A genome-wide association study of suicidal behavior

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 168, Issue 7, 2015, Pages 557-563

  Galfalvy, Hanga ^a   Haghighi, Fatemeh ^a   Hodgkinson, Colin ^b   Goldman, David ^b   Oquendo, Maria A ^a   Burke, Ainsley ^a   Huang, Yung yu ^a   Giegling, Ina ^c   Rujescu, Dan ^c   Bureau, Alexandre ^d   Turecki, Gustavo ^e   Mann, J John ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d UNIVERSITÉ LAVAL   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

GWAS; Immune response; Suicidal ideation; Suicide; Suicide attempt

Indexed keywords

ADAMTS14 GENE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; CTNNA3 GENE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DPP10 GENE; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PSME2 GENE; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STK3 GENE; STK32B GENE; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; TBX20 GENE; CASE CONTROL STUDY; CAUCASIAN; GENETIC MARKER; GENETIC SCREENING; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MAJOR DEPRESSION; MENTAL DISEASE; PROCEDURES; SUICIDAL IDEATION; SUICIDE;

GENETIC MARKER;

CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; GENETIC TESTING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MENTAL DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SUICIDAL IDEATION; SUICIDE; SUICIDE, ATTEMPTED;

EID: 84941600045     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32330     Document Type: Article

References (27)

1. Beck AT, Kovacs M, Weissman A. 1979. Assessment of suicidal intention: The Scale for Suicide Ideation. J Consult Clin Psychol 47:343-352.
2. Bernstein DI, Kashon M, Lummus ZL, Johnson VJ, Fluharty K, Gautrin D, Malo JL, Cartier A, Boulet LP, Sastre J, Quirce S, Germolec D, Tarlo SM, Cruz MJ, Munoz X, Luster MI, Yucesoy B. 2013. CTNNA3 (alpha-catenin) gene variants are associated with diisocyanate asthma: A replication study in a Caucasian worker population. Toxicol Sci 131:242-246.
3. Brent DA, Mann JJ. 2005. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet Part C Semin Med Genet 133C:13-24.
4. Carvalho FM, Tinoco EM, Deeley K, Duarte PM, Faveri M, Marques MR, Mendonca AC, Wang X, Cuenco K, Menezes R, Garlet GP, Vieira AR. 2010. FAM5C contributes to aggressive periodontitis. PloS ONE 5:e10053.
5. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. 2003. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301:386-389.
6. Cline JL, Beckie TM. 2013. The relationships between FAM5C SNP (rs10920501) variability and metabolic syndrome and inflammation in women with coronary heart disease. Biol Res Nurs 15:160-166.
7. Courtet P, Gottesman II, Jollant F, Gould TD. 2011. The neuroscience of suicidal behaviors: What can we expect from endophenotype strategies? Transl Psychiatry 1.
8. Cross-Disorder Group of the Psychiatric Genomics Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45:984-994.
9. Fiori LM, Turecki G. 2012. Broadening our horizons: Gene expression profiling to help better understand the neurobiology of suicide and depression. Neurobiol Dis 45:14-22.
10. Galfalvy H, Zalsman G, Huang YY, Murphy L, Rosoklija G, Dwork AJ, Haghighi F, Arango V, Mann JJ. 2013. A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry 14:574-582.
11. Kelly TM, Mann JJ. 1996. Validity of DSM-III-R diagnosis by psychological autopsy: A comparison with clinician ante-mortem diagnosis. Acta psychiatr Scand 94:337-343.
12. Koh HY 2013. Phospholipase C-beta1 and schizophrenia-related behaviors. Adv Biol Regul 53:242-248.
13. Liu W, Wu J, Xiao L, Bai Y, Qu A, Zheng Z, Yuan Z. 2012. Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway. PloS ONE 7:e36562.
14. Mann JJ, Currier DM. 2010. Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression. Eur Psychiatry 25:268-271.
15. Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, et al. 2010. Unifying candidate gene and GWAS Approaches in Asthma. PloS ONE 5:e13894.
16. Oquendo M., Halberstam B, Mann JJ. 2003. Risk factors for suicidal behavior: The utility and limitations of research instruments. In Standardized Evaluation in Clinical Practice., Vol. V. First MB. Arlington, American Psychiatric Publishing, Editor. 103-130.
17. Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, Hamilton SP, McMahon FJ, Schulze TG, Potash JB, et al. 2010. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 167:1499-1507.
18. Posch MG, Gramlich M, Sunde M, Schmitt KR, Lee SH, Richter S, Kersten A, Perrot A, Panek AN, Al Khatib IH. et al. 2010. A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. J Med Genet 47:230-235.
19. Posner K, Oquendo MA, Gould M, Stanley B, Davies M. 2007. Columbia classification algorithm of suicide assessment (C-CASA): Classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants. Am J Psychiatry 164:1035-1043.
20. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ, Sham PC. 2007. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575.
21. Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD, Gomez-Reino JJ, Gonzalez A. 2009. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage 17:321-327.
22. Schosser A, Butler AW, Ising M, Perroud N, Uher R, Ng MY, Cohen-Woods S, Craddock N, Owen MJ, Korszun A, et al. 2011. Genomewide association scan of suicidal thoughts and behaviour in major depression. PloS ONE 6:e20690.
23. Slavin TP, Feng T, Schnell A, Zhu X, Elston RC. 2011. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet 130:725-733.
24. Spitzer RL, Gibbon WJ, First MB. 1990. Structured clinical interview for DSM-III-R/DSM-IV patient edition (SCID-P). Washington, DC.: American Psychiatric Press.
25. St Pourcain B, Skuse DH, Mandy WP, Wang K, Hakonarson H, Timpson NJ, Evans DM, Kemp JP, Ring SM, McArdle WL, Golding J, Smith GD. 2014.. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. Mol Autism 5.
26. Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes FS, Mondimore FM, Mackinnon DF, et al. 2012. A genome-wide association study of attempted suicide. Mol Psychiatry 17:433-444.
27. Zheng DL, Huang QL, Zhou F, Huang QJ, Lin JY, Lin X. 2012. PA28beta regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1. J Cell Biochem 113:1537-1546.