Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Liu, Weizhe ^b,c   Wu, Junbing ^a,e   Xiao, Lei ^a,e   Bai, Yujie ^a,e   Qu, Aiqin ^c   Zheng, Zheng ^d   Yuan, Zengqiang ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; MAMMALIAN STE20 LIKE KINASE 2; RAF PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; STK3 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL NECROSIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CELL DEATH; CELL STRAIN HEK293; ENZYMOLOGY; GENETICS; HELA CELL; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA;

CELL DEATH; HEK293 CELLS; HELA CELLS; HUMANS; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; SIGNAL TRANSDUCTION;

EID: 84860745715     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036562     Document Type: Article

References (18)

1. Kim D, Shu S, Coppola MD, Kaneko S, Yuan ZQ, et al. (2010) Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS One 5: e9616.
2. Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, et al. (1998) Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. Embo J 17: 2224-2234.
3. Lee KK, Murakawa M, Nishida E, Tsubuki S, Kawashima S, et al. (1998) Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037.
4. O'Neill E, Rushworth L, Baccarini M, Kolch W, (2004) Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306: 2267-2270.
5. Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, et al. (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 27: 962-975.
6. Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, et al. (2010) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res 70: 1195-1203.
7. Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D, (1998) Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene 17: 3309-3318.
8. Yoshida K, (2007) Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage. Adv Exp Med Biol 604: 155-165.
9. Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, et al. (2000) Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 26: 633-646.
10. Cancino GI, Perez de Arce K, Castro PU, Toledo EM, von Bernhardi R, et al. (2010) c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Neurobiol Aging 32: 1249-1261.
11. Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yevenes LF, et al. (2008) STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain 131: 2425-2442.
12. Xiao L, Chen D, Hu P, Wu J, Liu W, et al. (2011) The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death. J Neurosci 31: 9611-9619.
13. Bi W, Xiao L, Jia Y, Wu J, Xie Q, et al. (2010) c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. J Biol Chem 285: 6259-6264.
14. Pan D The hippo signaling pathway in development and cancer. Dev Cell 19: 491-505.
15. Xiao L, Yuan Z, (2010) Redemystifying MST1/hippo signaling. Protein Cell 1: 706-708.
16. Bennett RL, Hoffmann FM, (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116: 953-966.
17. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001.
18. Yuan Z, Lehtinen MK, Merlo P, Villen J, Gygi S, et al. (2009) Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem 284: 11285-11292.