Profiling neuronal ion channelopathies with non-invasive brain imaging and dynamic causal models: Case studies of single gene mutations

NeuroImage

Volumn 124, Issue , 2016, Pages 43-53

  Gilbert, Jessica R ^a   Symmonds, Mkael ^b   Hanna, Michael G ^c   Dolan, Raymond J ^d   Friston, Karl J ^d   Moran, Rosalyn J ^a,e  

^a VIRGINIA TECH CARILION SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MAX PLANCK UCL CENTRE FOR COMPUTATIONAL PSYCHIATRY AND AGEING RESEARCH   (United Kingdom)

^e State University   (United States)

Author keywords

Biophysical models; Channelopathies; Dynamic causal modeling; Ion channel signaling; Magnetoencephalography

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; ION CHANNEL; LIGAND GATED ION CHANNEL; NEUROTRANSMITTER; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CHLORIDE CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; CACNA1A PROTEIN, HUMAN; CALCIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ2 PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CACNA1A GENE; CASE STUDY; CAUSAL MODELING; CLINICAL ARTICLE; CONTROLLED STUDY; DYNAMIC CAUSAL MODELING; FEASIBILITY STUDY; FEMALE; GENE MUTATION; HUMAN; KCNJ2 GENE; LOSS OF FUNCTION MUTATION; MAGNETOENCEPHALOGRAPHY; MIDDLE AGED; MISMATCH NEGATIVITY; MONOGENIC DISORDER; NEUROIMAGING; NEURONAL CHANNELOPATHY; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SYNAPTIC POTENTIAL; AGED; AUDITORY CORTEX; AUDITORY EVOKED POTENTIAL; AUDITORY STIMULATION; BIOLOGICAL MODEL; BRAIN; CASE REPORT; CHANNELOPATHY; COMPUTER SIMULATION; GENETICS; HEARING; MALE; MUTATION; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SYNAPSE; VERY ELDERLY; YOUNG ADULT;

ACOUSTIC STIMULATION; ADULT; AGED; AGED, 80 AND OVER; AUDITORY CORTEX; AUDITORY PERCEPTION; BRAIN; CALCIUM CHANNELS; CHANNELOPATHIES; COMPUTER SIMULATION; EVOKED POTENTIALS, AUDITORY; FEMALE; HUMANS; MAGNETOENCEPHALOGRAPHY; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; MUTATION; NEURONS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SYNAPSES; YOUNG ADULT;

EID: 84941918086     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2015.08.057     Document Type: Article

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