Gene expression profiling and association of circulating lactoferrin level with obesity-related phenotypes in Latino youth

Pediatric Obesity

Volumn 10, Issue 5, 2015, Pages 338-344

  Kim, J Y ^a   Campbell, L E ^b,c   Shaibi, G Q ^a,c,d   Coletta, D K ^b,c,e  

^a ARIZONA STATE UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Adiposity; gene expression; inflammation; paediatric

Indexed keywords

B LYMPHOCYTE RECEPTOR; LACTOFERRIN; TOLL LIKE RECEPTOR; BIOLOGICAL MARKER; LTF PROTEIN, HUMAN;

ADOLESCENT; AGE; ARTICLE; BLOOD SAMPLING; CHILDHOOD OBESITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HISPANIC; HUMAN; HUMAN TISSUE; INFLAMMATION; JUVENILE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MUTATION; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; ARIZONA; BLOOD; COMPLICATION; GENE EXPRESSION PROFILING;

ADOLESCENT; ARIZONA; BIOMARKERS; FEMALE; GENE EXPRESSION PROFILING; HISPANIC AMERICANS; HUMANS; INFLAMMATION; LACTOFERRIN; MALE; MICROARRAY ANALYSIS; PEDIATRIC OBESITY; PHENOTYPE;

EID: 84941567415     PISSN: 20476302     EISSN: 20476310     Source Type: Journal    
DOI: 10.1111/ijpo.269     Document Type: Article

References (30)

1. Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC,. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med 2010; 362: 485-493.
2. Dandona P, Aljada A, Bandyopadhyay A,. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4-7.
3. DeBoer MD,. Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions. Nutrition 2013; 29: 379-386.
4. Legrand D, Elass E, Carpentier M, Mazurier J,. Lactoferrin: a modulator of immune and inflammatory responses. Cell Mol Life Sci 2005; 62: 2549-2559.
5. Iyer S, Lonnerdal B,. Lactoferrin, lactoferrin receptors and iron metabolism. Eur J Clin Nutr 1993; 47: 232-241.
6. Tamano S, Sekine K, Takase M, Yamauchi K, Iigo M, Tsuda H,. Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Asian Pac J Cancer Prev 2008; 9: 313-316.
7. Ono T, Murakoshi M, Suzuki N, et al., Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets. Br J Nutr 2010; 104: 1688-1695.
8. Moreno-Navarrete JM, Ortega FJ, Bassols J, Castro A, Ricart W, Fernandez-Real JM,. Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. Clin Chem 2008; 54: 301-309.
9. Moreno-Navarrete JM, Ortega FJ, Bassols J, Ricart W, Fernandez-Real JM,. Decreased circulating lactoferrin in insulin resistance and altered glucose tolerance as a possible marker of neutrophil dysfunction in type 2 diabetes. J Clin Endocrinol Metab 2009; 94: 4036-4044.
10. Moreno-Navarrete JM, Serrano M, Sabater M, et al., Study of lactoferrin gene expression in human and mouse adipose tissue, human preadipocytes and mouse 3T3-L1 fibroblasts. Association with adipogenic and inflammatory markers. J Nutr Biochem 2013; 24: 1266-1275.
11. Bennett RM, Mohla C,. A solid-phase radioimmunoassay for the measurement of lactoferrin in human plasma: variations with age, sex, and disease. J Lab Clin Med 1976; 88: 156-166.
12. Shaibi GQ, Coletta DK, Vital V, Mandarino LJ,. The design and conduct of a community-based registry and biorepository: a focus on cardiometabolic health in Latinos. Clin Transl Sci 2013; 6: 429-434.
13. Li X, Jiang S, Tapping RI,. Toll-like receptor signaling in cell proliferation and survival. Cytokine 2010; 49: 1-9.
14. Jang HJ, Kim HS, Hwang DH, Quon MJ, Kim JA,. Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. Am J Physiol Endocrinol Metab 2013; 304: E1077-E1088.
15. Reyna SM, Ghosh S, Tantiwong P, et al., Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 2008; 57: 2595-2602.
16. Vijay-Kumar M, Aitken JD, Carvalho FA, et al., Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010; 328: 228-231.
17. Lauer S, Kunde YA, Apodaca TA, Goldstein B, Hong-Geller E,. Soluble MD2 increases TLR4 levels on the epithelial cell surface. Cell Immunol 2009; 255: 8-16.
18. Nagai Y, Akashi S, Nagafuku M, et al., Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 2002; 3: 667-672.
19. Puddu P, Latorre D, Carollo M, et al., Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells. PLoS ONE 2011; 6: e22504.
20. Yagi M, Suzuki N, Takayama T, et al., Lactoferrin suppress the adipogenic differentiation of MC3T3-G2/PA6 cells. J Oral Sci 2008; 50: 419-425.
21. Moreno-Navarrete JM, Ortega F, Sabater M, Ricart W, Fernandez-Real JM,. Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes. J Nutr Biochem 2011; 22: 1143-1149.
22. Moreno-Navarrete JM, Ortega FJ, Ricart W, Fernandez-Real JM,. Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation. Int J Obes (Lond) 2009; 33: 991-1000.
23. Ward PP, Paz E, Conneely OM,. Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci 2005; 62: 2540-2548.
24. de Heredia FP, Gomez-Martinez S, Marcos A,. Obesity, inflammation and the immune system. Proc Nutr Soc 2012; 71: 332-338.
25. Stegenga ME, van der Crabben SN, Blumer RM, et al., Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 2008; 112: 82-89.
26. Hardy OT, Kim A, Ciccarelli C, Hayman LL, Wiecha J,. Increased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents. Pediatr Obes 2013; 8: e19-e23.
27. Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC,. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007; 92: 3705-3711.
28. Min JL, Barrett A, Watts T, et al., Variability of gene expression profiles in human blood and lymphoblastoid cell lines. BMC Genomics 2010; 11: 96.
29. Hoffman RP, Vicini P, Sivitz WI, Cobelli C,. Pubertal adolescent male-female differences in insulin sensitivity and glucose effectiveness determined by the one compartment minimal model. Pediatr Res 2000; 48: 384-388.
30. Plow EF,. Leukocyte elastase release during blood coagulation. A potential mechanism for activation of the alternative fibrinolytic pathway. J Clin Invest 1982; 69: 564-572.