PINK1-parkin-mediated mitophagy protects mitochondrial integrity and prevents metabolic stress-induced endothelial injury

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Wu, Weiwei ^a   Xu, Hao ^a   Wang, Zemin ^a   Mao, Yun ^a   Yuan, Yun ^a   Luo, Wei ^a   Cui, Zhaoqiang ^a   Cui, Taixing ^a,b   Wang, Xing Li ^a,c,d   Shen, Ying H ^c,d  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d TEXAS HEART INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PALMITIC ACID; PARKIN; PHOSPHATASE; PROTEIN PINK1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ENDOTHELIUM; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METABOLIC STRESS; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; AUTOPHAGY; C57BL MOUSE; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTECTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; OBESITY; PALMITIC ACID; PROTECTIVE FACTORS; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84941344243     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132499     Document Type: Article

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