Chemotherapy-induced miRNA-29c/catenin-δ signaling suppresses metastasis in gastric cancer

Cancer Research

Volumn 75, Issue 7, 2015, Pages 1332-1344

  Wang, Yuxuan ^a,b   Liu, Changzheng ^a   Luo, Min ^a,c   Zhang, Zhengyi ^a   Gong, Jianan ^a   Li, Jingjing ^d   You, Lei ^d   Dong, Lei ^a   Su, Rui ^a   Lin, Haishuang ^a   Ma, Yanni ^a   Wang, Fang ^a   Wang, Yi ^e   Chen, Jie ^d   Zhang, Junwu ^a   Jia, Hongyan ^f   Kong, Yan ^g   Yu, Jia ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b Shanxi Dayi Hospital   (China)

^c CHENGDU FIRST PEOPLE S HOSPITAL   (China)

^d PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^e CANCER HOSPITAL   (China)

^f SHANXI MEDICAL UNIVERSITY   (China)

^g PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; CATENIN DELTA; CISPLATIN; COFILIN; DOCETAXEL; F ACTIN; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; MICRORNA 29C; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELTA CATENIN; MICRORNA; MIRN29 MICRORNA, HUMAN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TAXOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DOWN REGULATION; GASTRIC CANCER CELL LINE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MAJOR CLINICAL STUDY; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH CANCER; TUMOR INVASION; ANIMAL; CANCER TRANSPLANTATION; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; LUNG NEOPLASMS; METABOLISM; MORTALITY; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; SECONDARY; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATENINS; CELL LINE, TUMOR; CELL MOVEMENT; CISPLATIN; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MICE, NUDE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; STOMACH NEOPLASMS; TAXOIDS;

EID: 84941632448     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0787     Document Type: Article

References (31)

1. Shah MA, Ajani JA. Gastric cancer-an enigmatic and heterogeneous disease. JAMA 2010;303:1753-4.
2. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006;24:2137-50.
3. Schuhmacher C, Reim D, Novotny A. Neoadjuvant treatment for gastric cancer. J Gastric Cancer. 2013;13:73-8.
4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97.
5. Song JH, Meltzer SJ. MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers. Gastroenterology 2012;143:35-47 e2.
6. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007;26:6133-40.
7. Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, et al. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 2008;14:369-81.
8. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007;104:15805-10.
9. Cui Y, Su WY, Xing J, Wang YC, Wang P, Chen XY, et al. MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer. PLoS One 2011;6:e25872.
10. Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, et al. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis 2014;35:497-506.
11. Saito Y, Suzuki H, Imaeda H, Matsuzaki J, Hirata K, Tsugawa H, et al. The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. Int J Cancer 2013;132:1751-60.
12. Liu C, Yu J, Yu S, Lavker RM, Cai L, Liu W, et al. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. J Hepatol 2010;53:98-107.
13. Yu J, Peng H, Ruan Q, Fatima A, Getsios S, Lavker RM. MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2. FASEB J 2010;24:3950-9.
14. Yu S, Lu Z, Liu C, Meng Y, Ma Y, Zhao W, et al. miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Res 2010;70:6015-25.
15. Liang L, Li X, Zhang X, Lv Z, He G, Zhao W, et al. MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2. Gastroenterology 2013;144:624-35 e4.
16. Tagawa H, Ikeda S, Sawada K. Role of microRNA in the pathogenesis of malignant lymphoma. Cancer Sci 2013;104:801-9.
17. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 2007;27:91-105.
18. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol 2004;2:e363.
19. Dann SG, Golas J, Miranda M, Shi C, Wu J, Jin G, et al. p120 catenin is a key effector of a Ras-PKCvarepsilon oncogenic signaling axis. Oncogene 2014;33:1385-94.
20. Mayerle J, Friess H, Buchler MW, Schnekenburger J, Weiss FU, Zimmer KP, et al. Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer. Gastroenterology 2003;124:949-60.
21. Pieters T, van Hengel J, van Roy F. Functions of p120ctn in development and disease. Front Biosci (Landmark Ed) 2012;17:760-83.
22. Menke A, Giehl K. Regulation of adherens junctions by Rho GTPases and p120-catenin. Arch Biochem Biophys 2012;524:48-55.
23. DesMarais V, Ghosh M, Eddy R, Condeelis J. Cofilin takes the lead. J Cell Sci 2005;118:19-26.
24. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, et al. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 2010;70:2339-49.
25. Reynolds AB, Roczniak-Ferguson A. Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 2004;23:7947-56.
26. Thoreson MA, Reynolds AB. Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation 2002;70:583-9.
27. Seidel B, Braeg S, Adler G, Wedlich D, Menke A. E- and N-cadherin differ with respect to their associated p120ctn isoforms and their ability to suppress invasive growth in pancreatic cancer cells. Oncogene 2004;23:5532-42.
28. Reynolds AB, Carnahan RH. Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol 2004;15:657-63.
29. Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, et al. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 2011;19:470-83.
30. Anastasiadis PZ. p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta 2007;1773:34-46.
31. Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 2007;13:7003-11.