Role of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of hypertensive rats

American Journal of Translational Research

Volumn 7, Issue 8, 2015, Pages 1345-1356

  Shao, Shuai ^a   Cai, Wenwei ^a   Sheng, Jing ^a   Yin, Lingni ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Myocardial fibrosis; Myofibroblasts; Spontaneous hypertensive rat; Stromal cell derived factor 1; Wnt signaling pathway

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; BETA1 INTEGRIN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; STROMAL CELL DERIVED FACTOR 1; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEART EJECTION FRACTION; HEART MUSCLE FIBROSIS; HYPERTENSION; IMMUNOFLUORESCENCE; MYOFIBROBLAST; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; WOUND HEALING;

EID: 84941218159     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Rich MW. The year in quality of care in heart failure. J Card Fail 2011; 17: 443-450.
2. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Mc- Dermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND and Wylie-Rosett J. Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation 2011; 123: e18-e209.
3. Berk BC, Fujiwara K and Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest 2007; 117: 568-575.
4. Reed AL, Tanaka A, Sorescu D, Liu H, Jeong EM, Sturdy M, Walp ER, Dudley SC Jr and Sutliff RL. Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse. Am J Physiol Heart Circ Physiol 2011; 301: H824-831.
5. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T and Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995; 28: 495-500.
6. Zernecke A and Weber C. Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol 2014; 34: 742-750.
7. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd and Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003; 423: 448-452.
8. Segura AM, Frazier OH and Buja LM. Fibrosis and heart failure. Heart Fail Rev 2014; 19: 173-185.
9. Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, Kaye DM and Taylor AJ. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast- enhanced T1 mapping. J Am Coll Cardiol 2008; 52: 1574-1580.
10. Nagase H, Visse R and Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006; 69: 562-573.
11. Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O and Zlotnik A. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev 2014; 66: 1-79.
12. Gao C and Chen YG. Dishevelled: The hub of Wnt signaling. Cell Signal 2010; 22: 717-727.
13. Rao TP and Kuhl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 2010; 106: 1798-1806.
14. Kruithof BP, van Wijk B, Somi S, Kruithof-de Julio M, Perez Pomares JM, Weesie F, Wessels A, Moorman AF and van den Hoff MJ. BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage. Dev Biol 2006; 295: 507- 522.
15. Marguerie A, Bajolle F, Zaffran S, Brown NA, Dickson C, Buckingham ME and Kelly RG. Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc Res 2006; 71: 50- 60.
16. Bergmann MW. WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac development. Circ Res 2010; 107: 1198-1208.
17. Cerutti C, Kurdi M, Bricca G, Hodroj W, Paultre C, Randon J and Gustin MP. Transcriptional alterations in the left ventricle of three hypertensive rat models. Physiol Genomics 2006; 27: 295-308.
18. Schumann H, Holtz J, Zerkowski HR and Hatzfeld M. Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. Cardiovasc Res 2000; 45: 720-728.
19. Laeremans H, Rensen SS, Ottenheijm HC, Smits JF and Blankesteijn WM. Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovasc Res 2010; 87: 514-523.
20. He W, Zhang L, Ni A, Zhang Z, Mirotsou M, Mao L, Pratt RE and Dzau VJ. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A 2010; 107: 21110-21115.
21. Wang Z and Ma Q. Beta-catenin is a promising key factor in the SDF-1/CXCR4 axis on metastasis of pancreatic cancer. Med Hypotheses 2007; 69: 816-820.
22. Luo Y, Cai J, Xue H, Mattson MP and Rao MS. SDF1alpha/CXCR4 signaling stimulates betacatenin transcriptional activity in rat neural progenitors. Neurosci Lett 2006; 398: 291- 295.
23. Hu TH, Yao Y, Yu S, Han LL, Wang WJ, Guo H, Tian T, Ruan ZP, Kang XM, Wang J, Wang SH and Nan KJ. SDF-1/CXCR4 promotes epithelial- mesenchymal transition and progression of colorectal cancer by activation of the Wnt/beta- catenin signaling pathway. Cancer Lett 2014; 354: 417-426.
24. Desai VD, Hsia HC and Schwarzbauer JE. Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells. PLoS One 2014; 9: e86865.
25. Kania G, Blyszczuk P and Eriksson U. Mechanisms of cardiac fibrosis in inflammatory heart disease. Trends Cardiovasc Med 2009; 19: 247-252.
26. Ashrafian H, McKenna WJ and Watkins H. Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy. Circ Res 2011; 109: 86-96.