MiR-15b/16-2 deletion promotes B-cell malignancies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11636-11641

  Lovat, Francesca ^a   Fassan, Matteo ^b,c   Gasparini, Pierluigi ^a   Rizzotto, Lara ^a   Cascione, Luciano ^d,e   Pizzi, Marco ^b   Vicentini, Caterina ^c   Balatti, Veronica ^a   Palmieri, Dario ^a   Costinean, Stefan ^a   Croce, Carlo M ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d INSTITUTE OF ONCOLOGY RESEARCH   (Switzerland)

^e ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

B cells; Chronic lymphocytic leukemia; MiR 15b; MiRNAs; Murine models

Indexed keywords

CYCLIN D1; CYCLIN D2; MICRORNA; MICRORNA 15B; MICRORNA 16; MICRORNA 16 2; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; CCND1 PROTEIN, MOUSE; CCND2 PROTEIN, MOUSE; MIRN15 MICRORNA, HUMAN; MIRN15 MICRORNA, MOUSE; MIRN16 MICRORNA, HUMAN; MIRN16 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GENE TARGETING; HOMOLOGOUS RECOMBINATION; HUMAN; LARGE CELL LYMPHOMA; LUCIFERASE ASSAY; MONOCLONAL B CELL LYMPHOCYTOSIS; MOUSE; NONHUMAN; NORTHERN BLOTTING; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; SOUTHERN BLOTTING; SPLEEN; SPLENOMEGALY; UPREGULATION; WESTERN BLOTTING; ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE;

ANIMALS; CYCLIN D1; CYCLIN D2; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; MICE, KNOCKOUT; MICRORNAS; RECEPTOR, IGF TYPE 1;

EID: 84941696045     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514954112     Document Type: Article

References (28)

1. Ambros V (2004) The functions of animal microRNAs. Nature 431(7006): 350-355.
2. Calin GA, et al. (2005) A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353(17): 1793-1801.
3. Cimmino A, et al. (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102(39): 13944-13949.
4. Aqeilan RI, Calin GA, Croce CM (2010) miR-15a and miR-16-1 in cancer: Discovery, function and future perspectives. Cell Death Differ 17(2): 215-220.
5. Calin GA, et al. (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99(24): 15524-15529.
6. Calin GA, et al. (2008) MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA 105(13): 5166-5171.
7. Klein U, et al. (2010) The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 17(1): 28-40.
8. Careccia S, et al. (2009) A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. Oncogene 28(45): 4034-4040.
9. Garzon R, et al. (2007) MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 26(28): 4148-4157.
10. Jones KB, et al. (2012) miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res 72(7): 1865-1877.
11. Satzger I, et al. (2010) MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. Int J Cancer 126(11): 2553-2562.
12. Kanaan Z, et al. (2013) A plasma microRNA panel for detection of colorectal adenomas: A step toward more precise screening for colorectal cancer. Ann Surg 258(3): 400-408.
13. Sun L, et al. (2012) MiR-200b and miR-15b regulate chemotherapy-induced epithelialmesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene 31(4): 432-445.
14. Bonci D, et al. (2008) The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 14(11): 1271-1277.
15. Sherr CJ (2000) The Pezcoller Lecture: Cancer cell cycles revisited. Cancer Res 60(14): 3689-3695.
16. Jaroslav P, et al. (2005) Expression of cyclins D1, D2, and D3 and Ki-67 in leukemia. Leuk Lymphoma 46(11): 1605-1612.
17. Lossos IS, et al. (2004) Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. N Engl J Med 350(18): 1828-1837.
18. Paul JT, et al. (2005) Cyclin D expression in chronic lymphocytic leukemia. Leuk Lymphoma 46(9): 1275-1285.
19. Delmer A, et al. (1995) Overexpression of cyclin D2 in chronic B-cell malignancies. Blood 85(10): 2870-2876.
20. Fürstenberger G, Senn HJ (2002) Insulin-like growth factors and cancer. Lancet Oncol 3(5): 298-302.
21. Yaktapour N, et al. (2013) Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood 122(9): 1621-1633.
22. Zheng X, Chopp M, Lu Y, Buller B, Jiang F (2013) MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3. Cancer Lett 329(2): 146-154.
23. Xia L, et al. (2008) miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer 123(2): 372-379.
24. Chung GE, et al. (2010) High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma. Oncol Rep 23(1): 113-119.
25. Pichiorri F, et al. (2010) Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 18(4): 367-381.
26. Ventura A, et al. (2008) Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters. Cell 132(5): 875-886.
27. Morse HC, III, et al.; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium (2002) Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100(1): 246-258.
28. Nuovo GJ, et al. (2009) A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets. Nat Protoc 4(1): 107-115.