Proton pump inhibitors and hypomagnesemia: A rare but serious complication

Kidney International

Volumn 83, Issue 4, 2013, Pages 553-556

  Perazella, Mark A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; MAGNESIUM ION; PROTON PUMP INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6;

ARTICLE; ENERGY METABOLISM; ENZYME MECHANISM; GASTROINTESTINAL ABSORPTION; GLOMERULUS; HOMEOSTASIS; HUMAN; HYPOMAGNESEMIA; KIDNEY PROXIMAL TUBULE; MAGNESIUM URINE LEVEL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 84875711929     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.462     Document Type: Note

References (9)

1. Brewster UC, Perazella MA. Proton pump inhibitors and the kidney: critical review. Clin Nephrol 2007; 68: 65-72.
2. Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 2006; 355: 1834-1836.
3. Cundy T, MacKay J. Proton pump inhibitors and severe hypomagnesemia. Curr Opin Gastroenterol 2011; 27: 180-185.
4. Rondón LJ, Tiel Groenestege WM, Rayssiguier Y, Mazur A. Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Am J Physiol Regul Integr Comp Physiol 2008; 294: R2001-R2007.
5. Cundy T, Dissanayake A. Severe hypomagnesemia in long-term users of proton-pump inhibitors. Clin Endocrinol 2008; 69: 338-341.
6. Bai JPF, Hausman E, Lionberger R, Zhang X. Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1. Oral absorption of magnesium. Mol Pharm advance online publication, 11 October 2012, doi:10.1021/mp300323q.
7. Hoorn EJ, van der Hoek J, de Man RA et al. A case series of proton pump inhibitorinduced hypomagnesemia. Am J Kidney Dis 2010; 56: 112-116.
8. Faulhaber GA, Furlanetto TW. Could magnesium depletion play a role on fracture risk in PPI users? Arch Intern Med 2010; 170: 1776.
9. Danziger J, William JH, Scott DJ et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int 2013; 83: 692-699.