Restoration of hypoglycemia awareness after islet transplantation

Diabetes Care

Volumn 31, Issue 11, 2008, Pages 2113-2115

  Leitão, Cristiane B ^a,b   Tharavanij, Thipaporn ^a   Cure, Pablo ^a   Pileggi, Antonello ^a,c   Baidal, David A ^a   Ricordi, Camillo ^a,c,d   Alejandro, Rodolfo ^a,c  

^a DIABETES RESEARCH INSTITUTE   (United States)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; GRAFT DYSFUNCTION; GRAFT FAILURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; MALE; METABOLIC REGULATION; PANCREAS ISLET; RECIPIENT; BLOOD; COHORT ANALYSIS; GLUCOSE BLOOD LEVEL; MIDDLE AGED; PANCREAS ISLET TRANSPLANTATION; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ADULT; BLOOD GLUCOSE; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; HYPOGLYCEMIA; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 59249108588     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-0741     Document Type: Article

References (6)

1. Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A, Ferreira JV, Pugliese A, Esquenazi VV, Kenyon NS, Alejandro R: Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid- free immunosuppression: Miami experience. Am J Transplant 5:2037-2046, 2005
2. Rickels MR, Schutta MH, Mueller R, Kapoor S, Markmann JF, Naji A, Teff KL: Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients. J Clin Endocrinol Metab 92:873-879, 2007
3. Paty BW, Ryan EA, Shapiro AM, LakeyJR, Robertson RP: Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51:3428-3434, 2002
4. Clarke WL, Cox DJ, Gonder-Frederick LA, Julian D, Schlundt D, Polonsky W: Reduced awareness of hypoglycemia in adults with IDDM: a prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care 18:517-522, 1995
5. Liu D, McManus RM, Ryan EA: Improved counter-regulatory hormonal and symptomatic responses to hypoglycemia in patients with insulin-dependent diabetes mellitus after 3 months of less strict glycemic control. Clin Invest Med 19:71-82, 1996
6. Kendall DM, Rooney DP, Smets YF, Salazar Bolding L, Robertson RP: Pancreas transplantation restores epinephrine response and symptom recognition during hypoglycemia in patients with longstanding type I diabetes and autonomic neuropathy. Diabetes 46:249-257, 1997