Thalassaemia major and infectious risk: High Mobility Group Box-1 represents a novel diagnostic and prognostic biomarker

British Journal of Haematology

Volumn 171, Issue 1, 2015, Pages 130-136

  Chirico, Valeria ^a   Lacquaniti, Antonio ^a   Piraino, Basilia ^a   Cutrupi, Maricia ^a   Cuppari, Caterina ^a   Grasso, Luisa ^a   Rigoli, Luciana ^a   David, Antonio ^a   Arrigo, Teresa ^a   Salpietro, Carmelo ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Hepatitis C virus infection; HMGB1; Infection; Iron overload; Splenectomy; Thalassaemia

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; BIOLOGICAL MARKER; HMGB1 PROTEIN, HUMAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GRAM NEGATIVE INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR DIAGNOSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SPLENECTOMY; THALASSEMIA MAJOR; TREATMENT INDICATION; BETA-THALASSEMIA; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; INFECTION; RISK FACTOR;

ADULT; BETA-THALASSEMIA; BIOMARKERS; FEMALE; HMGB1 PROTEIN; HUMANS; INFECTION; MALE; PROGNOSIS; RISK FACTORS; SPLENECTOMY;

EID: 84941738222     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13530     Document Type: Article

References (22)

1. Ahluwalia, J., Datta, U., Marwaha, R.K. & Sehgal, S. (2000) Immune functions in splenectomized thalassaemic children. Indian Journal of Pediatrics, 67, 871-876.
2. Angus, D.C., Yang, L., Kong, L., Kellum, J.A., Delude, R.L., Tracey, K.J. & Weissfeld, L.GenIMS Investigators (2007) Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Critical Care Medicine, 35, 1061-1067.
3. Arrigo, T., Chirico, V., Salpietro, V., Munafò, C., Ferraù, V., Gitto, E., Lacquaniti, A. & Salpietro, C. (2013) High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children. European Journal of Endocrinology, 168, 631-638.
4. Chirico, V., Lacquaniti, A., Salpietro, V., Luca, N., Ferraù, V., Piraino, B., Rigoli, L., Salpietro, C. & Arrigo, T. (2013) Thyroid dysfunction in thalassaemic patients: ferritin as a prognostic marker and combined iron chelators as an ideal therapy. European Journal of Endocrinology, 169, 785-793.
5. Chirico, V., Lacquaniti, A., Salpietro, V., Munafò, C., Calabrò, M.P., Buemi, M., Arrigo, T. & Salpietro, C. (2014) High-mobility group box 1 (HMGB1) in childhood: from bench to bedside. European Journal of Pediatrics, 173, 1123-1136.
6. Chirico, V., Rigoli, L., Lacquaniti, A., Salpietro, V., Piraino, B., Amorini, M., Salpietro, C. & Arrigo, T. (2015a) Endocrinopathies, metabolic disorders, and iron overload in major and intermedia thalassemia: serum ferritin as diagnostic and predictive marker associated with liver and cardiac T2* MRI assessment. European Journal of Haematology, 94, 404-412.
7. Chirico, V., Lacquaniti, A., Leonardi, S., Grasso, L., Rotolo, N., Romano, C., Di Dio, G., Lionetti, E., David, A., Arrigo, T., Salpietro, C. & La Rosa, M. (2015b) Acute pulmonary exacerbation and lung function decline in patients with cystic fibrosis: high-mobility group box 1 (HMGB1) between inflammation and infection. Clinical Microbiology and Infection, 21, 1-9.
8. Farmakis, D., Giakoumis, A., Polymeropoulos, E. & Aessopos, A. (2003) Pathogenetic aspects of immune deficiency associated with β thalassemia. Medical Science Monitor, 9, 19-22.
9. Huston, J.M., Wang, H., Ochani, M., Ochani, K., Rosas-Ballina, M., Gallowitsch-Puerta, M., Ashok, M., Yang, L., Tracey, K.J. & Yang, H. (2008) Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. The Journal of Immunology, 181, 3535-3539.
10. Jung, J.H., Park, J.H., Jee, M.H., Keum, S.J., Cho, M.S., Yoon, S.K. & Jang, S.K. (2011) Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells. Journal of Virology, 85, 9359-9368.
11. Kim, H.J., Lee, S. & Jung, J.U. (2010) When autophagy meets viruses: a double-edged sword with functions in defense and offense. Seminars in Immunopathology, 32, 323-341.
12. Kono, H., Fujii, H., Ogiku, M., Hara, M., Tsuchiya, M., Ishii, K. & Hosomura, N. (2012) The Kupffer cell inhibition exacerbates but splenectomy prevents mortality in a rat septic peritonitis model. Journal of Surgical Research, 175, 101-112.
13. Lehner, J., Wittwer, C., Fersching, D., Siegele, B., Holdenrieder, S. & Stoetzer, O.J. (2012) Methodological and preanalytical evaluation of an HMGB1 immunoassay. Anticancer Research, 32, 2059-2062.
14. Pattanapanyasat, K., Thepthai, C., Lamchiagdhase, P., Lerdwana, S., Tachavanich, K., Thanomsuk, P., Wanachiwanawin, W., Fucharoen, S. & Darden, J.M. (2000) Lymphocyte subsets and specific T-cell immune response in thalassemia. Cytometry, 42, 11-17.
15. Rahav, G., Volach, V., Shapiro, M., Rund, D., Rachmilewitz, E.A. & Goldfarb, A. (2006) Severe infections in thalassaemic patients: prevalence and predisposing factors. British Journal of Haematology, 133, 667-674.
16. Sakran, W., Levin, C., Kenes, Y., Colodner, R. & Koren, A. (2012) Clinical spectrum of serious bacterial infections among splenectomised patients with hemoglobinopathies in Israel: a 37-year follow-up study. Infection, 40, 35-39.
17. Tang, D., Kang, R., Cao, L., Zhang, G., Yu, Y., Xiao, W., Wang, H. & Xiao, X. (2008) A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis. Critical Care Medicine, 36, 291-295.
18. Valdés-Ferrer, S.I., Rosas-Ballina, M., Olofsson, P.S., Lu, B., Dancho, M.E., Ochani, M., Li, J.H., Scheinerman, J.A., Katz, D.A., Levine, Y.A., Hudson, L.K., Yang, H., Pavlov, V.A., Roth, J., Blanc, L., Antoine, D.J., Chavan, S.S., Andersson, U., Diamond, B. & Tracey, K.J. (2013) HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors. Journal of Internal Medicine, 274, 381-390.
19. Walker, E.M. & Walker, S.M. (2000) Effects of iron overload on the immune system. Annals of Clinical & Laboratory Science, 30, 354-365.
20. Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J.M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., Manogue, K.R., Faist, E., Abraham, E., Andersson, J., Andersson, U., Molina, P.E., Abumrad, N.N., Sama, A. & Tracey, K.J. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science, 285, 248-251.
21. Wang, S.C., Lin, K.H., Chern, J.P., Lu, M.Y., Jou, S.T., Lin, D.T. & Lin, K.S. (2003) Severe bacterial infection in transfusion-dependent patients with thalassemia major. Clinical Infectious Diseases, 37, 984-988.
22. Wood, J.C., Enriquez, C., Ghugre, N., Tyzka, J.M., Carson, S., Nelson, M.D. & Coates, T.D. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005;106:1460-1465