메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 292-302

Chronic Myelomonocytic Leukemia: a Genetic and Clinical Update

Author keywords

ASXL1; CMML; Hypomethylating agents; Prognosis

Indexed keywords

ANTIANEMIC AGENT; AZACITIDINE; CAMPTOTHECIN; CD135 ANTIGEN; CYTARABINE; DECITABINE; DNA METHYLTRANSFERASE 3A; ELTROMBOPAG; HYDROXYUREA; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; JANUS KINASE 2; LONAFARNIB; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; POLYCOMB GROUP PROTEIN; PROTEIN P53; RAS PROTEIN; RECOMBINANT ERYTHROPOIETIN; TOPOTECAN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR RUNX1; VALPROIC ACID;

EID: 84941736530     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-015-0271-4     Document Type: Review
Times cited : (20)

References (91)
  • 2
    • 84898488422 scopus 로고    scopus 로고
    • Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review
    • PID: 24467717, A concise, up to date review on pathophysiology, genetics, and therapeutic options in chronic myelomonocytic leukemia
    • Patnaik MM, Parikh SA, Hanson CA, Tefferi A. Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review. Br J Haematol. 2014;165(3):273–86. doi:10.1111/bjh.12756. A concise, up to date review on pathophysiology, genetics, and therapeutic options in chronic myelomonocytic leukemia.
    • (2014) Br J Haematol , vol.165 , Issue.3 , pp. 273-286
    • Patnaik, M.M.1    Parikh, S.A.2    Hanson, C.A.3    Tefferi, A.4
  • 3
    • 0036464647 scopus 로고    scopus 로고
    • Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients
    • COI: 1:CAS:528:DC%2BD38XhtValsLk%3D, PID: 11806985
    • Onida F, Kantarjian HM, Smith TL, Ball G, Keating MJ, Estey EH, et al. Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. Blood. 2002;99(3):840–9.
    • (2002) Blood , vol.99 , Issue.3 , pp. 840-849
    • Onida, F.1    Kantarjian, H.M.2    Smith, T.L.3    Ball, G.4    Keating, M.J.5    Estey, E.H.6
  • 4
    • 84922332658 scopus 로고    scopus 로고
    • ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients
    • COI: 1:CAS:528:DC%2BC2cXmvV2gsLo%3D, PID: 24695057, A comprehensive and collaborative mutation analysis, resulting in the development of the Mayo Clinic Molecular Model for prognostication
    • Patnaik MM, Itzykson R, Lasho TL, Kosmider O, Finke CM, Hanson CA, et al. ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients. Leukemia. 2014;28(11):2206–12. doi:10.1038/leu.2014.125. A comprehensive and collaborative mutation analysis, resulting in the development of the Mayo Clinic Molecular Model for prognostication.
    • (2014) Leukemia , vol.28 , Issue.11 , pp. 2206-2212
    • Patnaik, M.M.1    Itzykson, R.2    Lasho, T.L.3    Kosmider, O.4    Finke, C.M.5    Hanson, C.A.6
  • 5
    • 84880263477 scopus 로고    scopus 로고
    • Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes
    • COI: 1:CAS:528:DC%2BC3sXhtFSiu7rP, PID: 23531518
    • Patnaik MM, Padron E, LaBorde RR, Lasho TL, Finke CM, Hanson CA, et al. Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes. Leukemia. 2013;27(7):1504–10. doi:10.1038/leu.2013.88.
    • (2013) Leukemia , vol.27 , Issue.7 , pp. 1504-1510
    • Patnaik, M.M.1    Padron, E.2    LaBorde, R.R.3    Lasho, T.L.4    Finke, C.M.5    Hanson, C.A.6
  • 6
    • 84877084272 scopus 로고    scopus 로고
    • Predictive factors of response and survival among chronic myelomonocytic leukemia patients treated with azacitidine
    • COI: 1:CAS:528:DC%2BC3sXisVGqtLo%3D, PID: 23415110
    • Ades L, Sekeres MA, Wolfromm A, Teichman ML, Tiu RV, Itzykson R, et al. Predictive factors of response and survival among chronic myelomonocytic leukemia patients treated with azacitidine. Leuk Res. 2013;37(6):609–13. doi:10.1016/j.leukres.2013.01.004.
    • (2013) Leuk Res , vol.37 , Issue.6 , pp. 609-613
    • Ades, L.1    Sekeres, M.A.2    Wolfromm, A.3    Teichman, M.L.4    Tiu, R.V.5    Itzykson, R.6
  • 7
    • 84874303759 scopus 로고    scopus 로고
    • Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance
    • COI: 1:CAS:528:DC%2BC3sXjtlahtbc%3D, PID: 23335386
    • Patnaik MM, Lasho TL, Finke CM, Hanson CA, Hodnefield JM, Knudson RA, et al. Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance. Am J Hematol. 2013;88(3):201–6. doi:10.1002/ajh.23373.
    • (2013) Am J Hematol , vol.88 , Issue.3 , pp. 201-206
    • Patnaik, M.M.1    Lasho, T.L.2    Finke, C.M.3    Hanson, C.A.4    Hodnefield, J.M.5    Knudson, R.A.6
  • 8
    • 84877069358 scopus 로고    scopus 로고
    • Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC3sXmsFehtLY%3D, PID: 23372164
    • Such E, Germing U, Malcovati L, Cervera J, Kuendgen A, Della Porta MG, et al. Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. Blood. 2013;121(15):3005–15. doi:10.1182/blood-2012-08-452938.
    • (2013) Blood , vol.121 , Issue.15 , pp. 3005-3015
    • Such, E.1    Germing, U.2    Malcovati, L.3    Cervera, J.4    Kuendgen, A.5    Della Porta, M.G.6
  • 9
    • 84888259429 scopus 로고    scopus 로고
    • Clinical characteristics and outcomes of therapy-related chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC3sXhs1Ohs77I, PID: 23896412, quiz 920
    • Takahashi K, Pemmaraju N, Strati P, Nogueras-Gonzalez G, Ning J, Bueso-Ramos C, et al. Clinical characteristics and outcomes of therapy-related chronic myelomonocytic leukemia. Blood. 2013;122(16):2807–11. doi:10.1182/blood-2013-03-491399. quiz 920.
    • (2013) Blood , vol.122 , Issue.16 , pp. 2807-2811
    • Takahashi, K.1    Pemmaraju, N.2    Strati, P.3    Nogueras-Gonzalez, G.4    Ning, J.5    Bueso-Ramos, C.6
  • 10
    • 0037103624 scopus 로고    scopus 로고
    • Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    • COI: 1:CAS:528:DC%2BD38XmtV2nt7g%3D, PID: 12181402
    • Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med. 2002;347(7):481–7. doi:10.1056/NEJMoa020150.
    • (2002) N Engl J Med , vol.347 , Issue.7 , pp. 481-487
    • Apperley, J.F.1    Gardembas, M.2    Melo, J.V.3    Russell-Jones, R.4    Bain, B.J.5    Baxter, E.J.6
  • 11
    • 33646532818 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature
    • COI: 1:CAS:528:DC%2BD28Xls1arurs%3D, PID: 16406016
    • Pardanani A, Ketterling RP, Li CY, Patnaik MM, Wolanskyj AP, Elliott MA, et al. FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res. 2006;30(8):965–70. doi:10.1016/j.leukres.2005.11.011.
    • (2006) Leuk Res , vol.30 , Issue.8 , pp. 965-970
    • Pardanani, A.1    Ketterling, R.P.2    Li, C.Y.3    Patnaik, M.M.4    Wolanskyj, A.P.5    Elliott, M.A.6
  • 12
    • 0038035638 scopus 로고    scopus 로고
    • Sensitivity to imatinib but low frequency of the TEL/PDGFRbeta fusion protein in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD3sXksVOnsLo%3D, PID: 12681968
    • Gunby RH, Cazzaniga G, Tassi E, Le Coutre P, Pogliani E, Specchia G, et al. Sensitivity to imatinib but low frequency of the TEL/PDGFRbeta fusion protein in chronic myelomonocytic leukemia. Haematologica. 2003;88(4):408–15.
    • (2003) Haematologica , vol.88 , Issue.4 , pp. 408-415
    • Gunby, R.H.1    Cazzaniga, G.2    Tassi, E.3    Le Coutre, P.4    Pogliani, E.5    Specchia, G.6
  • 13
    • 33947328520 scopus 로고    scopus 로고
    • Oncogenes in myeloproliferative disorders
    • COI: 1:CAS:528:DC%2BD2sXnvFygurw%3D, PID: 17351342
    • Tefferi A, Gilliland DG. Oncogenes in myeloproliferative disorders. Cell Cycle. 2007;6(5):550–66.
    • (2007) Cell Cycle , vol.6 , Issue.5 , pp. 550-566
    • Tefferi, A.1    Gilliland, D.G.2
  • 14
    • 79952349006 scopus 로고    scopus 로고
    • Cytogenetic risk stratification in chronic myelomonocytic leukemia
    • PID: 21109693, A seminal paper in CMML outlining risk based on a cytogenetic stratification system
    • Such E, Cervera J, Costa D, Sole F, Vallespi T, Luno E, et al. Cytogenetic risk stratification in chronic myelomonocytic leukemia. Haematologica. 2011;96(3):375–83. doi:10.3324/haematol.2010.030957. A seminal paper in CMML outlining risk based on a cytogenetic stratification system.
    • (2011) Haematologica , vol.96 , Issue.3 , pp. 375-383
    • Such, E.1    Cervera, J.2    Costa, D.3    Sole, F.4    Vallespi, T.5    Luno, E.6
  • 15
    • 84904406511 scopus 로고    scopus 로고
    • Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institution
    • PID: 24782398
    • Tang G, Zhang L, Fu B, Hu J, Lu X, Hu S, et al. Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institution. Am J Hematol. 2014;89(8):813–8. doi:10.1002/ajh.23751.
    • (2014) Am J Hematol , vol.89 , Issue.8 , pp. 813-818
    • Tang, G.1    Zhang, L.2    Fu, B.3    Hu, J.4    Lu, X.5    Hu, S.6
  • 16
    • 84921738528 scopus 로고    scopus 로고
    • Monosomal karyotype predicts adverse prognosis in patients diagnosed with chronic myelomonocytic leukemia: a single-institution experience
    • PID: 25027568
    • Alsahlawi A, Alkhateeb H, Patnaik M, Begna K, Elliott M, Hogan WJ, et al. Monosomal karyotype predicts adverse prognosis in patients diagnosed with chronic myelomonocytic leukemia: a single-institution experience. Clin Lymphoma Myeloma Leuk. 2014. doi:10.1016/j.clml.2014.06.007.
    • (2014) Clin Lymphoma Myeloma Leuk
    • Alsahlawi, A.1    Alkhateeb, H.2    Patnaik, M.3    Begna, K.4    Elliott, M.5    Hogan, W.J.6
  • 17
    • 79751531643 scopus 로고    scopus 로고
    • Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically worse than an otherwise complex karyotype
    • PID: 21072042
    • Patnaik MM, Hanson CA, Hodnefield J, Knudson R, Van Dyke D, Tefferi A. Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically worse than an otherwise complex karyotype. Leukemia. 2010;25(2):266–70.
    • (2010) Leukemia , vol.25 , Issue.2 , pp. 266-270
    • Patnaik, M.M.1    Hanson, C.A.2    Hodnefield, J.3    Knudson, R.4    Van Dyke, D.5    Tefferi, A.6
  • 18
    • 84922393115 scopus 로고    scopus 로고
    • Molecular and prognostic correlates of cytogenetic abnormalities in chronic myelomonocytic leukemia: a Mayo Clinic-French Consortium Study
    • COI: 1:CAS:528:DC%2BC2cXitVCjsbvE, PID: 25195656
    • Wassie EA, Itzykson R, Lasho TL, Kosmider O, Finke CM, Hanson CA, et al. Molecular and prognostic correlates of cytogenetic abnormalities in chronic myelomonocytic leukemia: a Mayo Clinic-French Consortium Study. Am J Hematol. 2014;89(12):1111–5. doi:10.1002/ajh.23846.
    • (2014) Am J Hematol , vol.89 , Issue.12 , pp. 1111-1115
    • Wassie, E.A.1    Itzykson, R.2    Lasho, T.L.3    Kosmider, O.4    Finke, C.M.5    Hanson, C.A.6
  • 19
    • 84858600403 scopus 로고    scopus 로고
    • Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
    • COI: 1:CAS:528:DC%2BC38Xpt1ajtL0%3D, PID: 22436456
    • Gelsi-Boyer V, Brecqueville M, Devillier R, Murati A, Mozziconacci MJ, Birnbaum D. Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases. J Hematol Oncol. 2012;5:12. doi:10.1186/1756-8722-5-12.
    • (2012) J Hematol Oncol , vol.5 , pp. 12
    • Gelsi-Boyer, V.1    Brecqueville, M.2    Devillier, R.3    Murati, A.4    Mozziconacci, M.J.5    Birnbaum, D.6
  • 20
    • 84877928684 scopus 로고    scopus 로고
    • Clonal architecture of chronic myelomonocytic leukemias
    • COI: 1:CAS:528:DC%2BC3sXltVyqtrY%3D, PID: 23319568, A contemporary prognostic model incorporating the ASXL1 mutation within a large data set
    • Itzykson R, Kosmider O, Renneville A, Morabito M, Preudhomme C, Berthon C, et al. Clonal architecture of chronic myelomonocytic leukemias. Blood. 2013;121(12):2186–98. doi:10.1182/blood-2012-06-440347. A contemporary prognostic model incorporating the ASXL1 mutation within a large data set.
    • (2013) Blood , vol.121 , Issue.12 , pp. 2186-2198
    • Itzykson, R.1    Kosmider, O.2    Renneville, A.3    Morabito, M.4    Preudhomme, C.5    Berthon, C.6
  • 21
    • 84857150890 scopus 로고    scopus 로고
    • Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC38XnsVKjtbk%3D, PID: 22395470
    • Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, et al. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics. 2012;7(2):201–7. doi:10.4161/epi.7.2.19015.
    • (2012) Epigenetics , vol.7 , Issue.2 , pp. 201-207
    • Yamazaki, J.1    Taby, R.2    Vasanthakumar, A.3    Macrae, T.4    Ostler, K.R.5    Shen, L.6
  • 22
    • 84922336738 scopus 로고    scopus 로고
    • Prognostic score including gene mutations in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC3sXht1GhtLjK, PID: 23690417
    • Itzykson R, Kosmider O, Renneville A, Gelsi-Boyer V, Meggendorfer M, Morabito M, et al. Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol. 2013;31(19):2428–36. doi:10.1200/JCO.2012.47.3314.
    • (2013) J Clin Oncol , vol.31 , Issue.19 , pp. 2428-2436
    • Itzykson, R.1    Kosmider, O.2    Renneville, A.3    Gelsi-Boyer, V.4    Meggendorfer, M.5    Morabito, M.6
  • 23
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • COI: 1:CAS:528:DC%2BC3cXhtl2jtrrP, PID: 21057493
    • Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468(7325):839–43. doi:10.1038/nature09586.
    • (2010) Nature , vol.468 , Issue.7325 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 24
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • COI: 1:CAS:528:DC%2BC3cXkvFKgs70%3D, PID: 20060365
    • Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010;17(1):13–27. doi:10.1016/j.ccr.2009.11.020.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3    Erpelinck-Verschueren, C.4    Deng, X.5    Christos, P.J.6
  • 25
    • 84908247072 scopus 로고    scopus 로고
    • TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
    • Bejar R, Lord A, Stevenson K, Bar-Natan M, Perez-Ladaga A, Zaneveld J, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 2014;127(17):2705–12. doi:10.1182/blood-2014-06-582809.
    • (2014) Blood , vol.127 , Issue.17 , pp. 2705-2712
    • Bejar, R.1    Lord, A.2    Stevenson, K.3    Bar-Natan, M.4    Perez-Ladaga, A.5    Zaneveld, J.6
  • 26
    • 84927745746 scopus 로고    scopus 로고
    • Chronic myelomonocytic leukemia in younger patients: molecular and cytogenetic predictors of survival and treatment outcome
    • Patnaik MM, Wassie EA, Padron E, Onida F, Itzykson R, Lasho TL, et al. Chronic myelomonocytic leukemia in younger patients: molecular and cytogenetic predictors of survival and treatment outcome. Blood Cancer J. 2015;4:e270. doi:10.1038/bcj.2014.90.
    • (2015) Blood Cancer J , vol.4 , pp. 270
    • Patnaik, M.M.1    Wassie, E.A.2    Padron, E.3    Onida, F.4    Itzykson, R.5    Lasho, T.L.6
  • 27
    • 79960227474 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • COI: 1:CAS:528:DC%2BC3MXoslOiurw%3D, PID: 21455215
    • Abdel-Wahab O, Pardanani A, Patel J, Wadleigh M, Lasho T, Heguy A, et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia. 2011;25(7):1200–2. doi:10.1038/leu.2011.58.
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1200-1202
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3    Wadleigh, M.4    Lasho, T.5    Heguy, A.6
  • 28
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • COI: 1:CAS:528:DC%2BC38XhtF2nsbjJ, PID: 22897849
    • Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22(2):180–93. doi:10.1016/j.ccr.2012.06.032.
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    LaFave, L.M.3    Gao, J.4    Hricik, T.5    Shih, A.H.6
  • 29
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • COI: 1:CAS:528:DC%2BD1MXosVartbw%3D, PID: 19388938
    • Gelsi-Boyer V, Trouplin V, Adelaide J, Bonansea J, Cervera N, Carbuccia N, et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol. 2009;145(6):788–800. doi:10.1111/j.1365-2141.2009.07697.x.
    • (2009) Br J Haematol , vol.145 , Issue.6 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3    Bonansea, J.4    Cervera, N.5    Carbuccia, N.6
  • 30
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • COI: 1:CAS:528:DC%2BC3MXhtFGnur3M, PID: 21909114
    • Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478(7367):64–9. doi:10.1038/nature10496.
    • (2011) Nature , vol.478 , Issue.7367 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3    Nowak, D.4    Nagata, Y.5    Yamamoto, R.6
  • 31
    • 84867253750 scopus 로고    scopus 로고
    • SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
    • COI: 1:CAS:528:DC%2BC38XhsFKku7vO, PID: 22919025
    • Meggendorfer M, Roller A, Haferlach T, Eder C, Dicker F, Grossmann V, et al. SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). Blood. 2012;120(15):3080–8. doi:10.1182/blood-2012-01-404863.
    • (2012) Blood , vol.120 , Issue.15 , pp. 3080-3088
    • Meggendorfer, M.1    Roller, A.2    Haferlach, T.3    Eder, C.4    Dicker, F.5    Grossmann, V.6
  • 32
    • 84855841586 scopus 로고    scopus 로고
    • SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value
    • COI: 1:CAS:528:DC%2BC38XhsVKltLs%3D, PID: 22096241
    • Patnaik MM, Lasho TL, Hodnefield JM, Knudson RA, Ketterling RP, Garcia-Manero G, et al. SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value. Blood. 2012;119(2):569–72.
    • (2012) Blood , vol.119 , Issue.2 , pp. 569-572
    • Patnaik, M.M.1    Lasho, T.L.2    Hodnefield, J.M.3    Knudson, R.A.4    Ketterling, R.P.5    Garcia-Manero, G.6
  • 33
    • 84862497037 scopus 로고    scopus 로고
    • Prognostic irrelevance of ring sideroblast percentage in World Health Organization-defined myelodysplastic syndromes without excess blasts
    • COI: 1:CAS:528:DC%2BC38XhtVGns7%2FM, PID: 22538853
    • Patnaik MM, Hanson CA, Sulai NH, Hodnefield JM, Knudson RA, Ketterling RP, et al. Prognostic irrelevance of ring sideroblast percentage in World Health Organization-defined myelodysplastic syndromes without excess blasts. Blood. 2012;119(24):5674–7.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5674-5677
    • Patnaik, M.M.1    Hanson, C.A.2    Sulai, N.H.3    Hodnefield, J.M.4    Knudson, R.A.5    Ketterling, R.P.6
  • 34
    • 33846939564 scopus 로고    scopus 로고
    • Activity of decitabine, a hypomethylating agent, in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD2sXis1Smt70%3D, PID: 17219444
    • Aribi A, Borthakur G, Ravandi F, Shan J, Davisson J, Cortes J, et al. Activity of decitabine, a hypomethylating agent, in chronic myelomonocytic leukemia. Cancer. 2007;109(4):713–7. doi:10.1002/cncr.22457.
    • (2007) Cancer , vol.109 , Issue.4 , pp. 713-717
    • Aribi, A.1    Borthakur, G.2    Ravandi, F.3    Shan, J.4    Davisson, J.5    Cortes, J.6
  • 35
    • 77956237515 scopus 로고    scopus 로고
    • Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8 % of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1
    • COI: 1:CAS:528:DC%2BC3cXhtFyhsrbL, PID: 20644105
    • Kohlmann A, Grossmann V, Klein HU, Schindela S, Weiss T, Kazak B, et al. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8 % of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol. 2010;28(24):3858–65. doi:10.1200/JCO.2009.27.1361.
    • (2010) J Clin Oncol , vol.28 , Issue.24 , pp. 3858-3865
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.U.3    Schindela, S.4    Weiss, T.5    Kazak, B.6
  • 36
    • 77950980368 scopus 로고    scopus 로고
    • RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant
    • COI: 1:CAS:528:DC%2BC3cXkslSmtbY%3D, PID: 20371679
    • Ricci C, Fermo E, Corti S, Molteni M, Faricciotti A, Cortelezzi A, et al. RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant. Clin Cancer Res. 2010;16(8):2246–56. doi:10.1158/1078-0432.CCR-09-2112.
    • (2010) Clin Cancer Res , vol.16 , Issue.8 , pp. 2246-2256
    • Ricci, C.1    Fermo, E.2    Corti, S.3    Molteni, M.4    Faricciotti, A.5    Cortelezzi, A.6
  • 37
    • 68749109365 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation
    • COI: 1:CAS:528:DC%2BD1MXpvF2kurg%3D, PID: 19282830
    • Kuo MC, Liang DC, Huang CF, Shih YS, Wu JH, Lin TL, et al. RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. Leukemia. 2009;23(8):1426–31. doi:10.1038/leu.2009.48.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1426-1431
    • Kuo, M.C.1    Liang, D.C.2    Huang, C.F.3    Shih, Y.S.4    Wu, J.H.5    Lin, T.L.6
  • 38
    • 84882396666 scopus 로고    scopus 로고
    • GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC3sXhtVartLzL, PID: 23632888
    • Padron E, Painter JS, Kunigal S, Mailloux AW, McGraw K, McDaniel JM, et al. GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia. Blood. 2013;121(25):5068–77. doi:10.1182/blood-2012-10-460170.
    • (2013) Blood , vol.121 , Issue.25 , pp. 5068-5077
    • Padron, E.1    Painter, J.S.2    Kunigal, S.3    Mailloux, A.W.4    McGraw, K.5    McDaniel, J.M.6
  • 39
    • 84880976662 scopus 로고    scopus 로고
    • Somatic SETBP1 mutations in myeloid malignancies
    • COI: 1:CAS:528:DC%2BC3sXhtVarsr7O, PID: 23832012
    • Makishima H, Yoshida K, Nguyen N, Przychodzen B, Sanada M, Okuno Y, et al. Somatic SETBP1 mutations in myeloid malignancies. Nat Genet. 2013;45(8):942–6. doi:10.1038/ng.2696.
    • (2013) Nat Genet , vol.45 , Issue.8 , pp. 942-946
    • Makishima, H.1    Yoshida, K.2    Nguyen, N.3    Przychodzen, B.4    Sanada, M.5    Okuno, Y.6
  • 40
    • 84885644431 scopus 로고    scopus 로고
    • SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML
    • COI: 1:CAS:528:DC%2BC3sXhsF2gt7zE, PID: 23558523
    • Laborde RR, Patnaik MM, Lasho TL, Finke CM, Hanson CA, Knudson RA, et al. SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. Leukemia. 2013;27(10):2100–2. doi:10.1038/leu.2013.97.
    • (2013) Leukemia , vol.27 , Issue.10 , pp. 2100-2102
    • Laborde, R.R.1    Patnaik, M.M.2    Lasho, T.L.3    Finke, C.M.4    Hanson, C.A.5    Knudson, R.A.6
  • 41
    • 0021988836 scopus 로고
    • Myelodysplastic syndromes: a scoring system with prognostic significance
    • COI: 1:STN:280:DyaL2M7it1GmsQ%3D%3D, PID: 3970861
    • Mufti GJ, Stevens JR, Oscier DG, Hamblin TJ, Machin D. Myelodysplastic syndromes: a scoring system with prognostic significance. Br J Haematol. 1985;59(3):425–33.
    • (1985) Br J Haematol , vol.59 , Issue.3 , pp. 425-433
    • Mufti, G.J.1    Stevens, J.R.2    Oscier, D.G.3    Hamblin, T.J.4    Machin, D.5
  • 42
    • 0027372507 scopus 로고
    • Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases
    • COI: 1:STN:280:DyaK3szot1WjtA%3D%3D, PID: 8371581
    • Morel P, Hebbar M, Lai JL, Duhamel A, Preudhomme C, Wattel E, et al. Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases. Leukemia. 1993;7(9):1315–23.
    • (1993) Leukemia , vol.7 , Issue.9 , pp. 1315-1323
    • Morel, P.1    Hebbar, M.2    Lai, J.L.3    Duhamel, A.4    Preudhomme, C.5    Wattel, E.6
  • 43
    • 85047820629 scopus 로고    scopus 로고
    • New prognostic parameters for chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD38XlsVWgu74%3D, PID: 12123232, author reply 2-3
    • Germing U, Strupp C, Aivado M, Gattermann N. New prognostic parameters for chronic myelomonocytic leukemia. Blood. 2002;100(2):731–2. author reply 2-3.
    • (2002) Blood , vol.100 , Issue.2 , pp. 731-732
    • Germing, U.1    Strupp, C.2    Aivado, M.3    Gattermann, N.4
  • 44
    • 53149113768 scopus 로고    scopus 로고
    • Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System
    • COI: 1:CAS:528:DC%2BD1cXhtFyls7rM, PID: 18618511
    • Kantarjian H, O’Brien S, Ravandi F, Cortes J, Shan J, Bennett JM, et al. Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System. Cancer. 2008;113(6):1351–61. doi:10.1002/cncr.23697.
    • (2008) Cancer , vol.113 , Issue.6 , pp. 1351-1361
    • Kantarjian, H.1    O’Brien, S.2    Ravandi, F.3    Cortes, J.4    Shan, J.5    Bennett, J.M.6
  • 45
    • 84888240132 scopus 로고    scopus 로고
    • Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet
    • COI: 1:CAS:528:DC%2BC3sXhslejurjF, PID: 23980065, Consensus recommendations for supportive care management in myelodysplastic system can be gathered for use in CMML, including transfusion support, infection prophylaxis, and growth factor utilization
    • Malcovati L, Hellstrom-Lindberg E, Bowen D, Ades L, Cermak J, Del Canizo C, et al. Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood. 2013;122(17):2943–64. doi:10.1182/blood-2013-03-492884. Consensus recommendations for supportive care management in myelodysplastic system can be gathered for use in CMML, including transfusion support, infection prophylaxis, and growth factor utilization.
    • (2013) Blood , vol.122 , Issue.17 , pp. 2943-2964
    • Malcovati, L.1    Hellstrom-Lindberg, E.2    Bowen, D.3    Ades, L.4    Cermak, J.5    Del Canizo, C.6
  • 46
    • 84892888839 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management
    • COI: 1:CAS:528:DC%2BC2cXhsVCjurk%3D, PID: 24464505
    • Garcia-Manero G. Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol. 2014;89(1):97–108. doi:10.1002/ajh.23642.
    • (2014) Am J Hematol , vol.89 , Issue.1 , pp. 97-108
    • Garcia-Manero, G.1
  • 47
    • 0028953367 scopus 로고
    • Efficacy of erythropoietin in the myelodysplastic syndromes: a meta-analysis of 205 patients from 17 studies
    • COI: 1:STN:280:DyaK2M7jsVKrsQ%3D%3D, PID: 7833279
    • Hellstrom-Lindberg E. Efficacy of erythropoietin in the myelodysplastic syndromes: a meta-analysis of 205 patients from 17 studies. Br J Haematol. 1995;89(1):67–71.
    • (1995) Br J Haematol , vol.89 , Issue.1 , pp. 67-71
    • Hellstrom-Lindberg, E.1
  • 48
    • 44449088313 scopus 로고    scopus 로고
    • Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis
    • COI: 1:CAS:528:DC%2BD1cXmt12rurk%3D, PID: 18351340
    • Moyo V, Lefebvre P, Duh MS, Yektashenas B, Mundle S. Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis. Ann Hematol. 2008;87(7):527–36. doi:10.1007/s00277-008-0450-7.
    • (2008) Ann Hematol , vol.87 , Issue.7 , pp. 527-536
    • Moyo, V.1    Lefebvre, P.2    Duh, M.S.3    Yektashenas, B.4    Mundle, S.5
  • 49
    • 23044440179 scopus 로고    scopus 로고
    • Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF
    • PID: 15840690
    • Jadersten M, Montgomery SM, Dybedal I, Porwit-MacDonald A, Hellstrom-Lindberg E. Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF. Blood. 2005;106(3):803–11. doi:10.1182/blood-2004-10-3872.
    • (2005) Blood , vol.106 , Issue.3 , pp. 803-811
    • Jadersten, M.1    Montgomery, S.M.2    Dybedal, I.3    Porwit-MacDonald, A.4    Hellstrom-Lindberg, E.5
  • 50
    • 84901690058 scopus 로고    scopus 로고
    • An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin
    • COI: 1:CAS:528:DC%2BC2cXpsVentr8%3D, PID: 24635723
    • Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza MC, et al. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol. 2014;165(6):870–82. doi:10.1111/bjh.12838.
    • (2014) Br J Haematol , vol.165 , Issue.6 , pp. 870-882
    • Carrancio, S.1    Markovics, J.2    Wong, P.3    Leisten, J.4    Castiglioni, P.5    Groza, M.C.6
  • 51
    • 84973401093 scopus 로고    scopus 로고
    • Komrokji R, Garcia-Manero G, Ades L, Laadem A, Vo B, Prebet T, et al. An open-label, phase 2, dose-finding study of sotatercept (ACE-011) in patients with low or intermediate-1 (Int-1)-risk myelodysplastic syndromes (MDS) or non-proliferative chronic myelomonocytic leukemia (CMML) and anemia requiring transfusion. Blood. 2014;124(21):Abstract 3251.
    • Komrokji R, Garcia-Manero G, Ades L, Laadem A, Vo B, Prebet T, et al. An open-label, phase 2, dose-finding study of sotatercept (ACE-011) in patients with low or intermediate-1 (Int-1)-risk myelodysplastic syndromes (MDS) or non-proliferative chronic myelomonocytic leukemia (CMML) and anemia requiring transfusion. Blood. 2014;124(21):Abstract 3251.
  • 52
    • 84941735506 scopus 로고    scopus 로고
    • Platzbecker U, Germing U, Giagounidis A, Goetze K, Kiewe P, Mayer K, et al. ACE-536 increases hemoglobin and reduces transfusion burden in patients with low or intermediate-1 risk myelodysplastic syndromes (MDS): preliminary results from a phase 2 study. Blood. 2014;124(21):Abstract 411.
    • Platzbecker U, Germing U, Giagounidis A, Goetze K, Kiewe P, Mayer K, et al. ACE-536 increases hemoglobin and reduces transfusion burden in patients with low or intermediate-1 risk myelodysplastic syndromes (MDS): preliminary results from a phase 2 study. Blood. 2014;124(21):Abstract 411.
  • 53
    • 84973301607 scopus 로고    scopus 로고
    • Oliva E, Santini V, Zini G, Palumbo G, Poloni A, Cortelezzi A, et al. Efficacy and safety of eltrombopag for the treatment of thrombocytopenia of low and intermediate-1 IPSS risk myelodysplastic syndromes: interim analysis of a prospective, randomized, single-blind, placebo-controlled trial (EQoL-MDS). Blood. 2012;120:Abstract 923.
    • Oliva E, Santini V, Zini G, Palumbo G, Poloni A, Cortelezzi A, et al. Efficacy and safety of eltrombopag for the treatment of thrombocytopenia of low and intermediate-1 IPSS risk myelodysplastic syndromes: interim analysis of a prospective, randomized, single-blind, placebo-controlled trial (EQoL-MDS). Blood. 2012;120:Abstract 923.
  • 54
    • 84941735839 scopus 로고    scopus 로고
    • Mittelman M, Assouline S, Briasoulis E, Alonso A, Delgado R, O’Gorman P, et al. Eltrombopag treatment of thrombocytopenia in advanced myelodysplastic syndromes and acute myeloid leukemia: results of the 8-week open-label part of an ongoing study. Blood. 2012;120:Abstract 3822.
    • Mittelman M, Assouline S, Briasoulis E, Alonso A, Delgado R, O’Gorman P, et al. Eltrombopag treatment of thrombocytopenia in advanced myelodysplastic syndromes and acute myeloid leukemia: results of the 8-week open-label part of an ongoing study. Blood. 2012;120:Abstract 3822.
  • 55
    • 84920507199 scopus 로고    scopus 로고
    • Successful treatment of severe thrombocytopenia with the use of thrombopoeitin receptor agonist eltrombopag in a patient with chronic myelomonocytic leukemia
    • PID: 25063763
    • Modi Y, Shaaban H, Gauchan D, Maroules M. Successful treatment of severe thrombocytopenia with the use of thrombopoeitin receptor agonist eltrombopag in a patient with chronic myelomonocytic leukemia. J Oncol Pharm Pract. 2015;21(1):74–5. doi:10.1177/1078155214544076.
    • (2015) J Oncol Pharm Pract , vol.21 , Issue.1 , pp. 74-75
    • Modi, Y.1    Shaaban, H.2    Gauchan, D.3    Maroules, M.4
  • 56
    • 10144240361 scopus 로고    scopus 로고
    • A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group
    • COI: 1:CAS:528:DyaK28XmtFSjtbc%3D, PID: 8839839
    • Wattel E, Guerci A, Hecquet B, Economopoulos T, Copplestone A, Mahe B, et al. A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group. Blood. 1996;88(7):2480–7.
    • (1996) Blood , vol.88 , Issue.7 , pp. 2480-2487
    • Wattel, E.1    Guerci, A.2    Hecquet, B.3    Economopoulos, T.4    Copplestone, A.5    Mahe, B.6
  • 57
    • 0030054965 scopus 로고    scopus 로고
    • All-trans retinoic acid in adult chronic myelomonocytic leukemia: results of a pilot study
    • COI: 1:STN:280:DyaK283otlGrtw%3D%3D, PID: 8683997
    • Cambier N, Wattel E, Menot ML, Guerci A, Chomienne C, Fenaux P. All-trans retinoic acid in adult chronic myelomonocytic leukemia: results of a pilot study. Leukemia. 1996;10(7):1164–7.
    • (1996) Leukemia , vol.10 , Issue.7 , pp. 1164-1167
    • Cambier, N.1    Wattel, E.2    Menot, M.L.3    Guerci, A.4    Chomienne, C.5    Fenaux, P.6
  • 58
    • 0028144466 scopus 로고
    • A randomized phase II study of low-dose cytosine arabinoside (LD-AraC) plus granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in myelodysplastic syndromes (MDS) with a high risk of developing leukemia. EORTC Leukemia Cooperative Group
    • COI: 1:STN:280:DyaK2c7hvVGnsw%3D%3D, PID: 8289481
    • Gerhartz HH, Marcus R, Delmer A, Zwierzina H, Suciu S, Dardenne M, et al. A randomized phase II study of low-dose cytosine arabinoside (LD-AraC) plus granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in myelodysplastic syndromes (MDS) with a high risk of developing leukemia. EORTC Leukemia Cooperative Group. Leukemia. 1994;8(1):16–23.
    • (1994) Leukemia , vol.8 , Issue.1 , pp. 16-23
    • Gerhartz, H.H.1    Marcus, R.2    Delmer, A.3    Zwierzina, H.4    Suciu, S.5    Dardenne, M.6
  • 59
    • 0034034999 scopus 로고    scopus 로고
    • A phase-II trial of all trans retinoic acid and low-dose cytosine arabinoside for the treatment of high-risk myelodysplastic syndromes
    • COI: 1:CAS:528:DC%2BD3cXhvFCltr8%3D, PID: 10803936
    • Venditti A, Tamburini A, Buccisano F, Scimo MT, Del Poeta G, Maurillo L, et al. A phase-II trial of all trans retinoic acid and low-dose cytosine arabinoside for the treatment of high-risk myelodysplastic syndromes. Ann Hematol. 2000;79(3):138–42.
    • (2000) Ann Hematol , vol.79 , Issue.3 , pp. 138-142
    • Venditti, A.1    Tamburini, A.2    Buccisano, F.3    Scimo, M.T.4    Del Poeta, G.5    Maurillo, L.6
  • 60
    • 0032465406 scopus 로고    scopus 로고
    • Results of topotecan single-agent therapy in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD3cXlsV2kur4%3D, PID: 9922042
    • Beran M, Estey E, O’Brien SM, Giles FJ, Koller CA, Kornblau S, et al. Results of topotecan single-agent therapy in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leuk Lymphoma. 1998;31(5-6):521–31. doi:10.3109/10428199809057611.
    • (1998) Leuk Lymphoma , vol.31 , Issue.5-6 , pp. 521-531
    • Beran, M.1    Estey, E.2    O’Brien, S.M.3    Giles, F.J.4    Koller, C.A.5    Kornblau, S.6
  • 61
    • 0032884937 scopus 로고    scopus 로고
    • Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DyaK1MXmtlWru7Y%3D, PID: 10561358
    • Beran M, Estey E, O’Brien S, Cortes J, Koller CA, Giles FJ, et al. Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia. J Clin Oncol. 1999;17(9):2819–30.
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2819-2830
    • Beran, M.1    Estey, E.2    O’Brien, S.3    Cortes, J.4    Koller, C.A.5    Giles, F.J.6
  • 62
    • 33749633145 scopus 로고    scopus 로고
    • Activity of 9-nitro-camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD28XhtFersLvI, PID: 16955510
    • Quintas-Cardama A, Kantarjian H, O’Brien S, Jabbour E, Giles F, Ravandi F, et al. Activity of 9-nitro-camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia. Cancer. 2006;107(7):1525–9. doi:10.1002/cncr.22186.
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1525-1529
    • Quintas-Cardama, A.1    Kantarjian, H.2    O’Brien, S.3    Jabbour, E.4    Giles, F.5    Ravandi, F.6
  • 63
    • 35748962020 scopus 로고    scopus 로고
    • Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes
    • COI: 1:CAS:528:DC%2BD2sXhtFKrsrfL, PID: 17650442
    • Siitonen T, Timonen T, Juvonen E, Terava V, Kutila A, Honkanen T, et al. Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes. Haematologica. 2007;92(8):1119–22.
    • (2007) Haematologica , vol.92 , Issue.8 , pp. 1119-1122
    • Siitonen, T.1    Timonen, T.2    Juvonen, E.3    Terava, V.4    Kutila, A.5    Honkanen, T.6
  • 64
    • 51649113096 scopus 로고    scopus 로고
    • On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BD1cXhtVyqu7zF, PID: 18548095
    • Feldman EJ, Cortes J, DeAngelo DJ, Holyoake T, Simonsson B, O’Brien SG, et al. On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia. Leukemia. 2008;22(9):1707–11. doi:10.1038/leu.2008.156.
    • (2008) Leukemia , vol.22 , Issue.9 , pp. 1707-1711
    • Feldman, E.J.1    Cortes, J.2    DeAngelo, D.J.3    Holyoake, T.4    Simonsson, B.5    O’Brien, S.G.6
  • 65
    • 80053648633 scopus 로고    scopus 로고
    • Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial
    • COI: 1:CAS:528:DC%2BC3MXhtlCgtb%2FL, PID: 21828134
    • Braun T, Itzykson R, Renneville A, de Renzis B, Dreyfus F, Laribi K, et al. Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial. Blood. 2011;118(14):3824–31. doi:10.1182/blood-2011-05-352039.
    • (2011) Blood , vol.118 , Issue.14 , pp. 3824-3831
    • Braun, T.1    Itzykson, R.2    Renneville, A.3    de Renzis, B.4    Dreyfus, F.5    Laribi, K.6
  • 66
    • 79958794151 scopus 로고    scopus 로고
    • Activity of azacitidine in chronic myelomonocytic leukemia
    • COI: 1:CAS:528:DC%2BC3MXnt1Krtrc%3D, PID: 21656746
    • Costa R, Abdulhaq H, Haq B, Shadduck RK, Latsko J, Zenati M, et al. Activity of azacitidine in chronic myelomonocytic leukemia. Cancer. 2011;117(12):2690–6. doi:10.1002/cncr.25759.
    • (2011) Cancer , vol.117 , Issue.12 , pp. 2690-2696
    • Costa, R.1    Abdulhaq, H.2    Haq, B.3    Shadduck, R.K.4    Latsko, J.5    Zenati, M.6
  • 67
    • 84873351098 scopus 로고    scopus 로고
    • High rate of remissions in chronic myelomonocytic leukemia treated with 5-azacytidine: results of an Italian retrospective study
    • COI: 1:CAS:528:DC%2BC3sXit1Wltr0%3D, PID: 22873829
    • Fianchi L, Criscuolo M, Breccia M, Maurillo L, Salvi F, Musto P, et al. High rate of remissions in chronic myelomonocytic leukemia treated with 5-azacytidine: results of an Italian retrospective study. Leuk Lymphoma. 2013;54(3):658–61. doi:10.3109/10428194.2012.719617.
    • (2013) Leuk Lymphoma , vol.54 , Issue.3 , pp. 658-661
    • Fianchi, L.1    Criscuolo, M.2    Breccia, M.3    Maurillo, L.4    Salvi, F.5    Musto, P.6
  • 68
    • 79959318635 scopus 로고    scopus 로고
    • Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia
    • COI: 1:CAS:528:DC%2BC3MXpsVyqtr0%3D, PID: 21576646
    • Garcia-Manero G, Gore SD, Cogle C, Ward R, Shi T, Macbeth KJ, et al. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. J Clin Oncol. 2011;29(18):2521–7. doi:10.1200/JCO.2010.34.4226.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2521-2527
    • Garcia-Manero, G.1    Gore, S.D.2    Cogle, C.3    Ward, R.4    Shi, T.5    Macbeth, K.J.6
  • 69
    • 84862513949 scopus 로고    scopus 로고
    • Treatment of chronic myelomonocytic leukemia with 5-azacitidine: a case series and literature review
    • COI: 1:CAS:528:DC%2BC38Xnt1Cksbo%3D, PID: 22607959
    • Thorpe M, Montalvao A, Pierdomenico F, Moita F, Almeida A. Treatment of chronic myelomonocytic leukemia with 5-azacitidine: a case series and literature review. Leuk Res. 2012;36(8):1071–3. doi:10.1016/j.leukres.2012.04.024.
    • (2012) Leuk Res , vol.36 , Issue.8 , pp. 1071-1073
    • Thorpe, M.1    Montalvao, A.2    Pierdomenico, F.3    Moita, F.4    Almeida, A.5
  • 70
    • 39049137353 scopus 로고    scopus 로고
    • Efficacy of decitabine in the treatment of patients with chronic myelomonocytic leukemia (CMML)
    • COI: 1:CAS:528:DC%2BD1cXitlOhsLY%3D, PID: 17881052
    • Wijermans PW, Ruter B, Baer MR, Slack JL, Saba HI, Lubbert M. Efficacy of decitabine in the treatment of patients with chronic myelomonocytic leukemia (CMML). Leuk Res. 2008;32(4):587–91. doi:10.1016/j.leukres.2007.08.004.
    • (2008) Leuk Res , vol.32 , Issue.4 , pp. 587-591
    • Wijermans, P.W.1    Ruter, B.2    Baer, M.R.3    Slack, J.L.4    Saba, H.I.5    Lubbert, M.6
  • 71
    • 84879512426 scopus 로고    scopus 로고
    • Treatment of chronic myelomonocytic leukemia with azacitidine
    • COI: 1:CAS:528:DC%2BC3sXjvVagtb4%3D, PID: 22988826
    • Wong E, Seymour JF, Kenealy M, Westerman D, Herbert K, Dickinson M. Treatment of chronic myelomonocytic leukemia with azacitidine. Leuk Lymphoma. 2013;54(4):878–80. doi:10.3109/10428194.2012.730615.
    • (2013) Leuk Lymphoma , vol.54 , Issue.4 , pp. 878-880
    • Wong, E.1    Seymour, J.F.2    Kenealy, M.3    Westerman, D.4    Herbert, K.5    Dickinson, M.6
  • 72
    • 79952158522 scopus 로고    scopus 로고
    • Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer
    • COI: 1:CAS:528:DC%2BC3MXisVWlurs%3D, PID: 21345145
    • Thurn KT, Thomas S, Moore A, Munster PN. Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer. Future Oncol. 2011;7(2):263–83. doi:10.2217/fon.11.2.
    • (2011) Future Oncol , vol.7 , Issue.2 , pp. 263-283
    • Thurn, K.T.1    Thomas, S.2    Moore, A.3    Munster, P.N.4
  • 73
    • 84973361989 scopus 로고    scopus 로고
    • Sekeres MA, Othus M, List AF, Odenike O, Stone RM, Gore SD, et al. A randomized phase II study of azacitidine combined with lenalidomide or with vorinostat vs. azacitidine monotherapy in higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML): North American Intergroup Study SWOG S1117. Blood. 2014;124(21):Abstract LBA-5.
    • Sekeres MA, Othus M, List AF, Odenike O, Stone RM, Gore SD, et al. A randomized phase II study of azacitidine combined with lenalidomide or with vorinostat vs. azacitidine monotherapy in higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML): North American Intergroup Study SWOG S1117. Blood. 2014;124(21):Abstract LBA-5.
  • 74
    • 84906053256 scopus 로고    scopus 로고
    • First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML)
    • Kantarjian H, Jabbour E, Yee K, Kropf P, O’Connell C, Stock W, et al. First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML). Blood. 2013;122:497.
    • (2013) Blood , vol.122 , pp. 497
    • Kantarjian, H.1    Jabbour, E.2    Yee, K.3    Kropf, P.4    O’Connell, C.5    Stock, W.6
  • 75
    • 84973276405 scopus 로고    scopus 로고
    • Garcia-Manero G, Ritchie EK, Walsh K, Savona M, Kropf P, O’Connell C, et al. First clinical results of a randomized phase 2 dose-response study of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in 102 patients with intermediate (Int) or high risk (HR) myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). Blood. 2014;124(21):Abstract 529.
    • Garcia-Manero G, Ritchie EK, Walsh K, Savona M, Kropf P, O’Connell C, et al. First clinical results of a randomized phase 2 dose-response study of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in 102 patients with intermediate (Int) or high risk (HR) myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). Blood. 2014;124(21):Abstract 529.
  • 76
    • 79956054105 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for chronic myelomonocytic leukemia: relapse-free survival is determined by karyotype and comorbidities
    • PID: 20932924
    • Eissa H, Gooley TA, Sorror ML, Nguyen F, Scott BL, Doney K, et al. Allogeneic hematopoietic cell transplantation for chronic myelomonocytic leukemia: relapse-free survival is determined by karyotype and comorbidities. Biol Blood Marrow Transplant. 2011;17(6):908–15. doi:10.1016/j.bbmt.2010.09.018.
    • (2011) Biol Blood Marrow Transplant , vol.17 , Issue.6 , pp. 908-915
    • Eissa, H.1    Gooley, T.A.2    Sorror, M.L.3    Nguyen, F.4    Scott, B.L.5    Doney, K.6
  • 77
    • 33646809389 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation and donor lymphocyte infusions for chronic myelomonocytic leukemia
    • COI: 1:STN:280:DC%2BD283nslChtQ%3D%3D, PID: 16604096
    • Elliott MA, Tefferi A, Hogan WJ, Letendre L, Gastineau DA, Ansell SM, et al. Allogeneic stem cell transplantation and donor lymphocyte infusions for chronic myelomonocytic leukemia. Bone Marrow Transplant. 2006;37(11):1003–8. doi:10.1038/sj.bmt.1705369.
    • (2006) Bone Marrow Transplant , vol.37 , Issue.11 , pp. 1003-1008
    • Elliott, M.A.1    Tefferi, A.2    Hogan, W.J.3    Letendre, L.4    Gastineau, D.A.5    Ansell, S.M.6
  • 78
    • 77957949202 scopus 로고    scopus 로고
    • Allogeneic haematopoietic SCT for chronic myelomonocytic leukaemia: a single-centre experience
    • COI: 1:STN:280:DC%2BC3cfoslyltw%3D%3D, PID: 20098454
    • Krishnamurthy P, Lim ZY, Nagi W, Kenyon M, Mijovic A, Ireland R, et al. Allogeneic haematopoietic SCT for chronic myelomonocytic leukaemia: a single-centre experience. Bone Marrow Transplant. 2010;45(10):1502–7. doi:10.1038/bmt.2009.375.
    • (2010) Bone Marrow Transplant , vol.45 , Issue.10 , pp. 1502-1507
    • Krishnamurthy, P.1    Lim, Z.Y.2    Nagi, W.3    Kenyon, M.4    Mijovic, A.5    Ireland, R.6
  • 79
    • 0036067374 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
    • PID: 12100129
    • Kroger N, Zabelina T, Guardiola P, Runde V, Sierra J, Van Biezen A, et al. Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Br J Haematol. 2002;118(1):67–73.
    • (2002) Br J Haematol , vol.118 , Issue.1 , pp. 67-73
    • Kroger, N.1    Zabelina, T.2    Guardiola, P.3    Runde, V.4    Sierra, J.5    Van Biezen, A.6
  • 80
    • 2942585719 scopus 로고    scopus 로고
    • Allogeneic transplantation: a therapeutic option for myelofibrosis, chronic myelomonocytic leukemia and Philadelphia-negative/BCR-ABL-negative chronic myelogenous leukemia
    • COI: 1:STN:280:DC%2BD2c3ivFKntQ%3D%3D, PID: 15048141
    • Mittal P, Saliba RM, Giralt SA, Shahjahan M, Cohen AI, Karandish S, et al. Allogeneic transplantation: a therapeutic option for myelofibrosis, chronic myelomonocytic leukemia and Philadelphia-negative/BCR-ABL-negative chronic myelogenous leukemia. Bone Marrow Transplant. 2004;33(10):1005–9. doi:10.1038/sj.bmt.1704472.
    • (2004) Bone Marrow Transplant , vol.33 , Issue.10 , pp. 1005-1009
    • Mittal, P.1    Saliba, R.M.2    Giralt, S.A.3    Shahjahan, M.4    Cohen, A.I.5    Karandish, S.6
  • 81
    • 67349253841 scopus 로고    scopus 로고
    • Outcome of allo-SCT for chronic myelomonocytic leukemia
    • COI: 1:STN:280:DC%2BD1M3ptVGjtw%3D%3D, PID: 18997830
    • Ocheni S, Kroger N, Zabelina T, Zander AR, Bacher U. Outcome of allo-SCT for chronic myelomonocytic leukemia. Bone Marrow Transplant. 2009;43(8):659–61. doi:10.1038/bmt.2008.366.
    • (2009) Bone Marrow Transplant , vol.43 , Issue.8 , pp. 659-661
    • Ocheni, S.1    Kroger, N.2    Zabelina, T.3    Zander, A.R.4    Bacher, U.5
  • 82
    • 84973350141 scopus 로고    scopus 로고
    • Symeonidis A, van Biezen A, Mufti G, Finke J, Beelen D, Bornhauser M, et al. Allogeneic stem cell transplantation in patients with chronic myelomonocytic leukaemia: the impact of WHO classification and of the conditioning regimen on the transplantation outcome. Bone Marrow Transplant. 2010;45(S241):Abstract P803.
    • Symeonidis A, van Biezen A, Mufti G, Finke J, Beelen D, Bornhauser M, et al. Allogeneic stem cell transplantation in patients with chronic myelomonocytic leukaemia: the impact of WHO classification and of the conditioning regimen on the transplantation outcome. Bone Marrow Transplant. 2010;45(S241):Abstract P803.
  • 83
    • 84876706875 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire
    • PID: 23320648
    • Park S, Labopin M, Yakoub-Agha I, Delaunay J, Dhedin N, Deconinck E, et al. Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. Eur J Haematol. 2013;90(5):355–64. doi:10.1111/ejh.12073.
    • (2013) Eur J Haematol , vol.90 , Issue.5 , pp. 355-364
    • Park, S.1    Labopin, M.2    Yakoub-Agha, I.3    Delaunay, J.4    Dhedin, N.5    Deconinck, E.6
  • 84
    • 84973350142 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for adult chronic myelomonocytic leukemia
    • Duong HK, Akhtari M, Ahn KW, Hu Z-H, Popat UR, Alyea Iii EP, et al. Allogeneic hematopoietic cell transplantation for adult chronic myelomonocytic leukemia. Biol Blood Marrow Transplant. 2015;21(2, Supplement):S30–1. doi:10.1016/j.bbmt.2014.11.022.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 30-31
    • Duong, H.K.1    Akhtari, M.2    Ahn, K.W.3    Hu, Z.-H.4    Popat, U.R.5    Alyea Iii, E.P.6
  • 85
    • 84973372545 scopus 로고    scopus 로고
    • Platzbecker U, Wong R, Verma A, Abboud C, Araujo S, Chiou T et al. Placebo-controlled, randomized, phase I/II trial of the thrombopoietin receptor agonist eltrombopag in thrombocytopenic patients with advanced myelodysplastic syndromes or acute myeloid leukemia. Haematologica. 2013;98(s1):Abstract S1108.
    • Platzbecker U, Wong R, Verma A, Abboud C, Araujo S, Chiou T et al. Placebo-controlled, randomized, phase I/II trial of the thrombopoietin receptor agonist eltrombopag in thrombocytopenic patients with advanced myelodysplastic syndromes or acute myeloid leukemia. Haematologica. 2013;98(s1):Abstract S1108.
  • 86
    • 84941732884 scopus 로고    scopus 로고
    • Navada S, Garcia-Manero G, Wilhelm F, Hearn K, Odchimar-Reissig R, Demakos E, et al. A phase I/II study of the combination of oral rigosertib and azacitidine in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Blood. 2014;124(21):Abstract 3252.
    • Navada S, Garcia-Manero G, Wilhelm F, Hearn K, Odchimar-Reissig R, Demakos E, et al. A phase I/II study of the combination of oral rigosertib and azacitidine in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Blood. 2014;124(21):Abstract 3252.
  • 87
    • 84941741173 scopus 로고    scopus 로고
    • Garcia-Manero G, Atallah E, Odenike O, Medeiros B, Cortes J, Esquibel V, et al. Pracinostat in combination with azacitidine produces a high rate and rapid onset of disease remission in patients with previously untreated acute myeloid leukemia (AML). Blood. 2014;124(21):Abstract 947.
    • Garcia-Manero G, Atallah E, Odenike O, Medeiros B, Cortes J, Esquibel V, et al. Pracinostat in combination with azacitidine produces a high rate and rapid onset of disease remission in patients with previously untreated acute myeloid leukemia (AML). Blood. 2014;124(21):Abstract 947.
  • 88
    • 84973394613 scopus 로고    scopus 로고
    • Stein E, Altman JK, Collins R, DeAngelo DJ, Fathi AT, Flinn I, et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase I study in patients with IDH2 mutation positive advanced hematologic malignancies. Blood. 2014;124(21):Abstract 115.
    • Stein E, Altman JK, Collins R, DeAngelo DJ, Fathi AT, Flinn I, et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase I study in patients with IDH2 mutation positive advanced hematologic malignancies. Blood. 2014;124(21):Abstract 115.
  • 89
    • 84973337022 scopus 로고    scopus 로고
    • Clinical safety and activity in a phase I trial of AG-120, a first in class, selective, potent inhibitor of the IDH1-mutant protein, in patients with IDH1 mutant positive advanced hematologic malignancies
    • Pollyea DA, De Botton S, Fathi AT, Tallman MS, Agresta S, Bowden C, et al. Clinical safety and activity in a phase I trial of AG-120, a first in class, selective, potent inhibitor of the IDH1-mutant protein, in patients with IDH1 mutant positive advanced hematologic malignancies. Eur J Haematol. 2014;50:195.
    • (2014) Eur J Haematol , vol.50 , pp. 195
    • Pollyea, D.A.1    De Botton, S.2    Fathi, A.T.3    Tallman, M.S.4    Agresta, S.5    Bowden, C.6
  • 90
    • 84897108758 scopus 로고    scopus 로고
    • Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival
    • COI: 1:CAS:528:DC%2BC2cXisFejt7Y%3D, PID: 24522248
    • Pleyer L, Germing U, Sperr WR, Linkesch W, Burgstaller S, Stauder R, et al. Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival. Leuk Res. 2014;38(4):475–83.
    • (2014) Leuk Res , vol.38 , Issue.4 , pp. 475-483
    • Pleyer, L.1    Germing, U.2    Sperr, W.R.3    Linkesch, W.4    Burgstaller, S.5    Stauder, R.6
  • 91
    • 84904070660 scopus 로고    scopus 로고
    • A multi-centre phase 2 study of azacitidine in chronic myelomonocytic leukaemia
    • COI: 1:CAS:528:DC%2BC2cXkslGiu7Y%3D, PID: 24569776
    • Drummond MW, Pocock C, Boissinot M, Mills J, Brown J, Cauchy P, et al. A multi-centre phase 2 study of azacitidine in chronic myelomonocytic leukaemia. Leukemia. 2014;28(7):1570–2. doi:10.1038/leu.2014.85.
    • (2014) Leukemia , vol.28 , Issue.7 , pp. 1570-1572
    • Drummond, M.W.1    Pocock, C.2    Boissinot, M.3    Mills, J.4    Brown, J.5    Cauchy, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.