Tigecycline resistance in Acinetobacter baumannii mediated by frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 34, Issue 3, 2015, Pages 625-631

  Li, X ^a   Liu, L ^a   Ji, J ^a   Chen, Q ^a   Hua, X ^a   Jiang, Y ^a   Feng, Y ^a   Yu, Y ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACYL SN GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; ACYLTRANSFERASE; AZTREONAM; BACTERIAL DNA; BACTERIAL ENZYME; BACTERIAL PROTEIN; CEFOTAXIME; CEFTAZIDIME; CHLORAMPHENICOL; CIPROFLOXACIN; DOXYCYCLINE; GENOMIC DNA; GENTAMICIN; IMIPENEM; MINOCYCLINE; NORFLOXACIN; TETRACYCLINE; TIGECYCLINE; UNCLASSIFIED DRUG; 1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM CULTURE; CHROMOSOME SUBSTITUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLOW CYTOMETRY; FRAMESHIFT MUTATION; GROWTH RATE; LIQUID CULTURE; MEMBRANE POTENTIAL; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; OMP38 GENE; PLSC GENE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; ANALOGS AND DERIVATIVES; DRUG EFFECTS; ENZYMOLOGY; GENETIC COMPLEMENTATION; GENETIC SELECTION; GENETICS; HUMAN; VIRUS CULTURE;

1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; FRAMESHIFT MUTATION; GENETIC COMPLEMENTATION TEST; GENOME, BACTERIAL; HUMANS; MINOCYCLINE; SELECTION, GENETIC; SERIAL PASSAGE;

EID: 84941737354     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-014-2272-y     Document Type: Article

References (32)

1. Dijkshoorn L, Nemec A, Seifert H (2007) An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 5(12):939–951
2. Towner KJ (2009) Acinetobacter: an old friend, but a new enemy. J Hosp Infect 73(4):355–363
3. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA (2007) Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 51(10):3471–3484
4. Farrell DJ, Turnidge JD, Bell J, Sader HS, Jones RN (2010) The in vitro evaluation of tigecycline tested against pathogens isolated in eight countries in the Asia-Western Pacific region (2008). J Infect 60(6):440–451
5. Hidalgo L, Hopkins KL, Gutierrez B, Ovejero CM, Shukla S, Douthwaite S, Prasad KN, Woodford N, Gonzalez-Zorn B (2013) Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. J Antimicrob Chemother 68(7):1543–1550
6. Peterson LR (2008) A review of tigecycline–the first glycylcycline. Int J Antimicrob Agents 32 [Suppl 4]:S215–S222
7. Livermore DM (2005) Tigecycline: what is it, and where should it be used? J Antimicrob Chemother 56(4):611–614
8. Bauer G, Berens C, Projan SJ, Hillen W (2004) Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother 53(4):592–599
9. Chang KC, Lin MF, Lin NT, Wu WJ, Kuo HY, Lin TY, Yang TL, Chen YC, Liou ML (2012) Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern Taiwan. J Microbiol Immunol Infect 45(1):37–42
10. Anthony KB, Fishman NO, Linkin DR, Gasink LB, Edelstein PH, Lautenbach E (2008) Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline. Clin Infect Dis 46(4):567–570
11. Peleg AY, Potoski BA, Rea R, Adams J, Sethi J, Capitano B, Husain S, Kwak EJ, Bhat SV, Paterson DL (2007) Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. J Antimicrob Chemother 59(1):128–131
12. Ruzin A, Immermann FW, Bradford PA (2010) RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Microb Drug Resist 16(2):87–89
13. Coyne S, Rosenfeld N, Lambert T, Courvalin P, Perichon B (2010) Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob Agents Chemother 54(10):4389–4393
14. Yoon EJ, Courvalin P, Grillot-Courvalin C (2013) RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations. Antimicrob Agents Chemother 57(7):2989–2995
15. Amin IM, Richmond GE, Sen P, Koh TH, Piddock LJ, Chua KL (2013) A method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii. BMC Microbiol 13:158
16. Villa L, Feudi C, Fortini D, Garcia-Fernandez A, Carattoli A (2014) Genomics of KPC-Producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and Ribosomal S10 protein mutations in conferring tigecycline resistance. Antimicrob Agents Chemother 58(3):1707–1712
17. Linkevicius M, Sandegren L, Andersson DI (2013) Mechanisms and fitness costs of tigecycline resistance in Escherichia coli. J Antimicrob Chemother 68(12):2809–2819
18. Chen Q, Li X, Zhou H, Jiang Y, Chen Y, Hua X, Yu Y (2014) Decreased susceptibility to tigecycline in Acinetobacter baumannii mediated by a mutation in trm encoding SAM-dependent methyltransferase. J Antimicrob Chemother 69(1):72–76
19. Rock CO, Goelz SE, Cronan JE Jr (1981) Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate. J Biol Chem 256(2):736–742
20. Adams MD, Nickel GC, Bajaksouzian S, Lavender H, Murthy AR, Jacobs MR, Bonomo RA (2009) Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrob Agents Chemother 53(9):3628–3634
21. Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9(4):357–359
22. McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M, DePristo MA (2010) The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 20(9):1297–1303
23. Hunger M, Schmucker R, Kishan V, Hillen W (1990) Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene 87(1):45–51
24. Aranda J, Poza M, Pardo BG, Rumbo S, Rumbo C, Parreira JR, Rodriguez-Velo P, Bou G (2010) A rapid and simple method for constructing stable mutants of Acinetobacter baumannii. BMC Microbiol 10:279
25. Freddolino PL, Goodarzi H, Tavazoie S (2012) Fitness landscape transformation through a single amino acid change in the rho terminator. PLoS Genet 8(5):e1002744
26. Novo DJ, Perlmutter NG, Hunt RH, Shapiro HM (2000) Multiparameter flow cytometric analysis of antibiotic effects on membrane potential, membrane permeability, and bacterial counts of Staphylococcus aureus and Micrococcus luteus. Antimicrob Agents Chemother 44(4):827–834
27. Yao J, Rock CO (2013) Phosphatidic acid synthesis in bacteria. Biochim Biophys Acta 1831(3):495–502
28. Lu B, Jiang YJ, Man MQ, Brown B, Elias PM, Feingold KR (2005) Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. J Lipid Res 46(11):2448–2457
29. Richmond GE, Chua KL, Piddock LJ (2013) Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide). J Antimicrob Chemother 68(7):1594–1600
30. Arias CA, Panesso D, McGrath DM, Qin X, Mojica MF, Miller C, Diaz L, Tran TT, Rincon S, Barbu EM, Reyes J, Roh JH, Lobos E, Sodergren E, Pasqualini R, Arap W, Quinn JP, Shamoo Y, Murray BE, Weinstock GM (2011) Genetic basis for in vivo daptomycin resistance in enterococci. N Engl J Med 365(10):892–900
31. Moffatt JH, Harper M, Harrison P, Hale JD, Vinogradov E, Seemann T, Henry R, Crane B, St Michael F, Cox AD, Adler B, Nation RL, Li J, Boyce JD (2010) Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrob Agents Chemother 54(12):4971–4977
32. Smani Y, Fàbrega A, Roca I, Sanchez-Encinales V, Vila J, Pachón J (2013) Role of OmpA in the multidrug resistance phenotype of Acinetobacter baumannii. Antimicrobial agents and chemotherapy 58(3):1806–1808