Asthma is more severe in older adults

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Zein, Joe G ^a   Dweik, Raed A ^a   Comhair, Suzy A ^a   Bleecker, Eugene R ^b   Moore, Wendy C ^b   Peters, Stephen P ^b   Busse, William W ^c   Jarjour, Nizar N ^c   Calhoun, William J ^d   Castro, Mario ^e   Chung, K Fan ^f   Fitzpatrick, Anne ^g   Israel, Elliot ^h   Teague, W Gerald ⁱ   Wenzel, Sally E ^j   Love, Thomas E ^k   Gaston, Benjamin M ^l   Erzurum, Serpil C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ UNIVERSITY OF VIRGINIA   (United States)

^j UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^k METROHEALTH MEDICAL CENTER   (United States)

^l CASE WESTERN RESERVE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID;

ADULT; AGE DISTRIBUTION; AGED; AGING; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG USE; FEMALE; GASTROESOPHAGEAL REFLUX; HEALTH CARE NEED; HEALTH CARE UTILIZATION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; QUALITY OF LIFE; YOUNG ADULT; ADOLESCENT; AGE; CLINICAL TRIAL; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGING; ASTHMA; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84941248956     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133490     Document Type: Article

References (52)

1. Dunnill MS. Postnatal growth of the lung. Thorax. 1962; 17:329-33.
2. Angus GE, Thurlbeck WM. Number of alveoli in the human lung. Journal of applied physiology. 1972; 32(4):483-5. PMID: 5026496.
3. D'Amato G, Liccardi G, D'Amato M, Cazzola M. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Respir J. 2002; 20(3):763-76. PMID: 12358357.
4. Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma P. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59(5):469-78. doi:10.1111/j.1398-9995.2004.00526.x PMID: 15080825.
5. Krumpe PE, Knudson RJ, Parsons G, Reiser K. The aging respiratory system. Clinics in geriatric medicine. 1985; 1(1):143-75. PMID: 3913497.
6. Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. The European respiratory journal. 1999; 13(1):197-205. PMID: 10836348.
7. Niewoehner DE, Kleinerman J. Morphologic basis of pulmonary resistance in the human lung and effects of aging. Journal of applied physiology. 1974; 36(4):412-8. PMID: 4820322.
8. Milic-Emili J, Torchio R, D'Angelo E. Closing volume: A reappraisal (1967-2007). European journal of applied physiology. 2007; 99(6):567-83. doi:10.1007/s00421-006-0389-0 PMID: 17237952.
9. Anthonisen NR, Danson J, Robertson PC, Ross WR. Airway closure as a function of age. Respiration physiology. 1969; 8(1):58-65. PMID: 5366416.
10. Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, VandeWoestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspects. Chest. 1992; 101 (3):793-9. PMID: 1541148.
11. Ulrik CS, Lange P. Decline of lung function in adults with bronchial asthma. Am J Respir Crit Care Med. 1994; 150(3):629-34. doi:10.1164/ajrccm.150.3.8087330 PMID: 8087330.
12. Ronmark E, Lindberg A, Watson L, Lundback B. Outcome and severity of adult onset asthma-report from the obstructive lung disease in northern Sweden studies (OLIN). Respiratory medicine. 2007; 101 (11):2370-7. doi:10.1016/j.rmed.2007.06.011 PMID: 17689949.
13. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010; 181 (4):315-23. doi:10.1164/rccm.200906-0896OC PMID: 19892860; PubMed Central PMCID: PMC2822971.
14. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, et al. Cluster analysis and clinical asthma phenotypes. American journal of respiratory and critical care medicine. 2008; 178(3):218-24. doi:10.1164/rccm.200711-1754OC PMID: 18480428.
15. Kim TB, Jang AS, Kwon HS, Park JS, Chang YS, Cho SH, et al. Identification of asthma clusters in two independent Korean adult asthma cohorts. The European respiratory journal. 2013; 41(6):1308-14. doi:10.1183/09031936.00100811 PMID: 23060627.
16. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J. 2003; 22(3):470-7. PMID: 14516137.
17. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, et al. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012; 185(4):356-62. doi:10.1164/rccm.201107-1317PP PMID: 22095547; PubMed Central PMCID: PMC3297096.
18. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med. 2000; 162 (6):2341-51. PMID: 11112161.
19. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014; 43(2):343-73. doi:10.1183/09031936.00202013 PMID: 24337046.
20. Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK. Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax. 1992; 47(2):76-83. PMID: 1549827; PubMed Central PMCID: PMC463574.
21. Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Statistics in medicine. 1996; 15 (4):361-87. doi:10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 PMID: 8668867.
22. le Cessie S, van Houwelingen HC. Testing the fit of a regression model via score tests in random effects models. Biometrics. 1995; 51(2):600-14. PMID: 7662848.
23. Cleveland WS. Robust locally weighted regression and smoothing scatterplots. J American Statistical Association. 1979; 74:829-36.
24. Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodeling in asthma. The New England journal of medicine. 2011; 364(21):2006-15. doi:10.1056/NEJMoa1014350 PMID: 21612469.
25. Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, et al. A critical role for eosinophils in allergic airways remodeling. Science. 2004; 305(5691):1776-9. doi:10.1126/science.1100283 PMID: 15375268.
26. Cisternas MG, Blanc PD, Yen IH, Katz PP, Earnest G, Eisner MD, et al. A comprehensive study of the direct and indirect costs of adult asthma. The Journal of allergy and clinical immunology. 2003; 111 (6):1212-8. PMID: 12789219.
27. Serra-Batlles J, Plaza V, Morejon E, Comella A, Brugues J. Costs of asthma according to the degree of severity. Eur Respir J. 1998; 12(6):1322-6. PMID: 9877485.
28. Godard P, Chanez P, Siraudin L, Nicoloyannis N, Duru G. Costs of asthma are correlated with severity: A 1-yr prospective study. Eur Respir J. 2002; 19(1):61-7. PMID: 11843329.
29. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief. 2012;(94: ):1- 8. PMID: 22617340.
30. Dodge RR, Burrows B. The prevalence and incidence of asthma and asthma-like symptoms in a general population sample. The American review of respiratory disease. 1980; 122(4):567-75. PMID: 7436122.
31. Sennhauser FH, Kuhni CE. Prevalence of respiratory symptoms in Swiss children: Is bronchial asthma really more prevalent in boys? Pediatric pulmonology. 1995; 19(3):161-6. PMID: 7792118.
32. Asthma and respiratory symptoms in 6-7 yr old Italian children: gender, latitude, urbanization and socioeconomic factors. SIDRIA (Italian Studies on Respiratory Disorders in Childhood and the Environment). The European respiratory journal. 1997; 10(8):1780-6. PMID: 9272919.
33. Mandhane PJ, Greene JM, Cowan JO, Taylor DR, Sears MR. Sex differences in factors associated with childhood- And adolescent-onset wheeze. American journal of respiratory and critical care medicine. 2005; 172(1):45-54. doi:10.1164/rccm.200412-1738OC PMID: 15805179; PubMed Central PMCID: PMC2718447.
34. Almqvist C, Worm M, Leynaert B, working group of GALENWPG. Impact of gender on asthma in childhood and adolescence: A GA2LEN review. Allergy. 2008; 63(1):47-57. doi:10.1111/j.1398-9995.2007.01524.x PMID: 17822448.
35. Jenkins MA, Dharmage SC, Flander LB, Douglass JA, Ugoni AM, Carlin JB, et al. Parity and decreased use of oral contraceptives as predictors of asthma in young women. Clin Exp Allergy. 2006; 36(5):609- 13. doi:10.1111/j.1365-2222.2006.02475.x PMID: 16650045.
36. Rao CK, Moore CG, Bleecker E, Busse WW, Calhoun W, Castro M, et al. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. Chest. 2013; 143(4):984-92. doi:10.1378/chest.12-0973 PMID: 23632943; PubMed Central PMCID: PMC3747720.
37. Leynaert B, Sunyer J, Garcia-Esteban R, Svanes C, Jarvis D, Cerveri I, et al. Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: A population-based cohort. Thorax. 2012; 67(7):625-31. doi:10.1136/thoraxjnl-2011-201249 PMID: 22334535.
38. Schatz M, Camargo CA Jr. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann Allergy Asthma Immunol. 2003; 91(6):553-8. doi:10.1016/S1081-1206(10)61533-5 PMID: 14700439.
39. Troisi RJ, Speizer FE, Willett WC, Trichopoulos D, Rosner B. Menopause, postmenopausal estrogen preparations, and the risk of adult-onset asthma. A prospective cohort study. Am J Respir Crit Care Med. 1995; 152(4 Pt 1):1183-8. doi:10.1164/ajrccm.152.4.7551368 PMID: 7551368.
40. Gomez Real F, Svanes C, Bjornsson EH, Franklin KA, Gislason D, Gislason T, et al. Hormone replacement therapy, body mass index and asthma in perimenopausal women: A cross sectional survey. Thorax. 2006; 61(1):34-40. doi:10.1136/thx.2005.040881 PMID: 16244093; PubMed Central PMCID: PMC2080706.
41. Lange P, Parner J, Prescott E, Ulrik CS, Vestbo J. Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: A cross sectional study of the general population. Thorax. 2001; 56 (8):613-6. PMID: 11462063; PubMed Central PMCID: PMC1746111.
42. Real FG, Svanes C, Omenaas ER, Anto JM, Plana E, Jarvis D, et al. Lung function, respiratory symptoms, and the menopausal transition. J Allergy Clin Immunol. 2008; 121(1):72-80 e3. doi:10.1016/j.jaci.2007.08.057 PMID: 18028993.
43. Zein J, Comhair S, Bleecker E, Busse W, Calhoun W, Castro M, et al. The effect of aging and menopause on asthma severity in women. Chest. 2014; 145(3 Suppl):22A. doi:10.1378/chest.1783148.
44. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med. 1998; 339(17):1194-200. doi:10.1056/NEJM199810223391703 PMID: 9780339.
45. Peat JK, Woolcock AJ, Cullen K. Rate of decline of lung function in subjects with asthma. European journal of respiratory diseases. 1987; 70(3):171-9. PMID: 3569449.
46. Apostol GG, Jacobs DR Jr, Tsai AW, Crow RS, Williams OD, Townsend MC, et al. Early life factors contribute to the decrease in lung function between ages 18 and 40: The Coronary Artery Risk Development in Young Adults study. American journal of respiratory and critical care medicine. 2002; 166(2):166-72. doi:10.1164/rccm.2007035 PMID: 12119228.
47. Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature communications. 2014; 2:4172. doi:10.1038/ncomms5172 PMID: 24960204.
48. Fulop T, Larbi A, Douziech N, Fortin C, Guerard KP, Lesur O, et al. Signal transduction and functional changes in neutrophils with aging. Aging cell. 2004; 3(4):217-26. doi:10.1111/j.1474-9728.2004. 00110.x PMID: 15268755.
49. Meyer KC, Rosenthal NS, Soergel P, Peterson K. Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mechanisms of ageing and development. 1998; 104(2):169-81. PMID: 9792195.
50. Dijkstra A, Vonk JM, Jongepier H, Koppelman GH, Schouten JP, ten Hacken NH, et al. Lung function decline in asthma: Association with inhaled corticosteroids, smoking and sex. Thorax. 2006; 61(2):105- 10. doi:10.1136/thx.2004.039271 PMID: 16308336; PubMed Central PMCID: PMC2104585.
51. Hlatky MA, Pryor DB, Harrell FE Jr., Califf RM, Mark DB, Rosati RA. Factors affecting sensitivity and specificity of exercise electrocardiography. Multivariable analysis. Am J Med. 1984; 77(1):64-71. PMID: 6741986.
52. Hay WW Jr. American Pediatric Society presidential address 2008: research in early life-benefit and promise. Pediatr Res. 2009; 65(1):117-22. doi:10.1203/PDR.0b013e31818c7feb PMID: 18787504; PubMed Central PMCID: PMC2694512.