen effect
    • Crokart N, Radermacher K, Jordan BF, Baudelet C, Cron GO, Gregoire V, et al. Tumor radiosensitization by antiinflammatory drugs: evidence for a new mechanism involving the oxygen effect. Cancer Res 2005;65: 7911-6.
    • (2005) Cancer Res , vol.65 , pp. 7911-7916
    • Crokart, N.1    Radermacher, K.2    Jordan, B.F.3    Baudelet, C.4    Cron, G.O.5    Gregoire, V.6
  • 47
    • 84863741171 scopus 로고    scopus 로고
    • Electron paramagnetic resonance highlights that the oxygen effect contributes to the radiosensitizing effect of paclitaxel
    • Danhier F, Danhier P, Magotteaux N, De Preter G, Ucakar B, Karroum O, et al. Electron paramagnetic resonance highlights that the oxygen effect contributes to the radiosensitizing effect of paclitaxel. PLoS ONE 2012;7: e40772.
    • (2012) PLoS ONE , vol.7 , pp. e40772
    • Danhier, F.1    Danhier, P.2    Magotteaux, N.3    De Preter, G.4    Ucakar, B.5    Karroum, O.6
  • 48
    • 84902437461 scopus 로고    scopus 로고
    • Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo
    • Zhang T, Zhang L, Zhang T, Fan J, Wu K, Guan Z, et al. Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo. Radiat Res 2014;181:641-9.
    • (2014) Radiat Res , vol.181 , pp. 641-649
    • Zhang, T.1    Zhang, L.2    Zhang, T.3    Fan, J.4    Wu, K.5    Guan, Z.6
  • 49
    • 84864400472 scopus 로고    scopus 로고
    • Hypoxia imaging markers and applications for radiation treatment planning
    • Lin A, Hahn SM. Hypoxia imaging markers and applications for radiation treatment planning. Semin Nucl Med 2012;42:343-52.
    • (2012) Semin Nucl Med , vol.42 , pp. 343-352
    • Lin, A.1    Hahn, S.M.2


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