Assessment of the relationship between hypoglycaemia awareness and autonomic function following islet cell/pancreas transplantation

Diabetes/Metabolism Research and Reviews

Volumn 31, Issue 6, 2015, Pages 646-650

  Kamel, Jordan T ^a,b   Goodman, David J ^a   Howe, Kathy ^a   Cook, Mark J ^a,b   Ward, Glenn M ^a   Roberts, Leslie J ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Autonomic function testing; Autonomic neuropathy; Hypoglycaemia awareness

Indexed keywords

ADULT; ARTICLE; AUTONOMIC NEUROPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FISHER EXACT TEST; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET CELL; PANCREAS TRANSPLANTATION; PATIENT EDUCATION; PRIORITY JOURNAL; ADRENERGIC SYSTEM; ADVERSE EFFECTS; AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD; CARDIOVASCULAR SYSTEM; COHORT ANALYSIS; COMPLICATION; DIABETES MELLITUS, TYPE 1; DIABETIC NEUROPATHIES; INNERVATION; KIDNEY TRANSPLANTATION; MIDDLE AGED; NERVE CONDUCTION; PANCREAS ISLET TRANSPLANTATION; PATHOPHYSIOLOGY; SELF EVALUATION; SEVERITY OF ILLNESS INDEX; SKIN; SWEAT GLAND;

AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NERVOUS SYSTEM DISEASES; CARDIOVASCULAR SYSTEM; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DIABETIC NEUROPATHIES; DIAGNOSTIC SELF EVALUATION; FEMALE; HUMANS; HYPOGLYCEMIA; ISLETS OF LANGERHANS TRANSPLANTATION; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; NEURAL CONDUCTION; PANCREAS TRANSPLANTATION; SEVERITY OF ILLNESS INDEX; SKIN; SWEAT GLANDS; SYMPATHETIC NERVOUS SYSTEM;

EID: 84941259284     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2652     Document Type: Article

References (14)

1. Stephenson JM, Kempler P, Perin PC, Fuller JH. Is autonomic neuropathy a risk factor for severe hypoglycaemia? EURODIAB IDDM Compl Study Diabetologia 1996; 39(11): 1372-1376.
2. Ryder RE, Owens DR, Hayes TM, Ghatei MA, Bloom SR. Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy. BMJ 1990; 301(6755): 783-787.
3. Hoeldtke RD, Boden G, Shuman CR, Owen OE. Reduced epinephrine secretion and hypoglycemia unawareness in diabetic autonomic neuropathy. Ann Intern Med 1982; 96(4): 459-462.
4. Leitão CB, Tharavanij T, Cure P, et al. Restoration of hypoglycemia awareness after islet transplantation. Diabetes Care 2008; 31(11): 2113-2115.
5. Ryan EA, Shandro T, Green K, et al. Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation. Diabetes 2004; 53(4): 955-962.
6. Low PA, Benarroch EE (Eds). Clinical Autonomic Disorders (3rd edn). Lippincott Williams & Wilkins, 2008.
7. Ewing DJ, Clarke BF. Diagnosis and management of diabetic autonomic neuropathy. Br Med J (Clin Res Ed) 1982; 285(6346): 916-918.
8. Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997; 42(5): 727-736.
9. Solders G, Tydén G, Persson A, Groth CG. Improvement of nerve conduction in diabetic neuropathy. A follow-up study 4 yr after combined pancreatic and renal transplantation. Diabetes 1992; 41(8): 946-951.
10. Cryer PE. Mechanisms of hypoglycemia-associated autonomic failure in diabetes. N Engl J Med 2013; 369(4): 362-372.
11. Little SA, Leelarathna L, Barendse SM, et al. Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention. Diabetes Metab Res Rev 2014; 30(3): 175-190.
12. Rickels MR, Schutta MH, Mueller R, et al. Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients. J Clin Endocrinol Metab 2007; 92(3): 873-879.
13. Ang M, Meyer C, Brendel MD, Bretzel RG, Linn T. Magnitude and mechanisms of glucose counterregulation following islet transplantation in patients with type 1 diabetes suffering from severe hypoglycaemic episodes. Diabetologia 2014; 57(3): 623-632.
14. Meyer C, Hering BJ, Grossmann R, et al. Improved glucose counterregulation and autonomic symptoms after intraportal islet transplants alone in patients with long-standing type I diabetes mellitus. Transplantation 1998; 66(2): 233-240.