Population structure of Klebsiella pneumoniae causing bloodstream infections at a New York City tertiary care hospital: Diversification of multidrug-resistant isolates

Journal of Clinical Microbiology

Volumn 53, Issue 7, 2015, Pages 2060-2067

  Gomez Simmonds, Angela ^a   Greenman, Michelle ^a   Sullivan, Sean B ^a   Tanner, Joshua P ^a   Sowash, Madeleine G ^a   Whittier, Susan ^a   Uhlemann, Anne Catrin ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CEPHALOSPORIN;

ADULT; ARTICLE; BACTERIAL GENE; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; BLAKPC GENE; BLOODSTREAM INFECTION; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC VARIABILITY; HUMAN; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; POPULATION STRUCTURE; PRIORITY JOURNAL; TERTIARY CARE CENTER; UNITED STATES; WZI GENE; CLASSIFICATION; DNA SEQUENCE; DRUG EFFECTS; GENETIC VARIATION; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; NEW YORK; RETROSPECTIVE STUDY; SEPSIS;

KLEBSIELLA PNEUMONIAE;

DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GENES, BACTERIAL; GENETIC VARIATION; GENOTYPE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MULTILOCUS SEQUENCE TYPING; NEW YORK CITY; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; SEPSIS; SEQUENCE ANALYSIS, DNA; TERTIARY CARE CENTERS;

EID: 84932613778     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.03455-14     Document Type: Article

References (31)

1. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/drugresistance/threat-report-2013.
2. Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, Carmeli Y, Brolund A, Giske CG. 2009. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 53:3365-3370. http://dx.doi.org/10.1128/AAC.00126-09.
3. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, Kumarasamy K, Livermore DM, Maya JJ, Nordmann P, Patel JB, Paterson DL, Pitout J, Villegas MV, Wang H, Woodford N, Quinn JP. 2013. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13:785-796. http://dx.doi.org/10.1016/S1473-3099(13)70190-7.
4. Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. 2008. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 29:1099-1106. http://dx.doi.org/10.1086/592412.
5. Nordmann P, Cuzon G, Naas T. 2009. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9:228-236. http://dx.doi.org/10.1016/S1473-3099(09)70054-4.
6. Borer A, Saidel-Odes L, Riesenberg K, Eskira S, Peled N, Nativ R, Schlaeffer F, Sherf M. 2009. Attributable mortality rate for carbapenemresistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol 30:972-976. http://dx.doi.org/10.1086/605922.
7. Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, Prekates A, Themeli-Digalaki K, Tsakris A. 2011. Predictors of mortality in patients with bloodstream infections caused by KPCproducing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 17:1798-1803. http://dx.doi.org/10.1111/j.1469-0691.2011.03514.x.
8. Neuner EA, Yeh JY, Hall GS, Sekeres J, Endimiani A, Bonomo RA, Shrestha NK, Fraser TG, van Duin D. 2011. Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infections. Diagn Microbiol Infect Dis 69:357-362. http://dx.doi.org/10.1016/j.diagmicrobio.2010.10.013.
9. Ben-David D, Kordevani R, Keller N, Tal I, Marzel A, Gal-Mor O, Maor Y, Rahav G. 2012. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect 18:54-60. http://dx.doi.org/10.1111/j.1469-0691.2011.03478.x.
10. Deleo FR, Chen L, Porcella SF, Martens CA, Kobayashi SD, Porter AR, Chavda KD, Jacobs MR, Mathema B, Olsen RJ, Bonomo RA, Musser JM, Kreiswirth BN. 2014. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc Natl Acad Sci U S A111:4988-4993. http://dx.doi.org/10.1073/pnas.1321364111.
11. Diago-Navarro E, Chen L, Passet V, Burack S, Ulacia-Hernando A, Kodiyanplakkal RP, Levi MH, Brisse S, Kreiswirth BN, Fries BC. 2014. Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits. J Infect Dis 210: 803-813. http://dx.doi.org/10.1093/infdis/jiu157.
12. KPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob Agents Chemother 53:1998-2004. http://dx.doi.org/10.1128/AAC.01355-08.
13. KPC-2 gene. Emerg Infect Dis 16:1349-1356. http://dx.doi.org/10.3201/eid1609.091389.
14. KPC gene. Antimicrob Agents Chemother 52:1257-1263. http://dx.doi.org/10.1128/AAC.01451-07.
15. Tsai YK, Fung CP, Lin JC, Chen JH, Chang FY, Chen TL, Siu LK. 2011. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother 55:1485-1493. http://dx.doi.org/10.1128/AAC.01275-10.
16. Centers for Disease Control and Prevention. 2014. CDC/NHSN surveillance definitions for specific type of infections. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/nhsn/PDFs/pscManual/17pscNosInfDef-current.pdf.
17. Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. M100-S21. Clinical and Laboratory Standards Institute, Wayne, PA.
18. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. 2005. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 43:4178-4182. http://dx.doi.org/10.1128/JCM.43.8.4178-4182.2005.
19. Poirel L, Walsh TR, Cuvillier V, Nordmann P. 2011. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70:119-123. http://dx.doi.org/10.1016/j.diagmicrobio.2010.12.002.
20. Francis RO, Wu F, Della-Latta P, Shi J, Whittier S. 2012. Rapid detection of Klebsiella pneumoniae carbapenemase genes in Enterobacteriaceae directly from blood culture bottles by real-time PCR. Am J Clin Pathol 137:627-632. http://dx.doi.org/10.1309/AJCP9SNHJG2QGLWU.
21. Organ Procurement and Transplantation Network. 2014. Transplant center data, 2012-2013. Organ Procurement and Transplantation Network, Richmond, VA. http://optn.transplant.hrsa.gov/converge/LatestData/stateData.asp?typeo=center.
22. Landman D, Babu E, Shah N, Kelly P, Olawole O, Backer M, Bratu S, Quale J. 2012. Transmission of carbapenem-resistant pathogens in New York City hospitals: progress and frustration. J Antimicrob Chemother 67:1427-1431. http://dx.doi.org/10.1093/jac/dks063.
23. Essack SY, Hall LM, Pillay DG, McFadyen ML, Livermore DM. 2001. Complexity and diversity of Klebsiella pneumoniae strains with extendedspectrum β-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa. Antimicrob Agents Chemother 45:88-95. http://dx.doi.org/10.1128/AAC.45.1.88-95.2001.
24. Chen L, Chavda KD, Melano RG, Jacobs MR, Koll B, Hong T, Rojtman AD, Levi MH, Bonomo RA, Kreiswirth BN. 2014. Comparative genomic analysis of KPC-encoding pKpQIL-like plasmids and their distribution in New Jersey and New York hospitals. Antimicrob Agents Chemother 58: 2871-2877. http://dx.doi.org/10.1128/AAC.00120-14.
25. Mathers AJ, Cox HL, Kitchel B, Bonatti H, Brassinga AK, Carroll J, Scheld WM, Hazen KC, Sifri CD. 2011. Molecular dissection of an outbreak of carbapenem-resistant Enterobacteriaceae reveals intergenus KPC carbapenemase transmission through a promiscuous plasmid. mBio 2(6):e00204-11.
26. Kitchel B, Sundin DR, Patel JB. 2009. Regional dissemination of KPCproducing Klebsiella pneumoniae. Antimicrob Agents Chemother 53: 4511-4513. http://dx.doi.org/10.1128/AAC.00784-09.
27. Leavitt A, Carmeli Y, Chmelnitsky I, Goren MG, Ofek I, Navon-Venezia S. 2010. Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. Antimicrob Agents Chemother 54:3002-3006. http://dx.doi.org/10.1128/AAC.01818-09.
28. Schwaber MJ, Klarfeld-Lidji S, Navon-Venezia S, Schwartz D, Leavitt A, Carmeli Y. 2008. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 52:1028-1033. http://dx.doi.org/10.1128/AAC.01020-07.
29. Satlin MJ, Jenkins SG, Walsh TJ. 2014. The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin Infect Dis 58:1274-1283. http://dx.doi.org/10.1093/cid/ciu052.
30. Endimiani A, Depasquale JM, Forero S, Perez F, Hujer AM, Roberts-Pollack D, Fiorella PD, Pickens N, Kitchel B, Casiano-Colon AE, Tenover FC, Bonomo RA. 2009. Emergence of blaKPC -containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system. J Antimicrob Chemother 64:1102-1110. http://dx.doi.org/10.1093/jac/dkp327.
31. Won SY, Munoz-Price LS, Lolans K, Hota B, Weinstein RA, Hayden MK. 2011. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 53:532-540. http://dx.doi.org/10.1093/cid/cir482.