Improved glucose counterregulation and autonomic symptoms after intraportal islet transplants alone in patients with long-standing type I diabetes mellitus

Transplantation

Volumn 66, Issue 2, 1998, Pages 233-240

  Meyer, Christian ^a   Hering, Bernhard J ^a   Großmann, Ralf ^a   Brandhorst, Heide ^a   Brandhorst, Daniel ^a   Gerich, John ^b   Federlin, Konrad ^a   Bretzel, Reinhard G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b University of Giessen ^*

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; AUTONOMIC INNERVATION; CASE REPORT; DISEASE SEVERITY; FEMALE; GLUCAGON RELEASE; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; HYPOGLYCEMIA; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RECURRENT DISEASE; SYMPTOMATOLOGY;

ADULT; AUTONOMIC NERVOUS SYSTEM; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; HUMANS; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; MALE;

EID: 0032558096     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199807270-00017     Document Type: Article

References (48)

1. Cryer P. Iatrogenic hypoglycemia in IDDM: consequences, risk factors and prevention. Diabetes Ann 1993; 7: 317.
2. White NH, Skor DA, Cryer PE, Bier DM, Levandoski L, Santiago JV. Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 1983; 308: 485.
3. Bolli GB, DeFeo P, DeCosmo S, et al. A reliable and reproducible test for adequate glucose counterregulation in type I diabetes mellitus. Diabetes 1984; 33: 732.
4. Sjöbom N, Adamson U, Lins P-E. The prevalence of impaired glucose counterregulation during an insulin-infusion test in insulin-treated diabetic patients prone to severe hypoglycemia. Diabetologia 1989; 82: 818.
5. Gerich J, Mokan M, Veneman T, Korytkowski M, Mitrakou A. Hypoglycemia unawareness. Endocrinol Rev 1991; 12: 356.
6. Hepburn D, Patrick A, Eadington D, Ewing D, Frier B. Unawareness of hypoglycemia in insulin-treated diabetic patients: prevalence and relationship to autonomic neuropathy. Diabetic Med 1990; 7: 711.
7. Amiel S, Tamborlane W, Simonson D, Sherwin R. Defective glucose counterregulation after strict control of insulin-dependent, diabetes mellitus. N Engl J Med 1987; 316: 1376.
8. Amiel S, Sherwin R, Simonson D, Tamborlane W. Effect of intensive insulin therapy on glycemic thresholds for counter-regulatory hormone release. Diabetes 1988; 37: 901.
9. Boyle PJ, Schwartz NS, Shah SD, Clutter WE, Cryer PE. Plasma glucose concentrations at the onset of hypoglycemia symptoms in patients with poorly controlled diabetes and nondiabetics. N Engl J Med 1988; 318: 1487.
10. DCCT Research Group. Epidemiology of severe hypoglycemia in the diabetes control and complications trial. Am J Med 1991; 90: 450.
11. Gerich J, Langlois M, Noacco C, Karam J, Forsham P. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 1973; 182: 171.
12. Bolli G, DeFeo P, Compagnucci P, et al. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 1983; 32: 134.
13. Popp D, Shah S, Cryer P. The role of epinephrine-mediated beta-adrenergic mechanisms in hypoglycemic glucose counter-regulation and posthypoglycemic hyperglycemia in insulin-dependent diabetes mellitus. J Clin Invest 1982; 69: 315.
14. Mühlhauser I, Heinemann L, Fritsche E, vonLennep K, Berger M. Hypoglycemic symptoms and frequency of severe hypoglycemia in patients treated with human and animal insulin preparations. Diabetes Care 1991; 14: 745.
15. Fanelli C, Epifano L, Rambotti A, et al. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 1993; 42: 1683.
16. Fanelli C, Pampanelli S, Epifano L, et al. Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycemia, following institution of rational, intensive insulin therapy in IDDM. Diabetologia 1994; 37: 1265.
17. Dagogo-Jack S, Rattarason C, Cryer P. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation in IDDM. Diabetes 1994; 43: 1426.
18. Lingenfelser T, Buettner U, Martin J, et al. Improvement of impaired counterregulatory hormone response and symptom perception by short-term avoidance of hypoglycemia in IDDM. Diabetes Care 1995; 18: 321.
19. Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985; 8: 491.
20. Dyck PJ, Karnes JL, Daube J, O'Brian P, Service FJ. Clinical and neuropathological criteria for the diagnosis and staging of diabetic polyneuropathy. Brain 1985; 108: 861.
21. Dyck PJ, Zimmerman IR, O'Brian PC, et al. Introduction of automated systems to evaluate touch-pressure, vibration and thermal cutaneous sensation in man. Ann Neurol 1978; 4: 502.
22. Dyck PJ, Karnes J, O'Brian PC, Zimmerman IR. Detection thresholds of cutaneous sensation in humans. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R, eds. Peripheral neuropathy. Philadelphia: Saunders, 1984: 1103.
23. Ricordi C, Lacy PE, Olack B, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37: 413.
24. Lake SP, Basset PD, Larkins A, et al. Large-scale purification of human islets utilizing albumin gradient on IBM 2991 cell separator. Diabetes 1989; 38 (suppl 1): 143.
25. Brandhorst D, Brandhorst H, Hering BJ, Federlin K, Bretzel RG. Islet isolation from the pancreas of large mammals and humans: 10 years experience. Exp Clin Endocrinol Diabetes 1995; 103 (suppl 2): 3.
26. Bretzel RG, Alejandro R, Hering BJ, van Suylichem PT, Ricordi C. Clinical islet transplantation: guidelines for islet quality control. Transplant. Proc 1994; 26: 388.
27. Bretzel RG, Hering BJ, Federlin K. Islet cell transplantation in diabetes mellitus: from bench to bedside. Exp Clin Endocrinol Diabetes 1995; 103 (suppl 2): 143.
28. Emmrich J, Seyfarth M, Fleig WE, Emmrich F. Treatment of inflammatory bowel disease with anti-CD4 monoclonal anti-body. Lancet 1991; 338: 570.
29. Reinke P, Volk H-D, Miller H, et al. Anti-CD4 therapy of acute rejection in long-term renal allograft recipients. Lancet 1991; 338: 702.
30. Mitrakou A, Ryan C, Veneman T, et al. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 1991; 260: E67.
31. Andres R, Swerdloff R, Pozefsky T, Coleman D. Manual feedback technique for the control of blood glucose concentration. In: Skeggs L, ed. Automation in analytical chemistry. White Plains, NY: Mediad, 1966: 486.
32. Hepburn D, Deary I, Frier B. Classification of symptoms of hypoglycemia in insulin-treated diabetic patients using factor analysis: relationship to hypoglycemia unawareness. Diabetic Med 1992; 9: 70.
33. Towler D, Havlin C, Craft S, Cryer P. Mechanism of awareness of hypoglycemia: perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 1993; 42: 1791.
34. Bosi E, Piatti P, Secchi A, et al. Response of glucagon and insulin secretion to insulin-induced hypoglycemia in type I diabetic patients after pancreatic transplantation. Diabetes Nutr Metab 1988; 1: 21.
35. Diem P, Redman J, Abid M, et al. Glucagon, catecholamine, and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. J Clin Invest 1990; 86: 2008.
36. Bounder J, Wahrenberg H, Linde B, Tyden G, Groth C, Ostman J. Improved glucose counterregulation after pancreas transplantation in diabetic patients with unawareness of hypoglycemia. Transplant Proc 1991; 23: 1667.
37. Luzi L, Battezzati A, Perseghin G, et al. Lack of feedback inhibition of insulin secretion in denervated human pancreas. Diabetes 1992; 41: 1632.
38. Barrou Z, Seaquist E, Robertson R. Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia. Diabetes 1994; 43: 661.
39. Kendall DM, Rooney DP, Smets YFC, Salazar Bolding L, Robertson RP. Pancreas transplantation restores epinephrine respouse and symptom recognition during hypoglycemia in patients with long-standing type I diabetes and autonomic neuropathy. Diabetes 1997; 46: 249.
40. Teuscher A, Seaquist E, Kendall D, Robertsson R. Alpha cell function in human recipients of pancreatic islet autografts [Abstract]. Cell Transplant 1994; 3: 228.
41. Kendall DM, Teuscher AU, Robertson RP. Defective glucagon secretion during sustained hypoglycemia following successful islet auto- and allotransplantation in humans. Diabetes 1997; 46: 23.
42. Gupta V, Wahoff DC, Rooney DP, et al. The defective glucagon response from transplanted intrahepatic pancreatic islets during hypoglycemia is transplantation site-determined. Diabetes 1997; 46: 28.
43. Di Carlo A, Scharp D, Gingerich R, et al. Insulin and glucagon release from isolated, perifused human islets following low-temperature culture and cryopreservation. Transplant Proc 1994; 26: 821.
44. Ido Y, Vindini K, Stramm L, et al. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 1997; 277: 563.
45. Johansson B-L, Borg K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia 1996; 39: 687.
46. Campbell L, Kraegen E, Lazarus L. Defective blood glucose counterregulation in diabetes is a selective form of autonomic neuropathy. Br Med J 1977; 2: 1527.
47. Kennedy FP, Bolli GB, Go VLW, Cryer PE, Gerich JE. The significance of impaired pancreatic polypeptide and epinephrine responses to hypoglycemia in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987; 64: 602.
48. Battezzati A, Luzi L, Perseghin G, et al. Persistence of counter-regulatory abnormalities in insulin-dependent diabetes mellitus after pancreas transplantation. Eur J Clin Invest 1994; 24: 751.