Mendelian randomization study of body mass index and colorectal cancer risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 24, Issue 7, 2015, Pages 1024-1031

  Thrift, Aaron P ^a,b   Gong, Jian ^a   Peters, Ulrike ^a,c   Chang Claude, Jenny ^d   Rudolph, Anja ^d   Slattery, Martha L ^e   Chan, Andrew T ^f,g   Locke, Adam E ^h   Kahali, Bratati ⁱ   Justice, Anne E ^j   Pers, Tune H ^k,l,m,n   Gallinger, Steven ^o   Hayes, Richard B ^p   Baron, John A ^q   J caan, Bette ^r   Ogino, Shuji ^g,s,t   Berndt, Sonja I ^u   Chanock, Stephen J ^u   Casey, Graham ^v   Haile, Robert W ^w   Du, Mengmeng ^a,c,g   Harrison, Tabitha A ^a   Thornquist, Mark ^a   Duggan, David J ^x   Le Marchand, Loïc ^y   Lindor, Noralane M ^z   Seminara, Daniela ^u   Song, Mingyang ^t   Wu, Kana ^t   Thibodeau, Stephen N ^aa   Cotterchio, Michelle ^ab   Win, Aung Ko ^ac   Jenkins, Mark A ^ac   Hopper, John ^ac   Ulrich, Cornelia M ^ad   Potter, John D ^a,c,ae   Newcomb, Polly A ^a,c   Hoffmeister, Michael ^af   Brenner, Hermann ^d,af   White, Emily ^a,c   Hsu, Li ^a,c   Campbell, Peter T ^ag   more..

^a Fred Hutchinson Cancer Research Center   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h UNIVERSITY OF MICHIGAN   (United States)

ⁱ UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^j IL   (United States)

^k BOSTON CHILDREN S HOSPITAL   (United States)

^l BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^m HARVARD MEDICAL SCHOOL   (United States)

ⁿ TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^o MOUNT SINAI HOSPITAL   (Canada)

^p NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^q UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^r DIVISION OF RESEARCH   (United States)

^s DANA FARBER CANCER INSTITUTE   (United States)

^t HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^u NATIONAL CANCER INSTITUTE   (United States)

^v UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^w STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^x TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^y UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^z MAYO CLINIC   (United States)

^aa MAYO CLINIC   (United States)

^ab CANCER CARE ONTARIO   (Canada)

^ac UNIVERSITY OF MELBOURNE   (Australia)

^ad UNIVERSITY OF UTAH   (United States)

^ae MASSEY UNIVERSITY   (New Zealand)

^af Division of Clinical Epidemiology and Aging Research   (Germany)

^ag AMERICAN CANCER SOCIETY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL OBESITY; ADULT; ALLELE; ARTICLE; BODY MASS; CANCER RISK; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; INSTRUMENTAL VARIABLE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; OBSERVATIONAL STUDY; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; CLINICAL TRIAL; COLORECTAL NEOPLASMS; COMPLICATION; EUROPE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; MULTICENTER STUDY; OBESITY; ODDS RATIO; PROCEDURES; RISK FACTOR;

BODY MASS INDEX; COLORECTAL NEOPLASMS; EUROPE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; OBESITY; ODDS RATIO; RISK FACTORS;

EID: 84941781236     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-14-1309     Document Type: Article

References (33)

1. Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut 2013;62:933-47.
2. Schisterman EF, Cole SR, Platt RW. Overadjustment bias and unnecessary adjustment in epidemiologic studies. Epidemiology 2009;20:488-95.
3. Shields M, Connor Gorber S, Tremblay MS. Estimates of obesity based on self-report versus direct measures. Health Rep 2008;19:61-76.
4. Connor Gorber S, Tremblay M, Moher D, Gorber B. A comparison of direct vs. self-reportmeasures for assessing height, weight and body mass index: A systematic review. Obes Rev 2007;8:307-26.
5. Davey Smith G, Ebrahim S. M;endelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
6. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008;27:1133-63.
7. Greenland S. An introduction to instrumental variables for epidemiologists. Int J Epidemiol 2000;29:722-9.
8. Palmer TM, Lawlor DA, Harbord RM, Sheehan NA, Tobias JH, Timpson NJ, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res 2012;21:223-42.
9. Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, et al. Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis. Gastroenterology 2013;144:799-807.
10. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Kearney J, et al.Aprospective study of cigarettesmoking andrisk of colorectal adenoma and colorectal cancer in U.S. men. J Natl Cancer Inst 1994;86:183-91.
11. Giovannucci E, Colditz GA, Stampfer MJ, Hunter D, Rosner BA, Willett WC, et al. A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. women. J Natl Cancer Inst 1994;86:192-9.
12. Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II-a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol 2000; 10:125-34.
13. Prorok PC, Andriole GL, Bresalier RS, Buys SS, Chia D, Crawford ED, et al. Design of the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial. Control Clin Trials 2000;21(6 Suppl):273S-309S.
14. White E, Patterson RE, Kristal AR, Thornquist M, King I, Shattuck AL, et al. VITamins And Lifestyle cohort study: study design and characteristics of supplement users. Am J Epidemiol 2004;159:83-93.
15. Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group. Control Clin Trials 1998;19:61-109.
16. Newcomb PA, Baron J, Cotterchio M, Gallinger S, Grove J, Haile R, et al. Colon Cancer Family Registry: An international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol Biomarkers Prev 2007;16:2331-43.
17. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 2007;39:989-94.
18. Slattery ML, Friedman GD, Potter JD, Edwards S, Caan BJ, Samowitz W. A description of age, sex, and site distributions of colon carcinoma in three geographic areas. Cancer 1996;78:1666-70.
19. Slattery ML, Potter J, Caan B, Edwards S, Coates A, Ma KN, et al. Energy balance and colon cancer-beyond physical activity. Cancer Res 1997; 57:75-80.
20. Newcomb PA, Zheng Y, Chia VM, Morimoto LM, Doria-Rose VP, Templeton A, et al. Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women. Cancer Res 2007; 67:7534-9.
21. Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M. Protection from colorectal cancer after colonoscopy: A population-based, case-control study. Ann Intern Med 2011;154:22-30.
22. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-9.
23. Hutter CM, Chang-Claude J, Slattery ML, Pflugeisen BM, Lin Y, Duggan D, et al. Characterization of gene-environment interactions for colorectal cancer susceptibility loci. Cancer Res 2012;72:2036-44.
24. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015;518:197-206.
25. Palmer TM, Sterne JA, Harbord RM, Lawlor DA, Sheehan NA, Meng S, et al. Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses. Am J Epidemiol 2011;173:1392-403.
26. Staiger D, Stock JH. Instrumental variables regression with weak instruments. Econometrica 1997;65:557-86.
27. Baum CF, Schaffer ME, Stillman S. Instrumental variables and GMM: Estimation and testing. Stata Journal 2003;3:1-32.
28. Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015;518:187-96.
29. Campbell PT, Jacobs ET, Ulrich CM, Figueiredo JC, Poynter JN, McLaughlin JR, et al. Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst 2010;102:391-400.
30. Morikawa T, Kuchiba A, Lochhead P, Nishihara R, Yamauchi M, Imamura Y, et al. Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with beta-catenin (CTNNB1) status. Cancer Res 2013;73:1600-10.
31. Kuchiba A, Morikawa T, Yamauchi M, Imamura Y, Liao X, Chan AT, et al. Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study. J Natl Cancer Inst 2012; 104:415-20.
32. Aleman JO, Eusebi LH, Ricciardiello L, Patidar K, Sanyal AJ, Holt PR. Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 2014;146:357-73.
33. Kant P, Hull MA. Excess body weight and obesity-the link with gastrointestinal and hepatobiliary cancer. Nat Rev Gastroenterol Hepatol 2011; 8:224-38.