-
1
-
-
79957698619
-
-
Analysis of the prevalence of piperidines in drugs
-
Analysis of the prevalence of piperidines in drugs: Roughley, S. D.; Jordan, A. M. J. Med. Chem. 2011, 54, 3451
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3451
-
-
Roughley, S.D.1
Jordan, A.M.2
-
2
-
-
71049126548
-
-
Lovering, F.; Bikker, J.; Humblet, C. J. Med. Chem. 2009, 52, 6752
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6752
-
-
Lovering, F.1
Bikker, J.2
Humblet, C.3
-
3
-
-
80053928594
-
-
Walters, W. P.; Green, J.; Weiss, J. R.; Murcko, M. A. J. Med. Chem. 2011, 54, 6405
-
(2011)
J. Med. Chem.
, vol.54
, pp. 6405
-
-
Walters, W.P.1
Green, J.2
Weiss, J.R.3
Murcko, M.A.4
-
9
-
-
84859574809
-
-
Bull, J. A.; Mousseau, J. J.; Pelletier, G.; Charette, A. B. Chem. Rev. 2012, 112, 2642
-
(2012)
Chem. Rev.
, vol.112
, pp. 2642
-
-
Bull, J.A.1
Mousseau, J.J.2
Pelletier, G.3
Charette, A.B.4
-
10
-
-
84887473763
-
-
Silva, E. M. P.; Varandas, P. A. M. M.; Silva, A. M. S. Synthesis 2013, 45, 3053
-
(2013)
Synthesis
, vol.45
, pp. 3053
-
-
Silva, E.M.P.1
Varandas, P.A.M.M.2
Silva, A.M.S.3
-
11
-
-
14744305091
-
-
Mateeva, N. N.; Winfield, L. L.; Redda, K. K. Curr. Med. Chem. 2005, 12, 551
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 551
-
-
Mateeva, N.N.1
Winfield, L.L.2
Redda, K.K.3
-
13
-
-
84924255612
-
-
Tait, M. B.; Butterworth, S.; Clayden, J. Org. Lett. 2015, 17, 1236
-
(2015)
Org. Lett.
, vol.17
, pp. 1236
-
-
Tait, M.B.1
Butterworth, S.2
Clayden, J.3
-
14
-
-
84902097373
-
-
Ballete, R.; Perez, M.; Proto, S.; Amat, M.; Bosch, J. Angew. Chem., Int. Ed. 2014, 53, 6202
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 6202
-
-
Ballete, R.1
Perez, M.2
Proto, S.3
Amat, M.4
Bosch, J.5
-
15
-
-
84902009387
-
-
Pelletier, G. G.; Constantineau-Forget, L.; Charette, A. B. Chem. Commun. 2014, 50, 6883
-
(2014)
Chem. Commun.
, vol.50
, pp. 6883
-
-
Pelletier, G.G.1
Constantineau-Forget, L.2
Charette, A.B.3
-
17
-
-
84890895066
-
-
Mizoguchi, H.; Oikawa, H.; Oguri, H. Nat. Chem. 2014, 6, 57
-
(2014)
Nat. Chem.
, vol.6
, pp. 57
-
-
Mizoguchi, H.1
Oikawa, H.2
Oguri, H.3
-
18
-
-
84889675460
-
-
Jäkel, M.; Qu, J.; Schnitzer, T.; Helmchen, G. Chem.-Eur. J. 2013, 19, 16746
-
(2013)
Chem.-Eur. J.
, vol.19
, pp. 16746
-
-
Jäkel, M.1
Qu, J.2
Schnitzer, T.3
Helmchen, G.4
-
19
-
-
84877255528
-
-
Martin, T. J.; Rovis, T. Angew. Chem., Int. Ed. 2013, 52, 5368
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 5368
-
-
Martin, T.J.1
Rovis, T.2
-
20
-
-
84866390866
-
-
Potowski, M.; Bauer, J. O.; Strohmann, C.; Antonchick, A. P.; Waldmann, H. Angew. Chem., Int. Ed. 2012, 51, 9512
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 9512
-
-
Potowski, M.1
Bauer, J.O.2
Strohmann, C.3
Antonchick, A.P.4
Waldmann, H.5
-
21
-
-
84855695835
-
-
Brizgys, G. J.; Jung, H. H.; Floreancig, P. E. Chem. Sci. 2012, 3, 438
-
(2012)
Chem. Sci.
, vol.3
, pp. 438
-
-
Brizgys, G.J.1
Jung, H.H.2
Floreancig, P.E.3
-
22
-
-
84873804312
-
-
Chen, F.; Tan, C. K.; Yeung, Y.-Y. J. Am. Chem. Soc. 2013, 135, 1232
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 1232
-
-
Chen, F.1
Tan, C.K.2
Yeung, Y.-Y.3
-
25
-
-
41449111035
-
-
Colby, D. A.; Bergman, R. G.; Ellman, J. A. J. Am. Chem. Soc. 2008, 130, 3645
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 3645
-
-
Colby, D.A.1
Bergman, R.G.2
Ellman, J.A.3
-
26
-
-
84857887706
-
-
Duttwyler, S.; Lu, C.; Rheingold, A. L.; Bergman, R. G.; Ellman, J. A. J. Am. Chem. Soc. 2012, 134, 4064
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 4064
-
-
Duttwyler, S.1
Lu, C.2
Rheingold, A.L.3
Bergman, R.G.4
Ellman, J.A.5
-
27
-
-
84873509255
-
-
Duttwyler, S.; Chen, S.; Takase, M. K.; Wiberg, K. B.; Bergman, R. G.; Ellman, J. A. Science 2013, 339, 678
-
(2013)
Science
, vol.339
, pp. 678
-
-
Duttwyler, S.1
Chen, S.2
Takase, M.K.3
Wiberg, K.B.4
Bergman, R.G.5
Ellman, J.A.6
-
28
-
-
84874083310
-
-
Ischay, M. A.; Takase, M. K.; Bergman, R. G.; Ellman, J. A. J. Am. Chem. Soc. 2013, 135, 2478
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 2478
-
-
Ischay, M.A.1
Takase, M.K.2
Bergman, R.G.3
Ellman, J.A.4
-
29
-
-
84898076230
-
-
Duttwyler, S.; Chen, S.; Lu, C.; Mercado, B. Q.; Bergman, R. G.; Ellman, J. A. Angew. Chem., Int. Ed. 2014, 53, 3877
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 3877
-
-
Duttwyler, S.1
Chen, S.2
Lu, C.3
Mercado, B.Q.4
Bergman, R.G.5
Ellman, J.A.6
-
30
-
-
0006730959
-
-
Quick, J.; Khandelwal, Y.; Meltzer, P. C.; Weinberg, J. S. J. Org. Chem. 1983, 48, 5199
-
(1983)
J. Org. Chem.
, vol.48
, pp. 5199
-
-
Quick, J.1
Khandelwal, Y.2
Meltzer, P.C.3
Weinberg, J.S.4
-
31
-
-
0000351426
-
-
Asensio, G.; Mello, R.; Boix-Bernardini, C.; Gonzalez-Nunez, M. E.; Castellano, G. J. Org. Chem. 1995, 60, 3692
-
(1995)
J. Org. Chem.
, vol.60
, pp. 3692
-
-
Asensio, G.1
Mello, R.2
Boix-Bernardini, C.3
Gonzalez-Nunez, M.E.4
Castellano, G.5
-
32
-
-
0033603592
-
-
Asensio, G.; Boix-Bernardini, C.; Andreu, C.; Gonzalez-Nunez, M. E.; Mello, R.; Edwards, J. O.; Castellano, G. J. Org. Chem. 1999, 64, 4705
-
(1999)
J. Org. Chem.
, vol.64
, pp. 4705
-
-
Asensio, G.1
Boix-Bernardini, C.2
Andreu, C.3
Gonzalez-Nunez, M.E.4
Mello, R.5
Edwards, J.O.6
Castellano, G.7
-
33
-
-
0042160897
-
-
Gil, L.; Compere, D.; Guilloteau-Bertin, B.; Chiaroni, A.; Marazano, C. Synthesis 2000, 14, 2117
-
(2000)
Synthesis
, vol.14
, pp. 2117
-
-
Gil, L.1
Compere, D.2
Guilloteau-Bertin, B.3
Chiaroni, A.4
Marazano, C.5
-
34
-
-
0036305675
-
-
Edwards, A. S.; Wybrow, R. A. J.; Johnstone, C.; Adams, H.; Harrity, J. P. A. Chem. Commun. 2002, 1542
-
(2002)
Chem. Commun.
, pp. 1542
-
-
Edwards, A.S.1
Wybrow, R.A.J.2
Johnstone, C.3
Adams, H.4
Harrity, J.P.A.5
-
36
-
-
20844443487
-
-
Grishina, G. V.; Borisenko, A. A.; Veselov, I. S.; Petrenko, A. M. Russ. J. Org. Chem. 2005, 41, 272
-
(2005)
Russ. J. Org. Chem.
, vol.41
, pp. 272
-
-
Grishina, G.V.1
Borisenko, A.A.2
Veselov, I.S.3
Petrenko, A.M.4
-
37
-
-
53649111621
-
-
Aciro, C.; Claridge, T. D. W.; Davies, S. G.; Roberts, P. M.; Russell, A. J.; Thomson, J. E. Org. Biomol. Chem. 2008, 6, 3751
-
(2008)
Org. Biomol. Chem.
, vol.6
, pp. 3751
-
-
Aciro, C.1
Claridge, T.D.W.2
Davies, S.G.3
Roberts, P.M.4
Russell, A.J.5
Thomson, J.E.6
-
38
-
-
53549104716
-
-
Aciro, C.; Davies, S. G.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E. Org. Biomol. Chem. 2008, 6, 3762
-
(2008)
Org. Biomol. Chem.
, vol.6
, pp. 3762
-
-
Aciro, C.1
Davies, S.G.2
Roberts, P.M.3
Russell, A.J.4
Smith, A.D.5
Thomson, J.E.6
-
39
-
-
69549117003
-
-
Bond, C. W.; Cresswell, A. J.; Davies, S. G.; Kurosawa, W.; Lee, J. A.; Fletcher, A. M.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E. J. Org. Chem. 2009, 74, 6735
-
(2009)
J. Org. Chem.
, vol.74
, pp. 6735
-
-
Bond, C.W.1
Cresswell, A.J.2
Davies, S.G.3
Kurosawa, W.4
Lee, J.A.5
Fletcher, A.M.6
Roberts, P.M.7
Russell, A.J.8
Smith, A.D.9
Thomson, J.E.10
-
40
-
-
78449236740
-
-
Davies, S. G.; Fletcher, A. M.; Kurosawa, W.; Lee, J. A.; Poce, G.; Roberts, P. M.; Thomson, J. E.; Williamson, D. M. J. Org. Chem. 2010, 75, 7745
-
(2010)
J. Org. Chem.
, vol.75
, pp. 7745
-
-
Davies, S.G.1
Fletcher, A.M.2
Kurosawa, W.3
Lee, J.A.4
Poce, G.5
Roberts, P.M.6
Thomson, J.E.7
Williamson, D.M.8
-
41
-
-
79953165311
-
-
Bagal, S. K.; Davies, S. G.; Fletcher, A. M.; Lee, J. A.; Roberts, P. M.; Scott, P. M.; Thomson, J. E. Tetrahedron Lett. 2011, 52, 2216
-
(2011)
Tetrahedron Lett.
, vol.52
, pp. 2216
-
-
Bagal, S.K.1
Davies, S.G.2
Fletcher, A.M.3
Lee, J.A.4
Roberts, P.M.5
Scott, P.M.6
Thomson, J.E.7
-
42
-
-
84866081954
-
-
Brennan, M. B.; Claridge, T. D. W.; Compton, R. G.; Davies, S. G.; Fletcher, A. M.; Henstridge, M. C.; Hewings, D. S.; Kurosawa, W.; Lee, J. A.; Roberts, P. M.; Schoonen, A. K.; Thomson, J. E. J. Org. Chem. 2012, 77, 7241
-
(2012)
J. Org. Chem.
, vol.77
, pp. 7241
-
-
Brennan, M.B.1
Claridge, T.D.W.2
Compton, R.G.3
Davies, S.G.4
Fletcher, A.M.5
Henstridge, M.C.6
Hewings, D.S.7
Kurosawa, W.8
Lee, J.A.9
Roberts, P.M.10
Schoonen, A.K.11
Thomson, J.E.12
-
43
-
-
84902266263
-
-
Davies, S. G.; Fletcher, A. M.; Thomson, J. E. Org. Biomol. Chem. 2014, 12, 4544
-
(2014)
Org. Biomol. Chem.
, vol.12
, pp. 4544
-
-
Davies, S.G.1
Fletcher, A.M.2
Thomson, J.E.3
-
44
-
-
84927739617
-
-
Brennan, M. B.; Davies, S. G.; Fletcher, A. M.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E. Aust. J. Chem. 2015, 68, 610
-
(2015)
Aust. J. Chem.
, vol.68
, pp. 610
-
-
Brennan, M.B.1
Davies, S.G.2
Fletcher, A.M.3
Lee, J.A.4
Roberts, P.M.5
Russell, A.J.6
Thomson, J.E.7
-
46
-
-
79957878206
-
-
Cresswell, A. J.; Davies, S. G.; Lee, J. A. M.; Morris, J.; Roberts, P. M.; Thomson, J. E. J. Org. Chem. 2011, 76, 4617
-
(2011)
J. Org. Chem.
, vol.76
, pp. 4617
-
-
Cresswell, A.J.1
Davies, S.G.2
Lee, J.A.M.3
Morris, J.4
Roberts, P.M.5
Thomson, J.E.6
-
49
-
-
0000473902
-
-
Rao, A. S.; Paknikar, S. K.; Kirtane, J. G. Tetrahedron 1983, 39, 2323
-
(1983)
Tetrahedron
, vol.39
, pp. 2323
-
-
Rao, A.S.1
Paknikar, S.K.2
Kirtane, J.G.3
-
50
-
-
33845279387
-
-
Pocker, Y.; Ronald, B. P.; Anderson, K. W. J. Am. Chem. Soc. 1988, 110, 6492
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 6492
-
-
Pocker, Y.1
Ronald, B.P.2
Anderson, K.W.3
-
51
-
-
85017735140
-
-
For detailed information (structure, bioactivity, published studies, ongoing clinical trials, applications, and usage) of epoxide-containing drugs and drug candidates, enter the following names into PubChem (): spiriva (CID 5487426), scopoderm (CID 5184), kyprolis (CID 11556711), inspra (CID 443872), ixempra (CID 6445540), fumagillin (CID 6917655).
-
For detailed information (structure, bioactivity, published studies, ongoing clinical trials, applications, and usage) of epoxide-containing drugs and drug candidates, enter the following names into PubChem (http://pubchem.ncbi.nlm.nih.gov/): spiriva (CID 5487426), scopoderm (CID 5184), kyprolis (CID 11556711), inspra (CID 443872), ixempra (CID 6445540), fumagillin (CID 6917655).
-
-
-
-
52
-
-
85017747214
-
-
Synthetic details, characterization, and molecular structures obtained by X-ray structural analysis of compounds are described in the Supporting Information under CCDC nos. 1000666 (4a), 1000667 (4g), 1000668 (5a), 1000669 (5c), 1000670 (6a), and 1000671 (6b). These data can be obtained free of charge from the Cambridge Crystallographic Data Centre via.
-
Synthetic details, characterization, and molecular structures obtained by X-ray structural analysis of compounds are described in the Supporting Information under CCDC nos.: 1000666 (4a), 1000667 (4g), 1000668 (5a), 1000669 (5c), 1000670 (6a), and 1000671 (6b). These data can be obtained free of charge from the Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data
-
-
-
-
54
-
-
0001760756
-
-
Hamper, B. C.; Kurtzweil, M. L.; Beck, J. P. J. Org. Chem. 1992, 57, 5680
-
(1992)
J. Org. Chem.
, vol.57
, pp. 5680
-
-
Hamper, B.C.1
Kurtzweil, M.L.2
Beck, J.P.3
|