Effects of exenatide therapy on insulin resistance in the skeletal muscles of high-fat diet and low-dose streptozotocin-induced diabetic rats

Endocrine Research

Volumn 41, Issue 1, 2016, Pages 1-7

  Wu, Hui ^a,b   Sui, Chunhua ^b   Xia, Fangzhen ^b   Zhai, Hualing ^b   Zhang, Huixin ^b   Xu, Hui ^b   Weng, Pan ^b   Lu, Yingli ^b  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes; Glucagon like peptide 1 agonist; Insulin resistance; Skeletal muscle

Indexed keywords

CHOLESTEROL; DEOXYGLUCOSE; EXENDIN 4; GLUCOSE; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; PEPTIDE; STREPTOZOCIN; VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INFUSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; VENOMS;

EID: 84941254374     PISSN: 07435800     EISSN: 15324206     Source Type: Journal    
DOI: 10.3109/07435800.2015.1015726     Document Type: Article

References (25)

1. Bajpeyi S, Pasarica M, Moro C, et al. Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes. J Clin Endocrinol Metab 2011;96:1160-8.
2. Schirra J, Nicolaus M, Roggel R, et al. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloroduodenal motility in humans. Gut 2006;55:243-51.
3. Deane AM, Nguyen NQ, Stevens JE, et al. Endogenous glucagonlike peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab 2010;95: 215-21.
4. Wajcberg E, Tavaria A. Exenatide: clinical aspects of the first incretin-mimetic for the treatment of type 2 diabetes mellitus. Expert Opin Pharmacother 2009;10:135-42.
5. Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008;24:275-86.
6. Kiec-Klimczak ME, Pach DM, Pogwizd ME, Hubalewska-Dydejczyk AB. Incretins yesterday, pleiotropic gastrointestinal hormones today:glucagon-like peptide-1 (GLP-1) and glucosedependent insulinotropic polypeptide (GIP). Recent Pat Endocr Metab Immune Drug Discov 2011;5:176-82.
7. Bi Y, Cai M, Liang H, et al. Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats. Metabolism 2009;58:779-86.
8. Guo Z, Zhou L. Dual tail catheters for infusion and sampling in rats as an efficient platform for metabolic experiments. Lab Anim (NY) 2003;32:45-8.
9. Mahin DT, Lofberg RT. A simplified method of sample preparation for determination of tritium, carbon-14, or sulfur-35 in blood or tissue by liquid scintillation counting. Anal Biochem 1966;16: 500-9.
10. Vella A, Rizza RA. Application of isotopic techniques using constant specific activity or enrichment to the study of carbohydrate metabolism. Diabetes 2009;58:2168-74.
11. Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 2011;18:139-43.
12. Guo Z, Jensen MD. Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis. J Biol Chem 1999;274: 23702-6.
13. Kraegen EW, James DE, Bennett SP, Chisholm DJ. In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am J Physiol 1983;245:E1-7.
14. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-23.
15. DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 2009;32:S157-63.
16. Thiebaud D, Jacot E, DeFronzo RA, et al. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 1982;31:957-63.
17. Guo Z, Zhou L. Muscle type-dependent responses to insulin in intramyocellular triglyceride turnover in obese rats. Obes Res 2005; 13:2081-7.
18. DeFronzo RA, Jacot E, Jequier E, et al. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981;30: 1000-7.
19. Yang H, Egan JM, Wang Y, et al. GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am J Physiol 1998;275:C675-83.
20. D'Alessio DA, Prigeon RL, Ensinck JW. Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes: a physiological role of glucagon-like peptide I. Diabetes 1995;44:1433-7.
21. Arnés L, González N, Tornero-Esteban P, et al. Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle. Int J Mol Med 2008;22:127-32.
22. Shulman GI, Rothman DL, Jue T, et al. Quantitation of muscle glycogen synthesis in normal subjects and subjects with noninsulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990;322:223-8.
23. Hojlund K, Beck-Nielsen H. Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes. Curr Diabetes Rev 2006;2:375-95.
24. Sivitz WI, Yorek MA. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal 2010;12:537-77.
25. Hojlund K, Wrzesinski K, Larsen PM, et al. Proteome analysis reveals phosphorylation of ATP synthase beta-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes. J Biol Chem 2003;278:10436-42.