Markers of endothelial cell activation and immune activation are increased in patients with severe leptospirosis and associated with disease severity

Journal of Infection

Volumn 71, Issue 4, 2015, Pages 437-446

  Goeijenbier, Marco ^a   Gasem, M Hussein ^b,f   Meijers, Joost C M ^c,d   Hartskeerl, Rudy A ^e   Ahmed, Ahmed ^e   Goris, Marga G A ^e   Isbandrio, Bambang ^f   Schuller, Simone S ^g   Osterhaus, Albert D M E ^a,h   Martina, Byron E E ^a,h   van Gorp, Eric C M ^a   Nally, Jarlath E ⁱ   Wagenaar, Jiri F P ^a,e  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DIPONEGORO UNIVERSITY   (Indonesia)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d SANQUIN RESEARCH   (Netherlands)

^e ROYAL TROPICAL INSTITUTE   (Netherlands)

^f Department of Clinical Microbiology   (Indonesia)

^g UNIVERSITY OF BERN   (Switzerland)

^h Artemis One Health   (Netherlands)

ⁱ NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

E selectin; Endothelial cell; Leptospirosis; SFas ligand; SIL 2 receptor; Von Willebrand factor

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FAS LIGAND; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; SOLUBLE INTERLEUKIN 2 RECEPTOR; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER; FASLG PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LENGTH OF STAY; LEPTOSPIRA INTERROGANS SEROVAR COPENHAGENI; LEPTOSPIROSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRUS ENTRY; VIRUS REPLICATION; VIRUS SURVIVAL; VIRUS VIRULENCE; BLOOD; COHORT ANALYSIS; CYTOLOGY; IMMUNOLOGY; LEPTOSPIRA; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; ULTRASTRUCTURE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ADULT; BIOMARKERS; COHORT STUDIES; E-SELECTIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FAS LIGAND PROTEIN; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LEPTOSPIRA; LEPTOSPIROSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECEPTORS, INTERLEUKIN-2; SEVERITY OF ILLNESS INDEX; VON WILLEBRAND FACTOR;

EID: 84941744544     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2015.05.016     Document Type: Article

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