Effect of quercetin, genistein and kaempferol on glutathione and glutathione-redox cycle enzymes in 3T3-L1 preadipocytes

Drug and Chemical Toxicology

Volumn 39, Issue 3, 2016, Pages 239-247

  Boadi, William Y ^a   Amartey, Paul K ^a   Lo, Andrew ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Fenton's pathway; Flavonoids; glutathione peroxidase; glutathione reductase; oxidative damage; superoxide dismutase

Indexed keywords

GENISTEIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; KAEMPFEROL; QUERCETIN; SUPEROXIDE DISMUTASE; ANTIOXIDANT; FLAVONOID; KAEMPFEROL DERIVATIVE;

3T3 CELL LINE; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FENTON REACTION; FIBROBLAST; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; 3T3-L1 CELL LINE; ADIPOCYTE; ANIMAL; CELL CULTURE TECHNIQUE; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTIOXIDANTS; CELL CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GENISTEIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; KAEMPFEROLS; MICE; OXIDATIVE STRESS; QUERCETIN; SUPEROXIDE DISMUTASE;

EID: 84941254445     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2015.1082135     Document Type: Article

References (37)

1. Aherne SA, OBrien NM. (2000). Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione-induced DNA single strand breaks in Caco-2 cells. Free Radic Biol Med 29: 507-514
2. Alam ZI, Jenner A, Daniel E, et al. (1997a). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 69: 1196-1203
3. Alam ZI, Daniel SE, Lees AJ, et al. (1997b). A generalised increase in protein carbonyls in the brain in Parkinsons but not incidental Lewy body disease. J Neurochem 69: 1326-1329
4. Andres-Lacueva C, Shukitt-Hale B, Galli RL, et al. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 8: 111-120
5. Briviba K, Klotz LO, Sies H. (1999). Defenses against peroxynitrite. Methods Enzymol 301: 301-311
6. Boadi WY, Thaire L, Yannai S. (1991). Effects of dietary factors on antioxidant enzymes in rats exposed to hyperbaric oxygen. Vet Hum Toxicol 33: 105-109
7. Boadi WY, Iyere PA, Adunyah SE. (2003). Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate. J Appl Toxicol 23: 363-369
8. Boadi WY, Iyere PA, Adunyah SE. (2005). In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells. J Appl Toxicol 25: 82-88
9. Boadi WY, Harris S, Anderson JB, Adunyah SE. (2013). Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol 36:155-162
10. Catoni C, Martin Schaefer H, Peters A. (2008). Fruit for health: the effect of flavonoids on humoral immune response and food selection in a frugivorous bird. Funct Ecol 22: 649-654
11. Combs GF. (1981). Influence of dietary Vitamin E and selenium on the oxidant defense system of the chick. Poultry Sci 60: 2098-2105
12. Chung A, Maines MD. (1981). Effect of selenium on glutathione metabolism. Induction of gamma-glutamylcycteine synthetase and glutathione reductase in the rat liver. Biochem Pharmacol 30: 3217-3223
13. Costagliola C, Luliano G, Menzione M, et al. (1986). Effect of vitamin E on glutathione content in red blood cells, aqueous humor and lens of human and other species. Exp Eye Res 43: 905-914
14. Das NP, Ratty AK. (1986). Effects of flavonoids on induced non enzymic lipid peroxidation. Prog Clin Biol Med 213: 243-247
15. Das SK, Hinds JE, Hardy RE, et al. (1993). Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radic Biol Med 14: 139-147
16. Deneke SM, Fanburg BL. (1982). Oxygen toxicity of the lung: an update. Brit J Anaesth 54: 737-749
17. Di Carlo G, Mascolo N, Izzo AA, Capasso F. (1999). Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci 65: 337-353
18. Genestra M. (2007). Oxyl radicals, redox-sensitive signaling cascades and antioxidants. Cell Signal 19: 1807-1819
19. Hatia S, Septembre-Malaterre A, Le Sage F, et al. (2014). Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress. Free Radic Res 48: 387-401
20. Kalyanaraman B, Karoui H, Singh RJ, Felix CC. (1996). Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols-a high resolution ESR spin-trapping study at Q-band. Anal Biochem 241: 75-81
21. Kessler M, Ubeaud G, Jung L. (2003). Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 55: 131-142
22. Kennedy LJ, Moore K Jr, Caufield JL, et al. (1997). Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents. Chem Res Toxicol 10: 386-392
23. Kimbal RE, Reddy K, Schwarz PW, et al. (1976). Oxygen toxicity: augmentation of antioxidants defense mechanisms in rat lung. Am J Physiol 230: 1425-1431
24. Lakritz J, Plopper CG, Buckpitt AR. (1997). Validated high performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue sample. Anal Biochem 247: 63-68
25. Li Y, Maher P, Schubert D. (1997). A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron 19: 453-463
26. Lu SC. (2000). Regulation of glutathione synthesis. Curr Top Cell Regul 36: 95-116
27. Masella R, Benedetto RDi, Vari R, et al. (2005). Novel mechanisms of natural antioxidants compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nut Biochem 16: 577-586
28. Meister A, Tate SS. (1976). Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Ann Rev Biochem 45: 599-604
29. Meister A, Anderson ME. (1983). Glutathione. Ann Rev Biochem 52: 711-760
30. Rendeiro C, Spencer JPE, Vauzour D, et al. (2009). The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms. Genes Nutr 4: 251-270
31. Schafer FQ, Buettner GR. (2001). Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Rad Biol Med 30: 1191-1212
32. Stinson TJ, Jaw S, Jeffery EH, Plewa M. (1992). The relationship between nickel chloride-induced peroxidation and DNA strand breakage in rat liver. Toxicol Appl Pharmacol 117: 98-103
33. Taniguchi M, Hara T. (1983). Effects of riboflavin and selenium deficiencies on glutathione and its relating enzyme activities with respect to lipid peroxide content of rat livers. J Nutr Sci Vitaminol 29: 283-292
34. Takahashi T, Tabuchi T, Tamaki Y, et al. (2009). Carnosic and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochem Biophys Res Commun 382: 549-554
35. White AR, Cappai R. (2003). Neurotoxicity from glutathione depletion is dependent on extracellular trace copper. J Neurosci Res 15: 889-897
36. Yano T, Ishikawa G, Ichikawa T. (1993). Is vitamin E a useful agent to protect against oxy radical-promoted lung tumorigenesis in ddY mice? Carcinogenesis 14: 1133-1136
37. Yoritaka A, Hattori N, Uchida K, et al. (1996). Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinsons disease. Proc Natl Acad Sci USA 93: 2696-2701