Out-of-hospital use of proton pump inhibitors and hypomagnesemia at hospital admission: A nested case-control study

American Journal of Kidney Diseases

Volumn 62, Issue 4, 2013, Pages 730-737

  Koulouridis, Ioannis ^a,b   Alfayez, Mansour ^a,b   Tighiouart, Hocine ^c   Madias, Nicolaos E ^a,b   Kent, David M ^b,c   Paulus, Jessica K ^b,d   Jaber, Bertrand L ^a,b  

^a ST ELIZABETH'S MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

electrolyte disorders; Hypomagnesemia; proton pump inhibitors (PPIs)

Indexed keywords

CALCIUM; CREATININE; DIURETIC AGENT; ESOMEPRAZOLE; LANSOPRAZOLE; MAGNESIUM; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE; SERUM ALBUMIN;

ADULT; AGE; ALBUMIN BLOOD LEVEL; ARTICLE; CALCIUM BLOOD LEVEL; CASE CONTROL STUDY; COMORBIDITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DRUG EFFICACY; DRUG USE; ETHNICITY; FEMALE; GASTROESOPHAGEAL REFLUX; GENDER; GLOMERULUS FILTRATION RATE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; HYPOMAGNESEMIA; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEDICAL SERVICE; OUT OF HOSPITAL CARDIAC ARREST; PREDICTIVE VALUE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ELECTROLYTE DISORDERS; HYPOMAGNESEMIA; PROTON PUMP INHIBITORS (PPIS);

AGED; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPERCALCIURIA; MALE; NEPHROCALCINOSIS; PATIENT ADMISSION; PROSPECTIVE STUDIES; PROTON PUMP INHIBITORS; RENAL TUBULAR TRANSPORT, INBORN ERRORS; RETROSPECTIVE STUDIES;

EID: 84884532567     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2013.02.373     Document Type: Article

References (41)

1. P.J. Kahrilas, N.J. Shaheen, M.F. Vaezi American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease Gastroenterology 135 4 2008 1383 1391 1391 e1381-e1385
2. J.P. Bader, J.C. Delchier Clinical efficacy of pantoprazole compared with ranitidine Aliment Pharmacol Ther 8 suppl 1 1994 47 52
3. US Food and Drug Administration May 25, 2010 http://www.fda.gov/ ForConsumers/ConsumerUpdates/ucm213240.htm Accessed February 16, 2012
4. L. Pasina, A. Nobili, M. Tettamanti Co-prescription of gastroprotective agents in patients taking non-selective NSAIDs or COX-2 selective inhibitors: analysis of prescriptions Int J Clin Pharmacol Ther 48 11 2010 735 743
5. A.M. Fendrick, M. Shaw, B. Schachtel Self-selection and use patterns of over-the-counter omeprazole for frequent heartburn Clin Gastroenterol Hepatol 2 1 2004 17 21
6. Report by the IMS Institute for Healthcare Informatics: "Top Therapeutic Classes by US Spending" http://www.imshealth.com/deployedfiles/ ims/Global/Content/Corporate/Press%20Room/Top- Line%20Market%20Data%20&%20Trends/2011%20Top-line%20Market%20Data/ Top-Therapy-Classes-by-Sales.pdf Accessed March 30, 2013
7. E. Sheen, G. Triadafilopoulos Adverse effects of long-term proton pump inhibitor therapy Dig Dis Sci 56 4 2011 931 950
8. C.S. Eom, C.Y. Jeon, J.W. Lim, E.G. Cho, S.M. Park, K.S. Lee Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis CMAJ 183 3 2011 310 319
9. M. Epstein, S. McGrath, F. Law Proton-pump inhibitors and hypomagnesemic hypoparathyroidism N Engl J Med 355 17 2006 1834 1836
10. D.C. Metz, M.B. Sostek, P. Ruszniewski, C.E. Forsmark, J. Monyak, J.R. Pisegna Effects of esomeprazole on acid output in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion Am J Gastroenterol 102 12 2007 2648 2654
11. T. Cundy, A. Dissanayake Severe hypomagnesaemia in long-term users of proton-pump inhibitors Clin Endocrinol (Oxf) 69 2 2008 338 341
12. M. Francois, N. Levy-Bohbot, J. Caron, V. Durlach [Chronic use of proton-pump inhibitors associated with giardiasis: a rare cause of hypomagnesemic hypoparathyroidism?] Ann Endocrinol (Paris) 69 5 2008 446 448
13. N. Shabajee, E.J. Lamb, I. Sturgess, R.W. Sumathipala Omeprazole and refractory hypomagnesaemia BMJ 337 2008 a425
14. M.A. Broeren, E.A. Geerdink, H.L. Vader, A.W. van den Wall Bake Hypomagnesemia induced by several proton-pump inhibitors Ann Intern Med 151 10 2009 755 756
15. C. Hmu, P. Moulik, A. Macleod Severe hypomagnesaemia due to lansoprazole BMJ Case Rep 2009 2009
16. M.T. Kuipers, H.D. Thang, A.B. Arntzenius Hypomagnesaemia due to use of proton pump inhibitors - a review Neth J Med 67 5 2009 169 172
17. F.J. Fernandez-Fernandez, P. Sesma, T. Cainzos-Romero, L. Ferreira-Gonzalez Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole Neth J Med 68 10 2010 329 330
18. E.J. Hoorn, J. van der Hoek, R.A. de Man, E.J. Kuipers, C. Bolwerk, R. Zietse A case series of proton pump inhibitor-induced hypomagnesemia Am J Kidney Dis 56 1 2010 112 116
19. J.D. Mackay, P.T. Bladon Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series QJM 103 6 2010 387 395
20. A.L. Negri, E.E. Valle Hypomagnesaemia/hypokalemia associated with the use of esomeprazole Curr Drug Saf 6 3 2011 204 206
21. J. Doornebal, R. Bijlsma, R.M. Brouwer [An unknown but potentially serious side effect of proton pump inhibitors: hypomagnesaemia] Ned Tijdschr Geneeskd 153 2009 A711
22. G. Regolisti, A. Cabassi, E. Parenti, U. Maggiore, E. Fiaccadori Severe hypomagnesemia during long-term treatment with a proton pump inhibitor Am J Kidney Dis 56 1 2010 168 174
23. T. Cundy, J. Mackay Proton pump inhibitors and severe hypomagnesaemia Curr Opin Gastroenterol 27 2 2011 180 185
24. J. Ayuk, N.J. Gittoes How should hypomagnesaemia be investigated and treated? Clin Endocrinol (Oxf) 75 6 2011 743 746
25. A. Callejas Diaz, E. Montero Hernandez, M. Gil Navarro, P. Tutor-Ureta, M. Yebra Bango, J.A. Vargas Nunez [Omeprazole and hypomagnesemia] Rev Clin Esp 211 6 2011 e30 e33
26. T.W. Furlanetto, G.A. Faulhaber Hypomagnesemia and proton pump inhibitors: below the tip of the iceberg Arch Intern Med 171 15 2011 1391 1392
27. M. Quasdorff, J. Mertens, J. Dinter, H.M. Steffen Recurrent hypomagnesemia with proton-pump inhibitor rechallenge Ann Intern Med 155 6 2011 405 407
28. FDA website http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm Accessed February 16, 2012
29. Drugs.com http://www.drugs.com/fda/proton-pump-inhibitor-ppis-safety- communication-low-magnesium-levels-can-associated-long-term-12913.html Accessed February 16, 2012
30. D.E. Ho, K. Imai, G. King, E.A. Stuart MatchIt: nonparametric preprocessing for parametric causal inference J Stat Software 42 8 2011 1 28 http://www.jstatsoft.org/v42/i08/ Accessed March 10, 2011
31. C.A. Stedman, M.L. Barclay Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors Aliment Pharmacol Ther 14 8 2000 963 978
32. P. Richardson, C.J. Hawkey, W.A. Stack Proton pump inhibitors Pharmacology and rationale for use in gastrointestinal disorders Drugs 56 3 1998 307 335
33. R. Whang, E.M. Hampton, D.D. Whang Magnesium homeostasis and clinical disorders of magnesium deficiency Ann Pharmacother 28 2 1994 220 226
34. M.E. Charlson, P. Pompei, K.L. Ales, C.R. MacKenzie A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 5 1987 373 383
35. R.A. Deyo, D.C. Cherkin, M.A. Ciol Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases J Clin Epidemiol 45 6 1992 613 619
36. A.S. Levey, L.A. Stevens, C.H. Schmid A new equation to estimate glomerular filtration rate Ann Intern Med 150 9 2009 604 612
37. R Development Core Team R: A Language and Environment for Statistical Computing 2011 R Foundation for Statistical Computing Vienna, Austria http://www.R-project.org/ Accessed January 9, 2012
38. K.P. Schlingmann, S. Waldegger, M. Konrad, V. Chubanov, T. Gudermann TRPM6 and TRPM7 - gatekeepers of human magnesium metabolism Biochim Biophys Acta 1772 8 2007 813 821
39. S. Yasuda, S. Higashi, M. Murakami, Y. Tomono, M. Kawaguchi Antacids have no influence on the pharmacokinetics of rabeprazole, a new proton pump inhibitor, in healthy volunteers Int J Clin Pharmacol Ther 37 5 1999 249 253
40. J.T. Gau, Y.X. Yang, R. Chen, T.C. Kao Uses of proton pump inhibitors and hypomagnesemia Pharmacoepidemiol Drug Saf 21 5 2012 553 559
41. M.W. Hess, J.G. Hoenderop, R.J. Bindels, J.P. Drenth Systematic review: hypomagnesaemia induced by proton pump inhibition Aliment Pharmacol Ther 36 5 2012 405 413