Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 5687-5700

  Gehrmann, Mathias K ^a   Kimm, Melanie A ^b   Stangl, Stefan ^a   Schmid, Thomas E ^a   Noël, Peter B ^b   Rummeny, Ernst J ^b   Multhoff, Gabriele ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Heat shock protein 70; K edge; Multimodal CT; Multispectral CT; Theranostics; Tumor biomarker

Indexed keywords

CMHSP70.1 ANTIBODY; CMHSP70.1 ANTIBODY CONJUGATED GOLD NANOPARTICLE; GOLD NANOPARTICLE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; GOLD; IMMUNOGLOBULIN G; METAL NANOPARTICLE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENE INACTIVATION; IMAGING; IN VIVO STUDY; NONHUMAN; PROTEIN ANALYSIS; TUMOR CELL; ANIMAL; CELL MEMBRANE; CHEMISTRY; MOUSE; TUMOR CELL LINE; X-RAY COMPUTED TOMOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CELL MEMBRANE; GOLD; HSP70 HEAT-SHOCK PROTEINS; IMMUNOGLOBULIN G; METAL NANOPARTICLES; MICE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84941254975     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S87174     Document Type: Article

References (44)

1. Vanderstraeten B, Duthoy W, De Gersem W, De Neve W, Thierens H. [18F]fluoro-deoxy-glucose positron emission tomography ([18F]FDG-PET) voxel intensity-based intensity-modulated radiation therapy (IMRT) for head and neck cancer. Radiother Oncol. 2006;79(3):249–258.
2. Bal H, Guerin L, Casey ME, et al. Improving PET spatial resolution and detectability for prostate cancer imaging. Phys Med Biol. 2014;59(15):4411–4426.
3. Cormode DP, Naha PC, Fayad ZA. Nanoparticle contrast agents for computed tomography: a focus on micelles. Contrast Media Mol Imaging. 2014;9(1):37–52.
4. Chen WH, Chen JX, Cheng H, et al. A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles. Chem Commun. 2013;49(57):6403–6405.
5. Cormode DP, Roessl E, Thran A, et al. Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles. Radiology. 2010;256(3):774–782.
6. De La Vega JC, Hafeli UO. Utilization of nanoparticles as X-ray contrast agents for diagnostic imaging applications. Contrast Media Mol Imaging. 2014;10(2):81–95.
7. Ashton JR, Clark DP, Moding EJ, et al. Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. PLoS One. 2014;9(2):e88129.
8. Sherman M, Multhoff G. Heat shock proteins in cancer. Ann N Y Acad Sci. 2007;1113:192–201.
9. Stangl S, Gehrmann M, Riegger J, et al. Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A. 2011;108(2):733–738.
10. Gehrmann M, Radons J, Molls M, Multhoff G. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress Chaperones. 2008;13(1):1–10.
11. Ran FA, Hsu PD, Lin CY, et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell. 2013;154(6):1380–1389.
12. Hsu PD, Scott DA, Weinstein JA, et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol. 2013;31(9):827–832.
13. Botzler C, Ellwart J, Gunther W, Eissner G, Multhoff G. Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells. Exp Hematol. 1999;27(3):470–478.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227(259):680–685.
15. Schilling D, Gehrmann M, Steinem C, et al. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009;23(8):2467–2477.
16. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979;76(9):4350–4354.
17. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9(7):671–675.
18. Gehrmann M, Stangl S, Foulds GA, et al. Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide. PLoS One. 2014;9(8):e105344.
19. Garofalakis A, Dubois A, Theze B, Czarny B, Tavitian B, Duconge F. Fusion of [(18)F]FDG PET with fluorescence diffuse optical tomography to improve validation of probes and tumor imaging. Mol Imaging Biol. 2013;15(3):316–325.
20. Apisarnthanarax S, Chao KS. Current imaging paradigms in radiation oncology. Radiat Res. 2005;163(1):1–25.
21. Gaertner FC, Furst S, Schwaiger M. PET/MR: a paradigm shift. Cancer Imaging. 2013;13:36–52.
22. Schlomka JP, Roessl E, Dorscheid R, et al. Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography. Phys Med Biol. 2008;53(15):4031–4047.
23. Almufti R, Wilbaux M, Oza A, et al. A critical review of the analytical approaches for circulating tumor biomarker kinetics during treatment. Ann Oncol. 2014;25(1):41–56.
24. Elf SE, Chen J. Targeting glucose metabolism in patients with cancer. Cancer. 2014;120(6):774–780.
25. Reuveni T, Motiei M, Romman Z, Popovtzer A, Popovtzer R. Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study. Int J Nanomedicine. 2011;6:2859–2864.
26. Bayer C, Liebhardt ME, Schmid TE, et al. Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models. Int J Radiat Oncol Biol Phys. 2014;88(3):694–700.
27. Gehrmann M, Specht HM, Bayer C, et al. Hsp70 – a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck. Radiat Oncol. 2014;9:131.
28. Kao HW, Lin YY, Chen CC, et al. Biological characterization of cetuximab-conjugated gold nanoparticles in a tumor animal model. Nanotechnology. 2014;25(29):295102.
29. Schubertova V, Martinez-Veracoechea FJ, Vacha R. Influence of ligand distribution on uptake efficiency. Soft Matter. 2015;11(14):2726–2730.
30. Lammers T, Kiessling F, Hennink WE, Storm G. Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release. 2012;161(2):175–187.
31. Gao H, Yang Z, Zhang S, et al. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep. 2013;3:2534.
32. Stangl S, Gehrmann M, Dressel R, et al. In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody. J Cell Mol Med. 2011;15(4):874–887.
33. Stangl S, Varga J, Freysoldt B, et al. Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 Peptide-based probe. Cancer Res. 2014;74(23):6903–6912.
34. Rothen-Rutishauser B, Kuhn DA, Ali Z, et al. Quantification of gold nanoparticle cell uptake under controlled biological conditions and adequate resolution. Nanomedicine. 2014;9(5):607–621.
35. Ng CT, Tang FM, Li JJ, Ong C, Yung LL, Bay BH. Clathrin-Mediated Endocytosis of Gold Nanoparticles In Vitro. Anat Rec. 2014;298(2):418–427.
36. Zhang W, Ji Y, Wu X, Xu H. Trafficking of gold nanorods in breast cancer cells: uptake, lysosome maturation, and elimination. ACS Appl Mater Interfaces. 2013;5(19):9856–9865.
37. Wang M, Zheng LN, Wang B, et al. Quantitative analysis of gold nanoparticles in single cells by laser ablation inductively coupled plasma-mass spectrometry. Anal Chem. 2014;86(20):10252–10256.
38. Chen X, Chen CB, Udalagama CN, et al. High-resolution 3D imaging and quantification of gold nanoparticles in a whole cell using scanning transmission ion microscopy. Biophys J. 2013;104(7):1419–1425.
39. Zhang XD, Wu HY, Wu D, et al. Toxicologic effects of gold nanoparticles in vivo by different administration routes. Int J Nanomedicine. 2010;5:771–781.
40. Dorsey JF, Sun L, Joh DY, et al. Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization. Transl Cancer Res. 2013;2(4):280–291.
41. Muddineti OS, Ghosh B, Biswas S. Current trends in using polymer coated gold nanoparticles for cancer therapy. Int J Pharm. 2015;484(1–2):252–267.
42. Hainfeld JF, Dilmanian FA, Zhong Z, Slatkin DN, Kalef-Ezra JA, Smilowitz HM. Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma. Phys Med Biol. 2010;55(11):3045–3059.
43. Mesbahi A. A review on gold nanoparticles radiosensitization effect in radiation therapy of cancer. Rep Pract Oncol Radiother. 2010;15(6):176–180.
44. Cho SH. Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol. 2005;50(15):N163–N173.