Mesenchymal stem cells inhibit breast cancer cell migration and invasion through secretion of tissue inhibitor of metalloproteinase-1 and -2

Molecular Carcinogenesis

Volumn 54, Issue 10, 2015, Pages 1214-1219

  Clarke, Mitchell R ^a   Imhoff, Floriane M ^a   Baird, Sarah K ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Bone marrow mesenchymal stem cells; Metastasis; TIMP 1; TIMP 2

Indexed keywords

MATRIGEL; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; COLLAGEN; CULTURE MEDIUM; DRUG COMBINATION; LAMININ; PROTEOGLYCAN; TIMP1 PROTEIN, HUMAN; TIMP2 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL MIGRATION; FILTERS AND MEMBRANES; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; METASTASIS; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; TUMOR INVASION; BREAST TUMOR; CELL MOTION; COCULTURE; CULTURE MEDIUM; DRUG COMBINATION; FEMALE; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; COCULTURE TECHNIQUES; COLLAGEN; CULTURE MEDIA, CONDITIONED; DRUG COMBINATIONS; FEMALE; HUMANS; LAMININ; MESENCHYMAL STROMAL CELLS; PROTEOGLYCANS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84941654120     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22178     Document Type: Article

References (22)

1. Bhowmick NA, Moses HL. Tumor-stroma interactions. Current Opin Genet Dev 2005; 15:97-101.
2. Hu M, Polyak K. Microenvironmental regulation of cancer development. Current Opin Genet Dev 2008; 18:27-34.
3. Pietras K, Östman A. Hallmarks of cancer: Interactions with the tumor stroma. Exp Cell Res 2010; 316:1324-1331.
4. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143-147.
5. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8:726-736.
6. Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 2000; 9:841-848.
7. Liu S, Ginestier C, Ou SJ, et al. Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 2011; 71:614-624.
8. Wang Y, Crisostomo PR, Wang M, Markel TA, Novotny NM, Meldrum DR. TGF-α increases human mesenchymal stem cell-secreted VEGF by MEK-and PI3-K but not JNK or ERK-dependent mechanisms. Am J Physiol 2008; 295:R1115-R1123.
9. Karnoub AE, Dash AB, Vo AP, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449:557-563.
10. Xu W, Bian Z, Fan Q, Li G, Tang T. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Lett 2009; 281:32-41.
11. Coffelt SB, Marini FC, Watson K, et al. The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. Proc Natl Acad Sci USA 2009; 106:3806-3811.
12. Sun B, Roh KH, Park JR, et al. Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy 2009; 11:289-298.
13. Wang H, Cao F, De A, et al. Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells 2009; 27:1548-1558.
14. Walsh LA, Cepeda MA, Damjanovski S. Analysis of the MMP-dependent and independent functions of tissue inhibitor of metalloproteinase-2 on the invasiveness of breast cancer cells. J Cell Commun Signal 2012; 6:87-95.
15. Farina AR, Cappabianca L, DeSantis G, et al. Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells. FEBS Lett 2011; 585:3328-3336.
16. Bloomston M, Shafii A, Zervos EE, Rosemurgy AS. TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis. J Surg Res 2002; 102:39-44.
17. Li H, Lindenmeyer F, Grenet C, et al. AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice. Hum Gene Ther 2001; 12:515-526.
18. Bandapalli OR, Paul E, Schirmacher P, Brand K. Opposite effects of tissue inhibitor of metalloproteinases-1 (TIMP-1) over-expression and knockdown on colorectal liver metastases. BMC Res Notes 2012; 5:14.
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
20. Hawkes SP, Li H, Taniguchi GT. Zymography and reverse zymography for detecting MMPs and TIMPs. Methods Mol Biol 2001; 151:399-410.
21. Kuvaja P, Hulkkonen S, Pasanen I, et al. Tumor tissue inhibitor of metalloproteinases-1 (TIMP-1) in hormone-independent breast cancer might originate in stromal cells, and improves stratification of prognosis together with nodal status. Exp Cell Res 2012; 318:1094-1103.
22. Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P. MMP-2, MT1-MMP and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: Differential regulation by inflammatory cytokines. Blood 2007; 109:4055-4063.