Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme i unveiled by solution NMR and X-ray scattering

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11565-11570

  Venditti, Vincenzo ^a,b   Schwieters, Charles D ^c   Grishaev, Alexander ^a,d   Clorea, G Marius ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

Conformational states; Dipolar couplings; Ligand binding; Multidomain protein dynamics; X ray scattering

Indexed keywords

BACTERIAL ENZYME; ENZYME I; PHOSPHOENOLPYRUVATE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; LIGAND; NITROGEN; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE; PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE; PROTEIN BINDING;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATION; DIMERIZATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RADIATION SCATTERING; SIGNAL TRANSDUCTION; SUGAR TRANSPORT; X RAY CRYSTALLOGRAPHY; ALGORITHM; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MUTATION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; X RAY;

ALGORITHMS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; ESCHERICHIA COLI; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; MUTATION; NITROGEN; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM; PHOSPHORYLATION; PHOSPHOTRANSFERASES (NITROGENOUS GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SCATTERING, RADIATION; SIGNAL TRANSDUCTION; X-RAYS;

EID: 84941624792     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515366112     Document Type: Article

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