Living donor kidney transplantation: Overcoming disparities in live kidney donation in the US—recommendations from a consensus conference

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 9, 2015, Pages 1687-1695

  Rodrigue, James R ^a   Kazley, Abby Swanson ^b   Mandelbrot, Didier A ^c   Hays, Rebecca ^c   Rudow, Dianne LaPointe ^d   Baliga, Prabhakar ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c University of Wisconsin Health   (United States)

^d MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL PRACTICE; CONSENSUS DEVELOPMENT; END STAGE RENAL DISEASE; FINANCIAL MANAGEMENT; GEOGRAPHICAL VARIATION (SPECIES); HUMAN; KIDNEY TRANSPLANTATION; LIVING DONOR; LOWEST INCOME GROUP; NEPHROLOGIST; QUALITY OF LIFE; SEX DIFFERENCE; AFRICAN AMERICAN; CONSENSUS; CULTURAL COMPETENCE; ECONOMICS; EDUCATION; EVIDENCE BASED MEDICINE; GRAFT RECIPIENT; HEALTH CARE DELIVERY; HEALTH CARE DISPARITY; INCOME; MINORITY GROUP; PATIENT EDUCATION; RESEARCH; STANDARDS; TRENDS; UNITED STATES;

AFRICAN AMERICANS; AGE FACTORS; CONSENSUS; CULTURAL COMPETENCY; EVIDENCE-BASED MEDICINE; HEALTH SERVICES ACCESSIBILITY; HEALTHCARE DISPARITIES; HUMANS; INCOME; KIDNEY TRANSPLANTATION; LIVING DONORS; MINORITY GROUPS; PATIENT EDUCATION AS TOPIC; RESEARCH; SEX FACTORS; TRANSPLANT RECIPIENTS; UNITED STATES;

EID: 84941204842     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.00700115     Document Type: Article

References (76)

1. Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR): OPTN/SRTR 2012 Annual Data Report, Rockville, MD, Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, 2014
2. : 2014 Annual Data Report: An Overview of the Epidemiology of Kidney Disease in the United States, Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2014
3. Purnell TS, Auguste P, Crews DC, Lamprea-Montealegre J, Olufade T, Greer R, Ephraim P, Sheu J, Kostecki D, Powe NR, Rabb H, Jaar B, Boulware LE: Comparison of life participation activities among adults treated by hemodialysis, peritoneal dialysis, and kidney transplantation: A systematic review. Am J Kidney Dis 62: 953–973, 2013
4. Ladin K, Rodrigue JR, Hanto DW: Framing disparities along the continuum of care from chronic kidney disease to transplantation: Barriers and interventions. Am J Transplant 9: 669–674, 2009
5. Gore JL, Danovitch GM, Litwin MS, Pham PT, Singer JS: Disparities in the utilization of live donor renal transplantation. Am J Transplant 9: 1124–1133, 2009
6. Axelrod DA, Dzebisashvili N, Schnitzler MA, Salvalaggio PR, Segev DL, Gentry SE, Tuttle-Newhall J, Lentine KL: The interplay of socioeconomic status, distance to center, and interdonor service area travel on kidney transplant access and outcomes. Clin J Am Soc Nephrol 5: 2276–2288, 2010
7. Gupta G, Unruh ML, Nolin TD, Hasley PB: Primary care of the renal transplant patient. J Gen Intern Med 25: 731–740, 2010
8. McGill RL, Ko TY: Transplantation and the primary care physician. Adv Chronic Kidney Dis 18: 433–438, 2011
9. Rodrigue JR, Schold JD, Mandelbrot DA: The decline in living kidney donation in the United States: Random variation or cause for concern? Transplantation 96: 767–773, 2013
10. LaPointe Rudow D, Hays R, Baliga P, Cohen DJ, Cooper M, Danovitch GM, Dew MA, Gordon EJ, Mandelbrot DA, McGuire S, Milton J, Moore DR, Morgievich M, Schold JD, Segev DL, Serur D, Steiner RW, Tan JC, Waterman AD, Zavala EY, Rodrigue JR: Consensus conference on best practices in live kidney donation: recommendations to optimize education, access, and care. Am J Transplant 15: 914–922, 2015
11. Leichtman A, Abecassis M, Barr M, Charlton M, Cohen D, Confer D, Cooper M, Danovitch G, Davis C, Delmonico F, Dew MA, Garvey C, Gaston R, Gill J, Gillespie B, Ibrahim H, Jacobs C, Kahn J, Kasiske B, Kim J, Lentine K, Manyalich M, Medina- Pestana J, Merion R, Moxey-Mims M, Odim J, Opelz G, Orlowski J, Rizvi A, Roberts J, Segev D, Sledge T, Steiner R, Taler S, Textor S, Thiel G, Waterman A, Williams E, Wolfe R, Wynn J, Matas AJ; Living Kidney Donor Follow-Up Conference Writing Group: Living kidney donor follow-up: state-of-the-art and future directions, conference summary and recommendations. Am J Transplant 11: 2561–2568, 2011
12. Melcher ML, Blosser CD, Baxter-Lowe LA, Delmonico FL, Gentry SE, Leishman R, Knoll GA, Leffell MS, Leichtman AB, Mast DA, Nickerson PW, Reed EF, Rees MA, Rodrigue JR, Segev DL, Serur D, Tullius SG, Zavala EY, Feng S: Dynamic challenges inhibiting optimal adoption of kidney paired donation: Findings of a consensus conference. Am J Transplant 13: 851–860, 2013
13. Purnell TS, Hall YN, Boulware LE: Understanding and overcoming barriers to living kidney donation among racial and ethnic minorities in the United States. Adv Chronic Kidney Dis 19: 244–251, 2012
14. Waterman AD, Rodrigue JR, Purnell TS, Ladin K, Boulware LE: Addressing racial and ethnic disparities in live donor kidney transplantation: Priorities for research and intervention. Semin Nephrol 30: 90–98, 2010
15. Freeman MA, Myaskovsky L: An overview of disparities and interventions in pediatric kidney transplantation worldwide [published online ahead of print October 15, 2014]. Pediatr Nephrol doi:10.1007/s00467-014-2879-3
16. Purnell TS, Xu P, Leca N, Hall YN: Racial differences in determinants of live donor kidney transplantation in theUnited States. Am J Transplant 13: 1557–1565, 2013
17. Stolzmann KL, Bautista LE, Gangnon RE, McElroy JA, Becker BN, Remington PL: Trends in kidney transplantation rates and disparities. J Natl Med Assoc 99: 923–932, 2007
18. Gordon EJ, Ladner DP, Caicedo JC, Franklin J: Disparities in kidney transplant outcomes: A review. Semin Nephrol 30: 81–89, 2010
19. Hall YN, Choi AI, Xu P, O’Hare AM, Chertow GM: Racial ethnic differences in rates and determinants of deceased donor kidney transplantation. J Am Soc Nephrol 22: 743–751, 2011
20. Lentine KL, Schnitzler MA, Xiao H, Saab G, Salvalaggio PR, AxelrodD, Davis CL, Abbott KC, BrennanDC: Racial variation in medical outcomes among living kidney donors. N Engl J Med 363: 724–732, 2010
21. Muzaale AD, Massie AB, Wang MC, Montgomery RA, McBride MA, Wainright JL, Segev DL: Risk of end-stage renal disease following live kidney donation. JAMA 311: 579–586, 2014
22. Pollak MR, Genovese G, Friedman DJ: APOL1 and kidney disease. Curr Opin Nephrol Hypertens 21: 179–182, 2012
23. Lentine KL, Segev DL: Health outcomes among non-Caucasian living kidney donors: Knowns and unknowns. Transpl Int 26: 853–864, 2013
24. Cohen DM, Mittalhenkle A, Scott DL, Young CJ, Norman DJ: African American living-kidney donors should be screened for APOL1 risk alleles. Transplantation 92: 722–725, 2011
25. Tan JC, Dew MA, Rudow DL, Steiner RW, Woodle S, Hays R, Rodrigue JR, Segev DL: Best practices in education for providers and potential donors regarding living kidney donation. Clin J Am Soc Nephrol 10: 1670–1677, 2015
26. Navaneethan SD, Singh S: A systematic review of barriers in access to renal transplantation among African Americans in the United States. Clin Transplant 20: 769–775, 2006
27. Shilling LM, Norman ML, Chavin KD, Hildebrand LG, Lunsford SL, Martin MS, Milton JE, Smalls GR, Baliga PK: Healthcare professionals’ perceptions of the barriers to living donor kidney transplantation among African Americans. J Natl Med Assoc 98: 834–840, 2006
28. Lunsford SL, Simpson KS, Chavin KD, Hildebrand LG, Miles LG, Shilling LM, Smalls GR, Baliga PK: Racial differences in coping with the need for kidney transplantation and willingness to ask for live organ donation. Am J Kidney Dis 47: 324–331, 2006
29. Siegel JT, Alvaro EM, Hohman ZP, Maurer D: “Can you spare an organ?”: Exploring Hispanic Americans’ willingness to discuss living organ donationwith loved ones. Health Commun 26: 754–764, 2011
30. Boulware LE, Meoni LA, Fink NE, Parekh RS, Kao WH, Klag MJ, Powe NR: Preferences, knowledge, communication and patientphysician discussion of living kidney transplantation in African American families. Am J Transplant 5: 1503–1512, 2005
31. Rodrigue JR, Paek MJ, Egbuna O, Waterman AD, Schold JD, Pavlakis M, Mandelbrot DA: Readiness of wait-listed black patients to pursue live donor kidney transplant. Prog Transplant 24: 355–361, 2014
32. Rodrigue JR, Leishman R, Vishnevsky T, Evenson A, Mandelbrot DA: Concerns of ABO incompatible and crossmatch-positive potential donors and recipients about participating in kidney exchanges. Clin Transplant 29: 233–241, 2015
33. Boulware LE, Ratner LE, Sosa JA, Cooper LA, LaVeist TA, Powe NR: Determinants of willingness to donate living related and cadaveric organs: Identifying opportunities for intervention. Transplantation 73: 1683–1691, 2002
34. Robinson DH, Klammer SM, Perryman JP, Thompson NJ, Arriola KR: Understanding African American’s religious beliefs and organ donation intentions. J Relig Health 53: 1857–1872, 2014
35. Siegel JT, Alvaro EM, Lac A, Crano WD, Dominick A: Intentions of becoming a living organ donor among Hispanics: A theorybased approach exploring differences between living and nonliving organ donation. J Health Commun 13: 80–99, 2008
36. Tong A, Chapman JR, Wong G, Josephson MA, Craig JC: Public awareness and attitudes to living organ donation: Systematic review and integrative synthesis. Transplantation 96: 429–437, 2013
37. Lunsford SL, Simpson KS, Chavin KD, Menching KJ, Miles LG, Shilling LM, Smalls GR, Baliga PK: Racial disparities in living kidney donation: Is there a lack ofwilling donors or an excess ofmedically unsuitable candidates? Transplantation 82: 876–881, 2006
38. Bratton C, Chavin K, Baliga P: Racial disparities in organ donation and why. Curr Opin Organ Transplant 16: 243–249, 2011
39. Schold JD, Heaphy EL, Buccini LD, Poggio ED, Srinivas TR, Goldfarb DA, Flechner SM, Rodrigue JR, Thornton JD, Sehgal AR: Prominent impact of community risk factors on kidney transplant candidate processes and outcomes. Am J Transplant 13: 2374–2383, 2013
40. Gill JS, Gill J, Barnieh L, Dong J, Rose C, Johnston O, Tonelli M, Klarenbach S: Income of living kidney donors and the income difference between living kidney donors and their recipients in the United States. Am J Transplant 12: 3111–3118, 2012
41. Clarke KS, Klarenbach S, Vlaicu S, Yang RC, Garg AX; Donor NephrectomyOutcomes Research (DONOR)Network: The direct and indirect economic costs incurred by living kidney donors-a systematic review. Nephrol Dial Transplant 21: 1952–1960, 2006
42. Dew MA, Jacobs CL: Psychosocial and socioeconomic issues facing the living kidney donor. Adv Chronic Kidney Dis 19: 237–243, 2012
43. Klarenbach S, Gill JS, Knoll G, Caulfield T, Boudville N, Prasad GV, Karpinski M, Storsley L, Treleaven D, Arnold J, Cuerden M, Jacobs P, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network: Economic consequences incurred by living kidney donors: A Canadian multi-center prospective study. Am J Transplant 14: 916–922, 2014
44. Klarenbach S, Gill JS, Knoll G, Caulfield T, Boudville N, Prasad GV, Karpinski M, Storsley L, Treleaven D, Arnold J, Cuerden M, Jacobs P, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network: Economic consequences incurred by living kidney donors: a Canadian multi-center prospective study. Am J Transplant 14: 916–922, 2014
45. Rodrigue JR, Cross NJ, Newman RC, Widows MR, Guenther RT, Kaplan B, Morgan MA, Howard RJ: Patient-reported outcomes for open versus laparoscopic living donor nephrectomy. Prog Transplant 16: 162–169, 2006
46. Rodrigue JR, Cross NJ, Newman RC, Widows MR, Guenther RT, Kaplan B, Morgan MA, Howard RJ: Patient-reported outcomes for open versus laparoscopic living donor nephrectomy. Prog Transplant 16: 162–169, 2006
47. Gill J, Dong J, Rose C, Johnston O, Landsberg D, Gill J: The effect of race and income on living kidney donation in the United States. J Am Soc Nephrol 24: 1872–1879, 2013
48. Gill J, Dong J, Gill J: Population income and longitudinal trends in living kidney donation in the United States. J Am Soc Nephrol 26: 201–207, 2015
49. Weng FL, Reese PP, Mulgaonkar S, Patel AM: Barriers to living donor kidney transplantation among black or older transplant candidates. Clin J Am Soc Nephrol 5: 2338–2347, 2010
50. Israni AK, Salkowski N, Gustafson S, Snyder JJ, Friedewald JJ, Formica RN, Wang X, Shteyn E, Cherikh W, Stewart D, Samana CJ, Chung A, Hart A, Kasiske BL: New national allocation policy for deceased donor kidneys in the United States and possible effect on patient outcomes. J Am Soc Nephrol 25: 1842–1848, 2014
51. Agarwal S, Oak N, Siddique J, Harland RC, Abbo ED: Changes in pediatric renal transplantation after implementation of the revised deceased donor kidney allocation policy. Am J Transplant 9: 1237–1242, 2009
52. Ahmadi AR, Lafranca JA, Claessens LA, Imamdi RM, IJzermans JN, Betjes MG, Dor FJ: Shifting paradigms in eligibility criteria for live kidney donation: A systematic review. Kidney Int 87: 31–45, 2015
53. Young A, Kim SJ, Speechley MR, Huang A, Knoll GA, Prasad GV, Treleaven D, Diamant M, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network: Accepting kidneys from older living donors: Impact on transplant recipient outcomes. Am J Transplant 11: 743–750, 2011
54. Gillespie A, Hammer H, Kolenikov S, Polychronopoulou A, Ouzienko V, Obradovic Z, Urbanski MA, Browne T, Silva P: Sex differences and attitudes toward living donor kidney transplantation among urban black patients on hemodialysis. Clin J Am Soc Nephrol 9: 1764–1772, 2014
55. Gill JS, Hendren E, Dong J, Johnston O, Gill J: Differential association of body mass index with access to kidney transplantation in men and women. Clin J Am Soc Nephrol 9: 951–959, 2014
56. US Renal Data System: USRDS 2013 Annual Data Report: Atlas of Chronic KidneyDisease and End-Stage Renal Disease in the United States, Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2013
57. Kayler LK, Meier-Kriesche HU, Punch JD, Campbell DA Jr, Leichtman AB, Magee JC, Rudich SM, Arenas JD, Merion RM: Gender imbalance in living donor renal transplantation. Transplantation 73: 248–252, 2002
58. Ashby VB, Kalbfleisch JD, Wolfe RA, Lin MJ, Port FK, Leichtman AB: Geographic variability in access to primary kidney transplantation in the United States, 1996-2005. Am J Transplant 7: 1412–1423, 2007
59. Davis AE, Mehrotra S, McElroy LM, Friedewald JJ, Skaro AI, Lapin B, Kang R, Holl JL, Abecassis MM, Ladner DP: The extent and predictors of waiting time geographic disparity in kidney transplantation in the United States. Transplantation 97: 1049–1057, 2014
60. Reese PP, Feldman HI, Bloom RD, Abt PL, Thomasson A, Shults J, Grossman R, Asch DA: Assessment of variation in live donor kidney transplantation across transplant centers in the United States. Transplantation 91: 1357–1363, 2011
61. Sullivan C, Leon JB, Sayre SS, Marbury M, Ivers M, Pencak JA, Bodziak KA, Hricik DE, Morrison EJ, Albert JM, Navaneethan SD, Reyes CM, Sehgal AR: Impact of navigators on completion of steps in the kidney transplant process: A randomized, controlled trial. Clin J Am Soc Nephrol 7: 1639–1645, 2012
62. Marlow NM, Simpson KN, Kazley AS, Balliet WE, Chavin KD, Baliga PK: Variations in coping stages for individuals with chronic kidney disease: Results from an exploratory study with patient navigators [published online ahead of print October 7, 2014]. J Health Psychol doi: 10.1177/1359105314551776
63. Rodrigue JR, Cornell DL, Lin JK, Kaplan B, Howard RJ: Increasing live donor kidney transplantation: A randomized controlled trial of a home-based educational intervention. Am J Transplant 7: 394–401, 2007
64. Rodrigue JR, Paek MJ, Egbuna O, Waterman AD, Schold JD, Pavlakis M, Mandelbrot DA: Making house calls increases living donor inquiries and evaluations for blacks on the kidney transplant waiting list. Transplantation 98: 979–986, 2014
65. Garonzik-Wang JM, Berger JC, Ros RL, Kucirka LM, Deshpande NA, Boyarsky BJ, Montgomery RA, Hall EC, James NT, Segev DL: Live donor champion: Finding live kidney donors by separating the advocate from the patient. Transplantation 93: 1147–1150, 2012
66. Pradel FG, Suwannaprom P, Mullins CD, Sadler J, Bartlett ST: Short-term impact of an educational program promoting live donor kidney transplantation in dialysis centers. Prog Transplant 18: 263–272, 2008
67. Boulware LE, Hill-Briggs F, Kraus ES, Melancon JK, Falcone B, Ephraim PL, Jaar BG, Gimenez L, Choi M, Senga M, Kolotos M, Lewis-Boyer L, Cook C, Light L, DePasquale N, Noletto T, Powe NR: Effectiveness of educational and social worker interventions to activate patients’ discussion and pursuit of preemptive living donor kidney transplantation: A randomized controlled trial. Am J Kidney Dis 61: 476–486, 2013
68. Waterman AD, Robbins ML, Paiva AL, Peipert JD, Kynard- Amerson CS, Goalby CJ, Davis LA, Thein JL, Schenk EA, Baldwin KA, Skelton SL, Amoyal NR, Brick LA: Your Path to Transplant: A randomized controlled trial of a tailored computer education intervention to increase living donor kidney transplant. BMC Nephrol 15: 166, 2014
69. Gordon EJ, Reddy E, Gil S, Feinglass J, Rodde J, Abecassis MM, Caicedo JC: Culturally competent transplant program improves Hispanics’ knowledge and attitudes about live kidney donation and transplant. Prog Transplant 24: 56–68, 2014
70. Warren PH, Gifford KA, Hong BA, Merion RM, Ojo AO: Development of the National Living Donor Assistance Center: Reducing financial disincentives to living organ donation. Prog Transplant 24: 76–81, 2014
71. Rodrigue JR, Crist K, Roberts JP, Freeman RB Jr, Merion RM, Reed AI: Stimulus for organ donation: Asurvey of the American Society of Transplant Surgeons membership. Am J Transplant 9: 2172–2176, 2009
72. Barnieh L, Klarenbach S, Gill JS, Caulfield T, Manns B: Attitudes toward strategies to increase organ donation: Views of the general public and health professionals. Clin J Am Soc Nephrol 7: 1956–1963, 2012
73. Tong A, Chapman JR, Wong G, Craig JC: Perspectives of transplant physicians and surgeons on reimbursement, compensation, and incentives for living kidney donors. Am J Kidney Dis 64: 622–632, 2014
74. Sickand M, Cuerden MS, Klarenbach SW, Ojo AO, Parikh CR, Boudville N, Garg AX; Donor Nephrectomy Outcomes Research Network: Reimbursing live organ donors for incurred non-medical expenses: A global perspective on policies and programs. Am J Transplant 9: 2825–2836, 2009
75. Lacetera N, Macis M, Stith SS: Removing financial barriers to organ and bone marrow donation: The effect of leave and tax legislation in the U.S. J Health Econ 33: 43–56, 2014
76. Venkataramani AS, Martin EG, Vijayan A, Wellen JR: The impact of tax policies on living organ donations in the United States. Am J Transplant 12: 2133–2140, 2012