Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models

International Journal of Radiation Oncology Biology Physics

Volumn 88, Issue 3, 2014, Pages 694-700

  Bayer, Christine ^a   Liebhardt, Michael E ^a   Schmid, Thomas E ^a   Trajkovic Arsic, Marija ^a   Hube, Kathrin ^a   Specht, Hanno M ^a   Schilling, Daniela ^a,b   Gehrmann, Mathias ^a   Stangl, Stefan ^a   Siveke, Jens T ^a   Wilkens, Jan J ^a   Multhoff, Gabriele ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CELL MEMBRANES; CYTOLOGY; MAMMALS; PROTEINS; RADIOTHERAPY;

CLINICAL OUTCOME; DUCTAL ADENOCARCINOMAS; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAT SHOCK PROTEIN 70; METHODS AND MATERIALS; RADIATION-INDUCED; SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECKS; TUMOR BIOMARKERS;

TUMORS;

HEAT SHOCK PROTEIN 70; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RADIOTHERAPY; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; HEAD AND NECK NEOPLASMS; HETEROGRAFTS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; PANCREATIC NEOPLASMS; RADIATION DOSAGE; SPHEROIDS, CELLULAR; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84893862822     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.11.008     Document Type: Article

References (33)

1. P.S. Mitchell, R.K. Parkin, and E.M. Kroh et al. Circulating micrornas as stable blood-based markers for cancer detection Proc Natl Acad Sci U S A 105 2008 10513 10518
2. N. Dakappagari, L. Neely, and S. Tangri et al. An investigation into the potential use of serum hsp70 as a novel tumour biomarker for hsp90 inhibitors Biomarkers 15 2010 31 38
3. Y. Fujita, T. Nakanishi, and Y. Miyamoto et al. Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma Cancer Lett 263 2008 280 290
4. S. Shukla, A. Pranay, and A.K. D'Cruz et al. Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response Cancer Biomark 5 2009 127 135
5. M. Ferrarini, S. Heltai, and M.R. Zocchi et al. Unusual expression and localization of heat-shock proteins in human tumor cells Int J Cancer 51 1992 613 619
6. G. Multhoff, C. Botzler, and M. Wiesnet et al. A stress-inducible 72-kda heat-shock protein (hsp72) is expressed on the surface of human tumor cells, but not on normal cells Int J Cancer 61 1995 272 279
7. U.H. Weidle, D. Maisel, and S. Klostermann et al. Intracellular proteins displayed on the surface of tumor cells as targets for therapeutic intervention with antibody-related agents Cancer Genomics Proteomics 8 2011 49 63
8. M. Gehrmann, J. Radons, and M. Molls et al. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (hsp70) expression by tumor cells Cell Stress Chaperones 13 2008 1 10
9. T.E. Schmid, and G. Multhoff Radiation-induced stress proteins - the role of heat shock proteins (hsp) in anti- tumor responses Curr Med Chem 19 2012 1765 1770
10. S.W. Krause, R. Gastpar, and R. Andreesen et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: A clinical phase I trial Clin Cancer Res 10 2004 3699 3707 (Pubitemid 38697603)
11. G. Multhoff Activation of natural killer cells by heat shock protein 70 2002 Int J Hyperthermia 25 2009 169 175
12. R. Gastpar, M. Gehrmann, and M.A. Bausero et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells Cancer Res 65 2005 5238 5247 (Pubitemid 40827334)
13. L.E. Hightower, and P.T. Guidon Jr. Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins J Cell Physiol 138 1989 257 266 (Pubitemid 19061205)
14. G.I. Lancaster, and M.A. Febbraio Exosome-dependent trafficking of hsp70: A novel secretory pathway for cellular stress proteins J Biol Chem 280 2005 23349 23355 (Pubitemid 40853248)
15. E. Schmitt, M. Gehrmann, and M. Brunet et al. Intracellular and extracellular functions of heat shock proteins: Repercussions in cancer therapy J Leukoc Biol 81 2007 15 27 (Pubitemid 46021247)
16. G. Multhoff, and L.E. Hightower Distinguishing integral and receptor-bound heat shock protein 70 (hsp70) on the cell surface by hsp70-specific antibodies Cell Stress Chaperones 16 2011 251 255
17. C.M. Ardito, B.M. Gruner, and K.K. Takeuchi et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis Cancer Cell 22 2012 304 317
18. G.E. Arteel, R.G. Thurman, and J.M. Yates et al. Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver Br J Cancer 72 1995 889 895
19. A.S. Ljungkvist, J. Bussink, and P.F. Rijken et al. Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas Int J Radiat Oncol Biol Phys 54 2002 215 228
20. C.O. Madu, and Y. Lu Novel diagnostic biomarkers for prostate cancer J Cancer 1 2010 150 177
21. M. Baumann, C. Liertz, and H. Baisch et al. Impact of overall treatment time of fractionated irradiation on local control of human fadu squamous cell carcinoma in nude mice Radiother Oncol 32 1994 137 143 (Pubitemid 24270735)
22. M.D. Hurwitz, P. Kaur, and G.M. Nagaraja et al. Radiation therapy induces circulating serum hsp72 in patients with prostate cancer Radiother Oncol 95 2010 350 358
23. S.S. Mambula, M.A. Stevenson, and K. Ogawa et al. Mechanisms for hsp70 secretion: Crossing membranes without a leader Methods 43 2007 168 175 (Pubitemid 47499072)
24. D.E. Misek, T.H. Patwa, and D.M. Lubman et al. Early detection and biomarkers in pancreatic cancer J Natl Compr Canc Netw 5 2007 1034 1041 (Pubitemid 350247711)
25. D.R. Ciocca, and S.K. Calderwood Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications Cell Stress Chaperones 10 2005 86 103 (Pubitemid 40942470)
26. M. Sakamoto, K. Effendi, and Y. Masugi Molecular diagnosis of multistage hepatocarcinogenesis Jpn J Clin Oncol 40 2010 891 896
27. M. Krepuska, Z. Szeberin, and P. Sotonyi et al. Serum level of soluble hsp70 is associated with vascular calcification Cell Stress Chaperones 16 2011 257 265
28. M. Nakhjavani, A. Morteza, and L. Khajeali et al. Increased serum hsp70 levels are associated with the duration of diabetes Cell Stress Chaperones 15 2010 959 964
29. B.H. Wright, J.M. Corton, and A.M. El-Nahas et al. Elevated levels of circulating heat shock protein 70 (hsp70) in peripheral and renal vascular disease Heart Vessels 15 2000 18 22
30. K. Suzuki, Y. Ito, and K. Wakai et al. Serum heat shock protein 70 levels and lung cancer risk: a case-control study nested in A large cohort study Cancer Epidemiol Biomarkers Prev 15 2006 1733 1737 (Pubitemid 44497111)
31. M. Zimmermann, S. Nickl, and C. Lambers et al. Discrimination of clinical stages in non-small cell lung cancer patients by serum hsp27 and hsp70: A multi-institutional case-control study Clin Chim Acta 413 2012 1115 1120
32. C.H. Yeh, R. Tseng, and Z. Zhang et al. Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia Leuk Res 33 2009 212 217
33. S.K. Dutta, M. Girotra, and M. Singla et al. Serum hsp70: A novel biomarker for early detection of pancreatic cancer Pancreas 41 2012 530 534