Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases

American Journal of Respiratory Cell and Molecular Biology

Volumn 53, Issue 3, 2015, Pages 285-290

  Sundar, Isaac K ^a   Yao, Hongwei ^a   Sellix, Michael T ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Asthma; Bmal1; Chronic obstructive pulmonary disease; REV ERB ; Sirtuin 1

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CRYPTOCHROME 1; GLUCOCORTICOID RECEPTOR; REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR; SIRTUIN 1; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; SIRTUIN;

AIR POLLUTANT; AUTOREGULATION; BACTERIAL INFECTION; CHRONIC RESPIRATORY TRACT DISEASE; CHRONOPHARMACOLOGY; CIRCADIAN RHYTHM; DEACETYLATION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DNA DAMAGE; DNA REPAIR; ENVIRONMENTAL FACTOR; ENVIRONMENTAL STRESS; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INFLUENZA A; LUNG ALVEOLUS CELL; LUNG FUNCTION; MOLECULAR BIOLOGY; MOLECULAR CLOCK; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; RESPIRATORY FUNCTION; RESPIRATORY TRACT INFECTION; REVIEW; SENESCENCE; ANIMAL; ASTHMA; CELL AGING; CHRONOTHERAPY; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

ANIMALS; ASTHMA; CELL AGING; CIRCADIAN CLOCKS; DNA DAMAGE; DRUG CHRONOTHERAPY; EPIGENESIS, GENETIC; HUMANS; LUNG; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIRTUINS;

EID: 84941559121     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0476TR     Document Type: Review

References (33)

1. Tsai CL, Brenner BE, Camargo CA Jr. Circadian-rhythm differences among emergency department patients with chronic obstructive pulmonary disease exacerbation. Chronobiol Int 2007;24:699-713.
2. Petty TL. Circadian variations in chronic asthma and chronic obstructive pulmonary disease. Am J Med 1988;85:21-23.
3. Mohawk JA, Green CB, Takahashi JS. Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 2012;35:445-462.
4. Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N. Antiphase circadian expression between bmal1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats. Biochem Biophys Res Commun 1998;253:199-203.
5. Gibbs JE, Beesley S, Plumb J, Singh D, Farrow S, Ray DW, Loudon AS. Circadian timing in the lung; a specific role for bronchiolar epithelial cells. Endocrinology 2009;150:268-276.
6. Hadden H, Soldin SJ, Massaro D. Circadian disruption alters mouse lung clock gene expression and lung mechanics. J Appl Physiol 1985;2012:385-392.
7. Sukumaran S, Jusko WJ, Dubois DC, Almon RR. Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action. J Appl Physiol 2011;110:1732-1747.
8. Gebel S, Gerstmayer B, Kuhl P, Borlak J, Meurrens K, Muller T. The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression. Toxicol Sci 2006;93:422-431.
9. Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, et al. The circadian clock regulates rhythmic activation of the nrf2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev 2014;28:548-560.
10. Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J 2014;28:176-194.
11. Vasu VT, Cross CE, Gohil K. Nr1d1, an important circadian pathway regulatory gene, is suppressed by cigarette smoke in murine lungs. Integr Cancer Ther 2009;8:321-328.
12. Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD Sci Rep 2015;4:9927.
13. Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, et al. Circadian rhythm reprogramming during lung inflammation. Nat Commun 2014;5:4753.
14. Gibbs J, Ince L, Matthews L, Mei J, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud M, et al. An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med 2014;20:919-926.
15. Dallmann R, Brown SA, Gachon F. Chronopharmacology: new insights and therapeutic implications. Annu Rev Pharmacol Toxicol 2014;54:339-361.
16. Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T. A circadian clock gene, rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of ccl2 expression. J Immunol 2014;192:407-417.
17. Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, et al. The nuclear receptor rev-erbalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci USA 2012;109:582-587.
18. Yang G, Wright CJ, Hinson MD, Fernando AP, Sengupta S, Biswas C, La P, Dennery PA. Oxidative stress and inflammation modulate rev-erbalpha signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal 2014;21:17-32.
19. Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S. Aryl hydrocarbon receptor-mediated cyp1a1 expression is modulated in a clock-dependent circadian manner. Toxicology 2011;290:203-207.
20. Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP. Early aging and age-related pathologies in mice deficient in bmal1, the core componentof the circadian clock. Genes Dev 2006;20:1868-1873.
21. Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene bmal1 regulates diurnal oscillations of ly6c(hi) inflammatory monocytes. Science 2013;341:1483-1488.
22. Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A, Maier B. A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci U S A 2009;106:21407-21412.
23. Burioka N, Fukuoka Y, Takata M, Endo M, Miyata M, Chikumi H, Tomita K, Kodani M, Touge H, Takeda K, et al. Circadian rhythms in the CNS and peripheral clock disorders: function of clock genes: influence of medication for bronchial asthma on circadian gene. J Pharmacol Sci 2007;103:144-149.
24. Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. Disruption of sirt1-mediated regulation of circadian molecular clock and inflammation in copd. Am J Respir Cell Mol Biol (In press)
25. Sellix MT, Evans JA, Leise TL, Castanon-Cervantes O, Hill DD, DeLisser P, Block GD, Menaker M, Davidson AJ. Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators. J Neurosci 2012;32:16193-16202.
26. Kondratov RV, Antoch MP. Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol 2007;17:311-317.
27. Grechez-Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F. The circadian clock component bmal1 is a critical regulator of p21waf1/cip1 expression and hepatocyte proliferation. J Biol Chem 2008;283:4535-4542.
28. Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, et al. Sirt1 protects against emphysema via foxo3-mediated reduction of premature senescence in mice. J Clin Invest 2012;122:2032-2045.
29. Burioka N, Takata M, Okano Y, Ohdo S, Fukuoka Y, Miyata M, Takane H, Endo M, Suyama H, Shimizu E. Dexamethasone influences human clock gene expression in bronchial epithelium and peripheral blood mononuclear cells in vitro. Chronobiol Int 2005;22:585-590.
30. Takata M, Burioka N, Ohdo S, Fukuoka Y, Miyata M, Endo M, Suyama H, Shimizu E. Beta2-adrenoceptor agonists induce the mammalian clock gene, hper1, mRNA in cultured human bronchial epithelium cells in vitro. Chronobiol Int 2005;22:777-783.
31. Chen Z, Yoo SH, Takahashi JS. Small molecule modifiers of circadian clocks. Cell Mol Life Sci 2013;70:2985-2998.
32. Kojetin DJ, Burris TP. Rev-erb and ror nuclear receptors as drug targets. Nat Rev Drug Discov 2014;13:197-216.
33. Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci USA 2014;111:16219-16224.