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Interobserver variance in myelodysplastic syndromes with less than 5 % bone marrow blasts: unilineage vs. multilineage dysplasia and reproducibility of the threshold of 2 % blasts
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Font P, Loscertales J, Soto C, et al. Interobserver variance in myelodysplastic syndromes with less than 5 % bone marrow blasts: unilineage vs. multilineage dysplasia and reproducibility of the threshold of 2 % blasts. Ann Hematol. 2015;94:565–73.
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Inter-observer variance with the diagnosis of myelodysplastic syndromes (MDS) following the 2008 WHO classification
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Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet
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Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes
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Diagnostic discrimination and cost effective assay strategy for leukocyte alkaline phosphatase
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COI: 1:CAS:528:DyaK28XkslKrtw%3D%3D, PID: 8919203
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Quantitative real-time reverse-transcription polymerase chain reaction for diagnosis of BCR-ABL positive leukemias and molecular monitoring following allogeneic stem cell transplantation
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COI: 1:CAS:528:DC%2BD3sXhsFOhsbs%3D, PID: 12631253
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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
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Molecular pathophysiology of myelodysplastic syndromes
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COI: 1:CAS:528:DC%2BC3sXltVKqsrw%3D, PID: 22934674, Excellent review on somatic mutations and the molecular pathology of MDS.
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Lindsley RC, Ebert BL. Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol. 2013;8:21–47. Excellent review on somatic mutations and the molecular pathology of MDS.
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Lindsley, R.C.1
Ebert, B.L.2
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Clinical effect of point mutations in myelodysplastic syndromes
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COI: 1:CAS:528:DC%2BC3MXosVeis7s%3D, PID: 21714648, This is one of three large studies to demonstrate that somatic mutations have prognostic significance independent of the IPSS.
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Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011;364:2496–506. This is one of three large studies to demonstrate that somatic mutations have prognostic significance independent of the IPSS.
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Bejar, R.1
Stevenson, K.2
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84888219405
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Clinical and biological implications of driver mutations in myelodysplastic syndromes
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COI: 1:CAS:528:DC%2BC3sXhvVKjsL%2FF, PID: 24030381, This is one of three large studies that examined patterns of mutations and their prognostic value in a large cohort of MDS patients.
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Papaemmanuil E, Gerstung M, Malcovati L, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122:3616–27. This is one of three large studies that examined patterns of mutations and their prognostic value in a large cohort of MDS patients.
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Blood
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Papaemmanuil, E.1
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84893772765
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Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
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COI: 1:CAS:528:DC%2BC3sXhvVyktL7N, This is one of three large studies that examined patterns of mutations and their prognostic value in a large cohort of MDS patients.
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Haferlach T, Nagata Y, Grossmann V, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leuk: Off J Leuk Soc Am, Leuk Res Fund, UK. 2014;28:241–7. This is one of three large studies that examined patterns of mutations and their prognostic value in a large cohort of MDS patients.
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Leuk: Off J Leuk Soc Am, Leuk Res Fund, UK
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Haferlach, T.1
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79960229916
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Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
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COI: 1:CAS:528:DC%2BC3MXoslOitL0%3D, PID: 21494260
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Itzykson R, Kosmider O, Cluzeau T, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia. 2011;25:1147–52.
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84891876933
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Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
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COI: 1:CAS:528:DC%2BC2cXmtVCqsA%3D%3D, PID: 24045501
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Traina F, Visconte V, Elson P, et al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Leukemia. 2014;28:78–87.
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84906809218
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Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation
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This article demonstrates the predictive value of somatic mutations in MDS patients undergoing allogeneic stem cell transplant.
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Bejar R, Stevenson KE, Caughey B, et al. Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. J Clin Oncol: Off J Am Soc Clin Oncol. 2014;32:2691–8. This article demonstrates the predictive value of somatic mutations in MDS patients undergoing allogeneic stem cell transplant.
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J Clin Oncol: Off J Am Soc Clin Oncol
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Bejar, R.1
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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
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COI: 1:CAS:528:DC%2BC2cXhvVygsrjF, PID: 25224413, This article demonstrates the predictive value of somatic mutations in MDS patients treated with hypomethylating agents.
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Bejar R, Lord A, Stevenson K, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 2014;124:2705–12. This article demonstrates the predictive value of somatic mutations in MDS patients treated with hypomethylating agents.
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Blood
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Bejar, R.1
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I walk the line: how to tell MDS from other bone marrow failure conditions
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Gondek LP, DeZern AE. I walk the line: how to tell MDS from other bone marrow failure conditions. Curr Hematol Malig Rep. 2014;9:389–99.
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Perspective on how to approach molecular diagnostics in acute myeloid leukemia and myelodysplastic syndromes in the era of next-generation sequencing
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Validation of the MD Anderson prognostic risk model for patients with myelodysplastic syndrome
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A prognostic score for patients with lower risk myelodysplastic syndrome
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Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
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COI: 1:CAS:528:DC%2BC3MXhtFGnur3M, PID: 21909114, This article describes somatic mutations in 8 splicing factor genes and their frequency in myeloid malignancies.
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PID: 25426837, This is one of two whole exome sequencing studies that describe age-related somatic mutations in the blood of GWAS participants.
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PID: 25426838, This is one of two whole exome sequencing studies that describe age-related somatic mutations in the blood of GWAS participants.
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Genovese G, Kahler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371:2477–87. This is one of two whole exome sequencing studies that describe age-related somatic mutations in the blood of GWAS participants.
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PID: 23015360, An excellent guide to the challenges associated with the diagnosis of MDS.
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