In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells

Journal of Applied Toxicology

Volumn 25, Issue 1, 2005, Pages 82-88

  Boadi, William Y ^a   Iyere, Peter A ^b   Adunyah, Samuel E ^c  

^a TENNESSEE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARKANSAS AT PINE BLUFF   (United States)

^c MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

Cu; Fe; Fenton's pathway; Flavonoids; Genistein; Glutathione; Lipid peroxidation; Quercetin; Thiobarbituric acid; U937 cells

Indexed keywords

COPPER; FLAVONOID; GENISTEIN; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; LIPID PEROXIDE; METAL ION; PENICILLIN G; QUERCETIN; STREPTOMYCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ARTICLE; CELL GROWTH; CELL STRAIN U937; CELL VIABILITY; CONTROLLED STUDY; EXPOSURE; FENTON REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTIOXIDANTS; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLAVONOIDS; GENISTEIN; GLUTATHIONE; HUMANS; IRON; LIPID PEROXIDES; OXIDATION-REDUCTION; QUERCETIN; THIOBARBITURIC ACID REACTIVE SUBSTANCES; U937 CELLS;

BOVINAE;

EID: 13244298411     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.1049     Document Type: Article

References (44)

1. Adunyah SE, Wheeler BJ, Cooper RS. 1997. Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem. Biophys. Res. Commun. 232: 754-758.
2. Afanas'ev IB, Dorozhko AL, Brodskii AV, Kostyuk VA, Potapovitch AI. 1989. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol. 38: 1763-1769.
3. Agullo G, Garnet L, Besson C, Demigné C, Remesy C. 1994. Quercetin exerts cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells. Cancer Lett. 87: 55-63.
4. Aust SD, Sringen BA. 1982. The role of iron in enzymatic lipid peroxidation. In Free Radicals in Biology, Pryor WA (ed.). Academic Press: Orlando, USA; 10-80.
5. Boadi WY, Thaire L, Kerem D, Yannai S. 1991. Effects of dietary supplementation with vitamin E, riboflavin and selenium on central nervous system oxygen toxicity. Pharmacol. Toxicol. 68: 77-82.
6. Boadi WY, Urbach J, Barnea ER, Brandes JM, Yannai S. 1992. Enzyme activities in the term human placenta: in vitro effect of cadmium. Pharmacol. Toxicol. 71: 209-212.
7. Boadi WY, Iyere PA, Adunyah SE. 2003. Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate. J. Appl. Toxicol. 23: 363-369.
8. Choi J, Liu R-M, Kundu RK, Sangiorgi F, Wu W, Maxson R, Forman HJ. 2000. Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 tat-transgenic mice. J. Biol. Chem. 275: 3693-3698.
9. Cotelle N, Bernier J-L, Bernier J-P, Catteau J, Pommery J, Wallet J-C, Gaydou EM. 1996. Antioxidant properties of hydroxyflavones. Free Radi. Biol. Med. 20: 35-43.
10. Das NP, Ratty AK. 1986. Effects of flavonoids on induced non enzymic lipid peroxidation. Prog. Clin. Biol. Med. 213: 243-247.
11. Devasagayam TPA, Subramanain M, Singh BB, Ramanathan R, Das NP. 1995. Protection of plasmid pBR322 DNA by flavonoids against single-strand breaks induced by singlet molecular oxygen. J. Photochem. Photobiol. 30: 97-103.
12. Devi RP, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. 2000. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiol. Res. 154: 455-460.
13. Di Carlo G, Mascolo N, Izzo AA, Capasso F. 1999. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 65: 337-353.
14. Duthie SJ, Collins AR, Duthie GG, Dobson VL. 1997. Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidized pyrimidines) in human lymphocytes. Mutat. Res. 393: 223-231.
15. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011.
16. Husain SR, Cillard J, Cillard P. 1987. Hydroxyl radical scavenging activity of flavonoids. Biochemistry 26: 2489-2494.
17. Jenkinson SG, Jordan JM, Lawrence RA. 1988. BCNU-induced protection from hyperbaric hypeorxia: role of glutathione metabolism. J. Appl. Physiol. 65: 2531-2536.
18. Kennedy LJ, Moore KJr, Caufield JL, Tannenbaum SR, Dedon PC. 1997. Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents. Chem. Res. Toxicol. 10: 386-392.
19. Kilic D, Sayan H, Gonul B, Egehan I. 2000. The effect of granulocyte macrophage-colony stimulating factor on glutathione and lipid peroxidation in a rat model. Eur. J. Surg. Oncol. 26: 701-704.
20. Laughton MJ, Halliwell B, Evans PJ, Hoult JRS. 1989. Antioxidant and prooxidant actions of the plant phenolics quercetin, gossypol and myricetin. Biochem. Pharmacol. 38: 2859-2865.
21. Lebkowsky JS, Laemmli UK. 1982. Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei. J. Mol. Biol. 156: 309-324.
22. Lin W-C, Liao Y-C, Liau M-C. 2003. Effect of CDA-II on cell viability, lipid peroxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes. Am. J. Chinese Med. 31: 415-423.
23. MacGregor JT. 1986. Mutagenic and carcinogenic effects of flavonoids. In Plant Flavonoids in Biology and Medicine: Biochemical. Pharmacological and Structure-Activity Relationships, Liss AR (ed.). CRC Press: Boca Raton, FL; 401-424.
24. Middleton E. 1993. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In The Flavonoids: Advances in Research since 1986, Harborne JB (ed.). Chapman and Hall: New York; 234-255.
25. Minotti G. 1993. Sources and role of iron in lipid peroxidation. Chem. Res. Toxicol. 6: 134-146.
26. Moran JF, Klugas RV, Renee RV, Abian J, Becana M. 1997. Complexes of iron with phenolic compounds from soybean nodules and other legume tissues: prooxidant and antioxidant properties. Free Rad. Biol. Med. 22: 861-870.
27. Morel I, Lescoat G, Cogrel P, Sergent O, Pasdeloup N, Brissot P, Cillard P, Cillard J. 1993. Antioxidant and iron-chelating activities of the flavonoids ctchin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmacol. 45: 13-19.
28. Ohnishi M, Morishita H, Iwahashi H, Toda S, Shirataki Y, Kimura M, Kido R. 1994. Inhibitory effects of chlorogenic acids on linoleic acid peroxidation and hemolysis. Phytochemistry 36: 579-583.
29. Ono K, Nakane K. 1990. Mechanisms of inhibition of various cellular DNA and RNA polymerases by several flavonoids. J. Biochem. 108: 609-613.
30. Osawa T, Katsuzaki H, Hagiwara Y, Hagiwara H, Shibamoto T. 1992. A novel antioxidant isolated from young green barley leaves. J. Agric. Food Chem. 40: 1135-1138.
31. Rehncroma S, Folbergrova J, Smith DS, Siesjo BK. 1980. Influence of complete and pronounced incomplete cerebral ischemia and subsequent recirculation on cortical concentrations of oxidized and reduced glutathione in the rat. J. Neurochem. 34: 477-486.
32. Reichelt KL, Fonnum F. 1969. Subcellular localization of N-acetyl-asparty-glutamate, N-acetyl-glutamate and glutathione in brain. J. Neurochem. 16: 1409-1416.
33. Rimbach G, Gohil K, Matsugo S, Moini H, Saliou C, Virgili F, Weber SU, Packer L. 2001. Induction of glutathione synthesis in human keratinocytes by ginkgo biloba extract (EGb761). Biofactors 15: 39-52.
34. Rice-Evans CA, Miller NJ, Paganga G. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad. Biol. 20: 35-43.
35. Rueff J, Laires A, Borba H, Chaveca T, Gomes ML, Halpern M. 1986. Genetic toxicology of flavonoids: the role of metabolic conditions in the induction of reverse mutation. SOS functions and sister-chromatid exchanges. Mutagenesis 1: 179-183.
36. Sachan AS, Kannan GM, Kumar P, Flora SJS. 1996. Effects of chelation therapy on hepatic glutathione, lipid peroxidation and phospholipids contents in lead-poisoned rats. Ind. J. Physiol. Pharmacol. 40: 180-182.
37. Sahu SC, Washington MC. 1991. Effects of antioxidants on quercetin-induced nuclear DNA damage and lipid peroxidation. Cancer Lett. 60. 259-264.
38. Shimoi K, Masuda S, Furugori M, Esaki S, Kinae N. 1994. Radioprotective effect of antioxidative flavonoids in γ-ray irradiated mice. Carcinogenesis 15: 2669-2672.
39. Stinson TJ, Jaw S, Jeffery EH, Plewa M. 1992. The relationship between nickel chloride-induced peroxidation and DNA strand breakage in rat liver. Toxicol. Appl. Pharmacol. 117: 98-103.
40. Subramaniam SV, Cooper RS, Adunyah SE. 1999. Interleukin-17 induces rapid tyrosine phossphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937. Biochem. Biophys. Res. Commun. 262: 14-19.
41. 2 oxidation system. J. Agric. Food Chem. 39: 439-442.
42. Uma Devi P, Ganasoundari A. 1999. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Ind. J. Exp. Biol. 139: 262-268.
43. Uma Devi P, Ganasoundari B. Srinivasan KK, Unnikrishnan MK. 2000. Radiation protection by ocimum flavonoids orientin and vicenin: mechanisms of action. Radiol. Res. 154: 455-460.
44. Yuting C, Rongliang Z, Zhongjian J. 1991. Flavonoids as superoxide scavengers and antioxidants. Free Rad. Biol. Med. 9: 19-21.