Inhibition of kinin B1 receptors attenuates pulmonary hypertension and vascular remodeling

Hypertension

Volumn 66, Issue 4, 2015, Pages 906-912

  Murugesan, Priya ^a   Hildebrandt, Tobias ^b   Bernlöhr, Christian ^b   Lee, Dongwon ^a   Khang, Gilson ^a   Doods, Henri ^b   Wu, Dongmei ^a,c  

^a Chonbuk National University   (South Korea)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

hypertension; hypertrophy; inflammation; kinin B1 receptor antagonist; kinins; pulmonary; right heart hypertrophy; right ventricular; vascular remodeling

Indexed keywords

BI 113823; BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; CD68 ANTIGEN; CYCLINE; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MONOCROTALINE; UNCLASSIFIED DRUG; DNA; KININ;

AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG ARTERY PRESSURE; LUNG LAVAGE; LUNG RESECTION; MACROPHAGE; MALE; NEOINTIMA; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR REMODELING; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DNA; GENE EXPRESSION REGULATION; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; KININS; MALE; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; VASCULAR REMODELING;

EID: 84941208565     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05338     Document Type: Article

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