메뉴 건너뛰기




Volumn 75, Issue 8, 2016, Pages 1541-1549

Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

FRIEND LEUKAEMIA INTEGRATION 1 PROTEIN; NEUROPILIN 1; SEMAPHORIN 3A; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; FLI1 PROTEIN, HUMAN; SEMA3A PROTEIN, HUMAN; TRANSCRIPTION FACTOR FLI 1;

EID: 84941687226     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-207483     Document Type: Article
Times cited : (42)

References (48)
  • 1
    • 84885126599 scopus 로고    scopus 로고
    • 2013 classification criteria for systemic sclerosis: An American College of Rheumatology/European League against Rheumatism collaborative initiative
    • van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: An American College of Rheumatology/European League against Rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747-55.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1747-1755
    • Van Den Hoogen, F.1    Khanna, D.2    Fransen, J.3
  • 2
    • 77955142127 scopus 로고    scopus 로고
    • Mechanisms in the loss of capillaries in systemic sclerosis: Angiogenesis versus vasculogenesis
    • Manetti M, Guiducci S, Ibba-Manneschi L, et al. Mechanisms in the loss of capillaries in systemic sclerosis: Angiogenesis versus vasculogenesis. J Cell Mol Med 2010;14:1241-54.
    • (2010) J Cell Mol Med , vol.14 , pp. 1241-1254
    • Manetti, M.1    Guiducci, S.2    Ibba-Manneschi, L.3
  • 3
    • 84886222623 scopus 로고    scopus 로고
    • Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: Potential contribution to impaired angiogenesis and vasculogenesis
    • Manetti M, Guiducci S, Romano E, et al. Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis. Arthritis Res Ther 2013;15:R165.
    • (2013) Arthritis Res Ther , vol.15 , pp. R165
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 4
    • 61949107700 scopus 로고    scopus 로고
    • Guidance of vascular development: Lessons from the nervous system
    • Larrivée B, Freitas C, Suchting S, et al. Guidance of vascular development: lessons from the nervous system. Circ Res 2009;104:428-41.
    • (2009) Circ Res , vol.104 , pp. 428-441
    • Larrivée, B.1    Freitas, C.2    Suchting, S.3
  • 5
    • 0030847193 scopus 로고    scopus 로고
    • Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    • He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 1997;90:739-51.
    • (1997) Cell , vol.90 , pp. 739-751
    • He, Z.1    Tessier-Lavigne, M.2
  • 6
    • 0030829388 scopus 로고    scopus 로고
    • Neuropilin is a semaphorin III receptor
    • Kolodkin AL, Levengood DV, Rowe EG, et al. Neuropilin is a semaphorin III receptor. Cell 1997;90:753-62.
    • (1997) Cell , vol.90 , pp. 753-762
    • Kolodkin, A.L.1    Levengood, D.V.2    Rowe, E.G.3
  • 7
    • 34547520925 scopus 로고    scopus 로고
    • Structural basis for ligand and heparin binding to neuropilin B domains
    • Vander Kool CW, Jusino MA, Perman B, et al. Structural basis for ligand and heparin binding to neuropilin B domains. Proc Natl Acad Sci USA 2007;104:6152-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6152-6157
    • Vander Kool, C.W.1    Jusino, M.A.2    Perman, B.3
  • 8
    • 33747152506 scopus 로고    scopus 로고
    • Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration
    • Favier B, AlamA, Barron P, et al. Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood 2006;108:1243-50.
    • (2006) Blood , vol.108 , pp. 1243-1250
    • Favier, B.1    Alam, A.2    Barron, P.3
  • 9
    • 1542571789 scopus 로고    scopus 로고
    • Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    • Wang L, Zeng H, Wang P, et al. Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem 2003;278:48848-60.
    • (2003) J Biol Chem , vol.278 , pp. 48848-48860
    • Wang, L.1    Zeng, H.2    Wang, P.3
  • 10
    • 21844449129 scopus 로고    scopus 로고
    • Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability
    • Becker PM, Waltenberger J, Yachechko R, et al. Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ Res 2005;96:1257-65.
    • (2005) Circ Res , vol.96 , pp. 1257-1265
    • Becker, P.M.1    Waltenberger, J.2    Yachechko, R.3
  • 11
    • 55749110742 scopus 로고    scopus 로고
    • Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
    • Kawamura H, Li X, Goishi K, et al. Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood 2008;112:3638-49.
    • (2008) Blood , vol.112 , pp. 3638-3649
    • Kawamura, H.1    Li, X.2    Goishi, K.3
  • 12
    • 84856259334 scopus 로고    scopus 로고
    • Neuropilin signaling in angiogenesis
    • Koch S. Neuropilin signaling in angiogenesis. Biochem Soc Trans 2012;40:20-5.
    • (2012) Biochem Soc Trans , vol.40 , pp. 20-25
    • Koch, S.1
  • 13
    • 0033549556 scopus 로고    scopus 로고
    • Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165
    • Miao HQ, Soker S, Feiner L, et al. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol 1999;146:233-42.
    • (1999) J Cell Biol , vol.146 , pp. 233-242
    • Miao, H.Q.1    Soker, S.2    Feiner, L.3
  • 14
    • 34548839104 scopus 로고    scopus 로고
    • Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis
    • Guttmann-Raviv N, Shraga-Heled N, Varshavsky A, et al. Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis. J Biol Chem 2007;282:26294-305.
    • (2007) J Biol Chem , vol.282 , pp. 26294-26305
    • Guttmann-Raviv, N.1    Shraga-Heled, N.2    Varshavsky, A.3
  • 15
    • 0041530325 scopus 로고    scopus 로고
    • Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
    • Serini G, Valdembri D, Zanivan S, et al. Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature 2003;424:391-7.
    • (2003) Nature , vol.424 , pp. 391-397
    • Serini, G.1    Valdembri, D.2    Zanivan, S.3
  • 16
    • 70449428715 scopus 로고    scopus 로고
    • Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
    • Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest 2009;119:3356-72.
    • (2009) J Clin Invest , vol.119 , pp. 3356-3372
    • Maione, F.1    Molla, F.2    Meda, C.3
  • 17
    • 0038686623 scopus 로고    scopus 로고
    • Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    • Gu C, Rodriguez ER, Reimert DV, et al. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell 2003;5:45-57.
    • (2003) Dev Cell , vol.5 , pp. 45-57
    • Gu, C.1    Rodriguez, E.R.2    Reimert, D.V.3
  • 18
    • 79961002277 scopus 로고    scopus 로고
    • Nervous vascular parallels: Axon guidance and beyond
    • Arese M, Serini G, Bussolino F. Nervous vascular parallels: Axon guidance and beyond. Int J Dev Biol 2011;55:439-45.
    • (2011) Int J Dev Biol , vol.55 , pp. 439-445
    • Arese, M.1    Serini, G.2    Bussolino, F.3
  • 19
    • 36549056078 scopus 로고    scopus 로고
    • Structural studies of neuropilin/antibody complexes provide insights into semaphoring and VEGF binding
    • Appleton BA, Wu P, Maloney J, et al. Structural studies of neuropilin/antibody complexes provide insights into semaphoring and VEGF binding. EMBO J 2007;26:4902-12.
    • (2007) EMBO J , vol.26 , pp. 4902-4912
    • Appleton, B.A.1    Wu, P.2    Maloney, J.3
  • 20
    • 84855486320 scopus 로고    scopus 로고
    • Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer
    • Sakurai A, Doçi CL, Gutkind JS. Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res 2012;22:23-32.
    • (2012) Cell Res , vol.22 , pp. 23-32
    • Sakurai, A.1    Doçi, C.L.2    Gutkind, J.S.3
  • 21
    • 0023854176 scopus 로고
    • Scleroderma (systemic sclerosis): Classification, subsets, and pathogenesis
    • LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis. J Rheumatol 1988;15:202-5.
    • (1988) J Rheumatol , vol.15 , pp. 202-205
    • LeRoy, E.C.1    Black, C.2    Fleischmajer, R.3
  • 22
    • 84860917548 scopus 로고    scopus 로고
    • Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: Correlation with severity of skin and pulmonary fibrosis and vascular damage
    • Manetti M, Guiducci S, Romano E, et al. Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage. Ann Rheum Dis 2012;71:1064-72.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1064-1072
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 23
    • 84871756113 scopus 로고    scopus 로고
    • Differential expression of junctional adhesion molecules in different stages of systemic sclerosis
    • Manetti M, Guiducci S, Romano E, et al. Differential expression of junctional adhesion molecules in different stages of systemic sclerosis. Arthritis Rheum 2013;65:247-57.
    • (2013) Arthritis Rheum , vol.65 , pp. 247-257
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 24
    • 55849130694 scopus 로고    scopus 로고
    • Angiogenesis in systemic sclerosis: Impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions
    • Avouac J, Wipff J, Goldman O, et al. Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions. Arthritis Rheum 2008;58:3550-61.
    • (2008) Arthritis Rheum , vol.58 , pp. 3550-3561
    • Avouac, J.1    Wipff, J.2    Goldman, O.3
  • 25
    • 80155127962 scopus 로고    scopus 로고
    • Insights into the pathogenesis of systemic sclerosis based on the gene expression profile of progenitor-derived endothelial cells
    • Avouac J, Cagnard N, Distler JH, et al. Insights into the pathogenesis of systemic sclerosis based on the gene expression profile of progenitor-derived endothelial cells. Arthritis Rheum 2011;63:3552-62.
    • (2011) Arthritis Rheum , vol.63 , pp. 3552-3562
    • Avouac, J.1    Cagnard, N.2    Distler, J.H.3
  • 26
    • 79961031252 scopus 로고    scopus 로고
    • Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis
    • Manetti M, Guiducci S, Romano E, et al. Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Circ Res 2011;109:e14-26.
    • (2011) Circ Res , vol.109 , pp. e14-26
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 27
    • 80053560934 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro
    • Guiducci S, Manetti M, Romano E, et al. Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro. Ann Rheum Dis 2011;70:2011-21.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2011-2021
    • Guiducci, S.1    Manetti, M.2    Romano, E.3
  • 28
    • 84926084844 scopus 로고    scopus 로고
    • A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis
    • Saigusa R, Asano Y, Taniguchi T, et al. A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis. Exp Dermatol 2015;24:127-32.
    • (2015) Exp Dermatol , vol.24 , pp. 127-132
    • Saigusa, R.1    Asano, Y.2    Taniguchi, T.3
  • 29
    • 84926105685 scopus 로고    scopus 로고
    • Fli1 deficiency and beyond: A unique pathway linking peripheral vasculopathy and dermal fibrosis in systemic sclerosis
    • Manetti M. Fli1 deficiency and beyond: A unique pathway linking peripheral vasculopathy and dermal fibrosis in systemic sclerosis. Exp Dermatol 2015;24:256-7.
    • (2015) Exp Dermatol , vol.24 , pp. 256-257
    • Manetti, M.1
  • 30
    • 77956178350 scopus 로고    scopus 로고
    • The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis
    • Asano Y, Bujor AM, Trojanowska M. The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis. J Dermatol Sci 2010;59:153-62.
    • (2010) J Dermatol Sci , vol.59 , pp. 153-162
    • Asano, Y.1    Bujor, A.M.2    Trojanowska, M.3
  • 31
    • 84946201676 scopus 로고    scopus 로고
    • Bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: An in vitro study
    • Romano E, Bellando-Randone S, Manetti M, et al. Bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: An in vitro study. Clin Exp Rheumatol 2015;33(Suppl 91):S148-S152.
    • (2015) Clin Exp Rheumatol , vol.33 , pp. S148-S152
    • Romano, E.1    Bellando-Randone, S.2    Manetti, M.3
  • 32
    • 84953889054 scopus 로고    scopus 로고
    • Systemic sclerosis sera impair angiogenic performance of dermal microvascular endothelial cells: Therapeutic implications of cyclophosphamide
    • Borghini A, Manetti M, Nacci F, et al. Systemic sclerosis sera impair angiogenic performance of dermal microvascular endothelial cells: Therapeutic implications of cyclophosphamide. PLoS ONE 2015;10:e0130166.
    • (2015) PLoS ONE , vol.10 , pp. e0130166
    • Borghini, A.1    Manetti, M.2    Nacci, F.3
  • 33
    • 0030778454 scopus 로고    scopus 로고
    • Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    • Kitsukawa T, Shimizu M, Sanbo M, et al. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 1997;19:995-1005.
    • (1997) Neuron , vol.19 , pp. 995-1005
    • Kitsukawa, T.1    Shimizu, M.2    Sanbo, M.3
  • 34
    • 0032707249 scopus 로고    scopus 로고
    • A requirement for neuropilin-1 in embryonic vessel formation
    • Kawasaki T, Kitsukawa T, Bekku Y, et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 1999;126:4895-902.
    • (1999) Development , vol.126 , pp. 4895-4902
    • Kawasaki, T.1    Kitsukawa, T.2    Bekku, Y.3
  • 35
    • 16844380415 scopus 로고    scopus 로고
    • Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
    • Mukouyama YS, Gerber HP, Ferrara N, et al. Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback. Development 2005;32:941-52.
    • (2005) Development , vol.32 , pp. 941-952
    • Mukouyama, Y.S.1    Gerber, H.P.2    Ferrara, N.3
  • 36
    • 0037039360 scopus 로고    scopus 로고
    • Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): A mechanism contributing to VEGF-induced angiogenesis
    • Oh H, Takagi H, Otani A, et al. Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): A mechanism contributing to VEGF-induced angiogenesis. Proc Natl Acad Sci USA 2002;99:383-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 383-388
    • Oh, H.1    Takagi, H.2    Otani, A.3
  • 37
    • 84881361471 scopus 로고    scopus 로고
    • Review: Evidence that systemic sclerosis is a vascular disease
    • Matucci-Cerinic M, Kahaleh B, Wigley FM. Review: evidence that systemic sclerosis is a vascular disease. Arthritis Rheum 2013;65:1953-62.
    • (2013) Arthritis Rheum , vol.65 , pp. 1953-1962
    • Matucci-Cerinic, M.1    Kahaleh, B.2    Wigley, F.M.3
  • 38
    • 84864572676 scopus 로고    scopus 로고
    • Impaired angiogenesis in systemic sclerosis: The emerging role of the antiangiogenic VEGF (165)b splice variant
    • Manetti M, Guiducci S, Ibba-Manneschi L, et al. Impaired angiogenesis in systemic sclerosis: The emerging role of the antiangiogenic VEGF(165)b splice variant. Trends Cardiovasc Med 2011;21:204-10.
    • (2011) Trends Cardiovasc Med , vol.21 , pp. 204-210
    • Manetti, M.1    Guiducci, S.2    Ibba-Manneschi, L.3
  • 39
    • 3142670517 scopus 로고    scopus 로고
    • Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    • Distler O, Distler JH, Scheid A, et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004;95:109-16.
    • (2004) Circ Res , vol.95 , pp. 109-116
    • Distler, O.1    Distler, J.H.2    Scheid, A.3
  • 40
    • 84857042496 scopus 로고    scopus 로고
    • Angiogenesis and vasculopathy in systemic sclerosis: Evolving concepts
    • Rabquer BJ, Koch AE. Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts. Curr Rheumatol Rep 2012;14:56-63.
    • (2012) Curr Rheumatol Rep , vol.14 , pp. 56-63
    • Rabquer, B.J.1    Koch, A.E.2
  • 41
    • 35348891629 scopus 로고    scopus 로고
    • Antiangiogenic plasma activity in patients with systemic sclerosis
    • Mulligan-Kehoe MJ, Drinane MC, Mollmark J, et al. Antiangiogenic plasma activity in patients with systemic sclerosis. Arthritis Rheum 2007;56:3448-58.
    • (2007) Arthritis Rheum , vol.56 , pp. 3448-3458
    • Mulligan-Kehoe, M.J.1    Drinane, M.C.2    Mollmark, J.3
  • 42
    • 84880135938 scopus 로고    scopus 로고
    • Increased plasma levels of the VEGF165b splice variant are associated with the severity of nailfold capillary loss in systemic sclerosis
    • Manetti M, Guiducci S, Romano E, et al. Increased plasma levels of the VEGF165b splice variant are associated with the severity of nailfold capillary loss in systemic sclerosis. Ann Rheum Dis 2013;72:1425-7.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1425-1427
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 43
    • 33748479489 scopus 로고    scopus 로고
    • A VEGF-A splice variant defective for heparin sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2
    • Cébe Suarez S, Pieren M, Cariolato L, et al. A VEGF-A splice variant defective for heparin sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci 2006;63:2067-77.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2067-2077
    • Cébe Suarez, S.1    Pieren, M.2    Cariolato, L.3
  • 44
    • 49649088463 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    • Kawamura H, Li X, Harper SJ, et al. Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 2008;68:4683-92.
    • (2008) Cancer Res , vol.68 , pp. 4683-4692
    • Kawamura, H.1    Li, X.2    Harper, S.J.3
  • 45
    • 79960690759 scopus 로고    scopus 로고
    • Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
    • Ballmer-Hofer K, Andersson AE, Ratcliffe LE, et al. Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output. Blood 2011;118:816-26.
    • (2011) Blood , vol.118 , pp. 816-826
    • Ballmer-Hofer, K.1    Andersson, A.E.2    Ratcliffe, L.E.3
  • 46
    • 84923114126 scopus 로고    scopus 로고
    • Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis
    • Chora I, Guiducci S, Manetti M, et al. Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis. Autoimmun Rev 2015;14:314-22.
    • (2015) Autoimmun Rev , vol.14 , pp. 314-322
    • Chora, I.1    Guiducci, S.2    Manetti, M.3
  • 47
    • 84892736489 scopus 로고    scopus 로고
    • MiR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1
    • Wu YY, Chen YL, Jao YC, et al. miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1. Angiogenesis 2014;17:247-60.
    • (2014) Angiogenesis , vol.17 , pp. 247-260
    • Wu, Y.Y.1    Chen, Y.L.2    Jao, Y.C.3
  • 48
    • 84908506366 scopus 로고    scopus 로고
    • The role of genetics and epigenetics in the pathogenesis of systemic sclerosis
    • Broen JC, Radstake TR, Rossato M. The role of genetics and epigenetics in the pathogenesis of systemic sclerosis. Nat Rev Rheumatol 2014;10:671-81.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 671-681
    • Broen, J.C.1    Radstake, T.R.2    Rossato, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.