Pathogenetic aspects of immune deficiency associated with β thalassemia

Medical Science Monitor

Volumn 9, Issue 1, 2003, Pages

  Farmakis, Dimitrios ^a,b   Giakoumis, Anastasios ^a   Polymeropoulos, Evaggelos ^a   Aessopos, Athanasios ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NONE   (Greece)

Author keywords

Immune deficiency; Infections; Iron overload; Thalassemia

Indexed keywords

B LYMPHOCYTE; BETA THALASSEMIA; BLOOD TRANSFUSION; CHEMOTAXIS; COMPLEMENT SYSTEM; DISEASE ASSOCIATION; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOGLOBULIN PRODUCTION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; IRON OVERLOAD; LEUKEMIA; LYMPHOMA; PATHOGENESIS; PHAGOCYTOSIS; REVIEW; T LYMPHOCYTE;

BETA-THALASSEMIA; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; IRON;

EID: 18244414472     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. Lukens JN: The thalassemias and related disorders: Quantitative disorders of hemoglobin synthesis. In: Lee GR, Foerster J, Lukens J, Paraskevas F, Greet JP, Rodgers GM (eds). Wintrobe's Clinical Hematology. 10th edition, Lippincott Williams & Wilkins, 1999; 1405-48
2. Borgna-Pignatti C, Rugolotto S, De Stefano P et al: Survival and disease complications in thalassemia major. Ann N Y Acad Sci, 1998; 850: 227-31
3. Zurlo MG, De Stefano P, Borgna-Pignatti C et al: Survival and causes of death in thalassaemia major. Lancet, 1989; 2: 27-30
4. Dwyer J, Wood C, McNamara J et al: Abnormalities in the immune system of children with beta-thalassemia major. Clin Exp Immunol, 1987; 68: 621-9
5. Khalifa AS, Maged Z, Khalil R et al: T-cell functions in infants and children with beta-thalassemia. Acta Haematol, 1988; 79: 153-6
6. Ezer U, Gulderen F, Culha VK et al: Immunological status of thalassemia syndrome. Pediatr Hematol Oncol, 2002; 19: 51-8
7. Dua D, Choudhury M, Prakash K: Altered T and B lymphocytes in multitransfused patients of thalassemia major. Indian Pediatr, 1993; 30: 893-6
8. Umiel T, Friedman E, Luria D et al: Impaired immune regulation in children and adolescents with hemophilia and thalassemia in Israel. Am J Pediatr Hematol Oncol, 1984; 6: 371-8
9. Sen L, Goicoa MA, Nualart PJ et al: [Immunologic studies in thalassemia major.] Medicina (B Aires), 1989; 49: 131-4
10. Speer CP, Gahr M, Schuff-Werner P, Schroter W: Immunologic evaluation of children with homozygous beta-thallassemia treated with desferrioxamine. Acta Haematol, 1990; 83: 76-81
11. Sinniah D, Yadav M: Elevated IgG and decreased complement component C3 and factor B in B-thalassaemia major. Acta Paediatr Scand, 1981; 70: 547-50
12. Quintiliani L, Mastromonaco A, Giuliani E et al: Immune profile alterations in thalassaemic patients. Boll Ist Sieroter Milan, 1983; 62(6): 524-30
13. Sternbach MS, Tsoukas C, Paquin M et al: Monocyte-macrophage (M-M) functions in asymptomatic hemophiliacs and supertransfused thalassemics. Clin Invest Med, 1987; 10: 275-81
14. Matzner Y, Goldfarb A, Abrahamov A et al: Impaired neutrophil chemotaxis in patients with thalassaemia major. Br J Haematol, 1993; 85: 153-8
15. Skoutelis AT, Lianou E, Papavassiliou T et al: Defective phagocytic and bactericidal function of polymorphonuclear leukocytes in patients with beta-thalassaemia major. J Infect, 1984; 8: 118-22
16. Olivieri NF: The Beta-Thalassemias. N Engl J Med. 1999; 341: 99-109
17. Walker EM, Walker SM: Effects of iron overload on the immune system. Ann Clin Lab Sci, 2000; 30: 354-65
18. De Sousa M: T lymphocytes and iron overload: novel correlations of possible significance to the biology of the immunological system. Mem Inst Oswaldo Cruz, 1992; 87(Suppl 5): 23-9
19. De Sousa M: Immune cell functions in iron overload. Clin Exp Immunol, 1989: 75: 1-6
20. Cantinieaux B, Janssens A, Boelaert JR et al: Ferritin-associated iron induces neutrophil dysfunction in hemosiderosis. J Lab Clin Med, 1999; 133: 353-61
21. Wonke B: Clinical management of beta-thalassemia major. Semin Hematol, 2001; 38: 350-9
22. Singer ST, Wu V, Mignacca R et al: Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly. Asian descent. Blood, 2000; 96: 3369-73
23. Hodge G, Lloyd JV, Hodge S et al: Functional lymphocyte immunophenotypes observed in thalassaemia and haemophilia patients receiving current blood product preparations. Br J Haematol, 1999; 105: 817-25
24. Lombardi G, Matera R, Minervini MM et al: Serum levels of cytokines and soluble antigens in polytransfused patients with beta-thalassemia major: relationship to immune status. Hematologica, 1994; 79: 406-412
25. Grady RW, Akbar AN, de Sousa M, et al: Transfusion-related immunologic abnormalities in beta-thalassemia major. Birth Defects Orig Artic Ser, 1987; 25: 587-93
26. Dessi C, Clemente MG, Diana G et al: Cryoglobulinemia in transfusion-dependent thalassemia major. Clin Exp Rheumatol, 1995; 13(Suppl 13): 149-51
27. Perniola R, De Rinaldis C, Accogli E, Lobreglio G: Prevalence and clinical features of cryoglobulinaemia in multitransfused beta-thalassaemia patients. Ann Rheum Dis, 1999; 58: 698-702
28. Consolini R, Calleri A, Legitimo A, Massei F: Immunological evaluation of patients with beta-thalassemia major. Acta Haematol, 2001; 105: 7-12
29. Cunningham-Rundles S, Bockman RS, Lin A et al: Physiological and pharmacological effects of zinc on immune response. Ann N Y Acad Sci, 1990; 587: 113-22
30. Ahluwalia J, Datta U, Marwaha RK, Sehgal S: Immune functions in splenectomized thalassaemic children. Indian J Pediatr, 2000; 67: 871-6
31. Pattanapanyasat K, Thepthai C, Lamchiagdhase P et al: Lymphocyte subsets and specific T-cell immune response in thalassemia. Cytometry, 2000; 42: 11-7
32. Mandalenaki-Lambrou K, Vrachnou E, Calogeropoulou C et al: Immunological profile after splenectomy in children with beta-thalassaemia major. Acta Haematol, 1987; 78: 243-8
33. Wanachiwanawin W, Siripanyaphinyo U, Fucharoen S et al: Activation of monocytes for the immune clearance of red cells in beta zero-thalassaemia/HbE. Br J Haematol, 1993; 85: 773-7