메뉴 건너뛰기




Volumn 16, Issue 13, 2015, Pages 1513-1520

Atomoxetine pharmacogenetics: Associations with pharmacokinetics, treatment response and tolerability

Author keywords

ADHD; atomoxetine; CYP2D6; pharmacogenetics

Indexed keywords

ATOMOXETINE; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; NORADRENALIN TRANSPORTER; PAROXETINE; PLACEBO; ADRENERGIC RECEPTOR AFFECTING AGENT;

EID: 84941658089     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/PGS.15.93     Document Type: Review
Times cited : (14)

References (51)
  • 1
    • 84941647027 scopus 로고    scopus 로고
    • [package insert]. Eli Lilly and Company, IN, USA
    • STRATTERA® (atomoxetine) [package insert]. Eli Lilly and Company, IN, USA (2015).
    • (2015) STRATTERA® (Atomoxetine)
  • 2
  • 5
    • 84872778823 scopus 로고    scopus 로고
    • Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004-2006
    • Pastor PN, Reuben CA. Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004-2006. Vital Health Stat. 10(237), 1-14 (2008).
    • (2008) Vital Health Stat. , vol.10 , Issue.237 , pp. 1-14
    • Pastor, P.N.1    Reuben, C.A.2
  • 6
    • 79957898817 scopus 로고    scopus 로고
    • Trends in the prevalence of developmental disabilities in US children, 1997-2008
    • Boyle CA, Boulet S, Schieve LA et al. Trends in the prevalence of developmental disabilities in US children, 1997-2008. Pediatrics 127(6), 1034-1042 (2011).
    • (2011) Pediatrics , vol.127 , Issue.6 , pp. 1034-1042
    • Boyle, C.A.1    Boulet, S.2    Schieve, L.A.3
  • 7
    • 85035146867 scopus 로고    scopus 로고
    • The prevalence and correlates of adult ADHD in the United States: Results from the National Comorbidity Survey Replication
    • Kessler RC, Adler L, Barkley R et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am. J. Psychiatry 163(4), 716-723 (2006).
    • (2006) Am. J. Psychiatry , vol.163 , Issue.4 , pp. 716-723
    • Kessler, R.C.1    Adler, L.2    Barkley, R.3
  • 8
    • 2642525267 scopus 로고    scopus 로고
    • Stimulant treatment over five years: Adherence, effectiveness, and adverse effects
    • Charach A, Ickowicz A, Schachar R. Stimulant treatment over five years: adherence, effectiveness, and adverse effects. J. Am. Acad. Child Adolesc. Psychiatry 43(5), 559-567 (2004).
    • (2004) J. Am. Acad. Child Adolesc. Psychiatry , vol.43 , Issue.5 , pp. 559-567
    • Charach, A.1    Ickowicz, A.2    Schachar, R.3
  • 9
    • 0019997797 scopus 로고
    • A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain
    • Wong DT, Threlkeld PG, Best KL, Bymaster FP. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J. Pharmacol. Exp. Ther. 222(1), 61-65 (1982).
    • (1982) J. Pharmacol. Exp. Ther. , vol.222 , Issue.1 , pp. 61-65
    • Wong, D.T.1    Threlkeld, P.G.2    Best, K.L.3    Bymaster, F.P.4
  • 10
    • 0027162344 scopus 로고
    • Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites
    • Gehlert DR, Gackenheimer SL, Robertson DW. Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites. Neurosci. Lett. 157(2), 203-206 (1993).
    • (1993) Neurosci. Lett. , vol.157 , Issue.2 , pp. 203-206
    • Gehlert, D.R.1    Gackenheimer, S.L.2    Robertson, D.W.3
  • 11
    • 0036212339 scopus 로고    scopus 로고
    • Delayed pharmacological effects of antidepressants
    • Frazer A, Benmansour S. Delayed pharmacological effects of antidepressants. Mol. Psychiatry 7(Suppl. 1), S23-S28 (2002).
    • (2002) Mol. Psychiatry , vol.7 , pp. S23-S28
    • Frazer, A.1    Benmansour, S.2
  • 12
    • 84925496852 scopus 로고    scopus 로고
    • The efficacy of atomoxetine for the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A comprehensive review of over a decade of clinical research
    • Savill NC, Buitelaar JK, Anand E et al. The efficacy of atomoxetine for the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a comprehensive review of over a decade of clinical research. CNS Drugs 29(2), 131-151 (2015).
    • (2015) CNS Drugs , vol.29 , Issue.2 , pp. 131-151
    • Savill, N.C.1    Buitelaar, J.K.2    Anand, E.3
  • 13
    • 60449113063 scopus 로고    scopus 로고
    • Safety and tolerability of atomoxetine over 3 to 4 years in children and adolescents with ADHD
    • Donnelly C, Bangs M, Trzepacz P et al. Safety and tolerability of atomoxetine over 3 to 4 years in children and adolescents with ADHD. J. Am. Acad. Child Adolesc. Psychiatry 48(2), 176-185 (2009).
    • (2009) J. Am. Acad. Child Adolesc. Psychiatry , vol.48 , Issue.2 , pp. 176-185
    • Donnelly, C.1    Bangs, M.2    Trzepacz, P.3
  • 14
    • 84886690638 scopus 로고    scopus 로고
    • Complexities of CYP2D6 gene analysis and interpretation
    • Gaedigk A. Complexities of CYP2D6 gene analysis and interpretation. Int. Rev. Psychiatry 25(5), 534-553 (2013).
    • (2013) Int. Rev. Psychiatry , vol.25 , Issue.5 , pp. 534-553
    • Gaedigk, A.1
  • 15
    • 0035511622 scopus 로고    scopus 로고
    • Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled, dose-response study
    • Michelson D, Faries D, Wernicke J et al. Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study. Pediatrics 108(5), E83 (2001).
    • (2001) Pediatrics , vol.108 , Issue.5 , pp. E83
    • Michelson, D.1    Faries, D.2    Wernicke, J.3
  • 17
    • 0013499111 scopus 로고    scopus 로고
    • Disposition and metabolic fate of atomoxetine hydrochloride: The role of CYP2D6 in human disposition and metabolism
    • Sauer JM, Ponsler GD, Mattiuz EL et al. Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism. Drug Metab. Dispos. 31(1), 98-107 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , Issue.1 , pp. 98-107
    • Sauer, J.M.1    Ponsler, G.D.2    Mattiuz, E.L.3
  • 18
    • 0036181544 scopus 로고    scopus 로고
    • Identification of the human cytochromes P450 responsible for atomoxetine metabolism
    • Ring BJ, Gillespie JS, Eckstein JA, Wrighton SA. Identification of the human cytochromes P450 responsible for atomoxetine metabolism. Drug Metab. Dispos. 30(3), 319-323 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.3 , pp. 319-323
    • Ring, B.J.1    Gillespie, J.S.2    Eckstein, J.A.3    Wrighton, S.A.4
  • 19
    • 70149110672 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 enzymes and its clinical impact
    • Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab. Rev. 41(2), 89-295 (2009).
    • (2009) Drug Metab. Rev. , vol.41 , Issue.2 , pp. 89-295
    • Zhou, S.F.1    Liu, J.P.2    Chowbay, B.3
  • 21
    • 84896355622 scopus 로고    scopus 로고
    • Challenges in CYP2D6 phenotype assignment from genotype data: A critical assessment and call for standardization
    • Hicks JK, Swen JJ, Gaedigk A. Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization. Curr. Drug Metab. 15(2), 218-232 (2014).
    • (2014) Curr. Drug Metab. , vol.15 , Issue.2 , pp. 218-232
    • Hicks, J.K.1    Swen, J.J.2    Gaedigk, A.3
  • 23
    • 84907875737 scopus 로고    scopus 로고
    • Individualizing the use of medications in children: Making Goldilocks happy
    • Leeder JS, Brown JT, Soden SE. Individualizing the use of medications in children: making Goldilocks happy. Clin. Pharmacol. Ther. 96(3), 304-306 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , Issue.3 , pp. 304-306
    • Leeder, J.S.1    Brown, J.T.2    Soden, S.E.3
  • 25
    • 34548625125 scopus 로고    scopus 로고
    • Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6∗10 allele
    • Cui YM, Teng CH, Pan AX et al. Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6∗10 allele. Br. J. Clin. Pharmacol. 64(4), 445-449 (2007).
    • (2007) Br. J. Clin. Pharmacol. , vol.64 , Issue.4 , pp. 445-449
    • Cui, Y.M.1    Teng, C.H.2    Pan, A.X.3
  • 26
    • 84860181023 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of atomoxetine and effect of CYP2D6∗10/∗10 genotype in healthy Japanese men
    • Matsui A, Azuma J, Witcher JW et al. Pharmacokinetics, safety, and tolerability of atomoxetine and effect of CYP2D6∗10/∗10 genotype in healthy Japanese men. J. Clin. Pharmacol. 52(3), 388-403 (2012).
    • (2012) J. Clin. Pharmacol. , vol.52 , Issue.3 , pp. 388-403
    • Matsui, A.1    Azuma, J.2    Witcher, J.W.3
  • 29
    • 84941697202 scopus 로고    scopus 로고
    • Single dose pharmacokinetics of atomoxetine in children with attention deficit hyperactivity disorder stratified by their CYP2D6 activity score (abstract)
    • Brown JT, Abdel-Rahman SM, Van Haandel L, Gaedigk A, Leeder JS. Single dose pharmacokinetics of atomoxetine in children with attention deficit hyperactivity disorder stratified by their CYP2D6 activity score (abstract). Clin. Pharmacol. Ther. 97(S1), S97 (2015).
    • (2015) Clin. Pharmacol. Ther. , vol.97 , Issue.S1 , pp. S97
    • Brown, J.T.1    Abdel-Rahman, S.M.2    Van Haandel, L.3    Gaedigk, A.4    Leeder, J.S.5
  • 30
    • 34248596149 scopus 로고    scopus 로고
    • The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 or CYP2C19
    • de Leon J. The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 or CYP2C19. J. Clin. Psychopharmacol. 27(3), 241-245 (2007).
    • (2007) J. Clin. Psychopharmacol. , vol.27 , Issue.3 , pp. 241-245
    • De Leon, J.1
  • 32
    • 38949171689 scopus 로고    scopus 로고
    • Enhancement of atomoxetine serum levels by co-administration of paroxetine
    • Paulzen M, Clement HW, Gründer G. Enhancement of atomoxetine serum levels by co-administration of paroxetine. Int. J. Neuropsychopharmacol. 11(2), 289-291 (2008).
    • (2008) Int. J. Neuropsychopharmacol. , vol.11 , Issue.2 , pp. 289-291
    • Paulzen, M.1    Clement, H.W.2    Gründer, G.3
  • 33
    • 84880482333 scopus 로고    scopus 로고
    • Noradrenergic modulation of cognition: Therapeutic implications
    • Chamberlain SR, Robbins TW. Noradrenergic modulation of cognition: therapeutic implications. J. Psychopharmacol. 27(8), 694-718 (2013).
    • (2013) J. Psychopharmacol. , vol.27 , Issue.8 , pp. 694-718
    • Chamberlain, S.R.1    Robbins, T.W.2
  • 34
    • 0029924275 scopus 로고    scopus 로고
    • The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder
    • Arnsten AF, Steere JC, Hunt RD. The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder. Arch. Gen. Psychiatry 53(5), 448-455 (1996).
    • (1996) Arch. Gen. Psychiatry , vol.53 , Issue.5 , pp. 448-455
    • Arnsten, A.F.1    Steere, J.C.2    Hunt, R.D.3
  • 35
    • 79958290847 scopus 로고    scopus 로고
    • Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders
    • Arnsten AF, Pliszka SR. Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacol. Biochem. Behav. 99(2), 211-216 (2011).
    • (2011) Pharmacol. Biochem. Behav. , vol.99 , Issue.2 , pp. 211-216
    • Arnsten, A.F.1    Pliszka, S.R.2
  • 36
    • 80053592197 scopus 로고    scopus 로고
    • An analysis of rat prefrontal cortex in mediating executive function
    • Kesner RP, Churchwell JC. An analysis of rat prefrontal cortex in mediating executive function. Neurobiol. Learn Mem. 96(3), 417-431 (2011).
    • (2011) Neurobiol. Learn Mem. , vol.96 , Issue.3 , pp. 417-431
    • Kesner, R.P.1    Churchwell, J.C.2
  • 37
    • 84905374350 scopus 로고    scopus 로고
    • Atomoxetine-induced increases in monoamine release in the prefrontal cortex are similar in spontaneously hypertensive rats and Wistar-Kyoto rats
    • Ago Y, Umehara M, Higashino K et al. Atomoxetine-induced increases in monoamine release in the prefrontal cortex are similar in spontaneously hypertensive rats and Wistar-Kyoto rats. Neurochem. Res. 39(5), 825-832 (2014).
    • (2014) Neurochem. Res. , vol.39 , Issue.5 , pp. 825-832
    • Ago, Y.1    Umehara, M.2    Higashino, K.3
  • 38
    • 0036848458 scopus 로고    scopus 로고
    • Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: A potential mechanism for efficacy in attention deficit/hyperactivity disorder
    • Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27(5), 699-711 (2002).
    • (2002) Neuropsychopharmacology , vol.27 , Issue.5 , pp. 699-711
    • Bymaster, F.P.1    Katner, J.S.2    Nelson, D.L.3
  • 39
    • 77149136065 scopus 로고    scopus 로고
    • NICE guideline: Attention deficit hyperactivity disorder
    • Atkinson M, Hollis C. NICE guideline: attention deficit hyperactivity disorder. Arch. Dis. Child Educ. Pract. Ed. 95(1), 24-27 (2010).
    • (2010) Arch. Dis. Child Educ. Pract. Ed. , vol.95 , Issue.1 , pp. 24-27
    • Atkinson, M.1    Hollis, C.2
  • 40
    • 33744827954 scopus 로고    scopus 로고
    • The Texas Children's Medication Algorithm Project: Revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder
    • Pliszka SR, Crismon ML, Hughes CW et al. The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry 45(6), 642-657 (2006).
    • (2006) J. Am. Acad. Child Adolesc. Psychiatry , vol.45 , Issue.6 , pp. 642-657
    • Pliszka, S.R.1    Crismon, M.L.2    Hughes, C.W.3
  • 41
    • 77953790089 scopus 로고    scopus 로고
    • A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
    • Faraone SV, Glatt SJ. A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J. Clin. Psychiatry 71(6), 754-763 (2010).
    • (2010) J. Clin. Psychiatry , vol.71 , Issue.6 , pp. 754-763
    • Faraone, S.V.1    Glatt, S.J.2
  • 42
    • 36049048226 scopus 로고    scopus 로고
    • Treating attentiondeficit/hyperactivity disorder with a stimulant transdermal patch: The clinical art
    • Arnold LE, Lindsay RL, López FA et al. Treating attentiondeficit/hyperactivity disorder with a stimulant transdermal patch: the clinical art. Pediatrics 120(5), 1100-1106 (2007).
    • (2007) Pediatrics , vol.120 , Issue.5 , pp. 1100-1106
    • Arnold, L.E.1    Lindsay, R.L.2    López, F.A.3
  • 43
    • 84921021519 scopus 로고    scopus 로고
    • Differential response profiles in children and adolescents with attention-deficit/hyperactivity disorder: Treatment with atomoxetine
    • Wietecha LA, Wang S, Saylor KE, Day KA, Wu SH, Kelsey D. Differential response profiles in children and adolescents with attention-deficit/hyperactivity disorder: treatment with atomoxetine. Clin. Pediatr. (Phila), 54(2), 164-173 (2015).
    • (2015) Clin. Pediatr. (Phila) , vol.54 , Issue.2 , pp. 164-173
    • Wietecha, L.A.1    Wang, S.2    Saylor, K.E.3    Day, K.A.4    Wu, S.H.5    Kelsey, D.6
  • 44
    • 84895550603 scopus 로고    scopus 로고
    • Systematic review of atomoxetine data in childhood and adolescent attention-deficit hyperactivity disorder 2009-2011: Focus on clinical efficacy and safety
    • Bushe CJ, Savill NC. Systematic review of atomoxetine data in childhood and adolescent attention-deficit hyperactivity disorder 2009-2011: focus on clinical efficacy and safety. J. Psychopharmacol. 28(3), 204-211 (2014).
    • (2014) J. Psychopharmacol. , vol.28 , Issue.3 , pp. 204-211
    • Bushe, C.J.1    Savill, N.C.2
  • 45
    • 67650290119 scopus 로고    scopus 로고
    • Clinical responses to atomoxetine in attention-deficit/hyperactivity disorder: The Integrated Data Exploratory Analysis (IDEA) study
    • Newcorn JH, Sutton VK, Weiss MD, Sumner CR. Clinical responses to atomoxetine in attention-deficit/hyperactivity disorder: the Integrated Data Exploratory Analysis (IDEA) study. J. Am. Acad. Child Adolesc. Psychiatry 48(5), 511-518 (2009).
    • (2009) J. Am. Acad. Child Adolesc. Psychiatry , vol.48 , Issue.5 , pp. 511-518
    • Newcorn, J.H.1    Sutton, V.K.2    Weiss, M.D.3    Sumner, C.R.4
  • 47
    • 77955530358 scopus 로고    scopus 로고
    • Recognition of impaired atomoxetine metabolism because of low CYP2D6 activity
    • ter Laak MA, Temmink HA, Koeken A et al. Recognition of impaired atomoxetine metabolism because of low CYP2D6 activity. Pediatr. Neurol. 43(3), 159-162.
    • Pediatr. Neurol. , vol.43 , Issue.3 , pp. 159-162
    • Ter Laak, M.A.1    Temmink, H.A.2    Koeken, A.3
  • 48
    • 67651100726 scopus 로고    scopus 로고
    • A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD)
    • Ramoz N, Boni C, Downing AM et al. A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology 34(9), 2135-2142 (2009).
    • (2009) Neuropsychopharmacology , vol.34 , Issue.9 , pp. 2135-2142
    • Ramoz, N.1    Boni, C.2    Downing, A.M.3
  • 49
    • 84879555010 scopus 로고    scopus 로고
    • Adrenergic neurotransmitter system transporter and receptor genes associated with atomoxetine response in attention-deficit hyperactivity disorder children
    • Yang L, Qian Q, Liu L, Li H, Faraone SV, Wang Y. Adrenergic neurotransmitter system transporter and receptor genes associated with atomoxetine response in attention-deficit hyperactivity disorder children. J. Neural. Transm. 120(7), 1127-1133 (2013).
    • (2013) J. Neural. Transm. , vol.120 , Issue.7 , pp. 1127-1133
    • Yang, L.1    Qian, Q.2    Liu, L.3    Li, H.4    Faraone, S.V.5    Wang, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.