Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells

Journal of Lipid Research

Volumn 56, Issue 8, 2015, Pages 1583-1593

  Cheng, Dongmei ^a   Weckerle, Allison ^a   Yu, Yi ^a   Ma, Lijun ^b   Zhu, Xuewei ^a   Murea, Mariana ^b   Freedman, Barry I ^b   Parks, John S ^a   Shelness, Gregory S ^a  

^a Department of Internal Medicine Sections on Molecular Medicine and Nephrology   (China)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoprotein L1; Apolipoproteins; Apoptosis; Endoplasmic reticulum; Liver

Indexed keywords

MEMBRANE PROTEIN; PROTEIN APOL1; UNCLASSIFIED DRUG; APOL1 PROTEIN, HUMAN; APOLIPOPROTEIN; HIGH DENSITY LIPOPROTEIN; PROTEASOME;

ANIMAL CELL; ANIMAL EXPERIMENT; APOL1 GENE; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL MIGRATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CELL; LIVER CELL CARCINOMA; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PYROPTOSIS; RAT; REGULATORY MECHANISM; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; HUMAN; LIVER TUMOR; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEINS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HEPATOCYTES; HUMANS; LIPOPROTEINS, HDL; LIVER NEOPLASMS; MALE; MICE; MOLECULAR SEQUENCE DATA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PYROPTOSIS; RATS;

EID: 84941274459     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M059733     Document Type: Article

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