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Volumn 21, Issue 7, 2011, Pages 204-210

Impaired Angiogenesis in Systemic Sclerosis: The Emerging Role of the Antiangiogenic VEGF165b Splice Variant

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN 165; VASCULOTROPIN 165B; VASCULOTROPIN A;

EID: 84864572676     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2012.05.011     Document Type: Review
Times cited : (48)

References (63)
  • 1
    • 78349245213 scopus 로고    scopus 로고
    • Investigation of antiangiogenic tumor therapy potential of microencapsulated HEK293 VEGF165b producing cells
    • Afkhami F., Durocher Y., Prakash S. Investigation of antiangiogenic tumor therapy potential of microencapsulated HEK293 VEGF165b producing cells. J Biomed Biotechnol 2010, 2010:645610.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 645610
    • Afkhami, F.1    Durocher, Y.2    Prakash, S.3
  • 2
    • 70450196976 scopus 로고    scopus 로고
    • Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary
    • Artac R.A., McFee R.M., Smith R.A., et al. Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary. Biol Reprod 2009, 81:978-988.
    • (2009) Biol Reprod , vol.81 , pp. 978-988
    • Artac, R.A.1    McFee, R.M.2    Smith, R.A.3
  • 3
    • 79960690759 scopus 로고    scopus 로고
    • Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
    • Ballmer-Hofer K., Andersson A.E., Ratcliffe L.E., Berger P. Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output. Blood 2011, 118:816-826.
    • (2011) Blood , vol.118 , pp. 816-826
    • Ballmer-Hofer, K.1    Andersson, A.E.2    Ratcliffe, L.E.3    Berger, P.4
  • 4
    • 77955381324 scopus 로고    scopus 로고
    • Neutralization of vascular endothelial growth factor antiangiogenic isoforms or administration of proangiogenic isoforms stimulates vascular development in the rat testis
    • Baltes-Breitwisch M.M., Artac R.A., Bott R.C., et al. Neutralization of vascular endothelial growth factor antiangiogenic isoforms or administration of proangiogenic isoforms stimulates vascular development in the rat testis. Reproduction 2010, 140:319-329.
    • (2010) Reproduction , vol.140 , pp. 319-329
    • Baltes-Breitwisch, M.M.1    Artac, R.A.2    Bott, R.C.3
  • 5
    • 0037098860 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is downregulated in renal cell carcinoma
    • Bates D.O., Cui T.G., Doughty J.M., et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is downregulated in renal cell carcinoma. Cancer Res 2002, 62:4123-4131.
    • (2002) Cancer Res , vol.62 , pp. 4123-4131
    • Bates, D.O.1    Cui, T.G.2    Doughty, J.M.3
  • 6
    • 33646711885 scopus 로고    scopus 로고
    • The endogenous antiangiogenic family of splice variants of VEGF, VEGFxxxb, are downregulated in preeclamptic placentae at term
    • Bates D.O., MacMillan P.P., Manjaly J.G., et al. The endogenous antiangiogenic family of splice variants of VEGF, VEGFxxxb, are downregulated in preeclamptic placentae at term. Clin Sci (Lond) 2006, 110:575-585.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 575-585
    • Bates, D.O.1    MacMillan, P.P.2    Manjaly, J.G.3
  • 7
    • 56749179738 scopus 로고    scopus 로고
    • The alternatively spliced antiangiogenic family of VEGF isoforms, VEGFxxxb, in human kidney development
    • Bevan H.S., van den Akker N.M., Qiu Y., et al. The alternatively spliced antiangiogenic family of VEGF isoforms, VEGFxxxb, in human kidney development. Nephron Physiol 2008, 110:57-67.
    • (2008) Nephron Physiol , vol.110 , pp. 57-67
    • Bevan, H.S.1    van den Akker, N.M.2    Qiu, Y.3
  • 8
    • 84855452428 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease
    • Bielecki M., Kowal K., Lapinska A., et al. Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease. Adv Med Sci 2011, 56:255-263.
    • (2011) Adv Med Sci , vol.56 , pp. 255-263
    • Bielecki, M.1    Kowal, K.2    Lapinska, A.3
  • 9
    • 60549093223 scopus 로고    scopus 로고
    • Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia
    • Bills V.L., Varet J., Millar A., et al. Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia. Clin Sci (Lond) 2009, 116:265-272.
    • (2009) Clin Sci (Lond) , vol.116 , pp. 265-272
    • Bills, V.L.1    Varet, J.2    Millar, A.3
  • 10
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • Byrne A.M., Bouchier-Hayes D.J., Harmey J.H. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 2005, 9:777-794.
    • (2005) J Cell Mol Med , vol.9 , pp. 777-794
    • Byrne, A.M.1    Bouchier-Hayes, D.J.2    Harmey, J.H.3
  • 11
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000, 6:389-395.
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 12
    • 34248995307 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in autoimmune diseases
    • Carvalho J.F., Blank M., Shoenfeld Y. Vascular endothelial growth factor (VEGF) in autoimmune diseases. J Clin Immunol 2007, 27:246-256.
    • (2007) J Clin Immunol , vol.27 , pp. 246-256
    • Carvalho, J.F.1    Blank, M.2    Shoenfeld, Y.3
  • 13
    • 33748479489 scopus 로고    scopus 로고
    • A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2
    • Cébe Suarez S., Pieren M., Cariolato L., et al. A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci 2006, 63:2067-2077.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2067-2077
    • Cébe Suarez, S.1    Pieren, M.2    Cariolato, L.3
  • 14
    • 0038166874 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor in systemic sclerosis
    • Choi J.J., Min D.J., Cho M.L., et al. Elevated vascular endothelial growth factor in systemic sclerosis. J Rheumatol 2003, 30:1529-1533.
    • (2003) J Rheumatol , vol.30 , pp. 1529-1533
    • Choi, J.J.1    Min, D.J.2    Cho, M.L.3
  • 15
    • 30744438818 scopus 로고    scopus 로고
    • The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
    • Davies C.A., Jeziorska M., Freemont A.J., Herrick A.L. The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis. Hum Pathol 2006, 37:190-197.
    • (2006) Hum Pathol , vol.37 , pp. 190-197
    • Davies, C.A.1    Jeziorska, M.2    Freemont, A.J.3    Herrick, A.L.4
  • 16
    • 47249094555 scopus 로고    scopus 로고
    • P73 isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis
    • Díaz R., Peña C., Silva J., et al. p73 isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis. Int J Cancer 2008, 123:1060-1067.
    • (2008) Int J Cancer , vol.123 , pp. 1060-1067
    • Díaz, R.1    Peña, C.2    Silva, J.3
  • 17
    • 34247564964 scopus 로고    scopus 로고
    • Angiogenic and angiostatic factors in systemic sclerosis: Increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    • Distler O., Del Rosso A., Giacomelli R., et al. Angiogenic and angiostatic factors in systemic sclerosis: Increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 2002, 4:R11.
    • (2002) Arthritis Res , vol.4
    • Distler, O.1    Del Rosso, A.2    Giacomelli, R.3
  • 18
    • 3142670517 scopus 로고    scopus 로고
    • Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    • Distler O., Distler J.H., Scheid A., et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004, 95:109-116.
    • (2004) Circ Res , vol.95 , pp. 109-116
    • Distler, O.1    Distler, J.H.2    Scheid, A.3
  • 19
    • 79961080792 scopus 로고    scopus 로고
    • The VEGF165b "ICE-o-form" puts a chill on the VEGF story
    • Dokun A.O., Annex B.H. The VEGF165b "ICE-o-form" puts a chill on the VEGF story. Circ Res 2011, 109:246-247.
    • (2011) Circ Res , vol.109 , pp. 246-247
    • Dokun, A.O.1    Annex, B.H.2
  • 20
    • 50549086120 scopus 로고    scopus 로고
    • Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma
    • Ergorul C., Ray A., Huang W., et al. Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma. Mol Vis 2008, 14:1517-1524.
    • (2008) Mol Vis , vol.14 , pp. 1517-1524
    • Ergorul, C.1    Ray, A.2    Huang, W.3
  • 21
    • 16644395747 scopus 로고    scopus 로고
    • The role of VEGF in the regulation of physiological and pathological angiogenesis
    • Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 2005, 94:209-231.
    • (2005) EXS , vol.94 , pp. 209-231
    • Ferrara, N.1
  • 22
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N., Carver-Moore K., Chen H., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996, 380:439-442.
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3
  • 23
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N., Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 161:851-858.
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 24
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995, 1:27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 26
    • 79951670868 scopus 로고    scopus 로고
    • The pathogenesis of systemic sclerosis revisited
    • Geyer M., Müller-Ladner U. The pathogenesis of systemic sclerosis revisited. Clin Rev Allergy Immunol 2011, 40:92-103.
    • (2011) Clin Rev Allergy Immunol , vol.40 , pp. 92-103
    • Geyer, M.1    Müller-Ladner, U.2
  • 28
    • 29144463738 scopus 로고    scopus 로고
    • Alternative splicing: A new drug target of the post-genome era
    • Hagiwara M. Alternative splicing: A new drug target of the post-genome era. Biochim Biophys Acta 2005, 1754:324-331.
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 324-331
    • Hagiwara, M.1
  • 29
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: The key to anti-angiogenic therapeutics?
    • Harper S.J., Bates D.O. VEGF-A splicing: The key to anti-angiogenic therapeutics?. Nat Rev Cancer 2008, 8:880-887.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 30
    • 84864561549 scopus 로고    scopus 로고
    • Prevalence, prognosis, and factors associated with left ventricular diastolic dysfunction in systemic sclerosis
    • Hinchcliff M., Desai C.S., Varga J., Shah S.J. Prevalence, prognosis, and factors associated with left ventricular diastolic dysfunction in systemic sclerosis. Clin Exp Rheumatol 2012, 30:S30-S37.
    • (2012) Clin Exp Rheumatol , vol.30
    • Hinchcliff, M.1    Desai, C.S.2    Varga, J.3    Shah, S.J.4
  • 31
    • 77955860259 scopus 로고    scopus 로고
    • Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    • Hua J., Spee C., Kase S., et al. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2010, 51:4282-4288.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 4282-4288
    • Hua, J.1    Spee, C.2    Kase, S.3
  • 32
    • 65649133084 scopus 로고    scopus 로고
    • Abnormalities in the regulators of angiogenesis in patients with scleroderma
    • Hummers L.K., Hall A., Wigley F.M., Simons M. Abnormalities in the regulators of angiogenesis in patients with scleroderma. J Rheumatol 2009, 36:576-582.
    • (2009) J Rheumatol , vol.36 , pp. 576-582
    • Hummers, L.K.1    Hall, A.2    Wigley, F.M.3    Simons, M.4
  • 33
    • 40149083876 scopus 로고    scopus 로고
    • Vascular disease in scleroderma: Mechanisms of vascular injury
    • Kahaleh B. Vascular disease in scleroderma: Mechanisms of vascular injury. Rheum Dis Clin North Am 2008, 34:57-71.
    • (2008) Rheum Dis Clin North Am , vol.34 , pp. 57-71
    • Kahaleh, B.1
  • 34
    • 49649088463 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    • Kawamura H., Li X., Harper S.J., et al. Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 2008, 68:4683-4692.
    • (2008) Cancer Res , vol.68 , pp. 4683-4692
    • Kawamura, H.1    Li, X.2    Harper, S.J.3
  • 35
    • 33646871534 scopus 로고    scopus 로고
    • VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice
    • Konopatskaya O., Churchill A.J., Harper S.J., et al. VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice. Mol Vis 2006, 12:626-632.
    • (2006) Mol Vis , vol.12 , pp. 626-632
    • Konopatskaya, O.1    Churchill, A.J.2    Harper, S.J.3
  • 36
    • 17544370003 scopus 로고    scopus 로고
    • Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: Relationship to organ systemic involvement
    • Kuryliszyn-Moskal A., Klimiuk P.A., Sierakowski S. Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: Relationship to organ systemic involvement. Clin Rheumatol 2005, 24:111-116.
    • (2005) Clin Rheumatol , vol.24 , pp. 111-116
    • Kuryliszyn-Moskal, A.1    Klimiuk, P.A.2    Sierakowski, S.3
  • 37
    • 0029905937 scopus 로고    scopus 로고
    • Systemic sclerosis: A vascular perspective
    • LeRoy E.C. Systemic sclerosis: A vascular perspective. Rheum Dis Clin North Am 1996, 22:675-694.
    • (1996) Rheum Dis Clin North Am , vol.22 , pp. 675-694
    • LeRoy, E.C.1
  • 38
    • 0036709471 scopus 로고    scopus 로고
    • Increased but imbalanced expression of VEGF and its receptors has no positive effect on angiogenesis in systemic sclerosis skin
    • Mackiewicz Z., Sukura A., Povilenaité D., et al. Increased but imbalanced expression of VEGF and its receptors has no positive effect on angiogenesis in systemic sclerosis skin. Clin Exp Rheumatol 2002, 20:641-646.
    • (2002) Clin Exp Rheumatol , vol.20 , pp. 641-646
    • Mackiewicz, Z.1    Sukura, A.2    Povilenaité, D.3
  • 39
    • 77955866848 scopus 로고    scopus 로고
    • VEGF-A165b is cytoprotective and antiangiogenic in the retina
    • Magnussen A.L., Rennel E.S., Hua J., et al. VEGF-A165b is cytoprotective and antiangiogenic in the retina. Invest Ophthalmol Vis Sci 2010, 51:4273-4281.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 4273-4281
    • Magnussen, A.L.1    Rennel, E.S.2    Hua, J.3
  • 40
    • 77955142127 scopus 로고    scopus 로고
    • Mechanisms in the loss of capillaries in systemic sclerosis: Angiogenesis versus vasculogenesis
    • Manetti M., Guiducci S., Ibba-Manneschi L., Matucci-Cerinic M. Mechanisms in the loss of capillaries in systemic sclerosis: Angiogenesis versus vasculogenesis. J Cell Mol Med 2010, 14:1241-1254.
    • (2010) J Cell Mol Med , vol.14 , pp. 1241-1254
    • Manetti, M.1    Guiducci, S.2    Ibba-Manneschi, L.3    Matucci-Cerinic, M.4
  • 41
    • 79961031252 scopus 로고    scopus 로고
    • Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis
    • Manetti M., Guiducci S., Romano E., et al. Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Circ Res 2011, 109:e14-e26.
    • (2011) Circ Res , vol.109
    • Manetti, M.1    Guiducci, S.2    Romano, E.3
  • 42
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999, 13:9-22.
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 43
    • 0030054913 scopus 로고    scopus 로고
    • Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants
    • Neufeld G., Cohen T., Gitay-Goren H., et al. Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants. Cancer Metastasis Rev 1996, 15:153-158.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 153-158
    • Neufeld, G.1    Cohen, T.2    Gitay-Goren, H.3
  • 44
    • 37749022477 scopus 로고    scopus 로고
    • Clinical burden of digital vasculopathy in limited and diffuse cutaneous systemic sclerosis
    • Nihtyanova S.I., Brough G.M., Black C.M., Denton C.P. Clinical burden of digital vasculopathy in limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis 2008, 67:120-123.
    • (2008) Ann Rheum Dis , vol.67 , pp. 120-123
    • Nihtyanova, S.I.1    Brough, G.M.2    Black, C.M.3    Denton, C.P.4
  • 45
    • 56349136033 scopus 로고    scopus 로고
    • Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    • Nowak D.G., Woolard J., Amin E.M., et al. Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. J Cell Sci 2008, 121:3487-3495.
    • (2008) J Cell Sci , vol.121 , pp. 3487-3495
    • Nowak, D.G.1    Woolard, J.2    Amin, E.M.3
  • 47
    • 77950260569 scopus 로고    scopus 로고
    • Innovative therapies for systemic sclerosis
    • Ong V.H., Denton C.P. Innovative therapies for systemic sclerosis. Curr Opin Rheumatol 2010, 22:264-272.
    • (2010) Curr Opin Rheumatol , vol.22 , pp. 264-272
    • Ong, V.H.1    Denton, C.P.2
  • 48
    • 77957954487 scopus 로고    scopus 로고
    • Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth
    • Peiris-Pagès M., Harper S.J., Bates D.O., Ramani P. Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth. J Pathol 2010, 222:138-147.
    • (2010) J Pathol , vol.222 , pp. 138-147
    • Peiris-Pagès, M.1    Harper, S.J.2    Bates, D.O.3    Ramani, P.4
  • 49
    • 27744489034 scopus 로고    scopus 로고
    • Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor
    • Perrin R.M., Konopatskaya O., Qiu Y., et al. Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor. Diabetologia 2005, 48:2422-2427.
    • (2005) Diabetologia , vol.48 , pp. 2422-2427
    • Perrin, R.M.1    Konopatskaya, O.2    Qiu, Y.3
  • 50
    • 34447316207 scopus 로고    scopus 로고
    • Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma
    • Pritchard-Jones R.O., Dunn D.B., Qiu Y., et al. Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Br J Cancer 2007, 97:223-230.
    • (2007) Br J Cancer , vol.97 , pp. 223-230
    • Pritchard-Jones, R.O.1    Dunn, D.B.2    Qiu, Y.3
  • 51
    • 42049083543 scopus 로고    scopus 로고
    • Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b
    • Qiu Y., Bevan H., Weeraperuma S., et al. Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b. FASEB J 2008, 22:1104-1112.
    • (2008) FASEB J , vol.22 , pp. 1104-1112
    • Qiu, Y.1    Bevan, H.2    Weeraperuma, S.3
  • 52
    • 70450203391 scopus 로고    scopus 로고
    • The antiangiogenic isoforms of VEGF in health and disease
    • Qiu Y., Hoareau-Aveilla C., Oltean S., et al. The antiangiogenic isoforms of VEGF in health and disease. Biochem Soc Trans 2009, 37:1207-1213.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1207-1213
    • Qiu, Y.1    Hoareau-Aveilla, C.2    Oltean, S.3
  • 53
    • 84857042496 scopus 로고    scopus 로고
    • Angiogenesis and vasculopathy in systemic sclerosis: Evolving concepts
    • Rabquer B.J., Koch A.E. Angiogenesis and vasculopathy in systemic sclerosis: Evolving concepts. Curr Rheumatol Rep 2012, 14:56-63.
    • (2012) Curr Rheumatol Rep , vol.14 , pp. 56-63
    • Rabquer, B.J.1    Koch, A.E.2
  • 54
    • 41649101428 scopus 로고    scopus 로고
    • The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
    • Rennel E., Waine E., Guan H., et al. The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice. Br J Cancer 2008, 98:1250-1257.
    • (2008) Br J Cancer , vol.98 , pp. 1250-1257
    • Rennel, E.1    Waine, E.2    Guan, H.3
  • 55
    • 69849084521 scopus 로고    scopus 로고
    • Therapeutic potential of manipulating VEGF splice isoforms in oncology
    • Rennel E.S., Harper S.J., Bates D.O. Therapeutic potential of manipulating VEGF splice isoforms in oncology. Future Oncol 2009, 5:703-712.
    • (2009) Future Oncol , vol.5 , pp. 703-712
    • Rennel, E.S.1    Harper, S.J.2    Bates, D.O.3
  • 56
    • 84855203266 scopus 로고    scopus 로고
    • Antiangiogenic isoforms of vascular endothelial growth factor predominate in subretinal fluid of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy
    • Ricker L.J., Dieudonné S.C., Kessels A.G., et al. Antiangiogenic isoforms of vascular endothelial growth factor predominate in subretinal fluid of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. Retina 2012, 32:54-59.
    • (2012) Retina , vol.32 , pp. 54-59
    • Ricker, L.J.1    Dieudonné, S.C.2    Kessels, A.G.3
  • 57
    • 33947217234 scopus 로고    scopus 로고
    • Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome
    • Schumacher V.A., Jeruschke S., Eitner F., et al. Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome. J Am Soc Nephrol 2007, 18:719-729.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 719-729
    • Schumacher, V.A.1    Jeruschke, S.2    Eitner, F.3
  • 58
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D.R., Galli S.J., Dvorak A.M., et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219:983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 59
    • 70349784606 scopus 로고    scopus 로고
    • The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis
    • Solanilla A., Villeneuve J., Auguste P., et al. The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis. Rheumatology 2009, 48:1036-1044.
    • (2009) Rheumatology , vol.48 , pp. 1036-1044
    • Solanilla, A.1    Villeneuve, J.2    Auguste, P.3
  • 60
    • 34347266509 scopus 로고    scopus 로고
    • Changes in causes of death in systemic sclerosis, 1972-2002
    • Steen V.D., Medsger T.A. Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis 2007, 66:940-944.
    • (2007) Ann Rheum Dis , vol.66 , pp. 940-944
    • Steen, V.D.1    Medsger, T.A.2
  • 61
    • 42149152015 scopus 로고    scopus 로고
    • VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: Balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
    • Varey A.H., Rennel E.S., Qiu Y., et al. VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: Balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 2008, 98:1366-1379.
    • (2008) Br J Cancer , vol.98 , pp. 1366-1379
    • Varey, A.H.1    Rennel, E.S.2    Qiu, Y.3
  • 62
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • Varga J., Abraham D. Systemic sclerosis: A prototypic multisystem fibrotic disorder. J Clin Invest 2007, 117:557-567.
    • (2007) J Clin Invest , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 63
    • 7444240909 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    • Woolard J., Wang W.Y., Bevan H.S., et al. VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res 2004, 64:7822-7835.
    • (2004) Cancer Res , vol.64 , pp. 7822-7835
    • Woolard, J.1    Wang, W.Y.2    Bevan, H.S.3


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