Clinical characteristics of children and adolescents with severe therapy-resistant asthma in Brazil;Características clínicas de crianças e adolescentes Brasileiros com asma grave resistente a terapia

Jornal Brasileiro de Pneumologia

Volumn 41, Issue 4, 2015, Pages 343-350

  Rodrigues, Andrea Mendonça ^a   Roncada, Cristian ^a   Santos, Giovana ^a   Heinzmann Filho, João Paulo ^a   de Souza, Rodrigo Godinho ^a   Vargas, Mauro Henrique Moraes ^a   Pinto, Leonardo Araújo ^a   Jones, Marcus Herbert ^a   Stein, Renato Tetelbom ^a   Pitrez, Paulo Márcio ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Allergy and immunology; Inflammation; Respiratory function tests; Sputum

Indexed keywords

ANTIASTHMATIC AGENT; OMALIZUMAB;

ADOLESCENT; ASTHMA; BRAZIL; CHILD; CYTOLOGY; DIAGNOSTIC IMAGING; DRUG RESISTANCE; ESOPHAGEAL PH MONITORING; FEMALE; HUMAN; HYPERSENSITIVITY; INFLAMMATION; LUNG FUNCTION TEST; MALE; PATHOPHYSIOLOGY; PRESCHOOL CHILD; QUALITY OF LIFE; RADIOGRAPHY; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SKIN TEST; SPUTUM; TREATMENT FAILURE;

ADOLESCENT; ANTI-ASTHMATIC AGENTS; ASTHMA; BRAZIL; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE; ESOPHAGEAL PH MONITORING; FEMALE; HUMANS; HYPERSENSITIVITY; INFLAMMATION; MALE; OMALIZUMAB; QUALITY OF LIFE; RADIOGRAPHY; RESPIRATORY FUNCTION TESTS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SKIN TESTS; SPUTUM; TREATMENT FAILURE;

EID: 84941913243     PISSN: 18063713     EISSN: 18063756     Source Type: Journal    
DOI: 10.1590/S1806-37132015000004462     Document Type: Article

References (31)

1. Global Initiative for Asthma [homepage on the Internet]. Bethesda: Global Strategy for Asthma Management and Prevention 2014; c2014 [cited 2014 Oct 27]. [Adobe Acrobat document, 148p.]. Available from: http://www.ginasthma.org/
2. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet. 1998;351(9111):1225-32. http://dx.doi.org/10.1016/S0140-6736(97)07302-9
3. Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014;18(11):1269-78. http://dx.doi.org/10.5588/ijtld.14.0170
4. Lang A, Carlsen KH, Haaland G, Devulapalli CS, Munthe-Kaas M, Mowinckel P, et al. Severe asthma in childhood: assessed in 10 year olds in a birth cohort study. Allergy. 2008;63(8):1054-60. Erratum in: Allergy. 2009;64(5):822. http://dx.doi.org/10.1111/j.1398-9995.2008.01672.x
5. Hedlin G, Bush A, Lødrup Carlsen K, Wennergren G, De Benedictis FM, Melén E, et al. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. Eur Respir J. 2010;36(1):196-201. http://dx.doi.org/10.1183/09031936.00104809
6. Bush A, Saglani S. Management of severe asthma in children. Lancet. 2010;376(9743):814-25. http://dx.doi.org/10.1016/S0140-6736(10)61054-9
7. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-73. Erratum in: Eur Respir J. 2014;43(4):1216. http://dx.doi.org/10.1183/09031936.00202013
8. Payne DN, Qiu Y, Zhu J, Peachey L, Scallan M, Bush A, et al. Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms. Thorax. 2004;59(10):862-9. http://dx.doi.org/10.1136/thx.2003.017244
9. Bossley CJ, Saglani S, Kavanagh C, Payne DN, Wilson N, Tsartsali L, et al. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma. Eur Respir J. 2009;34(5):1052-9. http://dx.doi.org/10.1183/09031936.00186508
10. Bossley CJ, Fleming L, Gupta A, Regamey N, Frith J, Oates T, et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol. 2012;129(4):974-82.e13.
11. Saglani S, Lui S, Ullmann N, Campbell GA, Sherburn RT, Mathie SA, et al. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol. 2013;132(3):676-685.e13.
12. Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapyresistant asthma. Thorax. 2014;69(6):508-15. http://dx.doi.org/10.1136/thoraxjnl-2013-203421
13. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2009;64(6):476-83. http://dx.doi.org/10.1136/thx.2008.106609
14. Centers for Disease Control and Prevention [homepage on the Internet]. Atlanta: CDC. [cited 2014 Oct 27].Clinical Growth Charts. Available from: http://www.cdc.gov/growthcharts/clinical_charts.htm
15. Loeb JS, Blower WC, Feldstein JF, Koch BA, Munlin AL, Hardie WD. Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria. Pediatr Pulmonol. 2008;43(10):1020-4. http://dx.doi.org/10.1002/ppul.20908
16. Lung Function in Growth and Aging: a united worldwide approach. Global Lung Function Initiative [homepage on the Internet]. Perth: the Initiative. 2013 [cited 2014 Oct 27]. Available from: http://www.lungfunction.org
17. Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax. 2012;67(8):675-81. http://dx.doi.org/10.1136/thoraxjnl-2011-201064
18. Roxo JP, Ponte EV, Ramos DC, Pimentel L, D’Oliveira Júnior A, Cruz AA. Portuguese-language version of the Asthma Control Test. J Bras Pneumol. 2010;36(2):159-66. http://dx.doi.org/10.1590/S1806-37132010000200002
19. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med. 2000;162(6):2341-51. http://dx.doi.org/10.1164/ajrccm.162.6.ats9-00
20. Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy. 2012;42(5):650-8. http://dx.doi.org/10.1111/j.1365-2222.2011.03929.x
21. Luisi F, Pinto LA, Marostica L, Jones MH, Stein RT, Pitrez PM. Persistent pulmonary function impairment in children and adolescents with asthma. J Bras Pneumol. 2012;38(2):158-66.
22. Jenkins HA, Cherniack R, Szefler SJ, Covar R, Gelfand EW, Spahn JD. A comparison of the clinical characteristics of children and adults with severe asthma. Chest. 2003;124(4):1318-24. http://dx.doi.org/10.1378/chest.124.4.1318
23. Bacharier LB, Strunk RC, Mauger D, White D, Lemanske RF Jr, Sorkness CA. Classifying asthma severity in children: mismatch between symptoms, medication use, and lungfunction. Am J Respir Crit Care Med. 2004;170(4):426-32. http://dx.doi.org/10.1164/rccm.200308-1178OC
24. Saglani S, Payne DN, Zhu J, Wang Z, Nicholson AG, Bush A, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med. 2007;176(9):858-64. http://dx.doi.org/10.1164/rccm.200702-212OC
25. Payne DN, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003;167(1):78-82. http://dx.doi.org/10.1164/rccm.200205-414OC
26. Gibson PG, Henry RL, Thomas P. Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate. Eur Respir J. 2000;16(5):1008-15.
27. Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, et al. Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern. Pediatr Pulmonol. 2005;39(4):318-24. http://dx.doi.org/10.1002/ppul.20159
28. Thakkar K, Boatright RO, Gilger MA, El-Serag HB. Gastroesophageal reflux and asthma in children: a systematic review. Pediatrics. 2010;125(4):e925-30. http://dx.doi.org/10.1542/peds.2009-2382
29. Fried AJ, Oettgen HC. Anti-IgE in the treatment of allergic disorders in pediatrics. Curr Opin Pediatr. 2010;22(6):758-64. http://dx.doi.org/10.1097/MOP.0b013e3283404201
30. Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011;364(11):1005-15. http://dx.doi.org/10.1056/NEJMoa1009705
31. Deschildre A, Marguet C, Salleron J, Pin I, Rittié JL, Derelle J, et al. Add-on omalizumab in children with severe allergic asthma: a 1-year real life survey. Eur Respir J. 2013;42(5):1224-33. http://dx.doi.org/10.1183/09031936.00149812