Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 10, 2015, Pages 1079-1088

  Jastrzębska Więsek, Magdalena ^a   Siwek, Agata ^a   Partyka, Anna ^a   Szewczyk, Bernadeta ^b   Sowa Kućma, Magdalena ^b   Wasik, Anna ^a   Kołaczkowski, Marcin ^a,c   Wesołowska, Anna ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c Adamed Ltd ^*  (Poland)

Author keywords

5 HT6 receptor agonist; Depression; Forced swim test; Olfactory bulbectomy model; Rats

Indexed keywords

5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; ANTIDEPRESSANT AGENT; EMD 386088; SEROTONIN AGONIST; UNCLASSIFIED DRUG; 5-CHLORO-2-METHYL-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE; INDOLE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 6 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL HYPERACTIVITY; FORCED SWIM TEST; LEARNING DISORDER; LOCOMOTION; MALE; NONHUMAN; OLFACTORY BULBECTOMY; PASSIVE AVOIDANCE TEST; RAT; ANIMAL; AVOIDANCE BEHAVIOR; DEPRESSION; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; SWIMMING;

ANIMALS; ANTIDEPRESSIVE AGENTS; AVOIDANCE LEARNING; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; INDOLES; INJECTIONS, INTRAPERITONEAL; MOTOR ACTIVITY; PYRIDINES; RATS; RECEPTORS, SEROTONIN; SEROTONIN RECEPTOR AGONISTS; SWIMMING;

EID: 84941316527     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1141-2     Document Type: Article

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